LOCUS       NM_003013               1996 bp    mRNA    linear   PRI 17-SEP-2024
DEFINITION  Homo sapiens secreted frizzled related protein 2 (SFRP2), mRNA.
ACCESSION   NM_003013 XM_050625
VERSION     NM_003013.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1996)
  AUTHORS   Zhang,R., Wu,M., Xiang,D., Zhu,J., Zhang,Q., Zhong,H., Peng,Y.,
            Wang,Z., Ma,G., Li,G., Liu,F., Ye,W., Shi,R., Zhou,X.,
            Babarinde,I.A., Su,H., Chen,J., Zhang,X., Qin,D., Hutchins,A.P.,
            Pei,D. and Li,D.
  TITLE     A primate-specific endogenous retroviral envelope protein
            sequesters SFRP2 to regulate human cardiomyocyte development
  JOURNAL   Cell Stem Cell 31 (9), 1298-1314 (2024)
   PUBMED   39146934
  REMARK    GeneRIF: A primate-specific endogenous retroviral envelope protein
            sequesters SFRP2 to regulate human cardiomyocyte development.
REFERENCE   2  (bases 1 to 1996)
  AUTHORS   Boughanem,H., Pilo,J., Garcia-Flores,L.A., Arranz,I.,
            Ramos-Fernandez,M., Ortega-Castan,M., Crujeiras,A.B., Sandoval,J.
            and Macias-Gonzalez,M.
  TITLE     Identification of epigenetic silencing of the SFRP2 gene in
            colorectal cancer as a clinical biomarker and molecular
            significance
  JOURNAL   J Transl Med 22 (1), 509 (2024)
   PUBMED   38802858
  REMARK    GeneRIF: Identification of epigenetic silencing of the SFRP2 gene
            in colorectal cancer as a clinical biomarker and molecular
            significance.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1996)
  AUTHORS   Lv,D., Lin,Z., Liao,X., Peng,R., Liu,H., Wu,T., Wu,K., Sun,Y. and
            Zhang,Z.
  TITLE     Sfrp2 promotes renal dysfunction of diabetic kidney disease via
            modulating Fzd5-induced cytosolic calcium ion concentration and
            CaMKII/Mek/Erk pathway in mesangial cells
  JOURNAL   Biochim Biophys Acta Mol Basis Dis 1870 (2), 166933 (2024)
   PUBMED   37951508
  REMARK    GeneRIF: Sfrp2 promotes renal dysfunction of diabetic kidney
            disease via modulating Fzd5-induced cytosolic calcium ion
            concentration and CaMKII/Mek/Erk pathway in mesangial cells.
REFERENCE   4  (bases 1 to 1996)
  AUTHORS   Yang,M., Li,L., Huang,X., Xing,H., Hong,L. and Jiang,C.
  TITLE     The DNA demethylation-regulated SFRP2 dictates the progression of
            endometriosis via activation of the Wnt/beta-catenin signaling
            pathway
  JOURNAL   BMC Mol Cell Biol 24 (1), 12 (2023)
   PUBMED   36991319
  REMARK    GeneRIF: The DNA demethylation-regulated SFRP2 dictates the
            progression of endometriosis via activation of the Wnt/beta-catenin
            signaling pathway.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1996)
  AUTHORS   Hsueh,Y.C., Pratt,R.E., Dzau,V.J. and Hodgkinson,C.P.
  TITLE     Novel method of differentiating human induced pluripotent stem
            cells to mature cardiomyocytes via Sfrp2
  JOURNAL   Sci Rep 13 (1), 3920 (2023)
   PUBMED   36894665
  REMARK    GeneRIF: Novel method of differentiating human induced pluripotent
            stem cells to mature cardiomyocytes via Sfrp2.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1996)
  AUTHORS   Chang,J.T., Esumi,N., Moore,K., Li,Y., Zhang,S., Chew,C.,
            Goodman,B., Rattner,A., Moody,S., Stetten,G., Campochiaro,P.A. and
            Zack,D.J.
  TITLE     Cloning and characterization of a secreted frizzled-related protein
            that is expressed by the retinal pigment epithelium
  JOURNAL   Hum Mol Genet 8 (4), 575-583 (1999)
   PUBMED   10072424
REFERENCE   7  (bases 1 to 1996)
  AUTHORS   Lescher,B., Haenig,B. and Kispert,A.
  TITLE     sFRP-2 is a target of the Wnt-4 signaling pathway in the developing
            metanephric kidney
  JOURNAL   Dev Dyn 213 (4), 440-451 (1998)
   PUBMED   9853965
REFERENCE   8  (bases 1 to 1996)
  AUTHORS   Hu,E., Zhu,Y., Fredrickson,T., Barnes,M., Kelsell,D., Beeley,L. and
            Brooks,D.
  TITLE     Tissue restricted expression of two human Frzbs in preadipocytes
            and pancreas
  JOURNAL   Biochem Biophys Res Commun 247 (2), 287-293 (1998)
   PUBMED   9642118
  REMARK    Erratum:[Biochem Biophys Res Commun 1998 Jul 30;248(3):941-3]
REFERENCE   9  (bases 1 to 1996)
  AUTHORS   Melkonyan,H.S., Chang,W.C., Shapiro,J.P., Mahadevappa,M.,
            Fitzpatrick,P.A., Kiefer,M.C., Tomei,L.D. and Umansky,S.R.
  TITLE     SARPs: a family of secreted apoptosis-related proteins
  JOURNAL   Proc Natl Acad Sci U S A 94 (25), 13636-13641 (1997)
   PUBMED   9391078
REFERENCE   10 (bases 1 to 1996)
  AUTHORS   Rattner,A., Hsieh,J.C., Smallwood,P.M., Gilbert,D.J.,
            Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     A family of secreted proteins contains homology to the
            cysteine-rich ligand-binding domain of frizzled receptors
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 2859-2863 (1997)
   PUBMED   9096311
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC020703.7, CN431016.1,
            BM906663.1, BM924815.1, BC008666.1, AA449032.1, AK075372.1,
            AK093922.1 and AF311912.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_003013.2.
            
            Summary: This gene encodes a member of the SFRP family that
            contains a cysteine-rich domain homologous to the putative
            Wnt-binding site of Frizzled proteins. SFRPs act as soluble
            modulators of Wnt signaling. Methylation of this gene is a
            potential marker for the presence of colorectal cancer. [provided
            by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.960010.1, AF311912.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2151358
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274063.5/ ENSP00000274063.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 AC020703.7         71236-71242         c
            8-8                 CN431016.1         10-10
            9-9                 BM906663.1         61-61
            10-10               BM924815.1         18-18
            11-30               BM906663.1         63-82
            31-379              BC008666.1         4-352
            380-458             AA449032.1         363-441
            459-1409            BC008666.1         432-1382
            1410-1800           AK075372.1         1396-1786
            1801-1995           AK093922.1         1762-1956
            1996-1996           AF311912.1         1985-1985
FEATURES             Location/Qualifiers
     source          1..1996
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.3"
     gene            1..1996
                     /gene="SFRP2"
                     /gene_synonym="FRP-2; SARP1; SDF-5"
                     /note="secreted frizzled related protein 2"
                     /db_xref="GeneID:6423"
                     /db_xref="HGNC:HGNC:10777"
                     /db_xref="MIM:604157"
     exon            1..750
                     /gene="SFRP2"
                     /gene_synonym="FRP-2; SARP1; SDF-5"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..1136
                     /gene="SFRP2"
                     /gene_synonym="FRP-2; SARP1; SDF-5"
                     /note="secreted apoptosis related protein 1; SARP-1;
                     sFRP-2; testicular tissue protein Li 170"
                     /codon_start=1
                     /product="secreted frizzled-related protein 2 precursor"
                     /protein_id="NP_003004.1"
                     /db_xref="CCDS:CCDS34082.1"
                     /db_xref="GeneID:6423"
                     /db_xref="HGNC:HGNC:10777"
                     /db_xref="MIM:604157"
                     /translation="MLQGPGSLLLLFLASHCCLGSARGLFLFGQPDFSYKRSNCKPIP
                     ANLQLCHGIEYQNMRLPNLLGHETMKEVLEQAGAWIPLVMKQCHPDTKKFLCSLFAPV
                     CLDDLDETIQPCHSLCVQVKDRCAPVMSAFGFPWPDMLECDRFPQDNDLCIPLASSDH
                     LLPATEEAPKVCEACKNKNDDDNDIMETLCKNDFALKIKVKEITYINRDTKIILETKS
                     KTIYKLNGVSERDLKKSVLWLKDSLQCTCEEMNDINAPYLVMGQKQGGELVITSVKRW
                     QKGQREFKRISRSIRKLQC"
     exon            751..831
                     /gene="SFRP2"
                     /gene_synonym="FRP-2; SARP1; SDF-5"
                     /inference="alignment:Splign:2.1.0"
     exon            832..1996
                     /gene="SFRP2"
                     /gene_synonym="FRP-2; SARP1; SDF-5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1970..1975
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SFRP2"
                     /gene_synonym="FRP-2; SARP1; SDF-5"
                     /note="hexamer: TATAAA"
     polyA_site      1996
                     /gene="SFRP2"
                     /gene_synonym="FRP-2; SARP1; SDF-5"
                     /note="major polyA site"
ORIGIN      
        1 gccccagcaa cggctcattc tgctcccccg ggtcggagcc ccccggagct gcgcgcgggc
       61 ttgcagcgcc tcgcccgcgc tgtcctcccg gtgtcccgct tctccgcgcc ccagccgccg
      121 gctgccagct tttcggggcc ccgagtcgca cccagcgaag agagcgggcc cgggacaagc
      181 tcgaactccg gccgcctcgc ccttccccgg ctccgctccc tctgccccct cggggtcgcg
      241 cgcccacgat gctgcagggc cctggctcgc tgctgctgct cttcctcgcc tcgcactgct
      301 gcctgggctc ggcgcgcggg ctcttcctct ttggccagcc cgacttctcc tacaagcgca
      361 gcaattgcaa gcccatccct gccaacctgc agctgtgcca cggcatcgaa taccagaaca
      421 tgcggctgcc caacctgctg ggccacgaga ccatgaagga ggtgctggag caggccggcg
      481 cttggatccc gctggtcatg aagcagtgcc acccggacac caagaagttc ctgtgctcgc
      541 tcttcgcccc cgtctgcctc gatgacctag acgagaccat ccagccatgc cactcgctct
      601 gcgtgcaggt gaaggaccgc tgcgccccgg tcatgtccgc cttcggcttc ccctggcccg
      661 acatgcttga gtgcgaccgt ttcccccagg acaacgacct ttgcatcccc ctcgctagca
      721 gcgaccacct cctgccagcc accgaggaag ctccaaaggt atgtgaagcc tgcaaaaata
      781 aaaatgatga tgacaacgac ataatggaaa cgctttgtaa aaatgatttt gcactgaaaa
      841 taaaagtgaa ggagataacc tacatcaacc gagataccaa aatcatcctg gagaccaaga
      901 gcaagaccat ttacaagctg aacggtgtgt ccgaaaggga cctgaagaaa tcggtgctgt
      961 ggctcaaaga cagcttgcag tgcacctgtg aggagatgaa cgacatcaac gcgccctatc
     1021 tggtcatggg acagaaacag ggtggggagc tggtgatcac ctcggtgaag cggtggcaga
     1081 aggggcagag agagttcaag cgcatctccc gcagcatccg caagctgcag tgctagtccc
     1141 ggcatcctga tggctccgac aggcctgctc cagagcacgg ctgaccattt ctgctccggg
     1201 atctcagctc ccgttcccca agcacactcc tagctgctcc agtctcagcc tgggcagctt
     1261 ccccctgcct tttgcacgtt tgcatcccca gcatttcctg agttataagg ccacaggagt
     1321 ggatagctgt tttcacctaa aggaaaagcc cacccgaatc ttgtagaaat attcaaacta
     1381 ataaaatcat gaatattttt atgaagttta aaaatagctc actttaaagc tagttttgaa
     1441 taggtgcaac tgtgacttgg gtctggttgg ttgttgtttg ttgttttgag tcagctgatt
     1501 ttcacttccc actgaggttg tcataacatg caaattgctt caattttctc tgtggcccaa
     1561 acttgtgggt cacaaaccct gttgagataa agctggctgt tatctcaaca tcttcatcag
     1621 ctccagactg agactcagtg tctaagtctt acaacaattc atcattttat accttcaatg
     1681 ggaacttaaa ctgttacatg tatcacattc cagctacaat acttccattt attagaagca
     1741 cattaaccat ttctatagca tgatttcttc aagtaaaagg caaaagatat aaattttata
     1801 attgacttga gtactttaag ccttgtttaa aacatttctt acttaacttt tgcaaattaa
     1861 acccattgta gcttacctgt aatatacata gtagtttacc tttaaaagtt gtaaaaatat
     1921 tgctttaacc aacactgtaa atatttcaga taaacattat attcttgtat ataaacttta
     1981 catcctgttt taccta
//
