LOCUS       NM_005066               3740 bp    mRNA    linear   PRI 20-FEB-2025
DEFINITION  Homo sapiens splicing factor proline and glutamine rich (SFPQ),
            transcript variant 1, mRNA.
ACCESSION   NM_005066 XR_110484 XR_110485 XR_110486 XR_112062 XR_112063
            XR_112064
VERSION     NM_005066.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3740)
  AUTHORS   Thivierge,C., Bellefeuille,M., Diwan,S.S., Dyakov,B.J.A.,
            Leventis,R., Perron,G., Najafabadi,H.S., Gravel,S.P., Gingras,A.C.
            and Duchaine,T.F.
  TITLE     Paraspeckle-independent co-transcriptional regulation of nuclear
            microRNA biogenesis by SFPQ
  JOURNAL   Cell Rep 43 (9), 114695 (2024)
   PUBMED   39250314
  REMARK    GeneRIF: Paraspeckle-independent co-transcriptional regulation of
            nuclear microRNA biogenesis by SFPQ.
REFERENCE   2  (bases 1 to 3740)
  AUTHORS   Khoroshkin,M., Buyan,A., Dodel,M., Navickas,A., Yu,J., Trejo,F.,
            Doty,A., Baratam,R., Zhou,S., Lee,S.B., Joshi,T., Garcia,K.,
            Choi,B., Miglani,S., Subramanyam,V., Modi,H., Carpenter,C.,
            Markett,D., Corces,M.R., Mardakheh,F.K., Kulakovskiy,I.V. and
            Goodarzi,H.
  TITLE     Systematic identification of post-transcriptional regulatory
            modules
  JOURNAL   Nat Commun 15 (1), 7872 (2024)
   PUBMED   39251607
  REMARK    Erratum:[Nat Commun. 2024 Oct 28;15(1):9277. doi:
            10.1038/s41467-024-52903-4.. PMID: 39468017]
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3740)
  AUTHORS   Murray-Nerger,L.A., Lozano,C., Burton,E.M., Liao,Y.,
            Ungerleider,N.A., Guo,R. and Gewurz,B.E.
  TITLE     The nucleic acid binding protein SFPQ represses EBV lytic
            reactivation by promoting histone H1 expression
  JOURNAL   Nat Commun 15 (1), 4156 (2024)
   PUBMED   38755141
  REMARK    GeneRIF: The nucleic acid binding protein SFPQ represses EBV lytic
            reactivation by promoting histone H1 expression.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3740)
  AUTHORS   Akhmedov,A.T. and Lopez,B.S.
  TITLE     Human 100-kDa homologous DNA-pairing protein is the splicing factor
            PSF and promotes DNA strand invasion
  JOURNAL   Nucleic Acids Res 28 (16), 3022-3030 (2000)
   PUBMED   10931916
REFERENCE   5  (bases 1 to 3740)
  AUTHORS   Lutz,C.S., Cooke,C., O'Connor,J.P., Kobayashi,R. and Alwine,J.C.
  TITLE     The snRNP-free U1A (SF-A) complex(es): identification of the
            largest subunit as PSF, the polypyrimidine-tract binding
            protein-associated splicing factor
  JOURNAL   RNA 4 (12), 1493-1499 (1998)
   PUBMED   9848648
REFERENCE   6  (bases 1 to 3740)
  AUTHORS   Teigelkamp,S., Mundt,C., Achsel,T., Will,C.L. and Luhrmann,R.
  TITLE     The human U5 snRNP-specific 100-kD protein is an RS
            domain-containing, putative RNA helicase with significant homology
            to the yeast splicing factor Prp28p
  JOURNAL   RNA 3 (11), 1313-1326 (1997)
   PUBMED   9409622
REFERENCE   7  (bases 1 to 3740)
  AUTHORS   Gozani,O., Patton,J.G. and Reed,R.
  TITLE     A novel set of spliceosome-associated proteins and the essential
            splicing factor PSF bind stably to pre-mRNA prior to catalytic step
            II of the splicing reaction
  JOURNAL   EMBO J 13 (14), 3356-3367 (1994)
   PUBMED   8045264
REFERENCE   8  (bases 1 to 3740)
  AUTHORS   Patton,J.G., Porro,E.B., Galceran,J., Tempst,P. and Nadal-Ginard,B.
  TITLE     Cloning and characterization of PSF, a novel pre-mRNA splicing
            factor
  JOURNAL   Genes Dev 7 (3), 393-406 (1993)
   PUBMED   8449401
REFERENCE   9  (bases 1 to 3740)
  AUTHORS   Zhang,W.W., Zhang,L.X., Busch,R.K., Farres,J. and Busch,H.
  TITLE     Purification and characterization of a DNA-binding heterodimer of
            52 and 100 kDa from HeLa cells
  JOURNAL   Biochem J 290 (Pt 1) (Pt 1), 267-272 (1993)
   PUBMED   8439294
REFERENCE   10 (bases 1 to 3740)
  AUTHORS   Gower,H.J., Moore,S.E., Dickson,G., Elsom,V.L., Nayak,R. and
            Walsh,F.S.
  TITLE     Cloning and characterization of a myoblast cell surface antigen
            defined by 24.1D5 monoclonal antibody
  JOURNAL   Development 105 (4), 723-731 (1989)
   PUBMED   2480877
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL590434.16, BC051192.1 and X70944.1.
            
            On Nov 22, 2018 this sequence version replaced NM_005066.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163658.308940.1, GQ900958.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357214.6/ ENSP00000349748.5
            RefSeq Select criteria :: based on conservation, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3                 AL590434.16        78692-78694         c
            4-11                BC051192.1         3-10
            12-2561             X70944.1           1-2550
            2562-3076           X70944.1           2552-3066
            3077-3740           AL590434.16        68485-69148         c
FEATURES             Location/Qualifiers
     source          1..3740
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p34.3"
     gene            1..3740
                     /gene="SFPQ"
                     /gene_synonym="POMP100; PPP1R140; PSF"
                     /note="splicing factor proline and glutamine rich"
                     /db_xref="GeneID:6421"
                     /db_xref="HGNC:HGNC:10774"
                     /db_xref="MIM:605199"
     exon            1..924
                     /gene="SFPQ"
                     /gene_synonym="POMP100; PPP1R140; PSF"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..2220
                     /gene="SFPQ"
                     /gene_synonym="POMP100; PPP1R140; PSF"
                     /note="polypyrimidine tract-binding protein-associated
                     splicing factor; polypyrimidine tract binding protein
                     associated; splicing factor proline/glutamine rich
                     (polypyrimidine tract binding protein associated);
                     epididymis secretory sperm binding protein; PTB-associated
                     splicing factor; 100 kDa DNA-pairing protein; DNA-binding
                     p52/p100 complex, 100 kDa subunit; protein phosphatase 1,
                     regulatory subunit 140; splicing factor
                     proline/glutamine-rich"
                     /codon_start=1
                     /product="splicing factor, proline- and glutamine-rich"
                     /protein_id="NP_005057.1"
                     /db_xref="CCDS:CCDS388.1"
                     /db_xref="GeneID:6421"
                     /db_xref="HGNC:HGNC:10774"
                     /db_xref="MIM:605199"
                     /translation="MSRDRFRSRGGGGGGFHRRGGGGGRGGLHDFRSPPPGMGLNQNR
                     GPMGPGPGQSGPKPPIPPPPPHQQQQQPPPQQPPPQQPPPHQPPPHPQPHQQQQPPPP
                     PQDSSKPVVAQGPGPAPGVGSAPPASSSAPPATPPTSGAPPGSGPGPTPTPPPAVTSA
                     PPGAPPPTPPSSGVPTTPPQAGGPPPPPAAVPGPGPGPKQGPGPGGPKGGKMPGGPKP
                     GGGPGLSTPGGHPKPPHRGGGEPRGGRQHHPPYHQQHHQGPPPGGPGGRSEEKISDSE
                     GFKANLSLLRRPGEKTYTQRCRLFVGNLPADITEDEFKRLFAKYGEPGEVFINKGKGF
                     GFIKLESRALAEIAKAELDDTPMRGRQLRVRFATHAAALSVRNLSPYVSNELLEEAFS
                     QFGPIERAVVIVDDRGRSTGKGIVEFASKPAARKAFERCSEGVFLLTTTPRPVIVEPL
                     EQLDDEDGLPEKLAQKNPMYQKERETPPRFAQHGTFEYEYSQRWKSLDEMEKQQREQV
                     EKNMKDAKDKLESEMEDAYHEHQANLLRQDLMRRQEELRRMEELHNQEMQKRKEMQLR
                     QEEERRRREEEMMIRQREMEEQMRRQREESYSRMGYMDPRERDMRMGGGGAMNMGDPY
                     GSGGQKFPPLGGGGGIGYEANPGVPPATMSGSMMGSDMRTERFGQGGAGPVGGQGPRG
                     MGPGTPAGYGRGREEYEGPNKKPRF"
     exon            925..1113
                     /gene="SFPQ"
                     /gene_synonym="POMP100; PPP1R140; PSF"
                     /inference="alignment:Splign:2.1.0"
     exon            1114..1415
                     /gene="SFPQ"
                     /gene_synonym="POMP100; PPP1R140; PSF"
                     /inference="alignment:Splign:2.1.0"
     exon            1416..1511
                     /gene="SFPQ"
                     /gene_synonym="POMP100; PPP1R140; PSF"
                     /inference="alignment:Splign:2.1.0"
     exon            1512..1708
                     /gene="SFPQ"
                     /gene_synonym="POMP100; PPP1R140; PSF"
                     /inference="alignment:Splign:2.1.0"
     exon            1709..1793
                     /gene="SFPQ"
                     /gene_synonym="POMP100; PPP1R140; PSF"
                     /inference="alignment:Splign:2.1.0"
     exon            1794..1911
                     /gene="SFPQ"
                     /gene_synonym="POMP100; PPP1R140; PSF"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..1960
                     /gene="SFPQ"
                     /gene_synonym="POMP100; PPP1R140; PSF"
                     /inference="alignment:Splign:2.1.0"
     exon            1961..2082
                     /gene="SFPQ"
                     /gene_synonym="POMP100; PPP1R140; PSF"
                     /inference="alignment:Splign:2.1.0"
     exon            2083..3740
                     /gene="SFPQ"
                     /gene_synonym="POMP100; PPP1R140; PSF"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3056..3061
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SFPQ"
                     /gene_synonym="POMP100; PPP1R140; PSF"
                     /note="hexamer: ATTAAA"
     polyA_site      3076
                     /gene="SFPQ"
                     /gene_synonym="POMP100; PPP1R140; PSF"
                     /note="major polyA site"
     regulatory      3547..3552
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SFPQ"
                     /gene_synonym="POMP100; PPP1R140; PSF"
                     /note="hexamer: TATAAA"
     polyA_site      3573
                     /gene="SFPQ"
                     /gene_synonym="POMP100; PPP1R140; PSF"
     regulatory      3722..3727
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SFPQ"
                     /gene_synonym="POMP100; PPP1R140; PSF"
                     /note="hexamer: CATAAA"
     polyA_site      3740
                     /gene="SFPQ"
                     /gene_synonym="POMP100; PPP1R140; PSF"
ORIGIN      
        1 gcctgtgtca tccgccattt tgtgagaagc aaggtggcct ccacgtttcc tgagcgtctt
       61 cttcgctttt gcctcgaccg ccccttgacc acagacatgt ctcgggatcg gttccggagt
      121 cgtggcggtg gcggtggtgg cttccacagg cgtggaggag gcggcggccg cggcggcctc
      181 cacgacttcc gttctccgcc gcccggcatg ggcctcaatc agaatcgcgg ccccatgggt
      241 cctggcccgg gccagagcgg ccctaagcct ccgatcccgc caccgcctcc acaccaacag
      301 cagcaacagc caccaccgca gcagccaccg ccgcagcagc cgccaccgca tcagccgccg
      361 ccgcatccac agccgcatca gcagcagcag ccgccgccac cgccgcagga ctcttccaag
      421 cccgtcgttg ctcagggacc cggccccgct cccggagtag gcagcgcacc accagcctcc
      481 agctcggccc cgcccgccac tccaccaacc tcgggggccc cgccagggtc cgggccaggc
      541 ccgactccga ccccgccgcc tgcagtcacc tcggcccctc ccggggcgcc gccacccacc
      601 ccgccaagca gcggggtccc taccacacct cctcaggccg gaggcccgcc gcctccgccc
      661 gcggcagtcc cgggcccggg tccagggcct aagcagggcc caggtccggg tggtcccaaa
      721 ggcggcaaaa tgcctggcgg gccgaagcca ggtggcggcc cgggcctaag tacgcctggc
      781 ggccacccca agccgccgca tcgaggcggc ggggagcccc gcgggggccg ccagcaccac
      841 ccgccctacc accagcagca tcaccagggg cccccgcccg gcgggcccgg cggccgcagc
      901 gaggagaaga tctcggactc ggaggggttt aaagccaatt tgtctctctt gaggaggcct
      961 ggagagaaaa cttacacaca gcgatgtcgg ttgtttgttg ggaatctacc tgctgatatc
     1021 acggaggatg aattcaaaag actatttgct aaatatggag aaccaggaga agtttttatc
     1081 aacaaaggca aaggattcgg atttattaag cttgaatcta gagctttggc tgaaattgcc
     1141 aaagccgaac tggatgatac acccatgaga ggtagacagc ttcgagttcg ctttgccaca
     1201 catgctgctg ccctttctgt tcgtaatctt tcaccttatg tttccaatga actgttggaa
     1261 gaagccttta gccaatttgg tcctattgaa agggctgttg taatagtgga tgatcgtgga
     1321 agatctacag ggaaaggcat tgttgaattt gcttctaagc cagcagcaag aaaggcattt
     1381 gaacgatgca gtgaaggtgt tttcttactg acgacaactc ctcgtccagt cattgtggaa
     1441 ccacttgaac aactagatga tgaagatggt cttcctgaaa aacttgccca gaagaatcca
     1501 atgtatcaaa aggagagaga aacccctcct cgttttgccc agcatggcac gtttgagtac
     1561 gaatattctc agcgatggaa gtctttggat gaaatggaaa aacagcaaag ggaacaagtt
     1621 gaaaaaaaca tgaaagatgc aaaagacaaa ttggaaagtg aaatggaaga tgcctatcat
     1681 gaacatcagg caaatctttt gcgccaagat ctgatgagac gacaggaaga attaagacgc
     1741 atggaagaac ttcacaatca agaaatgcag aaacgtaaag aaatgcaatt gaggcaagag
     1801 gaggaacgac gtagaagaga ggaagagatg atgattcgtc aacgtgagat ggaagaacaa
     1861 atgaggcgcc aaagagagga aagttacagc cgaatgggct acatggatcc acgggaaaga
     1921 gacatgcgaa tgggtggcgg aggagcaatg aacatgggag atccctatgg ttcaggaggc
     1981 cagaaatttc cacctctagg aggtggtggt ggcataggtt atgaagctaa tcctggcgtt
     2041 ccaccagcaa ccatgagtgg ttccatgatg ggaagtgaca tgcgtactga gcgctttggg
     2101 cagggaggtg cggggcctgt gggtggacag ggtcctagag gaatggggcc tggaactcca
     2161 gcaggatatg gtagagggag agaagagtac gaaggcccaa acaaaaaacc ccgattttag
     2221 atgtgatatt taggctttca ttccagtttg ttttgttttt ttgtttagat accaatcttt
     2281 taaattcttg cattttagta agaaagctat ctttttatgg atgttagcag tttattgacc
     2341 taatatttgt aaatggtctg tttgggcagg taaaattatg taatgcagtg tttggaacag
     2401 gagaattttt ttttcctttt tatttcttta ttttttcttt tttactgtat aatgtccctc
     2461 aagtttatgg cagtgtacct tgtgccactg aatttccaaa gtgtaccaat tttttttttt
     2521 ttactgtgct tcaaataaat agaaaaatag ttataatatt gatcttcaac tttgccattc
     2581 atgcttctat gcatattagg ctacgtattc cacattgaaa gcatgagagt gtctaggcct
     2641 ttgaatggca tatgccattt ctgggaaatg catctggagg ctaagtattg ctttctacaa
     2701 ataattgccc cctttgtttt aaaaagaaga aatgcatatt gaagtagttt gatgatttgt
     2761 ttggcatata ggaagcacgc tggtgctaag tattttttaa atggttatgt aagcaaagct
     2821 gaactgtaaa tcttcaggaa tatgtattaa gattgtggaa tgggtgtaag acaattggta
     2881 gggggtgaaa gtgggtttga ttaaatggat cttttatggc cctatgatct atcctttact
     2941 tgaaagcttt tgaaaagtgg aaaggtcatt ttgttgcatt tccccatttc ttgtttttaa
     3001 aagaccaaca aatctcaagc cctataaatg gcttgtattg aacttttaca tttgaattaa
     3061 agatgttaaa catgaagtct tttcatgtat tcaagtgatt tataaagatg gggtgtagtc
     3121 taaaaaacaa aacttgaaag taagaaggtt tagtaactgg gccgggcgcg gtggctcacg
     3181 cctgtaatcc cagcactttg ggaggctgag gtgggcaaat catgagatca ggagttcaag
     3241 accagcctgg ccaacatggt gaaaccccgt ctctactaaa aatacaaaaa attagctggg
     3301 cgtggtggca ggcgcctgta atcccagcta ctcgggaggc tgagccagga gaattgcttg
     3361 aacctggaga tggaggttgc agtgagctga gactgccact gcactccagc ctggacaaca
     3421 gagcgagact ctgtctcaaa aaaaaaaaaa ggtttagtac tgaagtaggt ttagttatat
     3481 atacatttgt actctgtaac ttttacatct ccttgtgcta cttctgttgg gcaaaatcta
     3541 taggactata aaaatctatt ggttctcttc taagagctag tggtgattgt taacaaatag
     3601 ggttgcagat aatcattctt attgtaaatt taacttgttt tcacatagtt tcgttttcat
     3661 gtagcactaa atctggagaa agttgctcat gctacacagt acaaatatcc cttcctccca
     3721 ccataaaggc ttggaatgtt
//
