LOCUS       NM_003012               4464 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens secreted frizzled related protein 1 (SFRP1), mRNA.
ACCESSION   NM_003012
VERSION     NM_003012.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4464)
  AUTHORS   Dong,L., Li,Y., Song,X., Sun,C. and Song,X.
  TITLE     SFRP1 mediates cancer-associated fibroblasts to suppress cancer
            cell proliferation and migration in head and neck squamous cell
            carcinoma
  JOURNAL   BMC Cancer 24 (1), 1165 (2024)
   PUBMED   39300373
  REMARK    GeneRIF: SFRP1 mediates cancer-associated fibroblasts to suppress
            cancer cell proliferation and migration in head and neck squamous
            cell carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4464)
  AUTHORS   Hu,X., Liu,Y., Shen,H., Zhang,T. and Liang,T.
  TITLE     MTF2 facilitates the advancement of osteosarcoma through mediating
            EZH2/SFRP1/Wnt signaling
  JOURNAL   J Orthop Surg Res 19 (1), 467 (2024)
   PUBMED   39118123
  REMARK    GeneRIF: MTF2 facilitates the advancement of osteosarcoma through
            mediating EZH2/SFRP1/Wnt signaling.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 4464)
  AUTHORS   Oveisgharan,S., Yu,L., de Paiva Lopes,K., Tasaki,S., Wang,Y.,
            Menon,V., Schneider,J.A., Seyfried,N.T. and Bennett,D.A.
  TITLE     Proteins linking APOE varepsilon4 with Alzheimer's disease
  JOURNAL   Alzheimers Dement 20 (7), 4499-4511 (2024)
   PUBMED   38856164
  REMARK    GeneRIF: Proteins linking APOE varepsilon4 with Alzheimer's
            disease.
REFERENCE   4  (bases 1 to 4464)
  AUTHORS   Cai,Y., Liu,Y., Sun,Y. and Ren,Y.
  TITLE     LncRNA DLG5-AS1 facilitates breast cancer cell proliferation and
            invasion by promoting EZH2-mediated transcriptional silencing of
            SFRP1
  JOURNAL   Arch Biochem Biophys 756, 110018 (2024)
   PUBMED   38677505
  REMARK    GeneRIF: LncRNA DLG5-AS1 facilitates breast cancer cell
            proliferation and invasion by promoting EZH2-mediated
            transcriptional silencing of SFRP1.
REFERENCE   5  (bases 1 to 4464)
  AUTHORS   Ding,Z., Wu,L., Sun,Y., Zhu,Y., Zuo,Q., Yuan,L., Wang,C., Sun,L.,
            Xu,Y. and Zhang,Y.
  TITLE     Downregulated PDIA3P1 lncRNA Impairs Trophoblast Phenotype by
            Regulating Snail and SFRP1 in PE
  JOURNAL   Anal Cell Pathol (Amst) 2024, 8972022 (2024)
   PUBMED   38715918
  REMARK    GeneRIF: Downregulated PDIA3P1 lncRNA Impairs Trophoblast Phenotype
            by Regulating Snail and SFRP1 in PE.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 4464)
  AUTHORS   Zhou,Z., Wang,J., Han,X., Zhou,J. and Linder,S.
  TITLE     Up-regulation of human secreted frizzled homolog in apoptosis and
            its down-regulation in breast tumors
  JOURNAL   Int J Cancer 78 (1), 95-99 (1998)
   PUBMED   9724099
REFERENCE   7  (bases 1 to 4464)
  AUTHORS   Melkonyan,H.S., Chang,W.C., Shapiro,J.P., Mahadevappa,M.,
            Fitzpatrick,P.A., Kiefer,M.C., Tomei,L.D. and Umansky,S.R.
  TITLE     SARPs: a family of secreted apoptosis-related proteins
  JOURNAL   Proc Natl Acad Sci U S A 94 (25), 13636-13641 (1997)
   PUBMED   9391078
REFERENCE   8  (bases 1 to 4464)
  AUTHORS   Finch,P.W., He,X., Kelley,M.J., Uren,A., Schaudies,R.P.,
            Popescu,N.C., Rudikoff,S., Aaronson,S.A., Varmus,H.E. and
            Rubin,J.S.
  TITLE     Purification and molecular cloning of a secreted, Frizzled-related
            antagonist of Wnt action
  JOURNAL   Proc Natl Acad Sci U S A 94 (13), 6770-6775 (1997)
   PUBMED   9192640
REFERENCE   9  (bases 1 to 4464)
  AUTHORS   Rattner,A., Hsieh,J.C., Smallwood,P.M., Gilbert,D.J.,
            Copeland,N.G., Jenkins,N.A. and Nathans,J.
  TITLE     A family of secreted proteins contains homology to the
            cysteine-rich ligand-binding domain of frizzled receptors
  JOURNAL   Proc Natl Acad Sci U S A 94 (7), 2859-2863 (1997)
   PUBMED   9096311
REFERENCE   10 (bases 1 to 4464)
  AUTHORS   Leung,A.K. and Robson,W.L.
  TITLE     Urinary tract infection in infancy and childhood
  JOURNAL   Adv Pediatr 38, 257-285 (1991)
   PUBMED   1927703
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC104393.6, BC036503.1,
            CN271890.1, CB956696.1, DA571541.1 and BQ002015.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003012.4.
            
            Summary: This gene encodes a member of the SFRP family that
            contains a cysteine-rich domain homologous to the putative
            Wnt-binding site of Frizzled proteins. Members of this family act
            as soluble modulators of Wnt signaling; epigenetic silencing of
            SFRP genes leads to deregulated activation of the Wnt-pathway which
            is associated with cancer. This gene may also be involved in
            determining the polarity of photoreceptor cells in the retina.
            [provided by RefSeq, Sep 2009].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036503.1, AF056087.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN03267752, SAMN03267761
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000220772.8/ ENSP00000220772.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2                 AC104393.6         1260-1261
            3-1321              BC036503.1         8-1326
            1322-2081           CN271890.1         3-762
            2082-2574           CB956696.1         72-564
            2575-3187           DA571541.1         86-698
            3188-4131           BC036503.1         3192-4135
            4132-4464           BQ002015.1         21-353              c
FEATURES             Location/Qualifiers
     source          1..4464
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8p11.21"
     gene            1..4464
                     /gene="SFRP1"
                     /gene_synonym="FRP; FRP-1; FRP1; FrzA; SARP2"
                     /note="secreted frizzled related protein 1"
                     /db_xref="GeneID:6422"
                     /db_xref="HGNC:HGNC:10776"
                     /db_xref="MIM:604156"
     exon            1..858
                     /gene="SFRP1"
                     /gene_synonym="FRP; FRP-1; FRP1; FrzA; SARP2"
                     /inference="alignment:Splign:2.1.0"
     CDS             315..1259
                     /gene="SFRP1"
                     /gene_synonym="FRP; FRP-1; FRP1; FrzA; SARP2"
                     /note="secreted apoptosis-related protein 2; SARP-2;
                     sFRP-1; frizzled-related protein"
                     /codon_start=1
                     /product="secreted frizzled-related protein 1 precursor"
                     /protein_id="NP_003003.3"
                     /db_xref="CCDS:CCDS34886.1"
                     /db_xref="GeneID:6422"
                     /db_xref="HGNC:HGNC:10776"
                     /db_xref="MIM:604156"
                     /translation="MGIGRSEGGRRGAALGVLLALGAALLAVGSASEYDYVSFQSDIG
                     PYQSGRFYTKPPQCVDIPADLRLCHNVGYKKMVLPNLLEHETMAEVKQQASSWVPLLN
                     KNCHAGTQVFLCSLFAPVCLDRPIYPCRWLCEAVRDSCEPVMQFFGFYWPEMLKCDKF
                     PEGDVCIAMTPPNATEASKPQGTTVCPPCDNELKSEAIIEHLCASEFALRMKIKEVKK
                     ENGDKKIVPKKKKPLKLGPIKKKDLKKLVLYLKNGADCPCHQLDNLSHHFLIMGRKVK
                     SQYLLTAIHKWDKKNKEFKNFMKKMKNHECPTFQSVFK"
     exon            859..936
                     /gene="SFRP1"
                     /gene_synonym="FRP; FRP-1; FRP1; FrzA; SARP2"
                     /inference="alignment:Splign:2.1.0"
     exon            937..4464
                     /gene="SFRP1"
                     /gene_synonym="FRP; FRP-1; FRP1; FrzA; SARP2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4442..4447
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SFRP1"
                     /gene_synonym="FRP; FRP-1; FRP1; FrzA; SARP2"
                     /note="hexamer: ACTAAA"
     polyA_site      4464
                     /gene="SFRP1"
                     /gene_synonym="FRP; FRP-1; FRP1; FrzA; SARP2"
                     /note="major polyA site"
ORIGIN      
        1 gcgcactcca gccctgcagc ctccggagtc agtgccgcgc gcccgccgcc ccgcgccttc
       61 ctgctcgccg cacctccggg agccggggcg cacccagccc gcagcgccgc ctccccgccc
      121 gcgccgcctc cgaccgcagg ccgagggccg ccactggccg gggggaccgg gcagcagctt
      181 gcggccgcgg agccgggcaa cgctggggac tgcgcctttt gtccccggag gtccctggaa
      241 gtttgcggca ggacgcgcgc ggggaggcgg cggaggcagc cccgacgtcg cggagaacag
      301 ggcgcagagc cggcatgggc atcgggcgca gcgagggggg ccgccgcggg gcagccctgg
      361 gcgtgctgct ggcgctgggc gcggcgcttc tggccgtggg ctcggccagc gagtacgact
      421 acgtgagctt ccagtcggac atcggcccgt accagagcgg gcgcttctac accaagccac
      481 ctcagtgcgt ggacatcccc gcggacctgc ggctgtgcca caacgtgggc tacaagaaga
      541 tggtgctgcc caacctgctg gagcacgaga ccatggcgga ggtgaagcag caggccagca
      601 gctgggtgcc cctgctcaac aagaactgcc acgccggcac ccaggtcttc ctctgctcgc
      661 tcttcgcgcc cgtctgcctg gaccggccca tctacccgtg tcgctggctc tgcgaggccg
      721 tgcgcgactc gtgcgagccg gtcatgcagt tcttcggctt ctactggccc gagatgctta
      781 agtgtgacaa gttccccgag ggggacgtct gcatcgccat gacgccgccc aatgccaccg
      841 aagcctccaa gccccaaggc acaacggtgt gtcctccctg tgacaacgag ttgaaatctg
      901 aggccatcat tgaacatctc tgtgccagcg agtttgcact gaggatgaaa ataaaagaag
      961 tgaaaaaaga aaatggcgac aagaagattg tccccaagaa gaagaagccc ctgaagttgg
     1021 ggcccatcaa gaagaaggac ctgaagaagc ttgtgctgta cctgaagaat ggggctgact
     1081 gtccctgcca ccagctggac aacctcagcc accacttcct catcatgggc cgcaaggtga
     1141 agagccagta cttgctgacg gccatccaca agtgggacaa gaaaaacaag gagttcaaaa
     1201 acttcatgaa gaaaatgaaa aaccatgagt gccccacctt tcagtccgtg tttaagtgat
     1261 tctcccgggg gcagggtggg gagggagcct cgggtggggt gggagcgggg gggacagtgc
     1321 cccgggaacc cggtgggtca cacacacgca ctgcgcctgt cagtagtgga cattgtaatc
     1381 cagtcggctt gttcttgcag cattcccgct cccttccctc catagccacg ctccaaaccc
     1441 cagggtagcc atggccgggt aaagcaaggg ccatttagat taggaaggtt tttaagatcc
     1501 gcaatgtgga gcagcagcca ctgcacagga ggaggtgaca aaccatttcc aacagcaaca
     1561 cagccactaa aacacaaaaa gggggattgg gcggaaagtg agagccagca gcaaaaacta
     1621 cattttgcaa cttgttggtg tggatctatt ggctgatcta tgcctttcaa ctagaaaatt
     1681 ctaatgattg gcaagtcacg ttgttttcag gtccagagta gtttctttct gtctgcttta
     1741 aatggaaaca gactcatacc acacttacaa ttaaggtcaa gcccagaaag tgataagtgc
     1801 agggaggaaa agtgcaagtc cattatgtaa tagtgacagc aaagggacca ggggagaggc
     1861 attgccttct ctgcccacag tctttccgtg tgattgtctt tgaatctgaa tcagccagtc
     1921 tcagatgccc caaagtttcg gttcctatga gcccggggca tgatctgatc cccaagacat
     1981 gtggaggggc agcctgtgcc tgcctttgtg tcagaaaaag gaaaccacag tgagcctgag
     2041 agagacggcg attttcgggc tgagaaggca gtagttttca aaacacatag ttaaaaaaga
     2101 aacaaatgaa aaaaatttta gaacagtcca gcaaattgct agtcagggtg aattgtgaaa
     2161 ttgggtgaag agcttaggat tctaatctca tgttttttcc ttttcacatt tttaaaagaa
     2221 caatgacaaa cacccactta tttttcaagg ttttaaaaca gtctacattg agcatttgaa
     2281 aggtgtgcta gaacaaggtc tcctgatccg tccgaggctg cttcccagag gagcagctct
     2341 ccccaggcat ttgccaaggg aggcggattt ccctggtagt gtagctgtgt ggctttcctt
     2401 cctgaagagt ccgtggttgc cctagaacct aacaccccct agcaaaactc acagagcttt
     2461 ccgttttttt ctttcctgta aagaaacatt tcctttgaac ttgattgcct atggatcaaa
     2521 gaaattcaga acagcctgcc tgtccccccg cactttttac atatatttgt ttcatttctg
     2581 cagatggaaa gttgacatgg gtggggtgtc cccatccagc gagagagttt caaaagcaaa
     2641 acatctctgc agtttttccc aagtaccctg agatacttcc caaagccctt atgtttaatc
     2701 agcgatgtat ataagccagt tcacttagac aactttaccc ttcttgtcca atgtacagga
     2761 agtagttcta aaaaaaatgc atattaattt cttcccccaa agccggattc ttaattctct
     2821 gcaacacttt gaggacattt atgattgtcc ctctgggcca atgcttatac ccagtgagga
     2881 tgctgcagtg aggctgtaaa gtggccccct gcggccctag cctgacccgg aggaaaggat
     2941 ggtagattct gttaactctt gaagactcca gtatgaaaat cagcatgccc gcctagttac
     3001 ctaccggaga gttatcctga taaattaacc tctcacagtt agtgatcctg tccttttaac
     3061 accttttttg tggggttctc tctgaccttt catcgtaaag tgctggggac cttaagtgat
     3121 ttgcctgtaa ttttggatga ttaaaaaatg tgtatatata ttagctaatt agaaatattc
     3181 tacttctctg ttgtcaaact gaaattcaga gcaagttcct gagtgcgtgg atctgggtct
     3241 tagttctggt tgattcactc aagagttcag tgctcatacg tatctgctca ttttgacaaa
     3301 gtgcctcatg caaccgggcc ctctctctgc ggcagagtcc ttagtggagg ggtttacctg
     3361 gaacattagt agttaccaca gaatacggaa gagcaggtga ctgtgctgtg cagctctcta
     3421 aatgggaatt ctcaggtagg aagcaacagc ttcagaaaga gctcaaaata aattggaaat
     3481 gtgaatcgca gctgtgggtt ttaccaccgt ctgtctcaga gtcccaggac cttgagtgtc
     3541 attagttact ttattgaagg ttttagaccc atagcagctt tgtctctgtc acatcagcaa
     3601 tttcagaacc aaaagggagg ctctctgtag gcacagagct gcactatcac gagcctttgt
     3661 ttttctccac aaagtatcta acaaaaccaa tgtgcagact gattggcctg gtcattggtc
     3721 tccgagagag gaggtttgcc tgtgatttcc taattatcgc tagggccaag gtgggatttg
     3781 taaagcttta caataatcat tctggataga gtcctgggag gtccttggca gaactcagtt
     3841 aaatctttga agaatatttg tagttatctt agaagatagc atgggaggtg aggattccaa
     3901 aaacatttta tttttaaaat atcctgtgta acacttggct cttggtacct gtgggttagc
     3961 atcaagttct ccccagggta gaattcaatc agagctccag tttgcatttg gatgtgtaaa
     4021 ttacagtaat cccatttccc aaacctaaaa tctgtttttc tcatcagact ctgagtaact
     4081 ggttgctgtg tcataacttc atagatgcag gaggctcagg tgatctgttt gaggagagca
     4141 ccctaggcag cctgcaggga ataacatact ggccgttctg acctgttgcc agcagataca
     4201 caggacatgg atgaaattcc cgtttcctct agtttcttcc tgtagtactc ctcttttaga
     4261 tcctaagtct cttacaaaag ctttgaatac tgtgaaaatg ttttacattc catttcattt
     4321 gtgttgtttt tttaactgca ttttaccaga tgttttgatg ttatcgctta tgttaatagt
     4381 aattcccgta cgtgttcatt ttattttcat gctttttcag ccatgtatca atattcactt
     4441 gactaaaatc actcaattaa tcaa
//
