LOCUS       NM_003019               1283 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens surfactant protein D (SFTPD), mRNA.
ACCESSION   NM_003019
VERSION     NM_003019.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1283)
  AUTHORS   Akhter,A., Moliva,J.I., Azad,A.K., Olmo-Fontanez,A.,
            Garcia-Vilanova,A., Scordo,J.M., Gavrilin,M.A., Diaz,P.T.,
            Endsley,J.J., Weintraub,S.T., Schlesinger,L.S., Wewers,M.D. and
            Torrelles,J.B.
  TITLE     HIV infection impairs the host response to Mycobacterium
            tuberculosis infection by altering surfactant protein D function in
            the human lung alveolar mucosa
  JOURNAL   Mucosal Immunol 17 (3), 461-475 (2024)
   PUBMED   38184074
  REMARK    GeneRIF: HIV infection impairs the host response to Mycobacterium
            tuberculosis infection by altering surfactant protein D function in
            the human lung alveolar mucosa.
REFERENCE   2  (bases 1 to 1283)
  AUTHORS   Avcibas,R., Vermul,A., Gluhovic,V., Boback,N., Arroyo,R.,
            Kingma,P., Isasi-Campillo,M., Garcia-Ortega,L., Griese,M.,
            Kuebler,W.M., Ochs,M., Lauster,D. and Lopez-Rodriguez,E.
  TITLE     Multivalent, calcium-independent binding of surfactant protein A
            and D to sulfated glycosaminoglycans of the alveolar epithelial
            glycocalyx
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 326 (5), L524-L538 (2024)
   PUBMED   38375572
  REMARK    GeneRIF: Multivalent, calcium-independent binding of surfactant
            protein A and D to sulfated glycosaminoglycans of the alveolar
            epithelial glycocalyx.
REFERENCE   3  (bases 1 to 1283)
  AUTHORS   Hata,K., Tsubouchi,K., Suzuki,K., Eto,D., Ando,H., Yanagihara,T.,
            Kan-O,K. and Okamoto,I.
  TITLE     Surfactant protein D prevents mucin overproduction in airway goblet
            cells via SIRPalpha
  JOURNAL   Sci Rep 14 (1), 1799 (2024)
   PUBMED   38245585
  REMARK    GeneRIF: Surfactant protein D prevents mucin overproduction in
            airway goblet cells via SIRPalpha.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1283)
  AUTHORS   De Luca,D., Arroyo,R., Foligno,S., Autilio,C., Touqui,L. and
            Kingma,P.S.
  TITLE     Early life surfactant protein-D levels in bronchoalveolar lavage
            fluids of extremely preterm neonates
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 325 (4), L411-L418 (2023)
   PUBMED   37489844
  REMARK    GeneRIF: Early life surfactant protein-D levels in bronchoalveolar
            lavage fluids of extremely preterm neonates.
REFERENCE   5  (bases 1 to 1283)
  AUTHORS   Rizvi,Z., Choudhry,N., Gondal,A.J. and Yasmin,N.
  TITLE     Association of Surfactant Protein D Single Nucleotide Polymorphisms
            rs721917, rs2243639, rs3088308 with Recurrent Aphthous Stomatitis
            in Pakistani Population
  JOURNAL   Genes (Basel) 14 (5), 1119 (2023)
   PUBMED   37239479
  REMARK    GeneRIF: Association of Surfactant Protein D Single Nucleotide
            Polymorphisms rs721917, rs2243639, rs3088308 with Recurrent
            Aphthous Stomatitis in Pakistani Population.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1283)
  AUTHORS   Crouch,E., Persson,A., Chang,D. and Heuser,J.
  TITLE     Molecular structure of pulmonary surfactant protein D (SP-D)
  JOURNAL   J Biol Chem 269 (25), 17311-17319 (1994)
   PUBMED   8006040
REFERENCE   7  (bases 1 to 1283)
  AUTHORS   Ogasawara,Y., Kuroki,Y. and Akino,T.
  TITLE     Pulmonary surfactant protein D specifically binds to
            phosphatidylinositol
  JOURNAL   J Biol Chem 267 (29), 21244-21249 (1992)
   PUBMED   1400434
REFERENCE   8  (bases 1 to 1283)
  AUTHORS   Lu,J., Willis,A.C. and Reid,K.B.
  TITLE     Purification, characterization and cDNA cloning of human lung
            surfactant protein D
  JOURNAL   Biochem J 284 (Pt 3) (Pt 3), 795-802 (1992)
   PUBMED   1339284
REFERENCE   9  (bases 1 to 1283)
  AUTHORS   Kuroki,Y., Shiratori,M., Ogasawara,Y., Tsuzuki,A. and Akino,T.
  TITLE     Characterization of pulmonary surfactant protein D: its
            copurification with lipids
  JOURNAL   Biochim Biophys Acta 1086 (2), 185-190 (1991)
   PUBMED   1932100
REFERENCE   10 (bases 1 to 1283)
  AUTHORS   Rust,K., Grosso,L., Zhang,V., Chang,D., Persson,A., Longmore,W.,
            Cai,G.Z. and Crouch,E.
  TITLE     Human surfactant protein D: SP-D contains a C-type lectin
            carbohydrate recognition domain
  JOURNAL   Arch Biochem Biophys 290 (1), 116-126 (1991)
   PUBMED   1898081
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC022318.1, BI820265.1 and
            BM985387.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003019.4.
            
            Summary: The protein encoded by this gene is part of the innate
            immune response, protecting the lungs against inhaled
            microorganisms and chemicals. The encoded protein may also be
            involved in surfactant metabolism. [provided by RefSeq, Jul 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC022318.1, BI821373.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            coronavirus related    :: involved in immune response or antiviral
                                      activity
            MANE Ensembl match     :: ENST00000372292.8/ ENSP00000361366.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-107               BC022318.1         2-108
            108-242             BI820265.1         80-214
            243-1063            BC022318.1         244-1064
            1064-1283           BM985387.1         17-236              c
FEATURES             Location/Qualifiers
     source          1..1283
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.3"
     gene            1..1283
                     /gene="SFTPD"
                     /gene_synonym="COLEC7; PSP-D; SFTP4; SP-D"
                     /note="surfactant protein D"
                     /db_xref="GeneID:6441"
                     /db_xref="HGNC:HGNC:10803"
                     /db_xref="MIM:178635"
     exon            1..40
                     /gene="SFTPD"
                     /gene_synonym="COLEC7; PSP-D; SFTP4; SP-D"
                     /inference="alignment:Splign:2.1.0"
     exon            41..242
                     /gene="SFTPD"
                     /gene_synonym="COLEC7; PSP-D; SFTP4; SP-D"
                     /inference="alignment:Splign:2.1.0"
     CDS             44..1171
                     /gene="SFTPD"
                     /gene_synonym="COLEC7; PSP-D; SFTP4; SP-D"
                     /note="surfactant-associated protein, pulmonary 4;
                     pulmonary surfactant apoprotein; pulmonary
                     surfactant-associated protein D; collectin-7; lung
                     surfactant protein D"
                     /codon_start=1
                     /product="pulmonary surfactant-associated protein D
                     precursor"
                     /protein_id="NP_003010.4"
                     /db_xref="CCDS:CCDS7362.1"
                     /db_xref="GeneID:6441"
                     /db_xref="HGNC:HGNC:10803"
                     /db_xref="MIM:178635"
                     /translation="MLLFLLSALVLLTQPLGYLEAEMKTYSHRTMPSACTLVMCSSVE
                     SGLPGRDGRDGREGPRGEKGDPGLPGAAGQAGMPGQAGPVGPKGDNGSVGEPGPKGDT
                     GPSGPPGPPGVPGPAGREGPLGKQGNIGPQGKPGPKGEAGPKGEVGAPGMQGSAGARG
                     LAGPKGERGVPGERGVPGNTGAAGSAGAMGPQGSPGARGPPGLKGDKGIPGDKGAKGE
                     SGLPDVASLRQQVEALQGQVQHLQAAFSQYKKVELFPNGQSVGEKIFKTAGFVKPFTE
                     AQLLCTQAGGQLASPRSAAENAALQQLVVAKNEAAFLSMTDSKTEGKFTYPTGESLVY
                     SNWAPGEPNDDGGSEDCVEIFTNGKWNDRACGEKRLVVCEF"
     exon            243..359
                     /gene="SFTPD"
                     /gene_synonym="COLEC7; PSP-D; SFTP4; SP-D"
                     /inference="alignment:Splign:2.1.0"
     exon            360..476
                     /gene="SFTPD"
                     /gene_synonym="COLEC7; PSP-D; SFTP4; SP-D"
                     /inference="alignment:Splign:2.1.0"
     exon            477..593
                     /gene="SFTPD"
                     /gene_synonym="COLEC7; PSP-D; SFTP4; SP-D"
                     /inference="alignment:Splign:2.1.0"
     exon            594..710
                     /gene="SFTPD"
                     /gene_synonym="COLEC7; PSP-D; SFTP4; SP-D"
                     /inference="alignment:Splign:2.1.0"
     exon            711..794
                     /gene="SFTPD"
                     /gene_synonym="COLEC7; PSP-D; SFTP4; SP-D"
                     /inference="alignment:Splign:2.1.0"
     exon            795..1283
                     /gene="SFTPD"
                     /gene_synonym="COLEC7; PSP-D; SFTP4; SP-D"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1255..1260
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SFTPD"
                     /gene_synonym="COLEC7; PSP-D; SFTP4; SP-D"
                     /note="hexamer: AATAAA"
     polyA_site      1283
                     /gene="SFTPD"
                     /gene_synonym="COLEC7; PSP-D; SFTP4; SP-D"
                     /note="major polyA site"
ORIGIN      
        1 agtttgcttg gagctcctgg ggcctaacaa aaagaaacct gccatgctgc tcttcctcct
       61 ctctgcactg gtcctgctca cacagcccct gggctacctg gaagcagaaa tgaagaccta
      121 ctcccacaga acaatgccca gtgcttgcac cctggtcatg tgtagctcag tggagagtgg
      181 cctgcctggt cgcgatggac gggatgggag agagggccct cggggcgaga agggggaccc
      241 aggtttgcca ggagctgcag ggcaagcagg gatgcctgga caagctggcc cagttgggcc
      301 caaaggggac aatggctctg ttggagaacc tggaccaaag ggagacactg ggccaagtgg
      361 acctccagga cctcccggtg tgcctggtcc agctggaaga gaaggtcccc tggggaagca
      421 ggggaacata ggacctcagg gcaagccagg cccaaaagga gaagctgggc ccaaaggaga
      481 agtaggtgcc ccaggcatgc agggctcggc aggggcaaga ggcctcgcag gccctaaggg
      541 agagcgaggt gtccctggtg agcgtggagt ccctggaaac acaggggcag cagggtctgc
      601 tggagccatg ggtccccagg gaagtccagg tgccagggga cccccgggat tgaaggggga
      661 caaaggcatt cctggagaca aaggagcaaa gggagaaagt gggcttccag atgttgcttc
      721 tctgaggcag caggttgagg ccttacaggg acaagtacag cacctccagg ctgctttctc
      781 tcagtataag aaagttgagc tcttcccaaa tggccaaagt gtcggggaga agattttcaa
      841 gacagcaggc tttgtaaaac catttacgga ggcacagctg ctgtgcacac aggctggtgg
      901 acagttggcc tctccacgct ctgccgctga gaatgccgcc ttgcaacagc tggtcgtagc
      961 taagaacgag gctgctttcc tgagcatgac tgattccaag acagagggca agttcaccta
     1021 ccccacagga gagtccctgg tctattccaa ctgggcccca ggggagccca acgatgatgg
     1081 cgggtcagag gactgtgtgg agatcttcac caatggcaag tggaatgaca gggcttgtgg
     1141 agaaaagcgt cttgtggtct gcgagttctg agccaactgg ggtgggtggg gcagtgcttg
     1201 gcccaggagt ttggccagaa gtcaaggctt agaccctcat gctgccaata tcctaataaa
     1261 aaggtgacca tctgtgccgg gaa
//
