LOCUS       NM_021115               6584 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens seizure related 6 homolog like (SEZ6L), transcript
            variant 1, mRNA.
ACCESSION   NM_021115
VERSION     NM_021115.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6584)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 6584)
  AUTHORS   Chapman,N.H., Nato,A.Q. Jr., Bernier,R., Ankenman,K., Sohi,H.,
            Munson,J., Patowary,A., Archer,M., Blue,E.M., Webb,S.J., Coon,H.,
            Raskind,W.H., Brkanac,Z. and Wijsman,E.M.
  TITLE     Whole exome sequencing in extended families with autism spectrum
            disorder implicates four candidate genes
  JOURNAL   Hum Genet 134 (10), 1055-1068 (2015)
   PUBMED   26204995
  REMARK    GeneRIF: SEZ6L, HISPPD1, FEZF1, SAMD11 gene variants may be
            associated with autism spectrum disorder.
REFERENCE   3  (bases 1 to 6584)
  AUTHORS   Xu,C., Mullersman,J.E., Wang,L., Bin Su,B., Mao,C., Posada,Y.,
            Camarillo,C., Mao,Y., Escamilla,M.A. and Wang,K.S.
  TITLE     Polymorphisms in seizure 6-like gene are associated with bipolar
            disorder I: evidence of gene x gender interaction
  JOURNAL   J Affect Disord 145 (1), 95-99 (2013)
   PUBMED   22920719
  REMARK    GeneRIF: This is the first demonstration that genetic variants in
            the SEZ6L gene are associated with bipolar disorder Iin female
            patients and provides additional compelling evidence for genetic
            variation at 22q11-13 that influences BD-I risk.
REFERENCE   4  (bases 1 to 6584)
  AUTHORS   Wilk,J.B., Shrine,N.R., Loehr,L.R., Zhao,J.H., Manichaikul,A.,
            Lopez,L.M., Smith,A.V., Heckbert,S.R., Smolonska,J., Tang,W.,
            Loth,D.W., Curjuric,I., Hui,J., Cho,M.H., Latourelle,J.C.,
            Henry,A.P., Aldrich,M., Bakke,P., Beaty,T.H., Bentley,A.R.,
            Borecki,I.B., Brusselle,G.G., Burkart,K.M., Chen,T.H., Couper,D.,
            Crapo,J.D., Davies,G., Dupuis,J., Franceschini,N., Gulsvik,A.,
            Hancock,D.B., Harris,T.B., Hofman,A., Imboden,M., James,A.L.,
            Khaw,K.T., Lahousse,L., Launer,L.J., Litonjua,A., Liu,Y.,
            Lohman,K.K., Lomas,D.A., Lumley,T., Marciante,K.D., McArdle,W.L.,
            Meibohm,B., Morrison,A.C., Musk,A.W., Myers,R.H., North,K.E.,
            Postma,D.S., Psaty,B.M., Rich,S.S., Rivadeneira,F., Rochat,T.,
            Rotter,J.I., Soler Artigas,M., Starr,J.M., Uitterlinden,A.G.,
            Wareham,N.J., Wijmenga,C., Zanen,P., Province,M.A., Silverman,E.K.,
            Deary,I.J., Palmer,L.J., Cassano,P.A., Gudnason,V., Barr,R.G.,
            Loos,R.J., Strachan,D.P., London,S.J., Boezen,H.M.,
            Probst-Hensch,N., Gharib,S.A., Hall,I.P., O'Connor,G.T., Tobin,M.D.
            and Stricker,B.H.
  TITLE     Genome-wide association studies identify CHRNA5/3 and HTR4 in the
            development of airflow obstruction
  JOURNAL   Am J Respir Crit Care Med 186 (7), 622-632 (2012)
   PUBMED   22837378
REFERENCE   5  (bases 1 to 6584)
  AUTHORS   Irvin,M.R., Wineinger,N.E., Rice,T.K., Pajewski,N.M.,
            Kabagambe,E.K., Gu,C.C., Pankow,J., North,K.E., Wilk,J.B.,
            Freedman,B.I., Franceschini,N., Broeckel,U., Tiwari,H.K. and
            Arnett,D.K.
  TITLE     Genome-wide detection of allele specific copy number variation
            associated with insulin resistance in African Americans from the
            HyperGEN study
  JOURNAL   PLoS One 6 (8), e24052 (2011)
   PUBMED   21901158
REFERENCE   6  (bases 1 to 6584)
  AUTHORS   Raji,O.Y., Agbaje,O.F., Duffy,S.W., Cassidy,A. and Field,J.K.
  TITLE     Incorporation of a genetic factor into an epidemiologic model for
            prediction of individual risk of lung cancer: the Liverpool Lung
            Project
  JOURNAL   Cancer Prev Res (Phila) 3 (5), 664-669 (2010)
   PUBMED   20424129
  REMARK    GeneRIF: the addition of SEZ6L improved the performance of the
            Liverpool Lung Project risk model.
            GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   7  (bases 1 to 6584)
  AUTHORS   Gorlov,I.P., Meyer,P., Liloglou,T., Myles,J., Boettger,M.B.,
            Cassidy,A., Girard,L., Minna,J.D., Fischer,R., Duffy,S.,
            Spitz,M.R., Haeussinger,K., Kammerer,S., Cantor,C., Dierkesmann,R.,
            Field,J.K. and Amos,C.I.
  TITLE     Seizure 6-like (SEZ6L) gene and risk for lung cancer
  JOURNAL   Cancer Res 67 (17), 8406-8411 (2007)
   PUBMED   17804757
  REMARK    GeneRIF: A role of the SEZ6L Met430Ile polymorphic variant in
            increasing lung cancer risk.
            GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   8  (bases 1 to 6584)
  AUTHORS   Nishioka,M., Kohno,T., Takahashi,M., Niki,T., Yamada,T., Sone,S.
            and Yokota,J.
  TITLE     Identification of a 428-kb homozygously deleted region disrupting
            the SEZ6L gene at 22q12.1 in a lung cancer cell line
  JOURNAL   Oncogene 19 (54), 6251-6260 (2000)
   PUBMED   11175339
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL022337.19, AY358405.1, AB041736.1 and AL078460.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_021115.4.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and it encodes the longest protein (isoform 1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803615.158973.1,
                                           SRR1803614.135029.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145743, SAMEA2154665
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000248933.11/ ENSP00000248933.6
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AL022337.19        87572-87583
            13-208              AY358405.1         1-196
            209-3253            AB041736.1         1-3045
            3254-6584           AL078460.6         524-3854
FEATURES             Location/Qualifiers
     source          1..6584
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="22"
                     /map="22q12.1"
     gene            1..6584
                     /gene="SEZ6L"
                     /gene_synonym="SEZ6L1"
                     /note="seizure related 6 homolog like"
                     /db_xref="GeneID:23544"
                     /db_xref="HGNC:HGNC:10763"
                     /db_xref="MIM:607021"
     exon            1..302
                     /gene="SEZ6L"
                     /gene_synonym="SEZ6L1"
                     /inference="alignment:Splign:2.1.0"
     CDS             209..3283
                     /gene="SEZ6L"
                     /gene_synonym="SEZ6L1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; seizure related gene 6-like; seizure 6-like
                     protein"
                     /codon_start=1
                     /product="seizure 6-like protein isoform 1 precursor"
                     /protein_id="NP_066938.2"
                     /db_xref="CCDS:CCDS13833.1"
                     /db_xref="GeneID:23544"
                     /db_xref="HGNC:HGNC:10763"
                     /db_xref="MIM:607021"
                     /translation="MPAARPPAAGLRGISLFLALLLGSPAAALERDALPEGDASPLGP
                     YLLPSGAPERGSPGKEHPEERVVTAPPSSSQSAEVLGELVLDGTAPSAHHDIPALSPL
                     LPEEARPKHALPPKKKLPSLKQVNSARKQLRPKATSAATVQRAGSQPASQGLDLLSSS
                     TEKPGPPGDPDPIVASEEASEVPLWLDRKESAVPTTPAPLQISPFTSQPYVAHTLPQR
                     PEPGEPGPDMAQEAPQEDTSPMALMDKGENELTGSASEESQETTTSTIITTTVITTEQ
                     APALCSVSFSNPEGYIDSSDYPLLPLNNFLECTYNVTVYTGYGVELQVKSVNLSDGEL
                     LSIRGVDGPTLTVLANQTLLVEGQVIRSPTNTISVYFRTFQDDGLGTFQLHYQAFMLS
                     CNFPRRPDSGDVTVMDLHSGGVAHFHCHLGYELQGAKMLTCINASKPHWSSQEPICSA
                     PCGGAVHNATIGRVLSPSYPENTNGSQFCIWTIEAPEGQKLHLHFERLLLHDKDRMTV
                     HSGQTNKSALLYDSLQTESVPFEGLLSEGNTIRIEFTSDQARAASTFNIRFEAFEKGH
                     CYEPYIQNGNFTTSDPTYNIGTIVEFTCDPGHSLEQGPAIIECINVRDPYWNDTEPLC
                     RAMCGGELSAVAGVVLSPNWPEPYVEGEDCIWKIHVGEEKRIFLDIQFLNLSNSDILT
                     IYDGDEVMPHILGQYLGNSGPQKLYSSTPDLTIQFHSDPAGLIFGKGQGFIMNYIEVS
                     RNDSCSDLPEIQNGWKTTSHTELVRGARITYQCDPGYDIVGSDTLTCQWDLSWSSDPP
                     FCEKIMYCTDPGEVDHSTRLISDPVLLVGTTIQYTCNPGFVLEGSSLLTCYSRETGTP
                     IWTSRLPHCVSEESLACDNPGLPENGYQILYKRLYLPGESLTFMCYEGFELMGEVTIR
                     CILGQPSHWNGPLPVCKVNQDSFEHALEVAEAAAETSLEGGNMALAIFIPVLIISLLL
                     GGAYIYITRCRYYSNLRLPLMYSHPYSQITVETEFDNPIYETGETREYEVSI"
     exon            303..1043
                     /gene="SEZ6L"
                     /gene_synonym="SEZ6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1044..1177
                     /gene="SEZ6L"
                     /gene_synonym="SEZ6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1178..1370
                     /gene="SEZ6L"
                     /gene_synonym="SEZ6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1371..1556
                     /gene="SEZ6L"
                     /gene_synonym="SEZ6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1557..1722
                     /gene="SEZ6L"
                     /gene_synonym="SEZ6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1723..1889
                     /gene="SEZ6L"
                     /gene_synonym="SEZ6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            1890..2084
                     /gene="SEZ6L"
                     /gene_synonym="SEZ6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2085..2223
                     /gene="SEZ6L"
                     /gene_synonym="SEZ6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2224..2420
                     /gene="SEZ6L"
                     /gene_synonym="SEZ6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2615
                     /gene="SEZ6L"
                     /gene_synonym="SEZ6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2616..2807
                     /gene="SEZ6L"
                     /gene_synonym="SEZ6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            2808..3002
                     /gene="SEZ6L"
                     /gene_synonym="SEZ6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3003..3035
                     /gene="SEZ6L"
                     /gene_synonym="SEZ6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3036..3150
                     /gene="SEZ6L"
                     /gene_synonym="SEZ6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3151..3253
                     /gene="SEZ6L"
                     /gene_synonym="SEZ6L1"
                     /inference="alignment:Splign:2.1.0"
     exon            3254..6584
                     /gene="SEZ6L"
                     /gene_synonym="SEZ6L1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6565..6570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SEZ6L"
                     /gene_synonym="SEZ6L1"
                     /note="hexamer: AATAAA"
     polyA_site      6584
                     /gene="SEZ6L"
                     /gene_synonym="SEZ6L1"
                     /note="major polyA site"
ORIGIN      
        1 actcgcccgc ccgcgcccgg cgcagctcgg ccagagcgac cgcggggctg agcgcgcgtc
       61 cgcccagggg gctccggaag ctgccccggc ccgcggcctc ctccctcgct cccgcttccc
      121 ctttctcgct caccgccgcc ctccttcccc agctccctcg ccgtccgccc gccccacagc
      181 cagcggctcc gcgccccctg cagccacgat gcccgcggcc cggccgcccg ccgcgggact
      241 ccgcgggatc tcgctgttcc tcgctctgct cctggggagc ccggcggcag cgctggagcg
      301 agatgctctt cccgagggag atgctagccc tttgggtcct tacctcctgc cctcaggagc
      361 cccggagaga ggcagtcctg gcaaagagca ccctgaagag agagtggtaa cagcgccccc
      421 cagttcctca cagtcggcgg aagtgctggg cgagctggtg ctggatggga ccgcaccctc
      481 tgcacatcac gacatcccag ccctgtcacc gctgcttcca gaggaggccc gccccaagca
      541 cgccttgccc cccaagaaga aactgccttc gctcaagcag gtgaactctg ccaggaagca
      601 gctgaggccc aaggccacct ccgcagccac tgtccaaagg gcagggtccc agccagcgtc
      661 ccagggccta gatctcctct cctcctccac ggagaagcct ggcccaccgg gggacccgga
      721 ccccatcgtg gcctccgagg aggcatcaga agtgcccctt tggctggacc gaaaggagag
      781 tgcggtccct acaacacccg cacccctgca aatctccccc ttcacttcgc agccctatgt
      841 ggcccacaca ctcccccaga ggccagaacc cggggagcct gggcctgaca tggcccagga
      901 ggccccccag gaggacacca gccccatggc cctgatggac aaaggtgaga atgagctgac
      961 tgggtcagcc tcagaggaga gccaggagac cactacctcc accattatca ccaccacggt
     1021 catcaccacc gagcaggcac cagctctctg cagtgtgagc ttctccaatc ctgaggggta
     1081 cattgactcc agcgactacc cactgctgcc cctcaacaac tttctggagt gcacatacaa
     1141 cgtgacagtc tacactggct atggggtgga gctccaggtg aagagtgtga acctgtccga
     1201 tggggaactg ctctccatcc gcggggtgga cggccctacc ctgaccgtcc tggccaacca
     1261 gacactcctg gtggaggggc aggtaatccg aagccccacc aacaccatct ccgtctactt
     1321 ccggaccttc caggacgacg gccttgggac cttccagctt cactaccagg ccttcatgct
     1381 gagctgcaac tttccccgcc ggcctgactc tggggatgtc acggtgatgg acctgcactc
     1441 aggtggggtg gcccactttc actgccacct gggctatgag ctccagggcg ctaagatgct
     1501 gacatgcatc aatgcctcca agccgcactg gagcagccag gagcccatct gctcagctcc
     1561 ttgtggaggg gcagtgcaca atgccaccat cggccgcgtc ctctccccaa gttaccctga
     1621 aaacacaaat gggagccaat tctgcatctg gacgattgaa gctccagagg gccagaagct
     1681 gcacctgcac tttgagaggc tgttgctgca tgacaaggac aggatgacgg ttcacagcgg
     1741 gcagaccaac aagtcagctc ttctctacga ctcccttcaa accgagagtg tcccttttga
     1801 gggcctgctg agcgaaggca acaccatccg catcgagttc acgtccgacc aggcccgggc
     1861 ggcctccacc ttcaacatcc gatttgaagc gtttgagaaa ggccactgct atgagcccta
     1921 catccagaat gggaacttca ctacatccga cccgacctat aacattggga ctatagtgga
     1981 gttcacctgc gaccccggcc actccctgga gcagggcccg gccatcatcg aatgcatcaa
     2041 tgtgcgggac ccatactgga atgacacaga gcccctgtgc agagccatgt gtggtgggga
     2101 gctctctgct gtggctgggg tggtattgtc cccaaactgg cccgagccct acgtggaagg
     2161 tgaagattgt atctggaaga tccacgtggg agaagagaaa cggatcttct tagatatcca
     2221 gttcctgaat ctgagcaaca gtgacatctt gaccatctac gatggcgacg aggtcatgcc
     2281 ccacatcttg gggcagtacc ttgggaacag tggcccccag aaactgtact cctccacgcc
     2341 agacttaacc atccagttcc attcggaccc tgctggcctc atctttggaa agggccaggg
     2401 atttatcatg aactacatag aggtatcaag gaatgactcc tgctcggatt tacccgagat
     2461 ccagaatggc tggaaaacca cttctcacac ggagttggtg cggggagcca gaatcaccta
     2521 ccagtgtgac cccggctatg acatcgtggg gagtgacacc ctcacctgcc agtgggacct
     2581 cagctggagc agcgaccccc cattttgtga gaaaattatg tactgcaccg accccggaga
     2641 ggtggatcac tcgacccgct taatttcgga tcctgtgctg ctggtgggga ccaccatcca
     2701 atacacctgc aaccccggtt ttgtgcttga agggagttct cttctgacct gctacagccg
     2761 tgaaacaggg actcccatct ggacgtctcg cctgccccac tgcgtttcgg aggagtccct
     2821 ggcatgtgac aacccagggc tgcctgaaaa tggataccaa atcctgtaca agcgactcta
     2881 cctgccagga gagtccctca ccttcatgtg ctacgaaggc tttgagctca tgggtgaagt
     2941 gaccatccgc tgcatcctgg gacagccatc ccactggaac gggcccctgc ccgtgtgtaa
     3001 agttaatcaa gacagttttg aacatgcttt agaagtagca gaagcggcag cagagacgtc
     3061 gctggaaggg gggaacatgg ccctggctat cttcatcccg gtcctcatca tctccttact
     3121 gctgggagga gcctacattt acatcacaag atgtcgctac tattccaacc tccgcctgcc
     3181 tctgatgtac tcccacccct acagccagat caccgtggaa accgagtttg acaaccccat
     3241 ttacgagaca ggggaaacca gagagtatga ggtttctatc taaagagagc tacacttgag
     3301 aaggggactt gtgaactcaa ccacaatctc ctcgagacat tcatccagag accatgtggc
     3361 acttgattga aaccccagaa tgtcgactgt cttttgttta gactctttat caaaggttta
     3421 ctgttttctt ccctgtattt attatattta aaagtgaaat aggtgtgggt ttggatgttt
     3481 cgcggcctca gccaaattca tgttacagcc tcaattctga aggcaggtgg aagacttgca
     3541 aaatggcaaa ccgcggcagc aaaaacacaa aacagcagat ggagtttctc ccatcagcaa
     3601 tgccatgcta aggctgcatt gaattgcatg catctttggg aaccatgccc atgatgtttt
     3661 cagtacaaat ctaagtccca agattaggtt ggaaagggta tttcttgttg gcttagtttg
     3721 ggttggaatt tagcatgggt acttaaaccc atttggagag ctgtgctcct aaacaaattc
     3781 tgtgtcctct cttcccattt tgccagcttc tgaaaggttt ttccacagcc cctccctctc
     3841 acggttcttc tgaaggtagc aaaggtgtta tataaacatt gtcttttacc actctggcct
     3901 cgctggacag tgacaaaaca agaaaacgtt ttctttctag aaaggtgata aacgaccaaa
     3961 ggcaattttt cagagacaaa tgagagattt gagagttcca atgaagaatt gggtgagggg
     4021 gatcattggg taagggaatt gggttaaaat gttcttttct ttgacactct ttcaatgatg
     4081 aaagagcgtg taatttatgc tacaagtgcc agaatcgatc accatgttca gcaagccact
     4141 ctcaagctgt ggtaataaac acacaggctt gggaggcacc agcggcccca ctcatacagt
     4201 gacaaggatt tgtgatggga aaaaggaggt gccatgtttg gaaatgcagg ggtgagctct
     4261 ggtttctcct ggggttctgg aatatctcag ccctcaaaat agaggagact caagtgcact
     4321 gattctctaa aaggtgtcat cttcagaata tacttgccat caagtatttc agggggcggg
     4381 agggtcccat gagaagaaac tatttttcta ttctccaaag ctgtctggat gttggagggt
     4441 ggtgtgaatg ctgactgagg aggtgcagag aacaggggca ggggatttta aatcacagca
     4501 gaccatccag tggaatcctg tatcatctga tctgaacatc aatgaagaca gagagaggaa
     4561 tttcattcag aaaggattcc atagccccac atctagtcac acgggcattc ctcttatttt
     4621 atcagggtct gttttccccc aacccagtga aaccggtgag tgtgtaactc ttgggaagat
     4681 tcttttctaa atacaggtat aaagagaagg tggagggtgc gggtgcatgg aagaaatact
     4741 atgtgtgaag cagattcacc ttcctgggac cggtgacatg gtggtgacag tcaatggctt
     4801 ggacagacag acgggcacag tggcatttgg aaccctcttt ggtgccctcc cattctctct
     4861 ggaattgttt caagtctgct ggttttcaaa caagaaaaga cctttctggc catagggaga
     4921 atagcaggga gtctatgttt tggtggttac attggaaaca tcttaagcaa gatagggaaa
     4981 gttgatttta ggcacacatg taccctcctt gacagcagga actcagactt caatcttggg
     5041 ggtctaagac cagaatattt tccttctgcc agaaaagaat cttgcacata tactcctgaa
     5101 ggcatgagtg tgtggtccat ggcaagaaat agctaaaggc tgctttccag gacccaaagc
     5161 cccatttaat gcaagaacca gagaagtgtt ctaggccatt agtggacaat gtcatgtttg
     5221 gagaaagata acaacacaaa taatgtaacc tttccttaaa aggcagaact caatccattt
     5281 tatttgatgc ttattctaac cctaaccctg ggtcacctgg aatgaagaac tctatgaata
     5341 atatttgatt ttacaacgtg ttatggttat gtgaaaacta aacatttgcc ttttataaag
     5401 actgacaaaa tataaatctt tattctaacc ctatccccaa aactagccag gccacacccc
     5461 agatgttctt attgactatt ggaaagatag aaaaggcgtt gtgttttttg tttttttgtt
     5521 gttgttgtca ttgttgtttt tttcagaaga ccagtgtctc agttctgtct tagtagtacc
     5581 acacccgtaa ccgtgtttta aaagtttgtt ttagcctaga gacagatcat acgagttcaa
     5641 caatgtacag tgtgattgaa aagacaggtt ggtgtctatt tttcttttta aaatatctga
     5701 atgtgtattt gtaatacgta aaggtaaaaa aaaatagtgc caaaaatgtg caaggcatct
     5761 cattacagct catgtacgtc tgtttttata agatcaatat taaaacccat tgggattaaa
     5821 tatttttgaa taggatacac tcttgagaaa ctcgagaatg gactgagcct tcctacaagc
     5881 cactctttgt ttttaaaaca gtggggaaat acgtttacag agattgtgag cttcagagaa
     5941 tgcatgtgat ggtgtgtatt acatgctaat tcatataagc tgtatctgtc agctaccacc
     6001 ctgtgcttta aaaatgcaca cactcaaccc tctttagctt ggagctcagc tttttgcttt
     6061 tttttttttt tttttgtaga attatttagc taacataagt attctgattg ctacctgatg
     6121 gccattctta cttagtttca tagatgtgct ttaactatga tcctttgaag ctcacccctt
     6181 ggagagccta cagaacctca ggctgatagc tttgaagact gccaaacagc ccagaaggaa
     6241 gcaaagcatc tgcataatca ggagggttgt ataacaagta gtgatttggc aaatatgtgg
     6301 gtagctttag gctgaggcac gggcctcagg caaaaatgcc cttcgagtga atccgaaggg
     6361 catgatcttc ctatgtcctt gactaggcat gacgagtcat ttgaggtcag atattatttg
     6421 agttgttcag cacccccaaa ggtaggcatt ctcctgggaa attttcattt ccattttatc
     6481 gccaaacaaa ataaaaagca aaacaaactt tctaagctag aataatgaaa ttaagtcatt
     6541 ttccactttg tatatattga tgctaataaa acagatgaaa aaga
//
