LOCUS       NM_006142               1308 bp    mRNA    linear   PRI 07-FEB-2025
DEFINITION  Homo sapiens stratifin (SFN), mRNA.
ACCESSION   NM_006142
VERSION     NM_006142.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1308)
  AUTHORS   Wang,F., Suo,X.G., Wang,J.N., Liu,C.Y., Liu,C.C., Wang,C., Li,J.,
            Duan,Z.H., Zhang,F.S., Xia,Y.M., Jiang,J.J., Hao,Y.W., Li,G.Y.,
            Meng,X.M., Shao,Y.X. and Wang,F.C.
  TITLE     SFN promotes renal fibrosis via binding with MYH9 in chronic kidney
            disease
  JOURNAL   Eur J Pharmacol 979, 176806 (2024)
   PUBMED   38986830
  REMARK    GeneRIF: SFN promotes renal fibrosis via binding with MYH9 in
            chronic kidney disease.
REFERENCE   2  (bases 1 to 1308)
  AUTHORS   Li,R., Yan,X., Zhong,W., Zheng,J., Li,X., Liang,J., Hu,Z., Liu,H.,
            Chen,G., Yang,Y., Zhang,J., Qu,E. and Liu,W.
  TITLE     Stratifin promotes the malignant progression of HCC via binding and
            hyperactivating AKT signaling
  JOURNAL   Cancer Lett 592, 216761 (2024)
   PUBMED   38490326
  REMARK    GeneRIF: Stratifin promotes the malignant progression of HCC via
            binding and hyperactivating AKT signaling.
REFERENCE   3  (bases 1 to 1308)
  AUTHORS   Fisch,D., Pfleiderer,M.M., Anastasakou,E., Mackie,G.M., Wendt,F.,
            Liu,X., Clough,B., Lara-Reyna,S., Encheva,V., Snijders,A.P.,
            Bando,H., Yamamoto,M., Beggs,A.D., Mercer,J., Shenoy,A.R.,
            Wollscheid,B., Maslowski,K.M., Galej,W.P. and Frickel,E.M.
  TITLE     PIM1 controls GBP1 activity to limit self-damage and to guard
            against pathogen infection
  JOURNAL   Science 382 (6666), eadg2253 (2023)
   PUBMED   37797010
REFERENCE   4  (bases 1 to 1308)
  AUTHORS   Segal,D., Maier,S., Mastromarco,G.J., Qian,W.W., Nabeel-Shah,S.,
            Lee,H., Moore,G., Lacoste,J., Larsen,B., Lin,Z.Y.,
            Selvabaskaran,A., Liu,K., Smibert,C., Zhang,Z., Greenblatt,J.,
            Peng,J., Lee,H.O., Gingras,A.C. and Taipale,M.
  TITLE     A central chaperone-like role for 14-3-3 proteins in human cells
  JOURNAL   Mol Cell 83 (6), 974-993 (2023)
   PUBMED   36931259
REFERENCE   5  (bases 1 to 1308)
  AUTHORS   Arakawa,N., Ushiki,A., Abe,M., Matsuyama,S., Saito,Y.,
            Kashiwada,T., Horimasu,Y., Gemma,A., Tatsumi,K., Hattori,N.,
            Tsushima,K., Miyashita,K., Saito,K., Nakamura,R., Toyoda,T.,
            Ogawa,K., Sato,M., Takamatsu,K., Mori,K., Nishiya,T., Izumi,T.,
            Ohno,Y., Saito,Y. and Hanaoka,M.
  TITLE     Stratifin as a novel diagnostic biomarker in serum for diffuse
            alveolar damage
  JOURNAL   Nat Commun 13 (1), 5854 (2022)
   PUBMED   36195613
  REMARK    GeneRIF: Stratifin as a novel diagnostic biomarker in serum for
            diffuse alveolar damage.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1308)
  AUTHORS   Chan,T.A., Hermeking,H., Lengauer,C., Kinzler,K.W. and
            Vogelstein,B.
  TITLE     14-3-3Sigma is required to prevent mitotic catastrophe after DNA
            damage
  JOURNAL   Nature 401 (6753), 616-620 (1999)
   PUBMED   10524633
  REMARK    Erratum:[Nature. 2023 Sep;621(7977):E28-E29. doi:
            10.1038/s41586-023-06446-1.. PMID: 37626188]
REFERENCE   7  (bases 1 to 1308)
  AUTHORS   Hermeking,H., Lengauer,C., Polyak,K., He,T.C., Zhang,L.,
            Thiagalingam,S., Kinzler,K.W. and Vogelstein,B.
  TITLE     14-3-3sigma is a p53-regulated inhibitor of G2/M progression
  JOURNAL   Mol Cell 1 (1), 3-11 (1997)
   PUBMED   9659898
REFERENCE   8  (bases 1 to 1308)
  AUTHORS   Leffers,H., Madsen,P., Rasmussen,H.H., Honore,B., Andersen,A.H.,
            Walbum,E., Vandekerckhove,J. and Celis,J.E.
  TITLE     Molecular cloning and expression of the transformation sensitive
            epithelial marker stratifin. A member of a protein family that has
            been involved in the protein kinase C signalling pathway
  JOURNAL   J Mol Biol 231 (4), 982-998 (1993)
   PUBMED   8515476
REFERENCE   9  (bases 1 to 1308)
  AUTHORS   Rasmussen,H.H., van Damme,J., Puype,M., Gesser,B., Celis,J.E. and
            Vandekerckhove,J.
  TITLE     Microsequences of 145 proteins recorded in the two-dimensional gel
            protein database of normal human epidermal keratinocytes
  JOURNAL   Electrophoresis 13 (12), 960-969 (1992)
   PUBMED   1286667
REFERENCE   10 (bases 1 to 1308)
  AUTHORS   Prasad,G.L., Valverius,E.M., McDuffie,E. and Cooper,H.L.
  TITLE     Complementary DNA cloning of a novel epithelial cell marker
            protein, HME1, that may be down-regulated in neoplastic mammary
            cells
  JOURNAL   Cell Growth Differ 3 (8), 507-513 (1992)
   PUBMED   1390337
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC023552.2 and BC001550.1.
            
            On Nov 23, 2018 this sequence version replaced NM_006142.4.
            
            Summary: This gene encodes a cell cycle checkpoint protein. The
            encoded protein binds to translation and initiation factors and
            functions as a regulator of mitotic translation. In response to DNA
            damage this protein plays a role in preventing DNA errors during
            mitosis. [provided by RefSeq, Aug 2017].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript is intronless :: BC000995.2, SRR3476690.659521.1
                                        [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000339276.6/ ENSP00000340989.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1213              BC023552.2         12-1224
            1214-1217           BC001550.1         1107-1110
            1218-1308           BC023552.2         1225-1315
FEATURES             Location/Qualifiers
     source          1..1308
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p36.11"
     gene            1..1308
                     /gene="SFN"
                     /gene_synonym="YWHAS"
                     /note="stratifin"
                     /db_xref="GeneID:2810"
                     /db_xref="HGNC:HGNC:10773"
                     /db_xref="MIM:601290"
     exon            1..1308
                     /gene="SFN"
                     /gene_synonym="YWHAS"
                     /inference="alignment:Splign:2.1.0"
     CDS             65..811
                     /gene="SFN"
                     /gene_synonym="YWHAS"
                     /note="epithelial cell marker protein 1"
                     /codon_start=1
                     /product="14-3-3 protein sigma"
                     /protein_id="NP_006133.1"
                     /db_xref="CCDS:CCDS288.1"
                     /db_xref="GeneID:2810"
                     /db_xref="HGNC:HGNC:10773"
                     /db_xref="MIM:601290"
                     /translation="MERASLIQKAKLAEQAERYEDMAAFMKGAVEKGEELSCEERNLL
                     SVAYKNVVGGQRAAWRVLSSIEQKSNEEGSEEKGPEVREYREKVETELQGVCDTVLGL
                     LDSHLIKEAGDAESRVFYLKMKGDYYRYLAEVATGDDKKRIIDSARSAYQEAMDISKK
                     EMPPTNPIRLGLALNFSVFHYEIANSPEEAISLAKTTFDEAMADLHTLSEDSYKDSTL
                     IMQLLRDNLTLWTADNAGEEGGEAPQEPQS"
     regulatory      1286..1291
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SFN"
                     /gene_synonym="YWHAS"
                     /note="hexamer: AATAAA"
     polyA_site      1308
                     /gene="SFN"
                     /gene_synonym="YWHAS"
                     /note="major polyA site"
ORIGIN      
        1 acagagtccg gcattggtcc caggcagcag ttagcccgcc gcccgcctgt gtgtccccag
       61 agccatggag agagccagtc tgatccagaa ggccaagctg gcagagcagg ccgaacgcta
      121 tgaggacatg gcagccttca tgaaaggcgc cgtggagaag ggcgaggagc tctcctgcga
      181 agagcgaaac ctgctctcag tagcctataa gaacgtggtg ggcggccaga gggctgcctg
      241 gagggtgctg tccagtattg agcagaaaag caacgaggag ggctcggagg agaaggggcc
      301 cgaggtgcgt gagtaccggg agaaggtgga gactgagctc cagggcgtgt gcgacaccgt
      361 gctgggcctg ctggacagcc acctcatcaa ggaggccggg gacgccgaga gccgggtctt
      421 ctacctgaag atgaagggtg actactaccg ctacctggcc gaggtggcca ccggtgacga
      481 caagaagcgc atcattgact cagcccggtc agcctaccag gaggccatgg acatcagcaa
      541 gaaggagatg ccgcccacca accccatccg cctgggcctg gccctgaact tttccgtctt
      601 ccactacgag atcgccaaca gccccgagga ggccatctct ctggccaaga ccactttcga
      661 cgaggccatg gctgatctgc acaccctcag cgaggactcc tacaaagaca gcaccctcat
      721 catgcagctg ctgcgagaca acctgacact gtggacggcc gacaacgccg gggaagaggg
      781 gggcgaggct ccccaggagc cccagagctg agtgttgccc gccaccgccc cgccctgccc
      841 cctccagtcc cccaccctgc cgagaggact agtatggggt gggaggcccc acccttctcc
      901 cctaggcgct gttcttgctc caaagggctc cgtggagagg gactggcaga gctgaggcca
      961 cctggggctg gggatcccac tcttcttgca gctgttgagc gcacctaacc actggtcatg
     1021 cccccacccc tgctctccgc acccgcttcc tcccgacccc aggaccaggc tacttctccc
     1081 ctcctcttgc ctccctcctg cccctgctgc ctctgatcgt aggaattgag gagtgtcccg
     1141 ccttgtggct gagaactgga cagtggcagg ggctggagat gggtgtgtgt gtgtgtgtgt
     1201 gtgtgtgtgt gtgtgtgcgc gcgcgccagt gcaagaccga gattgaggga aagcatgtct
     1261 gctgggtgtg accatgtttc ctctcaataa agttcccctg tgacactc
//
