LOCUS       NM_016329               4553 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens Scm like with four mbt domains 1 (SFMBT1), mRNA.
ACCESSION   NM_016329 NM_015479
VERSION     NM_016329.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4553)
  AUTHORS   Li,Y., Ma,C., Li,S., Wang,J., Li,W., Yang,Y., Li,X., Liu,J.,
            Yang,J., Liu,Y., Li,K., Li,J., Huang,D., Chen,R., Lv,L., Xiao,X.,
            Li,M. and Luo,X.J.
  TITLE     Regulatory Variant rs2535629 in ITIH3 Intron Confers Schizophrenia
            Risk By Regulating CTCF Binding and SFMBT1 Expression
  JOURNAL   Adv Sci (Weinh) 9 (6), e2104786 (2022)
   PUBMED   34978167
  REMARK    GeneRIF: Regulatory Variant rs2535629 in ITIH3 Intron Confers
            Schizophrenia Risk By Regulating CTCF Binding and SFMBT1
            Expression.
REFERENCE   2  (bases 1 to 4553)
  AUTHORS   Yuan,Y., Bao,J., Chen,Z., Villanueva,A.D., Wen,W., Wang,F.,
            Zhao,D., Fu,X., Cai,Q., Long,J., Shu,X.O., Zheng,D., Moreno,V.,
            Zheng,W., Lin,W. and Guo,X.
  TITLE     Multi-omics analysis to identify susceptibility genes for
            colorectal cancer
  JOURNAL   Hum Mol Genet 30 (5), 321-330 (2021)
   PUBMED   33481017
  REMARK    GeneRIF: Multi-omics analysis to identify susceptibility genes for
            colorectal cancer.
REFERENCE   3  (bases 1 to 4553)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 4553)
  AUTHORS   Liu,X., Simon,J.M., Xie,H., Hu,L., Wang,J., Zurlo,G., Fan,C.,
            Ptacek,T.S., Herring,L., Tan,X., Li,M., Baldwin,A.S., Kim,W.Y.,
            Wu,T., Kirschner,M.W., Gong,K. and Zhang,Q.
  TITLE     Genome-wide Screening Identifies SFMBT1 as an Oncogenic Driver in
            Cancer with VHL Loss
  JOURNAL   Mol Cell 77 (6), 1294-1306 (2020)
   PUBMED   32023483
  REMARK    GeneRIF: High SFMBT1 expression is associated with clear cell renal
            cell carcinomas.
REFERENCE   5  (bases 1 to 4553)
  AUTHORS   Li,R., Qiao,M., Zhao,X., Yan,J., Wang,X. and Sun,Q.
  TITLE     MiR-20a-3p regulates TGF-beta1/Survivin pathway to affect
            keratinocytes proliferation and apoptosis by targeting SFMBT1 in
            vitro
  JOURNAL   Cell Signal 49, 95-104 (2018)
   PUBMED   29886071
  REMARK    GeneRIF: SFMBT1 knockdown was demonstrated to inhibit cell growth
            and induced apoptosis, which was consistent with the function of
            miR-20a- 3p upregulation in HaCaT cells.
REFERENCE   6  (bases 1 to 4553)
  AUTHORS   Kottgen,A., Albrecht,E., Teumer,A., Vitart,V., Krumsiek,J.,
            Hundertmark,C., Pistis,G., Ruggiero,D., O'Seaghdha,C.M., Haller,T.,
            Yang,Q., Tanaka,T., Johnson,A.D., Kutalik,Z., Smith,A.V., Shi,J.,
            Struchalin,M., Middelberg,R.P., Brown,M.J., Gaffo,A.L., Pirastu,N.,
            Li,G., Hayward,C., Zemunik,T., Huffman,J., Yengo,L., Zhao,J.H.,
            Demirkan,A., Feitosa,M.F., Liu,X., Malerba,G., Lopez,L.M., van der
            Harst,P., Li,X., Kleber,M.E., Hicks,A.A., Nolte,I.M., Johansson,A.,
            Murgia,F., Wild,S.H., Bakker,S.J., Peden,J.F., Dehghan,A.,
            Steri,M., Tenesa,A., Lagou,V., Salo,P., Mangino,M., Rose,L.M.,
            Lehtimaki,T., Woodward,O.M., Okada,Y., Tin,A., Muller,C.,
            Oldmeadow,C., Putku,M., Czamara,D., Kraft,P., Frogheri,L.,
            Thun,G.A., Grotevendt,A., Gislason,G.K., Harris,T.B., Launer,L.J.,
            McArdle,P., Shuldiner,A.R., Boerwinkle,E., Coresh,J., Schmidt,H.,
            Schallert,M., Martin,N.G., Montgomery,G.W., Kubo,M., Nakamura,Y.,
            Tanaka,T., Munroe,P.B., Samani,N.J., Jacobs,D.R. Jr., Liu,K.,
            D'Adamo,P., Ulivi,S., Rotter,J.I., Psaty,B.M., Vollenweider,P.,
            Waeber,G., Campbell,S., Devuyst,O., Navarro,P., Kolcic,I.,
            Hastie,N., Balkau,B., Froguel,P., Esko,T., Salumets,A., Khaw,K.T.,
            Langenberg,C., Wareham,N.J., Isaacs,A., Kraja,A., Zhang,Q.,
            Wild,P.S., Scott,R.J., Holliday,E.G., Org,E., Viigimaa,M.,
            Bandinelli,S., Metter,J.E., Lupo,A., Trabetti,E., Sorice,R.,
            Doring,A., Lattka,E., Strauch,K., Theis,F., Waldenberger,M.,
            Wichmann,H.E., Davies,G., Gow,A.J., Bruinenberg,M., Stolk,R.P.,
            Kooner,J.S., Zhang,W., Winkelmann,B.R., Boehm,B.O., Lucae,S.,
            Penninx,B.W., Smit,J.H., Curhan,G., Mudgal,P., Plenge,R.M.,
            Portas,L., Persico,I., Kirin,M., Wilson,J.F., Mateo Leach,I., van
            Gilst,W.H., Goel,A., Ongen,H., Hofman,A., Rivadeneira,F.,
            Uitterlinden,A.G., Imboden,M., von Eckardstein,A., Cucca,F.,
            Nagaraja,R., Piras,M.G., Nauck,M., Schurmann,C., Budde,K.,
            Ernst,F., Farrington,S.M., Theodoratou,E., Prokopenko,I.,
            Stumvoll,M., Jula,A., Perola,M., Salomaa,V., Shin,S.Y.,
            Spector,T.D., Sala,C., Ridker,P.M., Kahonen,M., Viikari,J.,
            Hengstenberg,C., Nelson,C.P., Meschia,J.F., Nalls,M.A., Sharma,P.,
            Singleton,A.B., Kamatani,N., Zeller,T., Burnier,M., Attia,J.,
            Laan,M., Klopp,N., Hillege,H.L., Kloiber,S., Choi,H., Pirastu,M.,
            Tore,S., Probst-Hensch,N.M., Volzke,H., Gudnason,V., Parsa,A.,
            Schmidt,R., Whitfield,J.B., Fornage,M., Gasparini,P.,
            Siscovick,D.S., Polasek,O., Campbell,H., Rudan,I., Bouatia-Naji,N.,
            Metspalu,A., Loos,R.J., van Duijn,C.M., Borecki,I.B., Ferrucci,L.,
            Gambaro,G., Deary,I.J., Wolffenbuttel,B.H., Chambers,J.C., Marz,W.,
            Pramstaller,P.P., Snieder,H., Gyllensten,U., Wright,A.F., Navis,G.,
            Watkins,H., Witteman,J.C., Sanna,S., Schipf,S., Dunlop,M.G.,
            Tonjes,A., Ripatti,S., Soranzo,N., Toniolo,D., Chasman,D.I.,
            Raitakari,O., Kao,W.H., Ciullo,M., Fox,C.S., Caulfield,M.,
            Bochud,M. and Gieger,C.
  CONSRTM   LifeLines Cohort Study; CARDIoGRAM Consortium; DIAGRAM Consortium;
            ICBP Consortium; MAGIC Consortium
  TITLE     Genome-wide association analyses identify 18 new loci associated
            with serum urate concentrations
  JOURNAL   Nat Genet 45 (2), 145-154 (2013)
   PUBMED   23263486
REFERENCE   7  (bases 1 to 4553)
  AUTHORS   Jostins,L., Ripke,S., Weersma,R.K., Duerr,R.H., McGovern,D.P.,
            Hui,K.Y., Lee,J.C., Schumm,L.P., Sharma,Y., Anderson,C.A.,
            Essers,J., Mitrovic,M., Ning,K., Cleynen,I., Theatre,E.,
            Spain,S.L., Raychaudhuri,S., Goyette,P., Wei,Z., Abraham,C.,
            Achkar,J.P., Ahmad,T., Amininejad,L., Ananthakrishnan,A.N.,
            Andersen,V., Andrews,J.M., Baidoo,L., Balschun,T., Bampton,P.A.,
            Bitton,A., Boucher,G., Brand,S., Buning,C., Cohain,A., Cichon,S.,
            D'Amato,M., De Jong,D., Devaney,K.L., Dubinsky,M., Edwards,C.,
            Ellinghaus,D., Ferguson,L.R., Franchimont,D., Fransen,K.,
            Gearry,R., Georges,M., Gieger,C., Glas,J., Haritunians,T., Hart,A.,
            Hawkey,C., Hedl,M., Hu,X., Karlsen,T.H., Kupcinskas,L.,
            Kugathasan,S., Latiano,A., Laukens,D., Lawrance,I.C., Lees,C.W.,
            Louis,E., Mahy,G., Mansfield,J., Morgan,A.R., Mowat,C., Newman,W.,
            Palmieri,O., Ponsioen,C.Y., Potocnik,U., Prescott,N.J.,
            Regueiro,M., Rotter,J.I., Russell,R.K., Sanderson,J.D., Sans,M.,
            Satsangi,J., Schreiber,S., Simms,L.A., Sventoraityte,J.,
            Targan,S.R., Taylor,K.D., Tremelling,M., Verspaget,H.W., De Vos,M.,
            Wijmenga,C., Wilson,D.C., Winkelmann,J., Xavier,R.J., Zeissig,S.,
            Zhang,B., Zhang,C.K., Zhao,H., Silverberg,M.S., Annese,V.,
            Hakonarson,H., Brant,S.R., Radford-Smith,G., Mathew,C.G.,
            Rioux,J.D., Schadt,E.E., Daly,M.J., Franke,A., Parkes,M.,
            Vermeire,S., Barrett,J.C. and Cho,J.H.
  CONSRTM   International IBD Genetics Consortium (IIBDGC)
  TITLE     Host-microbe interactions have shaped the genetic architecture of
            inflammatory bowel disease
  JOURNAL   Nature 491 (7422), 119-124 (2012)
   PUBMED   23128233
REFERENCE   8  (bases 1 to 4553)
  AUTHORS   Yang,H.C., Liang,Y.J., Chen,J.W., Chiang,K.M., Chung,C.M., Ho,H.Y.,
            Ting,C.T., Lin,T.H., Sheu,S.H., Tsai,W.C., Chen,J.H., Leu,H.B.,
            Yin,W.H., Chiu,T.Y., Chern,C.L., Lin,S.J., Tomlinson,B., Guo,Y.,
            Sham,P.C., Cherny,S.S., Lam,T.H., Thomas,G.N. and Pan,W.H.
  TITLE     Identification of IGF1, SLC4A4, WWOX, and SFMBT1 as hypertension
            susceptibility genes in Han Chinese with a genome-wide gene-based
            association study
  JOURNAL   PLoS One 7 (3), e32907 (2012)
   PUBMED   22479346
  REMARK    GeneRIF: Data identified IGF1, SLC4A4, WWOX, and SFMBT1 as
            hypertension susceptibility genes by gene based association scan
            and gene expression analysis.
REFERENCE   9  (bases 1 to 4553)
  AUTHORS   Kato,T., Sato,H., Emi,M., Seino,T., Arawaka,S., Iseki,C.,
            Takahashi,Y., Wada,M. and Kawanami,T.
  TITLE     Segmental copy number loss of SFMBT1 gene in elderly individuals
            with ventriculomegaly: a community-based study
  JOURNAL   Intern Med 50 (4), 297-303 (2011)
   PUBMED   21325761
  REMARK    GeneRIF: A segmental copy number loss of the SFMBT1 gene may be
            involved in the pathological process in some individuals with
            ventriculomegaly/idiopathic normal pressure hydrocephalus.
REFERENCE   10 (bases 1 to 4553)
  AUTHORS   Wu,S., Trievel,R.C. and Rice,J.C.
  TITLE     Human SFMBT is a transcriptional repressor protein that selectively
            binds the N-terminal tail of histone H3
  JOURNAL   FEBS Lett 581 (17), 3289-3296 (2007)
   PUBMED   17599839
  REMARK    GeneRIF: The tandem MBT repeats form a functional structure
            required for biological activity of hSFMBT and predict similar
            properties for other MBT domain-containing proteins.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC096887.2, DB085221.1,
            BC014614.2, AC099667.2 and AI206996.1.
            
            On Nov 22, 2018 this sequence version replaced NM_016329.3.
            
            Summary: This gene shares high similarity with the Drosophila Scm
            (sex comb on midleg) gene. It encodes a protein which contains four
            malignant brain tumor repeat (mbt) domains and may be involved in
            antigen recognition. [provided by RefSeq, Jun 2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR18074967.2526614.1, BC014614.2
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000394752.8/ ENSP00000378235.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-258               AC096887.2         66060-66317         c
            259-524             DB085221.1         260-525
            525-3514            BC014614.2         409-3398
            3515-4367           AC099667.2         137835-138687       c
            4368-4553           AI206996.1         6-191               c
FEATURES             Location/Qualifiers
     source          1..4553
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p21.1"
     gene            1..4553
                     /gene="SFMBT1"
                     /gene_synonym="hSFMBT; RU1; SFMBT"
                     /note="Scm like with four mbt domains 1"
                     /db_xref="GeneID:51460"
                     /db_xref="HGNC:HGNC:20255"
                     /db_xref="MIM:607319"
     exon            1..258
                     /gene="SFMBT1"
                     /gene_synonym="hSFMBT; RU1; SFMBT"
                     /inference="alignment:Splign:2.1.0"
     exon            259..416
                     /gene="SFMBT1"
                     /gene_synonym="hSFMBT; RU1; SFMBT"
                     /inference="alignment:Splign:2.1.0"
     CDS             389..2989
                     /gene="SFMBT1"
                     /gene_synonym="hSFMBT; RU1; SFMBT"
                     /note="Scm-related gene containing four mbt domains;
                     Scm-related gene product containing four mbt domains;
                     renal ubiquitous protein 1"
                     /codon_start=1
                     /product="scm-like with four MBT domains protein 1"
                     /protein_id="NP_057413.2"
                     /db_xref="CCDS:CCDS2867.1"
                     /db_xref="GeneID:51460"
                     /db_xref="HGNC:HGNC:20255"
                     /db_xref="MIM:607319"
                     /translation="MNGEQQLDADAGSGMEEVELSWEDYLEETGSTAVPYGSFKHVDT
                     RLQNGFAPGMKLEVAVRTDPETYWVATVITTCEQLLLLRYDGYGEDRRADFWCDIRKA
                     DLYPIGWCEQNKKTLEAPEGIRDKVSDWDEFLRQTLIGACSPPVPLLEGLRNGRNPLD
                     LIAPGSRLECQAFQDSLSTWIVTVVENIGGRLKLRYEGLESSDNYEHWLYYLDPFLHH
                     VGWAAQQGYELQPPSAIRHLKNEAEWQEILAKVKEEEEEPLPSYLFKDKQVIGIHTFS
                     VNMKLEAVDPWSPFGISPATVVKVFDEKYFLVEMDDLRPENHARRSFVCHADSPGIFP
                     VQWSLKNGLHISPPPGYPSQDFDWADYLKQCGAEAAPQRCFPPLISEHEFKENMKLEA
                     VNPILPEEVCVATITAVRGSYLWLQLEGSKKPIPECIVSVESMDIFPLGWCETNGHPL
                     STPRRARVYKQRKIAVVQPEKQVPSSRTVHEGLRNQELNSTESVMINGKYCCPKIYFN
                     HRCFSGPYLNKGRIAELPQCVGPGNCVLVLREVLTLLINAAYKPSRVLRELQLDKDSV
                     WHGCGEVLKAKYKGKSYRATVEIVKTADRVTEFCRQTCIKLECCPNLFGPRMVLDKCS
                     ENCSVLTKTKYTHYYGKKKNKRIGRPPGGHSNLACALKKASKRRKRRKNVFVHKKKRS
                     SASVDNTPAGSPQGSGGEDEDDPDEGDDDSLSEGSTSEQQDELQEESEMSEKKSCSSS
                     PTQSEISTSLPPDRQRRKRELRTFSFSDDENKPPSPKEIRIEVAERLHLDSNPLKWSV
                     ADVVRFIRSTDCAPLARIFLDQEIDGQALLLLTLPTVQECMDLKLGPAIKLCHHIERI
                     KFAFYEQFAN"
     exon            417..511
                     /gene="SFMBT1"
                     /gene_synonym="hSFMBT; RU1; SFMBT"
                     /inference="alignment:Splign:2.1.0"
     exon            512..752
                     /gene="SFMBT1"
                     /gene_synonym="hSFMBT; RU1; SFMBT"
                     /inference="alignment:Splign:2.1.0"
     exon            753..841
                     /gene="SFMBT1"
                     /gene_synonym="hSFMBT; RU1; SFMBT"
                     /inference="alignment:Splign:2.1.0"
     exon            842..1088
                     /gene="SFMBT1"
                     /gene_synonym="hSFMBT; RU1; SFMBT"
                     /inference="alignment:Splign:2.1.0"
     exon            1089..1183
                     /gene="SFMBT1"
                     /gene_synonym="hSFMBT; RU1; SFMBT"
                     /inference="alignment:Splign:2.1.0"
     exon            1184..1285
                     /gene="SFMBT1"
                     /gene_synonym="hSFMBT; RU1; SFMBT"
                     /inference="alignment:Splign:2.1.0"
     exon            1286..1436
                     /gene="SFMBT1"
                     /gene_synonym="hSFMBT; RU1; SFMBT"
                     /inference="alignment:Splign:2.1.0"
     exon            1437..1519
                     /gene="SFMBT1"
                     /gene_synonym="hSFMBT; RU1; SFMBT"
                     /inference="alignment:Splign:2.1.0"
     exon            1520..1646
                     /gene="SFMBT1"
                     /gene_synonym="hSFMBT; RU1; SFMBT"
                     /inference="alignment:Splign:2.1.0"
     exon            1647..1760
                     /gene="SFMBT1"
                     /gene_synonym="hSFMBT; RU1; SFMBT"
                     /inference="alignment:Splign:2.1.0"
     exon            1761..1803
                     /gene="SFMBT1"
                     /gene_synonym="hSFMBT; RU1; SFMBT"
                     /inference="alignment:Splign:2.1.0"
     exon            1804..1868
                     /gene="SFMBT1"
                     /gene_synonym="hSFMBT; RU1; SFMBT"
                     /inference="alignment:Splign:2.1.0"
     exon            1869..2008
                     /gene="SFMBT1"
                     /gene_synonym="hSFMBT; RU1; SFMBT"
                     /inference="alignment:Splign:2.1.0"
     exon            2009..2118
                     /gene="SFMBT1"
                     /gene_synonym="hSFMBT; RU1; SFMBT"
                     /inference="alignment:Splign:2.1.0"
     exon            2119..2294
                     /gene="SFMBT1"
                     /gene_synonym="hSFMBT; RU1; SFMBT"
                     /inference="alignment:Splign:2.1.0"
     exon            2295..2473
                     /gene="SFMBT1"
                     /gene_synonym="hSFMBT; RU1; SFMBT"
                     /inference="alignment:Splign:2.1.0"
     exon            2474..2719
                     /gene="SFMBT1"
                     /gene_synonym="hSFMBT; RU1; SFMBT"
                     /inference="alignment:Splign:2.1.0"
     exon            2720..2848
                     /gene="SFMBT1"
                     /gene_synonym="hSFMBT; RU1; SFMBT"
                     /inference="alignment:Splign:2.1.0"
     exon            2849..4553
                     /gene="SFMBT1"
                     /gene_synonym="hSFMBT; RU1; SFMBT"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3489..3494
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SFMBT1"
                     /gene_synonym="hSFMBT; RU1; SFMBT"
                     /note="hexamer: ATTAAA"
     polyA_site      3514
                     /gene="SFMBT1"
                     /gene_synonym="hSFMBT; RU1; SFMBT"
                     /note="major polyA site"
     regulatory      3668..3673
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SFMBT1"
                     /gene_synonym="hSFMBT; RU1; SFMBT"
                     /note="hexamer: ACTAAA"
     polyA_site      3685
                     /gene="SFMBT1"
                     /gene_synonym="hSFMBT; RU1; SFMBT"
     regulatory      4530..4535
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SFMBT1"
                     /gene_synonym="hSFMBT; RU1; SFMBT"
                     /note="hexamer: AATATA"
     polyA_site      4553
                     /gene="SFMBT1"
                     /gene_synonym="hSFMBT; RU1; SFMBT"
ORIGIN      
        1 atattggaat gagtcggagc gcggagcgcc gccgccgcct ccgccggagc gcgggtggag
       61 gggggcgggg agagctgccg gccgccccgc tccgccgaac ccagcaggaa ggagggcgcg
      121 agcgggcgag cgcgggcagc acgggaggaa aaagcttccg cgcgggggag cgaaaagacg
      181 gaaagaaaga aagaaaacga gcgcgagagg gggaaaagcg agcgatcgag cgagcgcgcg
      241 cgcgaaaact ccgggcagca ctttcatttg gacccgtgga tacccattga acagatgctt
      301 gaaacctgca agtaatcttc agatcctagc agaaccatag gcctttcctt tgttttggga
      361 ggatatagcc tgcctatatg ctgtggaaat gaacggggag cagcagcttg atgcagatgc
      421 cggctctggt atggaagagg tagaattaag ctgggaagat tatctagaag aaacagggtc
      481 cacagcagtt ccctatgggt cttttaaaca tgtggacaca cgtttgcaaa atggatttgc
      541 tcctgggatg aagctggagg tggctgtgag aacagatcct gagacctact gggttgccac
      601 cgttatcact acctgtgagc agttgctcct tctccgctat gatggctatg gggaggatcg
      661 gagagcagat ttctggtgtg acatcaggaa ggctgatctc taccccattg ggtggtgtga
      721 gcagaataag aagacccttg aagccccaga aggcatcaga gataaagtat ctgactggga
      781 tgagtttctg cggcagaccc tgataggagc atgtagtcct cctgttccgc tgctagaggg
      841 cctccgtaat gggaggaatc ctttagatct cattgctcca ggatccagac tagaatgtca
      901 agctttccag gactctttaa gcacttggat tgttactgta gtagaaaaca ttggaggaag
      961 gctgaagcta cgttatgaag gacttgaaag ttctgacaat tatgaacatt ggttgtatta
     1021 cttggatcca tttcttcatc acgttggttg ggctgctcaa cagggatatg agcttcagcc
     1081 cccttcagcc attagacatc taaaaaatga agctgagtgg caagagattt tggccaaagt
     1141 gaaagaggaa gaggaagagc cattaccatc ttacttattt aaggacaaac aagttattgg
     1201 cattcataca ttctctgtaa acatgaaatt ggaagctgta gacccctggt ctccttttgg
     1261 gatctctcct gctacagttg ttaaggtttt tgatgagaag tactttctgg tggaaatgga
     1321 tgacttgcgt cctgagaacc acgcacggcg atcctttgtg tgccacgccg acagtcctgg
     1381 catcttccct gtgcagtgga gtctgaagaa tggcctacac atcagccccc ctccaggcta
     1441 cccaagccag gactttgact gggctgacta cctcaaacag tgtggtgctg aagctgctcc
     1501 ccagaggtgc ttccctccgt taatttctga acatgaattt aaggagaaca tgaagctcga
     1561 ggcggtgaac cccattctcc ctgaagaagt gtgtgttgct accatcactg cagtgagagg
     1621 ctcctacctg tggctccagc tggagggttc taagaagcct atacctgaat gtattgtgag
     1681 tgtggaatcc atggatatat ttcctttggg ctggtgtgaa accaacggcc accccctcag
     1741 cactcctcgc cgagcacgag tatataaaca gaggaaaatt gcagtggttc agccagaaaa
     1801 acaagtacca tcctcgagga ctgtccacga gggcctgagg aatcaggagc tgaactccac
     1861 agagtcagtt atgattaatg gaaaatattg ctgtccaaag atatacttca accaccgttg
     1921 cttctcaggg ccatatctta acaaaggaag aattgctgag ctgcctcaat gtgtaggacc
     1981 tgggaactgt gttctggtcc ttagagaggt cctcacttta cttatcaatg cagcctacaa
     2041 acccagccgt gtccttcggg agctccagct ggacaaagac tctgtgtggc acggatgtgg
     2101 ggaagtccta aaagccaaat ataaaggaaa gagttatcgg gctactgttg agatagtgaa
     2161 aacagcagat cgggtgactg aattctgccg gcaaacctgt atcaaactgg aatgctgtcc
     2221 taacctcttc ggtccacgga tggttctgga taagtgttct gagaactgtt ctgtacttac
     2281 aaagaccaaa tacacacact attacggaaa gaagaaaaat aaaagaattg ggaggccacc
     2341 tggtgggcat agtaacttag cttgtgccct gaaaaaagcc agtaagagga gaaagaggcg
     2401 gaaaaatgtt tttgttcata agaagaaacg ctcctctgca tctgttgata ataccccagc
     2461 gggctctccc cagggaagtg ggggtgaaga tgaggatgac ccagatgaag gggatgatga
     2521 ttccctaagt gaaggcagta catccgagca gcaggatgag ctacaggaag aatcagaaat
     2581 gtcagaaaaa aagtcatgct cctcttctcc cacccaaagt gagatatcca catcgctgcc
     2641 tccagataga caaaggagaa aaagggagct tcgcaccttt tcattttctg acgatgaaaa
     2701 taaacctcct tcaccaaagg aaataaggat cgaagttgct gaaaggcttc acctggacag
     2761 taaccccttg aagtggagtg tggcagacgt tgtgcggttc atcagatcca ctgactgtgc
     2821 tccattagca agaatattcc tagaccagga aattgatggg caggccctgt tgctccttac
     2881 ccttcccact gttcaagaat gcatggactt aaaattgggc cctgccatca aactttgcca
     2941 tcacatagag aggatcaagt ttgcttttta tgagcagttt gccaactgag aaggacaacc
     3001 aaagtgagct ggatctttga agcacaaatg cagcaaatcc ttcaccctgc tttataagtg
     3061 gagctggaat agtcctgggg ctctggggcc tgcaggtatc agcttgctct ctttgcactt
     3121 tcggggaagg aggactcaca gtgaggaagc aaaaactgtg cacagaagtg gatcacctgc
     3181 tggtggaaat gtggacatct cttgttcagc agatggcagt ttttaaaaaa taaaggttgt
     3241 gaggaaaaga cttatataag aagaaaagca tttccagtgg tgtggcctga aaacaaagaa
     3301 taacctaggc tgctggaaag cacccttttg gttgttttca ttctgttccc tcccattgta
     3361 gattgaactt tgttctctgc tttctttttc ttggaaagag aggacttagc tttaagtcag
     3421 cactgatttg ggactgttcc taaggcatat cagtgcttca ttgtcattgt gtttttaaac
     3481 tttttaaaat taaaacagtt cattttgggg atgattatgt ggctctaggg ttttgaatgt
     3541 atagtcacac tttgatcatt ttaaaatcga ttcttaggag ttcctttgtt tactacctct
     3601 gttgataatt gagcttacag ccatgtatga ggttttttgt atgatgccat ttttaagcta
     3661 cataaacact aaaattatga cagaatttgg agggggggaa actgtttgct ttcttaaaaa
     3721 cattatatgg ggcacttaca ccagttcctt aactgacctg atctgagaac tctactgtta
     3781 ctgttctcca tcttgaccca gccgaggctg cctgtgttaa gtaacatcac caagactgtt
     3841 agtatttctg tttaattgcc ctcttcctat tcattctcag agggacttca gtgactttta
     3901 ttttgtgttt acttttctct agagttgttt gtctacctct gtttcatttc taaggtcttt
     3961 actttgggtg aaaatcagta agtgttccat ggacccacag cgaagcccat ttgtccttct
     4021 ttccaggtgt ctccagtgta gaagcacagc acagaaaaca tgttttggag ggtaacgcag
     4081 agcatggagt ttctgttagc agtgtcctca gtggcaggat aaatactgag atgtggttaa
     4141 ggattctgga aacctctttg cctagccaca cttagacttt tttcagctaa tcctttaaat
     4201 tgaatataat ctttagtccg aggattccca tttaaacaac tcagtattct tttaagtgtg
     4261 tcttttagcc cagctcaagt taacatgaaa ctccaggtga attttcactt actattccat
     4321 tgctagctat tatagaataa tagcgtttgc tgcactattc tagtcatgag gagtgaggaa
     4381 aaacatacat aggttgtctc ccttaaatgg tttgctttgc tgaatttttt ttatcctaat
     4441 cacctgcaaa tttataaccc aatcattctt cctcaagatt tgaaaatgtt ttaatcctgc
     4501 aaactgggtg aattctaaac agctctacaa atataaggaa atattacagc aaa
//
