LOCUS       NM_001387889            8056 bp    mRNA    linear   PRI 22-SEP-2024
DEFINITION  Homo sapiens Scm like with four mbt domains 2 (SFMBT2), transcript
            variant 3, mRNA.
ACCESSION   NM_001387889 XM_011519611
VERSION     NM_001387889.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8056)
  AUTHORS   Xie,Q., Hu,B. and Li,H.
  TITLE     Acetylation- and ubiquitination-regulated SFMBT2 acts as a tumor
            suppressor in clear cell renal cell carcinoma
  JOURNAL   Biol Direct 19 (1), 37 (2024)
   PUBMED   38734627
  REMARK    GeneRIF: Acetylation- and ubiquitination-regulated SFMBT2 acts as a
            tumor suppressor in clear cell renal cell carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 8056)
  AUTHORS   Li,Y., Shi,L.H., Xie,X. and Fan,P.K.
  TITLE     [Effects of circ-SFMBT2 on Proliferation, Migration and Invasion of
            Acute Myeloid Leukemia Cells by Regulating miR-491-5p/HOXA9 Axis]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 31 (6), 1599-1607 (2023)
   PUBMED   38071034
  REMARK    GeneRIF: [Effects of circ-SFMBT2 on Proliferation, Migration and
            Invasion of Acute Myeloid Leukemia Cells by Regulating
            miR-491-5p/HOXA9 Axis].
REFERENCE   3  (bases 1 to 8056)
  AUTHORS   Chang,W., Shang,Z., Ming,X., Wu,J. and Xiao,Y.
  TITLE     Circ-SFMBT2 facilitates the malignant growth of acute myeloid
            leukemia cells by modulating miR-582-3p/ZBTB20 pathway
  JOURNAL   Histol Histopathol 37 (2), 137-149 (2022)
   PUBMED   34825699
  REMARK    GeneRIF: Circ-SFMBT2 facilitates the malignant growth of acute
            myeloid leukemia cells by modulating miR-582-3p/ZBTB20 pathway.
REFERENCE   4  (bases 1 to 8056)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   5  (bases 1 to 8056)
  AUTHORS   Luo,Y. and Huang,C.
  TITLE     CircSFMBT2 facilitates vascular smooth muscle cell proliferation by
            targeting miR-331-3p/HDAC5
  JOURNAL   Life Sci 264, 118691 (2021)
   PUBMED   33166591
  REMARK    GeneRIF: CircSFMBT2 facilitates vascular smooth muscle cell
            proliferation by targeting miR-331-3p/HDAC5.
REFERENCE   6  (bases 1 to 8056)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   7  (bases 1 to 8056)
  AUTHORS   Gwak,J., Shin,J.Y., Lee,K., Hong,S.K., Oh,S., Goh,S.H., Kim,W.S.
            and Ju,B.G.
  TITLE     SFMBT2 (Scm-like with four mbt domains 2) negatively regulates cell
            migration and invasion in prostate cancer cells
  JOURNAL   Oncotarget 7 (30), 48250-48264 (2016)
   PUBMED   27340776
  REMARK    GeneRIF: Findings suggest that regulation of SFMBT2 may provide a
            new therapeutic strategy to control prostate cancer metastasis as
            well as being a potential biomarker of metastatic prostate cancer.
REFERENCE   8  (bases 1 to 8056)
  AUTHORS   Lee,K., Na,W., Maeng,J.H., Wu,H. and Ju,B.G.
  TITLE     Regulation of DU145 prostate cancer cell growth by Scm-like with
            four mbt domains 2
  JOURNAL   J Biosci 38 (1), 105-112 (2013)
   PUBMED   23385818
  REMARK    GeneRIF: SFMBT2 may regulate cell growth via epigenetic regulation
            of HOXB13 gene expression in prostate cancer cells.
REFERENCE   9  (bases 1 to 8056)
  AUTHORS   Manning,A.K., Hivert,M.F., Scott,R.A., Grimsby,J.L.,
            Bouatia-Naji,N., Chen,H., Rybin,D., Liu,C.T., Bielak,L.F.,
            Prokopenko,I., Amin,N., Barnes,D., Cadby,G., Hottenga,J.J.,
            Ingelsson,E., Jackson,A.U., Johnson,T., Kanoni,S., Ladenvall,C.,
            Lagou,V., Lahti,J., Lecoeur,C., Liu,Y., Martinez-Larrad,M.T.,
            Montasser,M.E., Navarro,P., Perry,J.R., Rasmussen-Torvik,L.J.,
            Salo,P., Sattar,N., Shungin,D., Strawbridge,R.J., Tanaka,T., van
            Duijn,C.M., An,P., de Andrade,M., Andrews,J.S., Aspelund,T.,
            Atalay,M., Aulchenko,Y., Balkau,B., Bandinelli,S., Beckmann,J.S.,
            Beilby,J.P., Bellis,C., Bergman,R.N., Blangero,J., Boban,M.,
            Boehnke,M., Boerwinkle,E., Bonnycastle,L.L., Boomsma,D.I.,
            Borecki,I.B., Bottcher,Y., Bouchard,C., Brunner,E., Budimir,D.,
            Campbell,H., Carlson,O., Chines,P.S., Clarke,R., Collins,F.S.,
            Corbaton-Anchuelo,A., Couper,D., de Faire,U., Dedoussis,G.V.,
            Deloukas,P., Dimitriou,M., Egan,J.M., Eiriksdottir,G., Erdos,M.R.,
            Eriksson,J.G., Eury,E., Ferrucci,L., Ford,I., Forouhi,N.G.,
            Fox,C.S., Franzosi,M.G., Franks,P.W., Frayling,T.M., Froguel,P.,
            Galan,P., de Geus,E., Gigante,B., Glazer,N.L., Goel,A., Groop,L.,
            Gudnason,V., Hallmans,G., Hamsten,A., Hansson,O., Harris,T.B.,
            Hayward,C., Heath,S., Hercberg,S., Hicks,A.A., Hingorani,A.,
            Hofman,A., Hui,J., Hung,J., Jarvelin,M.R., Jhun,M.A., Johnson,P.C.,
            Jukema,J.W., Jula,A., Kao,W.H., Kaprio,J., Kardia,S.L.,
            Keinanen-Kiukaanniemi,S., Kivimaki,M., Kolcic,I., Kovacs,P.,
            Kumari,M., Kuusisto,J., Kyvik,K.O., Laakso,M., Lakka,T.,
            Lannfelt,L., Lathrop,G.M., Launer,L.J., Leander,K., Li,G., Lind,L.,
            Lindstrom,J., Lobbens,S., Loos,R.J., Luan,J., Lyssenko,V., Magi,R.,
            Magnusson,P.K., Marmot,M., Meneton,P., Mohlke,K.L., Mooser,V.,
            Morken,M.A., Miljkovic,I., Narisu,N., O'Connell,J., Ong,K.K.,
            Oostra,B.A., Palmer,L.J., Palotie,A., Pankow,J.S., Peden,J.F.,
            Pedersen,N.L., Pehlic,M., Peltonen,L., Penninx,B., Pericic,M.,
            Perola,M., Perusse,L., Peyser,P.A., Polasek,O., Pramstaller,P.P.,
            Province,M.A., Raikkonen,K., Rauramaa,R., Rehnberg,E., Rice,K.,
            Rotter,J.I., Rudan,I., Ruokonen,A., Saaristo,T., Sabater-Lleal,M.,
            Salomaa,V., Savage,D.B., Saxena,R., Schwarz,P., Seedorf,U.,
            Sennblad,B., Serrano-Rios,M., Shuldiner,A.R., Sijbrands,E.J.,
            Siscovick,D.S., Smit,J.H., Small,K.S., Smith,N.L., Smith,A.V.,
            Stancakova,A., Stirrups,K., Stumvoll,M., Sun,Y.V., Swift,A.J.,
            Tonjes,A., Tuomilehto,J., Trompet,S., Uitterlinden,A.G.,
            Uusitupa,M., Vikstrom,M., Vitart,V., Vohl,M.C., Voight,B.F.,
            Vollenweider,P., Waeber,G., Waterworth,D.M., Watkins,H.,
            Wheeler,E., Widen,E., Wild,S.H., Willems,S.M., Willemsen,G.,
            Wilson,J.F., Witteman,J.C., Wright,A.F., Yaghootkar,H.,
            Zelenika,D., Zemunik,T., Zgaga,L., Wareham,N.J., McCarthy,M.I.,
            Barroso,I., Watanabe,R.M., Florez,J.C., Dupuis,J., Meigs,J.B. and
            Langenberg,C.
  CONSRTM   DIAbetes Genetics Replication And Meta-analysis (DIAGRAM)
            Consortium; Multiple Tissue Human Expression Resource (MUTHER)
            Consortium
  TITLE     A genome-wide approach accounting for body mass index identifies
            genetic variants influencing fasting glycemic traits and insulin
            resistance
  JOURNAL   Nat Genet 44 (6), 659-669 (2012)
   PUBMED   22581228
  REMARK    Publication Status: Online-Only
REFERENCE   10 (bases 1 to 8056)
  AUTHORS   Deloukas,P., Earthrowl,M.E., Grafham,D.V., Rubenfield,M.,
            French,L., Steward,C.A., Sims,S.K., Jones,M.C., Searle,S.,
            Scott,C., Howe,K., Hunt,S.E., Andrews,T.D., Gilbert,J.G.,
            Swarbreck,D., Ashurst,J.L., Taylor,A., Battles,J., Bird,C.P.,
            Ainscough,R., Almeida,J.P., Ashwell,R.I., Ambrose,K.D.,
            Babbage,A.K., Bagguley,C.L., Bailey,J., Banerjee,R., Bates,K.,
            Beasley,H., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.C.,
            Burrill,W., Burton,J., Cahill,P., Camire,D., Carter,N.P.,
            Chapman,J.C., Clark,S.Y., Clarke,G., Clee,C.M., Clegg,S., Corby,N.,
            Coulson,A., Dhami,P., Dutta,I., Dunn,M., Faulkner,L., Frankish,A.,
            Frankland,J.A., Garner,P., Garnett,J., Gribble,S., Griffiths,C.,
            Grocock,R., Gustafson,E., Hammond,S., Harley,J.L., Hart,E.,
            Heath,P.D., Ho,T.P., Hopkins,B., Horne,J., Howden,P.J., Huckle,E.,
            Hynds,C., Johnson,C., Johnson,D., Kana,A., Kay,M., Kimberley,A.M.,
            Kershaw,J.K., Kokkinaki,M., Laird,G.K., Lawlor,S., Lee,H.M.,
            Leongamornlert,D.A., Laird,G., Lloyd,C., Lloyd,D.M., Loveland,J.,
            Lovell,J., McLaren,S., McLay,K.E., McMurray,A.,
            Mashreghi-Mohammadi,M., Matthews,L., Milne,S., Nickerson,T.,
            Nguyen,M., Overton-Larty,E., Palmer,S.A., Pearce,A.V., Peck,A.I.,
            Pelan,S., Phillimore,B., Porter,K., Rice,C.M., Rogosin,A.,
            Ross,M.T., Sarafidou,T., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Standring,L., Sycamore,N., Tester,J., Thorpe,A.,
            Torcasso,W., Tracey,A., Tromans,A., Tsolas,J., Wall,M., Walsh,J.,
            Wang,H., Weinstock,K., West,A.P., Willey,D.L., Whitehead,S.L.,
            Wilming,L., Wray,P.W., Young,L., Chen,Y., Lovering,R.C.,
            Moschonas,N.K., Siebert,R., Fechtel,K., Bentley,D., Durbin,R.,
            Hubbard,T., Doucette-Stamm,L., Beck,S., Smith,D.R. and Rogers,J.
  TITLE     The DNA sequence and comparative analysis of human chromosome 10
  JOURNAL   Nature 429 (6990), 375-381 (2004)
   PUBMED   15164054
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL139125.18, AL158046.12, AL138771.10 and AL590095.5.
            
            On Oct 19, 2020 this sequence version replaced XM_011519611.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.1677840.1,
                                           SRR14038192.892809.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397167.6/ ENSP00000380353.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               AL139125.18        43478-43651         c
            175-325             AL139125.18        14416-14566         c
            326-420             AL139125.18        2898-2992           c
            421-661             AL139125.18        266-506             c
            662-750             AL158046.12        37648-37736         c
            751-997             AL158046.12        35686-35932         c
            998-1095            AL158046.12        28674-28771         c
            1096-1197           AL158046.12        330-431             c
            1198-1345           AL138771.10        24385-24532         c
            1346-1428           AL138771.10        8682-8764           c
            1429-1555           AL138771.10        1238-1364           c
            1556-1669           AL590095.5         163546-163659       c
            1670-1712           AL590095.5         160211-160253       c
            1713-1783           AL590095.5         158145-158215       c
            1784-1923           AL590095.5         155279-155418       c
            1924-2033           AL590095.5         146355-146464       c
            2034-2209           AL590095.5         133721-133896       c
            2210-2376           AL590095.5         130226-130392       c
            2377-2640           AL590095.5         129626-129889       c
            2641-2769           AL590095.5         128659-128787       c
            2770-8056           AL590095.5         116355-121641       c
FEATURES             Location/Qualifiers
     source          1..8056
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10p14"
     gene            1..8056
                     /gene="SFMBT2"
                     /note="Scm like with four mbt domains 2"
                     /db_xref="GeneID:57713"
                     /db_xref="HGNC:HGNC:20256"
                     /db_xref="MIM:615392"
     exon            1..174
                     /gene="SFMBT2"
                     /inference="alignment:Splign:2.1.0"
     exon            175..325
                     /gene="SFMBT2"
                     /inference="alignment:Splign:2.1.0"
     CDS             226..2910
                     /gene="SFMBT2"
                     /note="isoform 1 is encoded by transcript variant 3;
                     Scm-related gene containing four mbt domains 2; scm-like
                     with four MBT domains protein 2; scm-like with 4 MBT
                     domains protein 2"
                     /codon_start=1
                     /product="scm-like with four MBT domains protein 2 isoform
                     1"
                     /protein_id="NP_001374818.1"
                     /db_xref="CCDS:CCDS31138.1"
                     /db_xref="GeneID:57713"
                     /db_xref="HGNC:HGNC:20256"
                     /db_xref="MIM:615392"
                     /translation="MESTLSASNMQDPSSSPLEKCLGSANGNGDLDSEEGSSLEETGF
                     NWGEYLEETGASAAPHTSFKHVEISIQSNFQPGMKLEVANKNNPDTYWVATIITTCGQ
                     LLLLRYCGYGEDRRADFWCDVVIADLHPVGWCTQNNKVLMPPDAIKEKYTDWTEFLIR
                     DLTGSRTAPANLLEGPLRGKGPIDLITVGSLIELQDSQNPFQYWIVSVIENVGGRLRL
                     RYVGLEDTESYDQWLFYLDYRLRPVGWCQENKYRMDPPSEIYPLKMASEWKCTLEKSL
                     IDAAKFPLPMEVFKDHADLRSHFFTVGMKLETVNMCEPFYISPASVTKVFNNHFFQVT
                     IDDLRPEPSKLSMLCHADSLGILPVQWCLKNGVSLTPPKGYSGQDFDWADYHKQHGAQ
                     EAPPFCFRNTSFSRGFTKNMKLEAVNPRNPGELCVASVVSVKGRLMWLHLEGLQTPVP
                     EVIVDVESMDIFPVGWCEANSYPLTAPHKTVSQKKRKIAVVQPEKQLPPTVPVKKIPH
                     DLCLFPHLDTTGTVNGKYCCPQLFINHRCFSGPYLNKGRIAELPQSVGPGKCVLVLKE
                     VLSMIINAAYKPGRVLRELQLVEDPHWNFQEETLKAKYRGKTYRAVVKIVRTSDQVAN
                     FCRRVCAKLECCPNLFSPVLISENCPENCSIHTKTKYTYYYGKRKKISKPPIGESNPD
                     SGHPKPARRRKRRKSIFVQKKRRSSAVDFTAGSGEESEEEDADAMDDDTASEETGSEL
                     RDDQTDTSSAEVPSARPRRAVTLRSGSEPVRRPPPERTRRGRGAPAASSAEEGEKCPP
                     TKPEGTEDTKQEEEERLVLESNPLEWTVTDVVRFIKLTDCAPLAKIFQEQDIDGQALL
                     LLTLPTVQECMELKLGPAIKLCHQIERVKVAFYAQYAN"
     exon            326..420
                     /gene="SFMBT2"
                     /inference="alignment:Splign:2.1.0"
     exon            421..661
                     /gene="SFMBT2"
                     /inference="alignment:Splign:2.1.0"
     exon            662..750
                     /gene="SFMBT2"
                     /inference="alignment:Splign:2.1.0"
     exon            751..997
                     /gene="SFMBT2"
                     /inference="alignment:Splign:2.1.0"
     exon            998..1095
                     /gene="SFMBT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1197
                     /gene="SFMBT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1198..1345
                     /gene="SFMBT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1346..1428
                     /gene="SFMBT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1429..1555
                     /gene="SFMBT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1669
                     /gene="SFMBT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1670..1712
                     /gene="SFMBT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1713..1783
                     /gene="SFMBT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1784..1923
                     /gene="SFMBT2"
                     /inference="alignment:Splign:2.1.0"
     exon            1924..2033
                     /gene="SFMBT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2034..2209
                     /gene="SFMBT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2210..2376
                     /gene="SFMBT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2377..2640
                     /gene="SFMBT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2641..2769
                     /gene="SFMBT2"
                     /inference="alignment:Splign:2.1.0"
     exon            2770..8056
                     /gene="SFMBT2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8046..8051
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SFMBT2"
                     /note="hexamer: AATAAA"
     polyA_site      8056
                     /gene="SFMBT2"
                     /note="major polyA site"
ORIGIN      
        1 atattggaat gagctgtagt gggagccgga ggaccggagc gggcgcgcga gggaggcggc
       61 gggcggggag cgagcgggca agggcgggcg agcgagcaag cgagcgaggc cggtgccctc
      121 ccgggcggcg accggggcct gggtccacgc cgagggcagg acgaacttca ccaggtaatt
      181 ttttctgcag gatgaattaa gagaagagac acttgctcat caggcatgga gagcactttg
      241 tcagcttcca atatgcaaga cccttcatct tcacccttgg aaaagtgtct cggctcagct
      301 aatggaaatg gagaccttga ttctgaagaa ggctcaagct tggaggaaac tggctttaac
      361 tggggagaat atttggaaga gacaggagca agtgctgctc cccacacatc attcaaacac
      421 gttgaaatca gcattcagag caacttccag ccaggaatga aattggaagt ggctaataag
      481 aacaacccgg acacgtactg ggtggccacg atcattacca cgtgcgggca gctgctgctt
      541 ctgcgctact gcggttacgg ggaggaccgc agggccgact tctggtgtga cgtagtcatc
      601 gcggatttgc accccgtggg gtggtgcaca cagaacaaca aggtgttgat gccgccggac
      661 gcaatcaaag agaagtacac agactggaca gaatttctca tacgtgactt gactggttcg
      721 aggacagcac ccgccaacct cctggaaggt cctctgcgag ggaaaggccc tatagacctc
      781 attacagttg gttccttaat agaacttcag gattcccaga acccttttca gtactggata
      841 gttagtgtga ttgaaaatgt tggaggaaga ttacgccttc gctatgtggg attggaggac
      901 actgaatcct atgaccagtg gttgttttac ttggattaca gacttcgacc agttggttgg
      961 tgtcaagaga ataaatacag aatggaccca ccttcagaaa tctatccttt gaagatggcc
     1021 tctgaatgga aatgtactct ggaaaaatcc cttattgatg ctgccaaatt tcctcttcca
     1081 atggaagtgt ttaaggatca cgcagatttg cgaagccatt tcttcacagt tgggatgaag
     1141 cttgagacag tgaatatgtg cgagcccttt tacatctctc ctgcgtcggt gactaaggtt
     1201 tttaacaatc acttttttca agtgactatt gatgacctaa gacctgaacc aagtaaactg
     1261 tcaatgctgt gccatgcaga ttctttgggg attttgccag tacagtggtg ccttaaaaat
     1321 ggagtcagcc tcactcctcc caaaggttac tctggccagg acttcgactg ggcagattat
     1381 cacaagcagc atggggcgca ggaagcccct cccttctgct tccgaaatac atcattcagt
     1441 cgaggtttca caaagaacat gaaacttgaa gctgtgaacc ccaggaatcc aggagaactg
     1501 tgtgtggcct ccgttgtgag tgtgaagggg cggctaatgt ggcttcacct ggaagggctg
     1561 cagactcctg ttccagaggt cattgttgat gtggaatcca tggacatctt cccagtgggc
     1621 tggtgtgaag ccaattctta tcctttgact gcaccacaca aaacagtctc acaaaagaag
     1681 agaaagattg cagtcgtgca accagagaaa caattgccgc ccacagtgcc tgttaagaaa
     1741 atacctcatg acctttgttt attccctcac ctggacacca caggaaccgt caacgggaaa
     1801 tactgctgtc ctcagctctt catcaaccac aggtgtttct caggccctta cctgaacaaa
     1861 ggaaggattg cagagctacc tcagtcggtg ggaccgggca aatgcgtgct ggttcttaaa
     1921 gaggttctta gcatgataat caacgcagcc tacaagcctg gaagggtatt aagagaatta
     1981 cagctggtag aagatcccca ctggaatttc caggaagaga cgctgaaggc caaatacaga
     2041 ggcaaaacat acagggctgt ggtcaaaatc gtacggacat ctgaccaagt cgcaaatttc
     2101 tgccgccgag tctgtgccaa gctagagtgc tgtccaaatt tgtttagtcc tgtgctgata
     2161 tctgaaaact gcccagagaa ctgctccatt cataccaaaa ccaaatacac ctattactat
     2221 ggaaagagaa agaagatctc caagcccccc atcggggaaa gcaaccccga cagcggacac
     2281 cccaaacccg ccaggcggag gaagcgacgg aaatccattt tcgtgcagaa gaaacggagg
     2341 tcttctgccg tggacttcac cgcgggctcg ggggaggaaa gtgaagagga ggacgctgac
     2401 gccatggacg atgacaccgc cagtgaggag accggctccg agctccggga tgaccagacg
     2461 gacacctcgt cggcggaggt gccctcggcc cggccccgga gggccgtcac cctgcggagc
     2521 ggctcagagc ccgtgcgccg gccaccccca gagaggacac gaaggggccg cggggcgccg
     2581 gctgcctcct cagcagagga aggggagaag tgcccgccga ccaagcccga ggggacagag
     2641 gacacgaaac aggaggagga ggagagactg gttctggaga gcaacccgtt ggagtggacg
     2701 gtcaccgacg tggtgaggtt cattaagctg acagactgtg cccccttggc caagatattt
     2761 caggagcagg atattgacgg ccaagcactc ctgcttctga cccttccgac ggtgcaggag
     2821 tgcatggagc tgaagctggg gcctgccatc aagttatgcc accagatcga gagagtcaaa
     2881 gtggctttct acgcccagta cgccaactga gtctgccctc gggaggtggc ccattattgc
     2941 tgggatgcgg tgttggtaaa ggtttccagg actgaaactt tgattttccg ggatatgtta
     3001 aatggtacag ccactaagta tcaccagaaa accagaagcc caggatcttc tgcctccgcc
     3061 agcctgtgag ctgtttccat gttttcaaag cacagcagca gtcgcttctg gggagtgcca
     3121 gttaaagtca tgcatcagac cctgccagac gtgggcctgc ttcttggctc acccacgttt
     3181 tgcctttctc ctgccccaaa tcaggcagct cccttggagc agggtttcct cagatgagga
     3241 ctgcattctt tgaaaacaaa gaatgtcgcc aaggaagaaa cctcacgcca tgctgtagtg
     3301 tttcctgtaa tcacacgagc acatttatat atgcagtttc ccatggatag gcgtgtgacc
     3361 ctggttgagt ggcacttgcg gtttcatctt ggtggcaact cctttgcaat gcagctggca
     3421 gcgacatcct tataaaaaca tgtgctaaag ctctgtcctc tgttagaggt gccttttagg
     3481 aatacgggga gtgaaggaag gccggcaggc atctccatgc aactagatgg tttgtttgtt
     3541 tgtttgtttg tttgttgttc attttgttgt gttttttgag acagggtctt gctctgtcgc
     3601 ccaggttgta atgcagtggc gcaatctcag ctcactgcaa cctctctctc ccgggttcaa
     3661 gtgattctcc tgcctcagcc tcccaagtag ctgggattac aggcacccac caccatgcct
     3721 ggctaatttt tgtatttttg gtagagacag ggtttcacca tgttggtcag gctagtcttg
     3781 aactcccaac ctcaagtgat ctgcccgcct cggcctccca acgtgctggg attacaggtg
     3841 tgagccacta cgccccggcc caactggatg gtttttgatt gaagcctaga acatctgtag
     3901 agacaaactc tacccagtct tttctagacc ctcaactatc tccagtgttg ttgtttaatc
     3961 gtagccggat cagggagtga gtcttttagg caaatgttgg attatatatc aaaggaaaag
     4021 cttagtttca gagaggagga agggaaagag atgtgaggga agcatttcat caaccagcta
     4081 cgtccccctt agaaggatca ctgcagcagg tcaccgagca ggagtccctc tgagcgtccc
     4141 ttctgtctcg ttctgcccta gctggcagca tatgaaccag gcatgatgca gcaggagcag
     4201 tgaatctgga gtcagccact tggcaccctg gtttcgctga gaacaaactc tgagatcttg
     4261 ggtgacttct catcactctg gacctccatt cctgtgaagt gacaggtgtg gaccctgagg
     4321 gtgcggtggt gagcacactg tctcctgctg gcattcaccc cactcatgct ggaaaggaag
     4381 atccagatcg tacaaaaatt agaaaaagaa agaataagaa gggtctggtc ccagttctga
     4441 ctcggccatt cttacagctc tttctggctt tgagtttgct tgtggaattt cctgggcagt
     4501 tgtgttaaat ccgccaggtc acgtgcagac aaagctgtgg ctgcgagagt tggctggcct
     4561 cttggaccag aagccatctc catatcctca tgagcgattc catatctcca ctcagaccct
     4621 gtggactaca gtgttccgct gtggtggctg ccaagatgcc ttcttaaact tatgcaagga
     4681 aaccaaaccc tcccacagtt cccaagcaga cactggaagc agaggcttct cacccttcct
     4741 gctttttcac cacaatcacc ttgagctcgt cccttggact agagtctcca cagttccagt
     4801 aaaattctgc ggtgggctga tgagctgctt gcatttctgt gacatttcca gatatgattc
     4861 tcagtgggat tttggaaact ttgattgctc aagctcaccc ttcttaacat tctgtaatgg
     4921 ttacagatga gaatggaaaa cacatatttt atggatgagg cgttttggtc tcccctgcag
     4981 tcgatttcta gaatcaagtt ttagagttcg gctgatgcat ctgcctgggg acctcagatg
     5041 ggaggagtgt gtcagttgta ccccgacaga aatgtctctg ggatctgtgg ctggcttgcc
     5101 ccgggcatct ctcctttaag ctcaagtttt gaactctctg cggttttcca cccctgcctt
     5161 ctcagccaca tgcttttggc cttaaacgct cagtcttgtg gagttcaact ctgtcaaacg
     5221 attggaaagg gcatccattt ccagatcttt ggcattttcc ccgcgctgac tctttgatga
     5281 tccttcactg tggccttttc aagctcagct gttcctgttg tatttgagac gagggtgagg
     5341 gaatgtggtg gccacaaaag aacagggact tgcagcacaa atgtcacttc tgtctccctt
     5401 ttcagtggta gcacggagga ggaggtgctg cgttggaggg aggggatcct ccaggagctc
     5461 tctggagccc atctaggaag ctagagtgtg tggcccgcca ggagctcagg aaggatacag
     5521 ccactgtcgc aggggaaagt gtttgcttcc cgtggagcca agcgcccaag actctccgta
     5581 tccttcaccc tgacagttta acttcagcgt ttctctgtgc agttgcggtc accatgggtg
     5641 agcactgtct gtgcacgtgc cagggaggag atggctggga ccactgcaca ggagggcgca
     5701 gcctggcgtc gccatgaaag ttgtctctgt gccatctctc cggtccttga ggagagccca
     5761 gaaagatttt aggacccagg aggtgctttt cctccagctg ttgccagtgt ccttctgagc
     5821 ctggattctc cggggatttc cgtcgtggtg gatggacttc acatcagcag cagttctggt
     5881 acagaattgt aatgtgtttt catttctctg taggattcac ctctcaccag cgtctgtctt
     5941 aaaggtaggg ccaatttcat ggagcatttt tctgtgtgtg tccttgttgc ttttgccaga
     6001 aaaagtggat ttgacatgcg tgccccgatg ccaccatagc ccctaggcca acaatgtcat
     6061 ggtctaaaca ccaaaaagtg atgccccgca ttccttccct ggatggtacc gtttcttctc
     6121 cgtctctctt tgatgattct ttgggaccaa agtcctctcc ttagtgcgcc tacttcctgt
     6181 gggcatcatg ccacttggaa cttattggaa ctggcccggg agactctgca gtctgcgccg
     6241 tttgaaaacc ctgagaaaga gatgccacct caacttgaat catgacagcc catcgctcag
     6301 tctcacccta aactcatgga gcttgtttca gctcctcact tcttgactgt atttgtacta
     6361 tgttgaaaaa atatcctgtc cacaaagaca taagcctaac aacctagaaa aacaacaggg
     6421 tactactggc attacagaac ttctttgcct ttcaaaacaa aagcaaaaca cagtgaactt
     6481 caccacggag ctgcacagcg tggggaactc atccatcact ttcaaaatta gagtcatttg
     6541 atccaagttg gagtcagaca cagtatttga gctgcacggc ttctgggttc tcccacctta
     6601 tttgatcata ttcgaaagat tatttcctgt gtttgctttg atttgttcct cagtacatta
     6661 aaatgatcca caccttgaac actgccctct ctagaaggtt gattttgatc agccttttga
     6721 agatgggtgt cgtttcccta acttatctca cagaattttg agtgttgtat ttggcaagtt
     6781 ctgagatttg ccttctgtct tatgccaaac acccctttct aagagctgtc cccgcttagt
     6841 tttagaagta ctaggggttt tcatacttat tttatagaac acccatttat atttatttct
     6901 gtatatagaa ctaaaaaaaa cagtagtgtt aaaaatcttt gttgtggttt gagcatcttt
     6961 gctgcttttg gattgagatg gcgaatcaag gcttcacttc ctctctcttc tgtctttaga
     7021 aagctgtgat cgtgcgtgca attatttgaa aggcaacata gtcaattaag aaacctgtag
     7081 ttgttaagga agaaattgtt ggcaagatat ccatactgcc catatctcgt tggtgcaata
     7141 attaaatagc aaaggaaatc tgtattggca actattataa ttcaataatt cttttgttta
     7201 ctgccctttt ctgttcaaga attttctgga aattactccc tttcacatgg ttgaactctt
     7261 aagttgacca gttctcatag ctctatcact agaatggttt gcagataccc caaacatact
     7321 atgataaaat caaattgtgc tacttttgac ccatgtaatt tacctaaaag ttgtaattgc
     7381 tgacagagta ctgccttgaa ttttggttta aaacctctct agtttcaatg acaagtaaca
     7441 actcaaataa ttccatattg tttgaggaag aggccataat ccttctgaat tgttggcact
     7501 aagtaatggg atttggccca gtaagtatga cggtcgtgtc gcctaaccaa cgcagagcag
     7561 tgctttttgt gtggctgaag cgatgtgctg acgaaaaaag gaaaattcta ggacaatcgt
     7621 tggctaaaaa tcaccttagg atgaaaaatt tgaggcaaat ttttttaaat gacagaaaaa
     7681 gataatcatc tcacttgctt gaaacaggag ccagcatgat ctctggaagc atcaactatc
     7741 cctcgtcgtg attgttgaaa gctctttcac tgttttgcat tctagtttga atagtttgta
     7801 ttgaaattgg attcctatct tgtgtatgtt tttggtgcgt aaaagggaaa aattggtgtc
     7861 attacttttg aaatttgcag gacgaagggc atgcttttgg tttgctgtaa gattgtattc
     7921 tgtatatatg ttttcatgta aataaatgaa aatctatatc agagttatat tttaattttt
     7981 attctaaatg aaaaaaaccc tttttacttc aaaaaaattg taagccacat tgttaataaa
     8041 gtaaaaataa attcta
//
