LOCUS       NM_205854                446 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens surfactant associated 2 (SFTA2), mRNA.
ACCESSION   NM_205854 XM_371808
VERSION     NM_205854.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 446)
  AUTHORS   Krause,M., Peukert,N., Hartig,W., Emmer,A., Mahr,C.V., Richter,C.,
            Dieckow,J., Puchta,J., Pirlich,M., Hoffmann,K.T., Nestler,U. and
            Schob,S.
  TITLE     Localization, Occurrence, and CSF Changes of SP-G, a New Surface
            Active Protein with Assumable Immunoregulatory Functions in the CNS
  JOURNAL   Mol Neurobiol 56 (4), 2433-2439 (2019)
   PUBMED   30032421
  REMARK    GeneRIF: SP-G is a potential new cerebrospinal fluid (CSF)
            biomarker, possibly not only reflecting aspects of CNS innate
            immune responses, but also rheo-dynamically relevant changes of CSF
            composition.
REFERENCE   2  (bases 1 to 446)
  AUTHORS   Rausch,F., Schicht,M., Paulsen,F., Ngueya,I., Brauer,L. and
            Brandt,W.
  TITLE     'SP-G', a putative new surfactant protein--tissue localization and
            3D structure
  JOURNAL   PLoS One 7 (10), e47789 (2012)
   PUBMED   23094088
  REMARK    GeneRIF: A novel secretory surfactant protein SFTA2 is expressed in
            different tissues (lung, eyelid, kidney, and testis)and possesses
            surface-regulatory properties.
REFERENCE   3  (bases 1 to 446)
  AUTHORS   Mittal,R.A., Hammel,M., Schwarz,J., Heschl,K.M., Bretschneider,N.,
            Flemmer,A.W., Herber-Jonat,S., Konigshoff,M., Eickelberg,O. and
            Holzinger,A.
  TITLE     SFTA2--a novel secretory peptide highly expressed in the lung--is
            modulated by lipopolysaccharide but not hyperoxia
  JOURNAL   PLoS One 7 (6), e40011 (2012)
   PUBMED   22768197
  REMARK    GeneRIF: SFTA2 was characterized as a novel unique secretory
            peptide highly expressed in the lung.
REFERENCE   4  (bases 1 to 446)
  AUTHORS   Barcellos,L.F., May,S.L., Ramsay,P.P., Quach,H.L., Lane,J.A.,
            Nititham,J., Noble,J.A., Taylor,K.E., Quach,D.L., Chung,S.A.,
            Kelly,J.A., Moser,K.L., Behrens,T.W., Seldin,M.F., Thomson,G.,
            Harley,J.B., Gaffney,P.M. and Criswell,L.A.
  TITLE     High-density SNP screening of the major histocompatibility complex
            in systemic lupus erythematosus demonstrates strong evidence for
            independent susceptibility regions
  JOURNAL   PLoS Genet 5 (10), e1000696 (2009)
   PUBMED   19851445
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 446)
  AUTHORS   Zhang,Z. and Henzel,W.J.
  TITLE     Signal peptide prediction based on analysis of experimentally
            verified cleavage sites
  JOURNAL   Protein Sci 13 (10), 2819-2824 (2004)
   PUBMED   15340161
REFERENCE   6  (bases 1 to 446)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC039677.1, AY359057.1, AI857998.1 and T94049.1.
            
            On Nov 22, 2018 this sequence version replaced NM_205854.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC039677.1, AY359057.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144333 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000359086.4/ ENSP00000351989.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-136               BC039677.1         6-141
            137-412             AY359057.1         120-395
            413-443             AI857998.1         1-31                c
            444-446             T94049.1           161-163
FEATURES             Location/Qualifiers
     source          1..446
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.33"
     gene            1..446
                     /gene="SFTA2"
                     /gene_synonym="GSGL541; SFTPG; SP-G; UNQ541"
                     /note="surfactant associated 2"
                     /db_xref="GeneID:389376"
                     /db_xref="HGNC:HGNC:18386"
     exon            1..135
                     /gene="SFTA2"
                     /gene_synonym="GSGL541; SFTPG; SP-G; UNQ541"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..311
                     /gene="SFTA2"
                     /gene_synonym="GSGL541; SFTPG; SP-G; UNQ541"
                     /note="surfactant-associated protein 2; surfactant
                     associated protein G"
                     /codon_start=1
                     /product="surfactant-associated protein 2 precursor"
                     /protein_id="NP_995326.1"
                     /db_xref="CCDS:CCDS4691.1"
                     /db_xref="GeneID:389376"
                     /db_xref="HGNC:HGNC:18386"
                     /translation="MGSGLPLVLLLTLLGSSHGTGPGMTLQLKLKESFLTNSSYESSF
                     LELLEKLCLLLHLPSGTSVTLHHARSQHHVVCNT"
     exon            136..224
                     /gene="SFTA2"
                     /gene_synonym="GSGL541; SFTPG; SP-G; UNQ541"
                     /inference="alignment:Splign:2.1.0"
     exon            225..446
                     /gene="SFTA2"
                     /gene_synonym="GSGL541; SFTPG; SP-G; UNQ541"
                     /inference="alignment:Splign:2.1.0"
     regulatory      421..426
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SFTA2"
                     /gene_synonym="GSGL541; SFTPG; SP-G; UNQ541"
                     /note="hexamer: AATAAA"
     polyA_site      446
                     /gene="SFTA2"
                     /gene_synonym="GSGL541; SFTPG; SP-G; UNQ541"
                     /note="major polyA site"
ORIGIN      
        1 gtagaaacag gcctgttaag gagaggccac cgggacttca gtgtctcctc catcccagga
       61 gcgcagtggc cactatgggg tctgggctgc cccttgtcct cctcttgacc ctccttggca
      121 gctcacatgg aacagggccg ggtatgactt tgcaactgaa gctgaaggag tcttttctga
      181 caaattcctc ctatgagtcc agcttcctgg aattgcttga aaagctctgc ctcctcctcc
      241 atctcccttc agggaccagc gtcaccctcc accatgcaag atctcaacac catgttgtct
      301 gcaacacatg acagccattg aagcctgtgt ccttcttggc ccgggctttt gggccgggga
      361 tgcaggaggc aggccccgac cctgtctttc agcaggcccc caccctcctg agcggcaata
      421 aataaaattc ggtatgctga attcaa
//
