LOCUS       NM_003014               2868 bp    mRNA    linear   PRI 29-OCT-2024
DEFINITION  Homo sapiens secreted frizzled related protein 4 (SFRP4), mRNA.
ACCESSION   NM_003014
VERSION     NM_003014.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2868)
  AUTHORS   Qi,B., Wang,H.Y., Ma,X., Chi,Y.F. and Gui,C.
  TITLE     Exploring the predictive values of SERP4 and FRZB in dilated
            cardiomyopathy based on an integrated analysis
  JOURNAL   BMC Cardiovasc Disord 24 (1), 577 (2024)
   PUBMED   39425025
  REMARK    GeneRIF: Exploring the predictive values of SERP4 and FRZB in
            dilated cardiomyopathy based on an integrated analysis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2868)
  AUTHORS   Sanchez-Pozos,K., Granados-Silvestre,M.A., Nieto-Velazquez,N.G.,
            Mejia-Blanquel,M.A., Galicia-Martinez,N., Mandujano-Ceron,J.,
            Jaimes-Santoyo,J. and Ortiz-Lopez,M.G.
  TITLE     Role of secreted frizzled-related protein 4 in prediabetes and type
            2 diabetes: a cross sectional study
  JOURNAL   BMC Endocr Disord 24 (1), 78 (2024)
   PUBMED   38834984
  REMARK    GeneRIF: Role of secreted frizzled-related protein 4 in prediabetes
            and type 2 diabetes: a cross sectional study.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2868)
  AUTHORS   Kida,H., Jiang,J.J., Matsui,Y., Takahashi,I., Hasebe,R.,
            Kawamura,D., Endo,T., Shibayama,H., Kondo,M., Nishio,Y.,
            Nishida,K., Matsuno,Y., Oikawa,T., Kubota,S.I., Hojyo,S.,
            Iwasaki,N., Hashimoto,S., Tanaka,Y. and Murakami,M.
  TITLE     Dupuytren's contracture-associated SNPs increase SFRP4 expression
            in non-immune cells including fibroblasts to enhance inflammation
            development
  JOURNAL   Int Immunol 35 (7), 303-312 (2023)
   PUBMED   36719100
  REMARK    GeneRIF: Dupuytren's contracture-associated SNPs increase SFRP4
            expression in non-immune cells including fibroblasts to enhance
            inflammation development.
REFERENCE   4  (bases 1 to 2868)
  AUTHORS   Guo,L., Chen,H., Chen,J., Gao,C., Fu,X., Zhou,S., Wu,W., Li,T.,
            Lin,J., Yang,T., Chen,Z. and Cao,L.
  TITLE     PBX1-promoted SFRP4 transcription inhibits cell proliferation and
            epithelial-mesenchymal transition in endometrial carcinoma
  JOURNAL   Tissue Cell 82, 102083 (2023)
   PUBMED   37054536
  REMARK    GeneRIF: PBX1-promoted SFRP4 transcription inhibits cell
            proliferation and epithelial-mesenchymal transition in endometrial
            carcinoma.
REFERENCE   5  (bases 1 to 2868)
  AUTHORS   Takaya,K., Asou,T. and Kishi,K.
  TITLE     Downregulation of senescence-associated secretory phenotype by
            knockdown of secreted frizzled-related protein 4 contributes to the
            prevention of skin aging
  JOURNAL   Aging (Albany NY) 14 (20), 8167-8178 (2022)
   PUBMED   36084952
  REMARK    GeneRIF: Downregulation of senescence-associated secretory
            phenotype by knockdown of secreted frizzled-related protein 4
            contributes to the prevention of skin aging.
REFERENCE   6  (bases 1 to 2868)
  AUTHORS   James,I.E., Kumar,S., Barnes,M.R., Gress,C.J., Hand,A.T.,
            Dodds,R.A., Connor,J.R., Bradley,B.R., Campbell,D.A., Grabill,S.E.,
            Williams,K., Blake,S.M., Gowen,M. and Lark,M.W.
  TITLE     FrzB-2: a human secreted frizzled-related protein with a potential
            role in chondrocyte apoptosis
  JOURNAL   Osteoarthritis Cartilage 8 (6), 452-463 (2000)
   PUBMED   11069730
REFERENCE   7  (bases 1 to 2868)
  AUTHORS   Schumann,H., Holtz,J., Zerkowski,H.R. and Hatzfeld,M.
  TITLE     Expression of secreted frizzled related proteins 3 and 4 in human
            ventricular myocardium correlates with apoptosis related gene
            expression
  JOURNAL   Cardiovasc Res 45 (3), 720-728 (2000)
   PUBMED   10728394
REFERENCE   8  (bases 1 to 2868)
  AUTHORS   Abu-Jawdeh,G., Comella,N., Tomita,Y., Brown,L.F., Tognazzi,K.,
            Sokol,S.Y. and Kocher,O.
  TITLE     Differential expression of frpHE: a novel human stromal protein of
            the secreted frizzled gene family, during the endometrial cycle and
            malignancy
  JOURNAL   Lab Invest 79 (4), 439-447 (1999)
   PUBMED   10211996
REFERENCE   9  (bases 1 to 2868)
  AUTHORS   Wolf,V., Ke,G., Dharmarajan,A.M., Bielke,W., Artuso,L., Saurer,S.
            and Friis,R.
  TITLE     DDC-4, an apoptosis-associated gene, is a secreted frizzled
            relative
  JOURNAL   FEBS Lett 417 (3), 385-389 (1997)
   PUBMED   9409757
REFERENCE   10 (bases 1 to 2868)
  AUTHORS   Rattner,A., Hsieh,J.C., Smallwood,P.M., Gilbert,D.J.,
            Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     A family of secreted proteins contains homology to the
            cysteine-rich ligand-binding domain of frizzled receptors
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 2859-2863 (1997)
   PUBMED   9096311
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC018634.3 and BT019679.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_003014.3.
            
            Summary: Secreted frizzled-related protein 4 (SFRP4) is a member of
            the SFRP family that contains a cysteine-rich domain homologous to
            the putative Wnt-binding site of Frizzled proteins. SFRPs act as
            soluble modulators of Wnt signaling. The expression of SFRP4 in
            ventricular myocardium correlates with apoptosis related gene
            expression. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.46119.1,
                                           SRR1803614.178948.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: downstream AUG is associated
                                                with N-terminal localization
                                                signal
            MANE Ensembl match               :: ENST00000436072.7/
                                                ENSP00000410715.2
            RefSeq Select criteria           :: based on single protein-coding
                                                transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-280               AC018634.3         76414-76693
            281-1319            BT019679.1         1-1039
            1320-2868           AC018634.3         85751-87299
FEATURES             Location/Qualifiers
     source          1..2868
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="7"
                     /map="7p14.1"
     gene            1..2868
                     /gene="SFRP4"
                     /gene_synonym="FRP-4; FRPHE; FRZB-2; PYL; sFRP-4"
                     /note="secreted frizzled related protein 4"
                     /db_xref="GeneID:6424"
                     /db_xref="HGNC:HGNC:10778"
                     /db_xref="MIM:606570"
     exon            1..725
                     /gene="SFRP4"
                     /gene_synonym="FRP-4; FRPHE; FRZB-2; PYL; sFRP-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             281..1321
                     /gene="SFRP4"
                     /gene_synonym="FRP-4; FRPHE; FRZB-2; PYL; sFRP-4"
                     /note="frizzled protein, human endometrium; secreted
                     frizzled-related protein 4; secreted frizzled-related
                     protein 4"
                     /codon_start=1
                     /product="secreted frizzled-related protein 4 precursor"
                     /protein_id="NP_003005.2"
                     /db_xref="CCDS:CCDS5453.1"
                     /db_xref="GeneID:6424"
                     /db_xref="HGNC:HGNC:10778"
                     /db_xref="MIM:606570"
                     /translation="MFLSILVALCLWLHLALGVRGAPCEAVRIPMCRHMPWNITRMPN
                     HLHHSTQENAILAIEQYEELVDVNCSAVLRFFLCAMYAPICTLEFLHDPIKPCKSVCQ
                     RARDDCEPLMKMYNHSWPESLACDELPVYDRGVCISPEAIVTDLPEDVKWIDITPDMM
                     VQERPLDVDCKRLSPDRCKCKKVKPTLATYLSKNYSYVIHAKIKAVQRSGCNEVTTVV
                     DVKEIFKSSSPIPRTQVPLITNSSCQCPHILPHQDVLIMCYEWRSRMMLLENCLVEKW
                     RDQLSKRSIQWEERLQEQRRTVQDKKKTAGRTSRSNPPKPKGKPPAPKPASPKKNIKT
                     RSAQKRTNPKRV"
     exon            726..806
                     /gene="SFRP4"
                     /gene_synonym="FRP-4; FRPHE; FRZB-2; PYL; sFRP-4"
                     /inference="alignment:Splign:2.1.0"
     exon            807..872
                     /gene="SFRP4"
                     /gene_synonym="FRP-4; FRPHE; FRZB-2; PYL; sFRP-4"
                     /inference="alignment:Splign:2.1.0"
     exon            873..1071
                     /gene="SFRP4"
                     /gene_synonym="FRP-4; FRPHE; FRZB-2; PYL; sFRP-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1072..1135
                     /gene="SFRP4"
                     /gene_synonym="FRP-4; FRPHE; FRZB-2; PYL; sFRP-4"
                     /inference="alignment:Splign:2.1.0"
     exon            1136..2868
                     /gene="SFRP4"
                     /gene_synonym="FRP-4; FRPHE; FRZB-2; PYL; sFRP-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1661..1666
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SFRP4"
                     /gene_synonym="FRP-4; FRPHE; FRZB-2; PYL; sFRP-4"
                     /note="hexamer: AATAAA"
     polyA_site      1685
                     /gene="SFRP4"
                     /gene_synonym="FRP-4; FRPHE; FRZB-2; PYL; sFRP-4"
                     /note="major polyA site"
     regulatory      1980..1985
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SFRP4"
                     /gene_synonym="FRP-4; FRPHE; FRZB-2; PYL; sFRP-4"
                     /note="hexamer: AATAAA"
     regulatory      1984..1989
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SFRP4"
                     /gene_synonym="FRP-4; FRPHE; FRZB-2; PYL; sFRP-4"
                     /note="hexamer: AATAAA"
     polyA_site      2000
                     /gene="SFRP4"
                     /gene_synonym="FRP-4; FRPHE; FRZB-2; PYL; sFRP-4"
     polyA_site      2005
                     /gene="SFRP4"
                     /gene_synonym="FRP-4; FRPHE; FRZB-2; PYL; sFRP-4"
     regulatory      2847..2852
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SFRP4"
                     /gene_synonym="FRP-4; FRPHE; FRZB-2; PYL; sFRP-4"
                     /note="hexamer: AATAAA"
     polyA_site      2868
                     /gene="SFRP4"
                     /gene_synonym="FRP-4; FRPHE; FRZB-2; PYL; sFRP-4"
ORIGIN      
        1 ggctgcgctc cgagctgcgg agtccgggac tggagctgcc cgggcgggtt cgcgccccga
       61 aggctgagag ctggcgctgc tcgtgccctg tgtgccagac ggcggagctc cgcggccgga
      121 ccccgcggcc ccgctttgct gccgactgga gtttggggga agaaactctc ctgcgcccca
      181 gaggatttct tcctcggcga agggacagcg aaagatgagg gtggcaggaa gagaagggcg
      241 ctttctgtct gccggggtcg cagcgcgaga gggcagtgcc atgttcctct ccatcctagt
      301 ggcgctgtgc ctgtggctgc acctggcgct gggcgtgcgc ggcgcgccct gcgaggcggt
      361 gcgcatccct atgtgccggc acatgccctg gaacatcacg cggatgccca accacctgca
      421 ccacagcacg caggagaacg ccatcctggc catcgagcag tacgaggagc tggtggacgt
      481 gaactgcagc gccgtgctgc gcttcttcct ctgtgccatg tacgcgccca tttgcaccct
      541 ggagttcctg cacgacccta tcaagccgtg caagtcggtg tgccaacgcg cgcgcgacga
      601 ctgcgagccc ctcatgaaga tgtacaacca cagctggccc gaaagcctgg cctgcgacga
      661 gctgcctgtc tatgaccgtg gcgtgtgcat ctcgcctgaa gccatcgtca cggacctccc
      721 ggaggatgtt aagtggatag acatcacacc agacatgatg gtacaggaaa ggcctcttga
      781 tgttgactgt aaacgcctaa gccccgatcg gtgcaagtgt aaaaaggtga agccaacttt
      841 ggcaacgtat ctcagcaaaa actacagcta tgttattcat gccaaaataa aagctgtgca
      901 gaggagtggc tgcaatgagg tcacaacggt ggtggatgta aaagagatct tcaagtcctc
      961 atcacccatc cctcgaactc aagtcccgct cattacaaat tcttcttgcc agtgtccaca
     1021 catcctgccc catcaagatg ttctcatcat gtgttacgag tggcgctcaa ggatgatgct
     1081 tcttgaaaat tgcttagttg aaaaatggag agatcagctt agtaaaagat ccatacagtg
     1141 ggaagagagg ctgcaggaac agcggagaac agttcaggac aagaagaaaa cagccgggcg
     1201 caccagtcgt agtaatcccc ccaaaccaaa gggaaagcct cctgctccca aaccagccag
     1261 tcccaagaag aacattaaaa ctaggagtgc ccagaagaga acaaacccga aaagagtgtg
     1321 agctaactag tttccaaagc ggagacttcc gacttcctta caggatgagg ctgggcattg
     1381 cctgggacag cctatgtaag gccatgtgcc ccttgcccta acaactcact gcagtgctct
     1441 tcatagacac atcttgcagc atttttctta aggctatgct tcagtttttc tttgtaagcc
     1501 atcacaagcc atagtggtag gtttgccctt tggtacagaa ggtgagttaa agctggtgga
     1561 aaaggcttat tgcattgcat tcagagtaac ctgtgtgcat actctagaag agtagggaaa
     1621 ataatgcttg ttacaattcg acctaatatg tgcattgtaa aataaatgcc atatttcaaa
     1681 caaaacacgt aattttttta cagtatgttt tattaccttt tgatatctgt tgttgcaatg
     1741 ttagtgatgt tttaaaatgt gatcgaaaat ataatgcttc taagaaggaa cagtagtgga
     1801 atgaatgtct aaaagatctt tatgtgttta tggtctgcag aaggattttt gtgatgaaag
     1861 gggatttttt gaaaaatcta gagaagtagc atatggaaaa ctataatgtg tcttttttac
     1921 aatgacttca gctctgtttt tagctagaaa ctctaaaaac aaaaataata ataaagaaaa
     1981 ataaataaaa aggagaggca gacaatgtct ggattcctgt tttttggtta cctgatttca
     2041 tgatcatgat gcttcttgtc aacaccctct taagcagcac cagaaacagt gagtttgtct
     2101 gtaccattag gagttaggta ctaattagtt ggctaatgct caagtatttt atacccacaa
     2161 gagaggtatg tcactcatct tacttcccag gacatccacc ctgagaataa tttgacaagc
     2221 ttaaaaatgg ccttcatgtg agtgccaaat tttgttttct tcatttaaat attttctttg
     2281 cctaaataca tgtgagagga gttaaatata aatgtacaga gaggaaagtt gaggttccac
     2341 ctctgaaatg agaattactt gacagttggg atactttaat cagaaaaaaa gaacttatct
     2401 tgcagcattt tatcaacaaa tttcataatt gtggacaatt ggaggcattt attttaaaaa
     2461 acaattttat tggccttttg ctaacacagt aagcatgtat tctctataag gcattcaata
     2521 aatgcacaac gcccaaagga aataaaatcc tatctaatcc tactctccac tacacagagg
     2581 taatcactat tagtattttg gcatattatt ctccaggtgt ttcttatgca cttataaaat
     2641 gatttgaaca aataaaacta ggaacctgct atacatgtgt ttcataacct gcctcctttg
     2701 cttggccctt tattgagata agttttcctg tcaagaaagc agaaaccatc tcatttctaa
     2761 cagctgtgtt atattccata gtatgcatta ctcaacaaac tgttgtgcta ttggatactt
     2821 aggtggtttc ttcactgaca atactgaata aacatctcaa tagtcaaa
//
