LOCUS       NM_005411               2215 bp    mRNA    linear   PRI 11-OCT-2024
DEFINITION  Homo sapiens surfactant protein A1 (SFTPA1), transcript variant 1,
            mRNA.
ACCESSION   NM_005411
VERSION     NM_005411.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2215)
  AUTHORS   Avcibas,R., Vermul,A., Gluhovic,V., Boback,N., Arroyo,R.,
            Kingma,P., Isasi-Campillo,M., Garcia-Ortega,L., Griese,M.,
            Kuebler,W.M., Ochs,M., Lauster,D. and Lopez-Rodriguez,E.
  TITLE     Multivalent, calcium-independent binding of surfactant protein A
            and D to sulfated glycosaminoglycans of the alveolar epithelial
            glycocalyx
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 326 (5), L524-L538 (2024)
   PUBMED   38375572
  REMARK    GeneRIF: Multivalent, calcium-independent binding of surfactant
            protein A and D to sulfated glycosaminoglycans of the alveolar
            epithelial glycocalyx.
REFERENCE   2  (bases 1 to 2215)
  AUTHORS   Jacob,I.B., Gemmiti,A., Xiong,W., Reynolds,E., Nicholas,B.,
            Thangamani,S., Jia,H. and Wang,G.
  TITLE     Human surfactant protein A inhibits SARS-CoV-2 infectivity and
            alleviates lung injury in a mouse infection model
  JOURNAL   Front Immunol 15, 1370511 (2024)
   PUBMED   38596675
  REMARK    GeneRIF: Human surfactant protein A inhibits SARS-CoV-2 infectivity
            and alleviates lung injury in a mouse infection model.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2215)
  AUTHORS   Dong,S., Pang,H., Li,F., Hua,M., Liang,M. and Song,C.
  TITLE     Immunoregulatory function of SP-A
  JOURNAL   Mol Immunol 166, 58-64 (2024)
   PUBMED   38244369
  REMARK    GeneRIF: Immunoregulatory function of SP-A.
            Review article
REFERENCE   4  (bases 1 to 2215)
  AUTHORS   Garcia,C.K. and Talbert,J.L.
  TITLE     Pulmonary Fibrosis Predisposition Overview
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   20301408
REFERENCE   5  (bases 1 to 2215)
  AUTHORS   Childs,R.A., Wright,J.R., Ross,G.F., Yuen,C.T., Lawson,A.M.,
            Chai,W., Drickamer,K. and Feizi,T.
  TITLE     Specificity of lung surfactant protein SP-A for both the
            carbohydrate and the lipid moieties of certain neutral glycolipids
  JOURNAL   J Biol Chem 267 (14), 9972-9979 (1992)
   PUBMED   1577827
REFERENCE   6  (bases 1 to 2215)
  AUTHORS   Katyal,S.L., Singh,G. and Locker,J.
  TITLE     Characterization of a second human pulmonary surfactant-associated
            protein SP-A gene
  JOURNAL   Am J Respir Cell Mol Biol 6 (4), 446-452 (1992)
   PUBMED   1372511
REFERENCE   7  (bases 1 to 2215)
  AUTHORS   Endo,H. and Oka,T.
  TITLE     An immunohistochemical study of bronchial cells producing
            surfactant protein A in the developing human fetal lung
  JOURNAL   Early Hum Dev 25 (3), 149-156 (1991)
   PUBMED   1935736
REFERENCE   8  (bases 1 to 2215)
  AUTHORS   Fisher,J.H., Kao,F.T., Jones,C., White,R.T., Benson,B.J. and
            Mason,R.J.
  TITLE     The coding sequence for the 32,000-dalton pulmonary
            surfactant-associated protein A is located on chromosome 10 and
            identifies two separate restriction-fragment-length polymorphisms
  JOURNAL   Am J Hum Genet 40 (6), 503-511 (1987)
   PUBMED   2884868
REFERENCE   9  (bases 1 to 2215)
  AUTHORS   Floros,J., Steinbrink,R., Jacobs,K., Phelps,D., Kriz,R., Recny,M.,
            Sultzman,L., Jones,S., Taeusch,H.W., Frank,H.A. et al.
  TITLE     Isolation and characterization of cDNA clones for the 35-kDa
            pulmonary surfactant-associated protein
  JOURNAL   J Biol Chem 261 (19), 9029-9033 (1986)
   PUBMED   3755136
REFERENCE   10 (bases 1 to 2215)
  AUTHORS   White,R.T., Damm,D., Miller,J., Spratt,K., Schilling,J.,
            Hawgood,S., Benson,B. and Cordell,B.
  TITLE     Isolation and characterization of the human pulmonary surfactant
            apoprotein gene
  JOURNAL   Nature 317 (6035), 361-363 (1985)
   PUBMED   2995821
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA588383.1, BI820937.1,
            BX248123.5 and BM996243.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 1, 2019 this sequence version replaced NM_005411.4.
            
            Summary: This gene encodes a lung surfactant protein that is a
            member of a subfamily of C-type lectins called collectins. The
            encoded protein binds specific carbohydrate moieties found on
            lipids and on the surface of microorganisms. This protein plays an
            essential role in surfactant homeostasis and in the defense against
            respiratory pathogens. Mutations in this gene are associated with
            idiopathic pulmonary fibrosis. Alternate splicing results in
            multiple transcript variants. [provided by RefSeq, May 2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript. Variants 1, 3 and 4 encode the same isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: JX502764.1, HQ021438.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142363, SAMEA2144333
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000398636.8/ ENSP00000381633.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-17                DA588383.1         1-17
            18-613              BI820937.1         1-596
            614-2002            BX248123.5         98137-99525
            2003-2212           BM996243.1         19-228              c
            2213-2215           BX248123.5         99736-99738
FEATURES             Location/Qualifiers
     source          1..2215
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q22.3"
     gene            1..2215
                     /gene="SFTPA1"
                     /gene_synonym="COLEC4; ILD1; PSAP; PSP-A; PSPA; SFTP1;
                     SFTPA1B; SP-A; SP-A1; SP-A1 beta; SP-A1 delta; SP-A1
                     epsilon; SP-A1 gamma; SPA; SPA1"
                     /note="surfactant protein A1"
                     /db_xref="GeneID:653509"
                     /db_xref="HGNC:HGNC:10798"
                     /db_xref="MIM:178630"
     exon            1..44
                     /gene="SFTPA1"
                     /gene_synonym="COLEC4; ILD1; PSAP; PSP-A; PSPA; SFTP1;
                     SFTPA1B; SP-A; SP-A1; SP-A1 beta; SP-A1 delta; SP-A1
                     epsilon; SP-A1 gamma; SPA; SPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            45..115
                     /gene="SFTPA1"
                     /gene_synonym="COLEC4; ILD1; PSAP; PSP-A; PSPA; SFTP1;
                     SFTPA1B; SP-A; SP-A1; SP-A1 beta; SP-A1 delta; SP-A1
                     epsilon; SP-A1 gamma; SPA; SPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            116..310
                     /gene="SFTPA1"
                     /gene_synonym="COLEC4; ILD1; PSAP; PSP-A; PSPA; SFTP1;
                     SFTPA1B; SP-A; SP-A1; SP-A1 beta; SP-A1 delta; SP-A1
                     epsilon; SP-A1 gamma; SPA; SPA1"
                     /inference="alignment:Splign:2.1.0"
     CDS             139..885
                     /gene="SFTPA1"
                     /gene_synonym="COLEC4; ILD1; PSAP; PSP-A; PSPA; SFTP1;
                     SFTPA1B; SP-A; SP-A1; SP-A1 beta; SP-A1 delta; SP-A1
                     epsilon; SP-A1 gamma; SPA; SPA1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; surfactant protein A1B; surfactant,
                     pulmonary-associated protein A1A; surfactant,
                     pulmonary-associated protein A1B; collectin-4; alveolar
                     proteinosis protein; 35 kDa pulmonary
                     surfactant-associated protein"
                     /codon_start=1
                     /product="pulmonary surfactant-associated protein A1
                     isoform 1 precursor"
                     /protein_id="NP_005402.3"
                     /db_xref="CCDS:CCDS44445.1"
                     /db_xref="GeneID:653509"
                     /db_xref="HGNC:HGNC:10798"
                     /db_xref="MIM:178630"
                     /translation="MWLCPLALNLILMAASGAVCEVKDVCVGSPGIPGTPGSHGLPGR
                     DGRDGLKGDPGPPGPMGPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLPAH
                     LDEELQATLHDFRHQILQTRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGG
                     RIAVPRNPEENEAIASFVKKYNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAG
                     RGKEQCVEMYTDGQWNDRNCLYSRLTICEF"
     exon            311..430
                     /gene="SFTPA1"
                     /gene_synonym="COLEC4; ILD1; PSAP; PSP-A; PSPA; SFTP1;
                     SFTPA1B; SP-A; SP-A1; SP-A1 beta; SP-A1 delta; SP-A1
                     epsilon; SP-A1 gamma; SPA; SPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            431..508
                     /gene="SFTPA1"
                     /gene_synonym="COLEC4; ILD1; PSAP; PSP-A; PSPA; SFTP1;
                     SFTPA1B; SP-A; SP-A1; SP-A1 beta; SP-A1 delta; SP-A1
                     epsilon; SP-A1 gamma; SPA; SPA1"
                     /inference="alignment:Splign:2.1.0"
     exon            509..2215
                     /gene="SFTPA1"
                     /gene_synonym="COLEC4; ILD1; PSAP; PSP-A; PSPA; SFTP1;
                     SFTPA1B; SP-A; SP-A1; SP-A1 beta; SP-A1 delta; SP-A1
                     epsilon; SP-A1 gamma; SPA; SPA1"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 gacttggagg cagagaccca agcagctgga ggctctgtgt gtgggtcgct gatttcttgg
       61 agcctgaaaa gaaagtaaca cagcagggat gaggacagat ggtgtgagtc agtgagagca
      121 gcgactggac ccagagccat gtggctgtgc cctctggccc tcaacctcat cttgatggca
      181 gcctctggtg ctgtgtgcga agtgaaggac gtttgtgttg gaagccctgg tatccccggc
      241 actcctggat cccacggcct gccaggcagg gacgggagag atggtctcaa aggagaccct
      301 ggccctccag gccccatggg tccacctgga gaaatgccat gtcctcctgg aaatgatggg
      361 ctgcctggag cccctggtat ccctggagag tgtggagaga agggggagcc tggcgagagg
      421 ggccctccag ggcttccagc tcatctagat gaggagctcc aagccacact ccacgacttt
      481 agacatcaaa tcctgcagac aaggggagcc ctcagtctgc agggctccat aatgacagta
      541 ggagagaagg tcttctccag caatgggcag tccatcactt ttgatgccat tcaggaggca
      601 tgtgccagag caggcggccg cattgctgtc ccaaggaatc cagaggaaaa tgaggccatt
      661 gcaagcttcg tgaagaagta caacacatat gcctatgtag gcctgactga gggtcccagc
      721 cctggagact tccgctactc agacgggacc cctgtaaact acaccaactg gtaccgaggg
      781 gagcccgcag gtcggggaaa agagcagtgt gtggagatgt acacagatgg gcagtggaat
      841 gacaggaact gcctgtactc ccgactgacc atctgtgagt tctgagaggc atttaggcca
      901 tgggacaggg aggacgctct ctggccttcg gcctccatcc tgaggctcca cttggtctgt
      961 gagatgctag aactcccttt caacagaatt cacttgtggc tattgggact ggaggcaccc
     1021 ttagccactt cattcctctg atgggccctg actcttcccc ataatcactg accagccttg
     1081 acactcccct tgcaaactct cccagcactg caccccaggc agccactctt agccttggcc
     1141 ttcgacatga gatggagccc tccttattcc ccatctggtc cagttccttc acttacagat
     1201 ggcagcagtg aggtcttggg gtagaaggac cctccaaagt cacacaaagt gcctgcctcc
     1261 tggtcccctc agctctctct ctgcaaccca gtgccatcag gatgagcaat cctggccaag
     1321 cataatgaca gagagaggca gacttcgggg aagccctgac tgtgcagagc taaggacaca
     1381 gtggagattc tctggcactc tgaggtctct gtggcaggcc tggtcaggct ctccatgagg
     1441 ttagaaggcc aggtagtgtt ccagcagggt ggtggccaag ccaaccccat gattgatgtg
     1501 tacgattcac tcctttgagt ctttgaatgg caactcagcc ccctgacctg aagacagcca
     1561 gcctaggcct ctagggtgac ctagagccgc cttcagatgt gacccgagta actttcaact
     1621 gatgaacaaa tctgcaccct acttcagatt tcagtgggca ttcacaccac cccccacacc
     1681 actggctctg ctttctcctt tcattaatcc attcacccag atatttcatt aaaattatca
     1741 cgtgccaggt cttaggatat gtcgtggggt gggcaaggta atcagtgaca gttgaagatt
     1801 tttttttccc agagcttatg tcttcatctg tgaaatggga ataagatact tgttgctgtc
     1861 acagttatta ccatcccccc agctaccaaa attactacca gaactgttac tatacacaga
     1921 ggctattgac tgagcaccta tcatttgcca agaaccttga caagcacttc taatacagca
     1981 tattatgtac tattcaatct ttacacaatg tcacgggacc agtattgttt cctcattttt
     2041 tataaggaca ctgaagcttg gaggagttaa atgttttgag tattattcca gagagcaagt
     2101 ggcagaggct ggatccaaac ccatcttcct ggacctgaag cttatgcttc cagccacccc
     2161 actcctgagc tgaataaaga tgatttaagc ttaataaatc gtgaatgtgt tcaca
//
