LOCUS       NM_001378956            3225 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens splicing factor 1 (SF1), transcript variant 11, mRNA.
ACCESSION   NM_001378956 XM_011545244
VERSION     NM_001378956.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3225)
  AUTHORS   Dottermusch,M., Ryba,A., Ricklefs,F.L., Flitsch,J., Schmid,S.,
            Glatzel,M., Saeger,W., Neumann,J.E. and Schuller,U.
  TITLE     Pituitary neuroendocrine tumors with PIT1/SF1 co-expression show
            distinct clinicopathological and molecular features
  JOURNAL   Acta Neuropathol 147 (1), 16 (2024)
   PUBMED   38228887
  REMARK    Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3225)
  AUTHORS   Chi,E.S., Stivison,E.A. and Blind,R.D.
  TITLE     SF-1 Induces Nuclear PIP2
  JOURNAL   Biomolecules 13 (10), 1509 (2023)
   PUBMED   37892191
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 3225)
  AUTHORS   Asa,S.L., Mete,O., Riddle,N.D. and Perry,A.
  TITLE     Multilineage Pituitary Neuroendocrine Tumors (PitNETs) Expressing
            PIT1 and SF1
  JOURNAL   Endocr Pathol 34 (3), 273-278 (2023)
   PUBMED   37268858
REFERENCE   4  (bases 1 to 3225)
  AUTHORS   Nameki,N., Takizawa,M., Suzuki,T., Tani,S., Kobayashi,N.,
            Sakamoto,T., Muto,Y. and Kuwasako,K.
  TITLE     Structural basis for the interaction between the first SURP domain
            of the SF3A1 subunit in U2 snRNP and the human splicing factor SF1
  JOURNAL   Protein Sci 31 (10), e4437 (2022)
   PUBMED   36173164
  REMARK    GeneRIF: Structural basis for the interaction between the first
            SURP domain of the SF3A1 subunit in U2 snRNP and the human splicing
            factor SF1.
REFERENCE   5  (bases 1 to 3225)
  AUTHORS   Zhang,D. and Childs,G.
  TITLE     Human ZFM1 protein is a transcriptional repressor that interacts
            with the transcription activation domain of stage-specific
            activator protein
  JOURNAL   J Biol Chem 273 (12), 6868-6877 (1998)
   PUBMED   9506990
REFERENCE   6  (bases 1 to 3225)
  AUTHORS   Caslini,C., Spinelli,O., Cazzaniga,G., Golay,J., De Gioia,L.,
            Pedretti,A., Breviario,F., Amaru,R., Barbui,T., Biondi,A.,
            Introna,M. and Rambaldi,A.
  TITLE     Identification of two novel isoforms of the ZNF162 gene: a growing
            family of signal transduction and activator of RNA proteins
  JOURNAL   Genomics 42 (2), 268-277 (1997)
   PUBMED   9192847
REFERENCE   7  (bases 1 to 3225)
  AUTHORS   Abovich,N. and Rosbash,M.
  TITLE     Cross-intron bridging interactions in the yeast commitment complex
            are conserved in mammals
  JOURNAL   Cell 89 (3), 403-412 (1997)
   PUBMED   9150140
REFERENCE   8  (bases 1 to 3225)
  AUTHORS   Arning,S., Gruter,P., Bilbe,G. and Kramer,A.
  TITLE     Mammalian splicing factor SF1 is encoded by variant cDNAs and binds
            to RNA
  JOURNAL   RNA 2 (8), 794-810 (1996)
   PUBMED   8752089
REFERENCE   9  (bases 1 to 3225)
  AUTHORS   Toda,T., Iida,A., Miwa,T., Nakamura,Y. and Imai,T.
  TITLE     Isolation and characterization of a novel gene encoding nuclear
            protein at a locus (D11S636) tightly linked to multiple endocrine
            neoplasia type 1 (MEN1)
  JOURNAL   Hum Mol Genet 3 (3), 465-470 (1994)
   PUBMED   7912130
REFERENCE   10 (bases 1 to 3225)
  AUTHORS   Kramer,A.
  TITLE     Purification of splicing factor SF1, a heat-stable protein that
            functions in the assembly of a presplicing complex
  JOURNAL   Mol Cell Biol 12 (10), 4545-4552 (1992)
   PUBMED   1406644
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP001462.3.
            
            On Mar 16, 2020 this sequence version replaced XM_011545244.1.
            
            Summary: This gene encodes a nuclear pre-mRNA splicing factor. The
            encoded protein specifically recognizes the intron branch point
            sequence at the 3' splice site, together with the large subunit of
            U2 auxiliary factor (U2AF), and is required for the early stages of
            spliceosome assembly. It also plays a role in nuclear pre-mRNA
            retention and transcriptional repression. The encoded protein
            contains an N-terminal U2AF ligand motif, a central hnRNP K
            homology motif and quaking 2 region which bind a key branch-site
            adenosine within the branch point sequence, a zinc knuckles domain,
            and a C-terminal proline-rich domain. Alternative splicing results
            in multiple transcript variants. [provided by RefSeq, Oct 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038192.1545459.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-556               AP001462.3         62262-62817         c
            557-685             AP001462.3         60773-60901         c
            686-761             AP001462.3         57705-57780         c
            762-914             AP001462.3         54531-54683         c
            915-1004            AP001462.3         54239-54328         c
            1005-1188           AP001462.3         53701-53884         c
            1189-1304           AP001462.3         53498-53613         c
            1305-1412           AP001462.3         53297-53404         c
            1413-1593           AP001462.3         52381-52561         c
            1594-1867           AP001462.3         51846-52119         c
            1868-1927           AP001462.3         51467-51526         c
            1928-2107           AP001462.3         51175-51354         c
            2108-2312           AP001462.3         50226-50430         c
            2313-3225           AP001462.3         48881-49793         c
FEATURES             Location/Qualifiers
     source          1..3225
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q13.1"
     gene            1..3225
                     /gene="SF1"
                     /gene_synonym="BBP; D11S636; MBBP; ZCCHC25; ZFM1; ZNF162"
                     /note="splicing factor 1"
                     /db_xref="GeneID:7536"
                     /db_xref="HGNC:HGNC:12950"
                     /db_xref="MIM:601516"
     exon            1..556
                     /gene="SF1"
                     /gene_synonym="BBP; D11S636; MBBP; ZCCHC25; ZFM1; ZNF162"
                     /inference="alignment:Splign:2.1.0"
     CDS             151..2442
                     /gene="SF1"
                     /gene_synonym="BBP; D11S636; MBBP; ZCCHC25; ZFM1; ZNF162"
                     /note="isoform 11 is encoded by transcript variant 11;
                     zinc finger protein 162; transcription factor ZFM1; branch
                     point-binding protein; zinc finger gene in MEN1 locus;
                     mammalian branch point-binding protein"
                     /codon_start=1
                     /product="splicing factor 1 isoform 11"
                     /protein_id="NP_001365885.1"
                     /db_xref="GeneID:7536"
                     /db_xref="HGNC:HGNC:12950"
                     /db_xref="MIM:601516"
                     /translation="MATGANATPLGKLGPPGLPPLPGPKGGFEPGPPPAPGPGAGLLA
                     PGPPPPPPVGSMGALTAAFPFAALPPPPPPPPPPPPQQPPPPPPPPSPGASYPPPQPP
                     PPPPLYQRVSPPQPPPPQPPRKDQQPGPAGGGGDFPSKKRKRSRWNQDTMEQKTVIPG
                     MPTVIPPGLTREQERAYIVQLQIEDLTRKLRTGDLGIPPNPEDRSPSPEPIYNSEGKR
                     LNTREFRTRKKLEEERHNLITEMVALNPDFKPPADYKPPATRVSDKVMIPQDEYPEIN
                     FVGLLIGPRGNTLKNIEKECNAKIMIRGKGSVKEGKVGRKDGQMLPGEDEPLHALVTA
                     NTMENVKKAVEQIRNILKQGIETPEDQNDLRKMQLRELARLNGTLREDDNRILRPWQS
                     SETRSITNTTVCTKCGGAGHIASDCKFQRPGDPQSAQDKARMDKEYLSLMAELGEAPV
                     PASVGSTSGPATTPLASAPRPAAPANNPPPPSLMSTTQSRPPWMNSGPSESRPYHGMH
                     GGGPGGPGGGPHSFPHPLPSLTGGHGGHPMQHNPNGPPPPWMQPPPPPMNQGPHPPGH
                     HGPPPMDQYLGSTPVGSGVYRLHQGKGMMPPPPMGMMPPPPPPPSGQPPPPPSGPLPP
                     WQQQQQQPPPPPPPSSSMASSTPLPWQQNTTTTTTSAGTGSIPPWQQQQAAAAASPGA
                     PQMQGNPTMVPLPPGVQPPLPPGAPPPPPPPPPGSAGMMIPPRGGDGPSHESEDFPRP
                     LVTLPGRQPQQRPWWTGWFGKAA"
     exon            557..685
                     /gene="SF1"
                     /gene_synonym="BBP; D11S636; MBBP; ZCCHC25; ZFM1; ZNF162"
                     /inference="alignment:Splign:2.1.0"
     exon            686..761
                     /gene="SF1"
                     /gene_synonym="BBP; D11S636; MBBP; ZCCHC25; ZFM1; ZNF162"
                     /inference="alignment:Splign:2.1.0"
     exon            762..914
                     /gene="SF1"
                     /gene_synonym="BBP; D11S636; MBBP; ZCCHC25; ZFM1; ZNF162"
                     /inference="alignment:Splign:2.1.0"
     exon            915..1004
                     /gene="SF1"
                     /gene_synonym="BBP; D11S636; MBBP; ZCCHC25; ZFM1; ZNF162"
                     /inference="alignment:Splign:2.1.0"
     exon            1005..1188
                     /gene="SF1"
                     /gene_synonym="BBP; D11S636; MBBP; ZCCHC25; ZFM1; ZNF162"
                     /inference="alignment:Splign:2.1.0"
     exon            1189..1304
                     /gene="SF1"
                     /gene_synonym="BBP; D11S636; MBBP; ZCCHC25; ZFM1; ZNF162"
                     /inference="alignment:Splign:2.1.0"
     exon            1305..1412
                     /gene="SF1"
                     /gene_synonym="BBP; D11S636; MBBP; ZCCHC25; ZFM1; ZNF162"
                     /inference="alignment:Splign:2.1.0"
     exon            1413..1593
                     /gene="SF1"
                     /gene_synonym="BBP; D11S636; MBBP; ZCCHC25; ZFM1; ZNF162"
                     /inference="alignment:Splign:2.1.0"
     exon            1594..1867
                     /gene="SF1"
                     /gene_synonym="BBP; D11S636; MBBP; ZCCHC25; ZFM1; ZNF162"
                     /inference="alignment:Splign:2.1.0"
     exon            1868..1927
                     /gene="SF1"
                     /gene_synonym="BBP; D11S636; MBBP; ZCCHC25; ZFM1; ZNF162"
                     /inference="alignment:Splign:2.1.0"
     exon            1928..2107
                     /gene="SF1"
                     /gene_synonym="BBP; D11S636; MBBP; ZCCHC25; ZFM1; ZNF162"
                     /inference="alignment:Splign:2.1.0"
     exon            2108..2312
                     /gene="SF1"
                     /gene_synonym="BBP; D11S636; MBBP; ZCCHC25; ZFM1; ZNF162"
                     /inference="alignment:Splign:2.1.0"
     exon            2313..3225
                     /gene="SF1"
                     /gene_synonym="BBP; D11S636; MBBP; ZCCHC25; ZFM1; ZNF162"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3199..3204
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SF1"
                     /gene_synonym="BBP; D11S636; MBBP; ZCCHC25; ZFM1; ZNF162"
                     /note="hexamer: AATAAA"
     polyA_site      3225
                     /gene="SF1"
                     /gene_synonym="BBP; D11S636; MBBP; ZCCHC25; ZFM1; ZNF162"
                     /note="major polyA site"
ORIGIN      
        1 gtgcgtctcg cgccgccgcc gcccgccgcg tgagaggacg ggctccgcgc gctccggcag
       61 cgcattcggg tcccctcccc ccgggaggct tgcgaaggag aagccgccgc agaggaaaag
      121 caggtgccgg tgcctgtccc cgggggcgcc atggcgaccg gagcgaacgc cacgccgttg
      181 ggtaagctgg gcccccccgg gctgcccccg ctccccgggc ccaaaggagg cttcgagccg
      241 ggccctccgc ctgcacccgg gcctggggcg gggctgctgg ctcccgggcc gccgccgccc
      301 ccgcccgtgg gctcgatggg ggccctgacc gcggccttcc ccttcgcggc gctgcctccg
      361 ccgcctccgc cgccgccccc tccgcctccc cagcagccgc cgccgcctcc accgccaccg
      421 tcccccggcg cctcgtaccc gccgccgcag ccgccccctc cgccgccgct ctaccagcgc
      481 gtgtcgccgc cgcagccgcc gccaccccag ccgccgcgta aggaccagca gccgggcccg
      541 gccggcggcg gaggagactt cccaagtaag aagcggaaga ggagccgctg gaaccaagac
      601 acaatggaac agaagacagt gattccagga atgcctacag ttattccccc tggacttact
      661 cgagaacaag aaagagctta tatagtgcaa ctgcagatag aagacctgac tcgtaaactg
      721 cgcacaggag acctgggcat cccccctaac cctgaggaca ggtccccttc ccctgagccc
      781 atctacaata gcgaggggaa gcggcttaac acccgagagt tccgcacccg caaaaagctg
      841 gaagaggagc ggcacaacct catcacagag atggttgcac tcaatccgga tttcaagcca
      901 cctgcagatt acaaacctcc agcaacacgt gtgagtgata aagtcatgat tccacaagat
      961 gagtacccag aaatcaactt tgtggggctg ctcatcgggc ccagagggaa caccctgaag
     1021 aacatagaga aggagtgcaa tgccaagatt atgatccggg ggaaagggtc tgtgaaagaa
     1081 gggaaggttg ggcgcaaaga tggccagatg ttgccaggag aagatgagcc acttcatgcc
     1141 ctggttactg ccaatacaat ggagaacgtc aaaaaggcag tggaacagat aagaaacatc
     1201 ctgaagcagg gtatcgagac tccagaggac cagaatgatc tacggaagat gcagcttcgg
     1261 gagttggctc gcttaaatgg gacccttcgg gaagacgata acaggatctt aagaccctgg
     1321 cagagctcag agacccgcag cattaccaac accacagtgt gtaccaagtg tggaggggct
     1381 ggccacattg cttcagactg taaattccaa aggcctggtg atcctcagtc agctcaggat
     1441 aaagcacgga tggataaaga atatttgtcc ctcatggctg aactgggtga agcacctgtc
     1501 ccagcatctg tgggctccac ctctgggcct gccaccacac ccctggccag cgcacctcgt
     1561 cctgctgctc ccgccaacaa cccacctcca ccgtctctca tgtctaccac ccagagccgc
     1621 ccaccctgga tgaattctgg cccttcagag agtcggccct accacggcat gcatggaggt
     1681 ggtcctggtg ggcccggagg tggcccccac agcttcccac acccattacc cagcctgaca
     1741 ggtgggcatg gtggacatcc catgcagcac aaccccaatg gacccccacc cccttggatg
     1801 cagccaccac caccaccgat gaaccagggc ccccaccctc ctgggcacca tggccctcct
     1861 ccaatggatc agtacctggg aagtacgcct gtgggctctg gggtctatcg cctgcatcaa
     1921 ggaaaaggta tgatgccgcc accacctatg ggcatgatgc cgccgccgcc gccgcctccc
     1981 agtgggcagc ccccaccccc tccctctggt cctcttcccc catggcaaca acagcagcag
     2041 cagcctccgc caccccctcc gcccagcagc agtatggctt ccagtacccc cttgccatgg
     2101 cagcaaaata cgacgactac caccacgagc gctggcacag ggtccatccc gccatggcaa
     2161 cagcagcagg cggctgccgc agcttctcca ggagcccctc agatgcaagg caaccccact
     2221 atggtgcccc tgccccccgg ggtccagccg cctctgccgc ctggggcccc tccccctccg
     2281 ccgcctccac cgcctggttc cgccggcatg atgatccctc cccgcggcgg cgatggcccg
     2341 agccatgaga gtgaggactt tccgcgccca ttggtgaccc ttccaggcag acagcctcag
     2401 caacgcccct ggtggacagg atggttcggc aaagcagcct gagttatttt tgtggacgga
     2461 atcggaacac gctggctcca tatcgtgaaa tttttattaa tttttttctt tttcctttgt
     2521 tacttcttta tcttttcctt tcttcagact ccgtccaagg agatgctctc cccggtcttc
     2581 tgctgcaatt tagattcctt tcccttctct ccagttctcc ttcccttacc aaggagaggg
     2641 gagcaaatgg ttttgggcaa gggctttggc cattcatgtc aagctggttg tgggtttttc
     2701 aaggtgccat agccaccccc aaagatgttt gtttaaagcg tggggttttt taatctctgc
     2761 cacccttgtc aagggagtct tgtaaagttg ccgagggtag gttcatctcc aggtttcggg
     2821 attcccatcc gtcctggcga tcctgccagc agtgggtggg cagcctgagc tccctcgggc
     2881 tcgcctgcca gcctggagtt cttcctgtgc tccttgatca cctgagctgc ctcagattcc
     2941 atttggtcct ctccttcctg gaaggcttcc ttttatgttt tgttttaatc ccaaatgtct
     3001 gaatgttttg cagtgtgtag gggtttgagc cccttgttca ttctccttcc tttttcctcc
     3061 cgcttccctc tccatgaagt gattctgttg acaataatgt atactgcgcg ttctcttcac
     3121 tggtttatct gcagaaattt ctctgggctt ttttcggtgt tagattcaac actgcgctaa
     3181 agcggggatg ttccattgaa taaaagagca gtgtggtttt ctggg
//
