LOCUS       NM_145169               1033 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens SFT2 domain containing 1 (SFT2D1), transcript variant
            1, mRNA.
ACCESSION   NM_145169
VERSION     NM_145169.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1033)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 1033)
  AUTHORS   Mungall,A.J., Palmer,S.A., Sims,S.K., Edwards,C.A., Ashurst,J.L.,
            Wilming,L., Jones,M.C., Horton,R., Hunt,S.E., Scott,C.E.,
            Gilbert,J.G., Clamp,M.E., Bethel,G., Milne,S., Ainscough,R.,
            Almeida,J.P., Ambrose,K.D., Andrews,T.D., Ashwell,R.I.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Barker,D.J.,
            Barlow,K.F., Bates,K., Beare,D.M., Beasley,H., Beasley,O.,
            Bird,C.P., Blakey,S., Bray-Allen,S., Brook,J., Brown,A.J.,
            Brown,J.Y., Burford,D.C., Burrill,W., Burton,J., Carder,C.,
            Carter,N.P., Chapman,J.C., Clark,S.Y., Clark,G., Clee,C.M.,
            Clegg,S., Cobley,V., Collier,R.E., Collins,J.E., Colman,L.K.,
            Corby,N.R., Coville,G.J., Culley,K.M., Dhami,P., Davies,J.,
            Dunn,M., Earthrowl,M.E., Ellington,A.E., Evans,K.A., Faulkner,L.,
            Francis,M.D., Frankish,A., Frankland,J., French,L., Garner,P.,
            Garnett,J., Ghori,M.J., Gilby,L.M., Gillson,C.J., Glithero,R.J.,
            Grafham,D.V., Grant,M., Gribble,S., Griffiths,C., Griffiths,M.,
            Hall,R., Halls,K.S., Hammond,S., Harley,J.L., Hart,E.A.,
            Heath,P.D., Heathcott,R., Holmes,S.J., Howden,P.J., Howe,K.L.,
            Howell,G.R., Huckle,E., Humphray,S.J., Humphries,M.D., Hunt,A.R.,
            Johnson,C.M., Joy,A.A., Kay,M., Keenan,S.J., Kimberley,A.M.,
            King,A., Laird,G.K., Langford,C., Lawlor,S., Leongamornlert,D.A.,
            Leversha,M., Lloyd,C.R., Lloyd,D.M., Loveland,J.E., Lovell,J.,
            Martin,S., Mashreghi-Mohammadi,M., Maslen,G.L., Matthews,L.,
            McCann,O.T., McLaren,S.J., McLay,K., McMurray,A., Moore,M.J.,
            Mullikin,J.C., Niblett,D., Nickerson,T., Novik,K.L., Oliver,K.,
            Overton-Larty,E.K., Parker,A., Patel,R., Pearce,A.V., Peck,A.I.,
            Phillimore,B., Phillips,S., Plumb,R.W., Porter,K.M., Ramsey,Y.,
            Ranby,S.A., Rice,C.M., Ross,M.T., Searle,S.M., Sehra,H.K.,
            Sheridan,E., Skuce,C.D., Smith,S., Smith,M., Spraggon,L.,
            Squares,S.L., Steward,C.A., Sycamore,N., Tamlyn-Hall,G., Tester,J.,
            Theaker,A.J., Thomas,D.W., Thorpe,A., Tracey,A., Tromans,A.,
            Tubby,B., Wall,M., Wallis,J.M., West,A.P., White,S.S.,
            Whitehead,S.L., Whittaker,H., Wild,A., Willey,D.J., Wilmer,T.E.,
            Wood,J.M., Wray,P.W., Wyatt,J.C., Young,L., Younger,R.M.,
            Bentley,D.R., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E.,
            Dunham,I., Rogers,J. and Beck,S.
  TITLE     The DNA sequence and analysis of human chromosome 6
  JOURNAL   Nature 425 (6960), 805-811 (2003)
   PUBMED   14574404
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB476616.1, BC018969.1 and AL833217.1.
            
            On Nov 23, 2018 this sequence version replaced NM_145169.2.
            
            Transcript Variant: This variant (1) encodes the protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.392332.1,
                                           SRR1163655.64535.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155751, SAMEA2156266
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000361731.4/ ENSP00000354590.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                DB476616.1         62-120
            60-486              BC018969.1         26-452
            487-1033            AL833217.1         2879-3425
FEATURES             Location/Qualifiers
     source          1..1033
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q27"
     gene            1..1033
                     /gene="SFT2D1"
                     /gene_synonym="C6orf83; pRGR1"
                     /note="SFT2 domain containing 1"
                     /db_xref="GeneID:113402"
                     /db_xref="HGNC:HGNC:21102"
     exon            1..127
                     /gene="SFT2D1"
                     /gene_synonym="C6orf83; pRGR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..544
                     /gene="SFT2D1"
                     /gene_synonym="C6orf83; pRGR1"
                     /note="SFT2 domain-containing protein 1"
                     /codon_start=1
                     /product="vesicle transport protein SFT2A"
                     /protein_id="NP_660152.1"
                     /db_xref="CCDS:CCDS5292.1"
                     /db_xref="GeneID:113402"
                     /db_xref="HGNC:HGNC:21102"
                     /translation="MEKLRRVLSGQDDEEQGLTAQVLDASSLSFNTRLKWFAICFVCG
                     VFFSILGTGLLWLPGGIKLFAVFYTLGNLAALASTCFLMGPVKQLKKMFEATRLLATI
                     VMLLCFIFTLCAALWWHKKGLAVLFCILQFLSMTWYSLSYIPYARDAVIKCCSSLLS"
     exon            128..214
                     /gene="SFT2D1"
                     /gene_synonym="C6orf83; pRGR1"
                     /inference="alignment:Splign:2.1.0"
     exon            215..297
                     /gene="SFT2D1"
                     /gene_synonym="C6orf83; pRGR1"
                     /inference="alignment:Splign:2.1.0"
     exon            298..379
                     /gene="SFT2D1"
                     /gene_synonym="C6orf83; pRGR1"
                     /inference="alignment:Splign:2.1.0"
     exon            380..415
                     /gene="SFT2D1"
                     /gene_synonym="C6orf83; pRGR1"
                     /inference="alignment:Splign:2.1.0"
     exon            416..474
                     /gene="SFT2D1"
                     /gene_synonym="C6orf83; pRGR1"
                     /inference="alignment:Splign:2.1.0"
     exon            475..504
                     /gene="SFT2D1"
                     /gene_synonym="C6orf83; pRGR1"
                     /inference="alignment:Splign:2.1.0"
     exon            505..1033
                     /gene="SFT2D1"
                     /gene_synonym="C6orf83; pRGR1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      712..717
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SFT2D1"
                     /gene_synonym="C6orf83; pRGR1"
                     /note="hexamer: ATTAAA"
     polyA_site      733
                     /gene="SFT2D1"
                     /gene_synonym="C6orf83; pRGR1"
                     /note="major polyA site"
     regulatory      877..882
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SFT2D1"
                     /gene_synonym="C6orf83; pRGR1"
                     /note="hexamer: ATTAAA"
     polyA_site      901
                     /gene="SFT2D1"
                     /gene_synonym="C6orf83; pRGR1"
     regulatory      1009..1014
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SFT2D1"
                     /gene_synonym="C6orf83; pRGR1"
                     /note="hexamer: AATAAA"
     polyA_site      1033
                     /gene="SFT2D1"
                     /gene_synonym="C6orf83; pRGR1"
                     /note="major polyA site"
ORIGIN      
        1 gtttcctggt gggcgtcagg ggcaggcaac agagtggcgg ccgctacggc cctgtaacag
       61 ggccatggag aagctgcggc gagtcctgag cggccaggac gacgaggagc agggcctgac
      121 tgcgcaggtc ctggatgcct catcccttag tttcaacacc agattgaaat ggtttgccat
      181 ctgcttcgta tgtggcgttt tcttttctat tcttggaact ggattgctgt ggcttccggg
      241 cggcataaag ctttttgcag tgttttatac cctcggcaat cttgctgcgt tagccagtac
      301 atgcttttta atgggacctg tgaagcaact gaagaaaatg tttgaagcaa caagattgct
      361 tgcaacaatt gttatgcttt tgtgtttcat atttaccctg tgtgctgctc tttggtggca
      421 taagaaggga ctggctgtgt tattctgcat attgcagttc ttgtcaatga cctggtatag
      481 cctgtcgtac atcccatatg caagggatgc agttattaaa tgctgttctt ctctcctaag
      541 ttgaaaatca gaaacttgtg gaaaagagca cttgaatgtt ggtactctat gtttggtgaa
      601 gtttgctttt ccccataaaa cactccagga acaactgacg tgacagttga agaccgtttt
      661 gtactaagtc tcattttgta tactggtaaa aactacatgc ttgattaaac cattaaatgc
      721 ttgtaacttt aaattcatta tgtgtcatta atatactttt ccaaagataa gatttttaat
      781 cactgccagt tgtaaattat ttttagccaa tttttaaatc ttttcaaagc agctttgaaa
      841 tgtgaatatt taaaggtaga cctgtgctgc aagataatta aacttttttg cttttaaaaa
      901 atgtctgcat ttttaagatt ttttttactt taaatgtgaa acttatttta agctaaaaat
      961 tgcttattat atgtaataaa aataatatat aaatctttac aattttgaaa taaacccatc
     1021 cttggaaaaa taa
//
