LOCUS       NM_003015               1883 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens secreted frizzled related protein 5 (SFRP5), mRNA.
ACCESSION   NM_003015
VERSION     NM_003015.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1883)
  AUTHORS   Koutaki,D., Paltoglou,G., Manou,M., Vourdoumpa,A., Ramouzi,E.,
            Tzounakou,A.M., Michos,A., Bacopoulou,F., Mantzou,E., Zoumakis,E.,
            Papadopoulou,M., Kassari,P. and Charmandari,E.
  TITLE     The Role of Secreted Frizzled-Related Protein 5 (Sfrp5) in
            Overweight and Obesity in Childhood and Adolescence
  JOURNAL   Nutrients 16 (18), 3133 (2024)
   PUBMED   39339733
  REMARK    GeneRIF: The Role of Secreted Frizzled-Related Protein 5 (Sfrp5) in
            Overweight and Obesity in Childhood and Adolescence.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1883)
  AUTHORS   Wang,X., Chen,S., Yu,C., Lu,R., Sun,Y., Guan,Z. and Gao,Y.
  TITLE     Secreted frizzled-related protein 5 overexpression reverses
            oxLDL-induced lipid accumulation in human vascular smooth muscle
            cells
  JOURNAL   Biosci Biotechnol Biochem 88 (7), 776-783 (2024)
   PUBMED   38714325
  REMARK    GeneRIF: Secreted frizzled-related protein 5 overexpression
            reverses oxLDL-induced lipid accumulation in human vascular smooth
            muscle cells.
REFERENCE   3  (bases 1 to 1883)
  AUTHORS   Yuan,Y., Zhu,H., Huang,S., Zhang,Y. and Shen,Y.
  TITLE     SFRP5 Partially Inhibits the Proliferation and Migration of Airway
            Smooth Muscle Cells in Children with Asthma by Regulating the
            Wnt/beta-Catenin Signaling Pathway
  JOURNAL   Discov Med 36 (181), 323-331 (2024)
   PUBMED   38409837
  REMARK    GeneRIF: SFRP5 Partially Inhibits the Proliferation and Migration
            of Airway Smooth Muscle Cells in Children with Asthma by Regulating
            the Wnt/beta-Catenin Signaling Pathway.
REFERENCE   4  (bases 1 to 1883)
  AUTHORS   Zeng,M., Wei,X., He,Y.L., Chen,J.X. and Lin,W.T.
  TITLE     TFAP2C inhibits cell autophagy to alleviate myocardial
            ischemia/reperfusion injury by regulating miR-23a-5p/SFRP5/Wnt5a
            axis
  JOURNAL   FASEB J 37 (6), e22959 (2023)
   PUBMED   37191968
  REMARK    GeneRIF: TFAP2C inhibits cell autophagy to alleviate myocardial
            ischemia/reperfusion injury by regulating miR-23a-5p/SFRP5/Wnt5a
            axis.
REFERENCE   5  (bases 1 to 1883)
  AUTHORS   Chu,D.T. and Nguyen,T.L.
  TITLE     Frizzled receptors and SFRP5 in lipid metabolism: Current findings
            and potential applications
  JOURNAL   Prog Mol Biol Transl Sci 194, 377-393 (2023)
   PUBMED   36631199
  REMARK    GeneRIF: Frizzled receptors and SFRP5 in lipid metabolism: Current
            findings and potential applications.
REFERENCE   6  (bases 1 to 1883)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
REFERENCE   7  (bases 1 to 1883)
  AUTHORS   Chang,J.T., Esumi,N., Moore,K., Li,Y., Zhang,S., Chew,C.,
            Goodman,B., Rattner,A., Moody,S., Stetten,G., Campochiaro,P.A. and
            Zack,D.J.
  TITLE     Cloning and characterization of a secreted frizzled-related protein
            that is expressed by the retinal pigment epithelium
  JOURNAL   Hum Mol Genet 8 (4), 575-583 (1999)
   PUBMED   10072424
REFERENCE   8  (bases 1 to 1883)
  AUTHORS   Hu,E., Zhu,Y., Fredrickson,T., Barnes,M., Kelsell,D., Beeley,L. and
            Brooks,D.
  TITLE     Tissue restricted expression of two human Frzbs in preadipocytes
            and pancreas
  JOURNAL   Biochem Biophys Res Commun 247 (2), 287-293 (1998)
   PUBMED   9642118
  REMARK    Erratum:[Biochem Biophys Res Commun 1998 Jul 30;248(3):941-3]
REFERENCE   9  (bases 1 to 1883)
  AUTHORS   Melkonyan,H.S., Chang,W.C., Shapiro,J.P., Mahadevappa,M.,
            Fitzpatrick,P.A., Kiefer,M.C., Tomei,L.D. and Umansky,S.R.
  TITLE     SARPs: a family of secreted apoptosis-related proteins
  JOURNAL   Proc Natl Acad Sci U S A 94 (25), 13636-13641 (1997)
   PUBMED   9391078
REFERENCE   10 (bases 1 to 1883)
  AUTHORS   Rattner,A., Hsieh,J.C., Smallwood,P.M., Gilbert,D.J.,
            Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     A family of secreted proteins contains homology to the
            cysteine-rich ligand-binding domain of frizzled receptors
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 2859-2863 (1997)
   PUBMED   9096311
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL358938.8 and BC050435.1.
            
            On May 17, 2008 this sequence version replaced NM_003015.2.
            
            Summary: Secreted frizzled-related protein 5 (SFRP5) is a member of
            the SFRP family that contains a cysteine-rich domain homologous to
            the putative Wnt-binding site of Frizzled proteins. SFRPs act as
            soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be
            involved in determining the polarity of photoreceptor cells in the
            retina. SFRP5 is highly expressed in the retinal pigment
            epithelium, and moderately expressed in the pancreas. [provided by
            RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF017988.2, AF117758.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2147920 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000266066.4/ ENSP00000266066.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-186               AL358938.8         45394-45579         c
            187-1447            BC050435.1         144-1404
            1448-1883           AL358938.8         40331-40766         c
FEATURES             Location/Qualifiers
     source          1..1883
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q24.2"
     gene            1..1883
                     /gene="SFRP5"
                     /gene_synonym="SARP3"
                     /note="secreted frizzled related protein 5"
                     /db_xref="GeneID:6425"
                     /db_xref="HGNC:HGNC:10779"
                     /db_xref="MIM:604158"
     exon            1..695
                     /gene="SFRP5"
                     /gene_synonym="SARP3"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..1120
                     /gene="SFRP5"
                     /gene_synonym="SARP3"
                     /note="secreted apoptosis related protein 3; FRP-1b;
                     SARP-3; sFRP-5; frizzled-related protein 1b"
                     /codon_start=1
                     /product="secreted frizzled-related protein 5 precursor"
                     /protein_id="NP_003006.2"
                     /db_xref="CCDS:CCDS7472.1"
                     /db_xref="GeneID:6425"
                     /db_xref="HGNC:HGNC:10779"
                     /db_xref="MIM:604158"
                     /translation="MRAAAAGGGVRTAALALLLGALHWAPARCEEYDYYGWQAEPLHG
                     RSYSKPPQCLDIPADLPLCHTVGYKRMRLPNLLEHESLAEVKQQASSWLPLLAKRCHS
                     DTQVFLCSLFAPVCLDRPIYPCRSLCEAVRAGCAPLMEAYGFPWPEMLHCHKFPLDND
                     LCIAVQFGHLPATAPPVTKICAQCEMEHSADGLMEQMCSSDFVVKMRIKEIKIENGDR
                     KLIGAQKKKKLLKPGPLKRKDTKRLVLHMKNGAGCPCPQLDSLAGSFLVMGRKVDGQL
                     LLMAVYRWDKKNKEMKFAVKFMFSYPCSLYYPFFYGAAEPH"
     exon            696..773
                     /gene="SFRP5"
                     /gene_synonym="SARP3"
                     /inference="alignment:Splign:2.1.0"
     exon            774..1883
                     /gene="SFRP5"
                     /gene_synonym="SARP3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1862..1867
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SFRP5"
                     /gene_synonym="SARP3"
                     /note="hexamer: ATTAAA"
     polyA_site      1877
                     /gene="SFRP5"
                     /gene_synonym="SARP3"
     polyA_site      1883
                     /gene="SFRP5"
                     /gene_synonym="SARP3"
                     /note="major polyA site"
ORIGIN      
        1 agtcggggcg cccgcagcgc aggctgccac ccacctgggc gacctccgcg gcggcggcgg
       61 cggcggctgg gtagagtcag ggccgggggc gcacgccgga acacctgggc cgccgggcac
      121 cgagcgtcgg ggggctgcgc ggcgcgcacc tggagagggc gcagccatgc gggcggcggc
      181 ggcggggggg ggcgtgcgga cggccgcgct ggcgctgctg ctgggggcgc tgcactgggc
      241 gccggcgcgc tgcgaggagt acgactacta tggctggcag gccgagccgc tgcacggccg
      301 ctcctactcc aagccgccgc agtgccttga catccctgcc gacctgccgc tctgccacac
      361 ggtgggctac aagcgcatgc ggctgcccaa cctgctggag cacgagagcc tggccgaagt
      421 gaagcagcag gcgagcagct ggctgccgct gctggccaag cgctgccact cggatacgca
      481 ggtcttcctg tgctcgctct ttgcgcccgt ctgtctcgac cggcccatct acccgtgccg
      541 ctcgctgtgc gaggccgtgc gcgccggctg cgcgccgctc atggaggcct acggcttccc
      601 ctggcctgag atgctgcact gccacaagtt ccccctggac aacgacctct gcatcgccgt
      661 gcagttcggg cacctgcccg ccaccgcgcc tccagtgacc aagatctgcg cccagtgtga
      721 gatggagcac agtgctgacg gcctcatgga gcagatgtgc tccagtgact ttgtggtcaa
      781 aatgcgcatc aaggagatca agatagagaa tggggaccgg aagctgattg gagcccagaa
      841 aaagaagaag ctgctcaagc cgggccccct gaagcgcaag gacaccaagc ggctggtgct
      901 gcacatgaag aatggcgcgg gctgcccctg cccacagctg gacagcctgg cgggcagctt
      961 cctggtcatg ggccgcaaag tggatggaca gctgctgctc atggccgtct accgctggga
     1021 caagaagaat aaggagatga agtttgcagt caaattcatg ttctcctacc cctgctccct
     1081 ctactaccct ttcttctacg gggcggcaga gccccactga agggcactcc tccttgccct
     1141 gccagctgtg ccttgcttgc cctctggccc cgccccaact tccaggctga cccggcccta
     1201 ctggagggtg ttttcacgaa tgttgttact ggcacaaggc ctaagggatg ggcacggagc
     1261 ccaggctgtc ctttttgacc caggggtcct ggggtccctg ggatgttggg cttcctctct
     1321 caggagcagg gcttcttcat ctgggtgaag acctcagggt ctcagaaagt aggcagggga
     1381 ggagagggta agggaaaggt ggaggggctc agggcaccct gaggcggagg tttcagagta
     1441 gaaggtggtg tcagctccag ctcccctctg tcggtggtgg ggcctcacct tgaagaggga
     1501 agtctcaata ttaggctaag ctatttggga aagttctccc caccgcccct gtacgcgtca
     1561 tcctagcccc ccttaggaaa ggagttaggg tctcagtgcc tccagccaca ccccctgcct
     1621 tccccagctt gcccatttcc ctgccccaag gcccagagct ccccccagac tggagagcaa
     1681 gcccagccca gcctcggcat agaccccctt ctggtccgcc cgcggctcga ttcccgggat
     1741 tcattcctca gcctctgctt ctccctttta tcccaataag ttattgctac tgctgtgagg
     1801 ccataggtac tagacaacca atacatgcag ggttgggttt tctaattttt ttaacttttt
     1861 aattaaatca aagaaaacaa taa
//
