LOCUS       NM_001320727            3714 bp    mRNA    linear   PRI 17-APR-2022
DEFINITION  Homo sapiens SETDB2-PHF11 readthrough (SETDB2-PHF11), transcript
            variant 1, mRNA.
ACCESSION   NM_001320727
VERSION     NM_001320727.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3714)
  AUTHORS   Zhang Y, Leaves NI, Anderson GG, Ponting CP, Broxholme J, Holt R,
            Edser P, Bhattacharyya S, Dunham A, Adcock IM, Pulleyn L, Barnes
            PJ, Harper JI, Abecasis G, Cardon L, White M, Burton J, Matthews L,
            Mott R, Ross M, Cox R, Moffatt MF and Cookson WO.
  TITLE     Positional cloning of a quantitative trait locus on chromosome
            13q14 that influences immunoglobulin E levels and asthma
  JOURNAL   Nat. Genet. 34 (2), 181-186 (2003)
   PUBMED   12754510
  REMARK    GeneRIF: detects readthrough transcripts by PCR
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL136218.26 and AL139321.28.
            
            On Jun 2, 2019 this sequence version replaced NM_001320727.1.
            
            Summary: This gene represents naturally-occurring readthrough
            transcription between the upstream SETDB2 (SET domain bifurcated 2)
            gene to the downstream PHF11 (PHD finger protein 11) gene.
            Readthrough transcripts may encode fusion proteins with similarity
            to proteins encoded by each of the individual genes or may encode
            candidates for nonsense-mediated decay (NMD). [provided by RefSeq,
            Mar 2016].
            
            Transcript Variant: This variant (1) encodes a putative protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            RNAseq introns :: partial sample support SAMEA1965299, SAMEA1966682
                              [ECO:0000350]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            readthrough transcript    :: includes exons from GeneID 51131,
                                         83852
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-584               AL136218.26        115393-115976
            585-941             AL136218.26        122672-123028
            942-1067            AL136218.26        131226-131351
            1068-1133           AL136218.26        132216-132281
            1134-1230           AL136218.26        138983-139079
            1231-1794           AL136218.26        147595-148158
            1795-1911           AL136218.26        151338-151454
            1912-2081           AL136218.26        152066-152235
            2082-2307           AL136218.26        153856-154081
            2308-2407           AL136218.26        154583-154682
            2408-2501           AL136218.26        156749-156842
            2502-2623           AL139321.28        17991-18112
            2624-2731           AL139321.28        24415-24522
            2732-2865           AL139321.28        29374-29507
            2866-2912           AL139321.28        32250-32296
            2913-2977           AL139321.28        33399-33463
            2978-3044           AL139321.28        34531-34597
            3045-3176           AL139321.28        35441-35572
            3177-3248           AL139321.28        37743-37814
            3249-3714           AL139321.28        39867-40332
FEATURES             Location/Qualifiers
     source          1..3714
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.2"
     gene            1..3714
                     /gene="SETDB2-PHF11"
                     /note="SETDB2-PHF11 readthrough"
                     /db_xref="GeneID:107303344"
     exon            1..584
                     /gene="SETDB2-PHF11"
                     /inference="alignment:Splign:2.1.0"
     exon            585..941
                     /gene="SETDB2-PHF11"
                     /inference="alignment:Splign:2.1.0"
     CDS             926..3403
                     /gene="SETDB2-PHF11"
                     /codon_start=1
                     /product="SETDB2-PHF11 protein"
                     /protein_id="NP_001307656.1"
                     /db_xref="GeneID:107303344"
                     /translation="MGEKNGDAKTFWMELEDDGKVDFIFEQVQNVLQSLKQKIKDGSA
                     TNKEYIQAMILVNEATIINSSTSIKDPMPVTQKEQENKSNAFPSTSCENSFPEDCTFL
                     TTENKEILSLEDKVVDFREKDSSSNLSYQSHDCSGACLMKMPLNLKGENPLQLPIKCH
                     FQRRHAKTNSHSSALHVSYKTPCGRSLRNVEEVFRYLLETECNFLFTDNFSFNTYVQL
                     ARNYPKQKEVVSDVDISNGVESVPISFCNEIDSRKLPQFKYRKTVWPRAYNLTNFSSM
                     FTDSCDCSEGCIDITKCACLQLTARNAKTSPLSSDKITTGYKYKRLQRQIPTGIYECS
                     LLCKCNRQLCQNRVVQHGPQVRLQVFKTEQKGWGVRCLDDIDRGTFVCIYSGRLLSRA
                     NTEKSYGIDENGRDENTMKNIFSKKRKLEVACSDCEVEVLPLGLETHPRTAKTEKCPP
                     KFSNNPKELTVETKYDNISRIQYHSVIRDPESKTAIFQHNGKKMEFVSSESVTPEDND
                     GFKPPREHLNSKTKGAQSVFQVAEKMEKRTCALCPKDVEYNVLYFAQSENIAAHENCL
                     LYSSGLVECEDQDPLNPDRSFDVESVKKEIQRGRKLKCKFCHKRGATVGCDLKNCNKN
                     YHFFCAKKDDAVPQSDGVRGIYKLLCQQHAQFPIIAQSAKFSGVKRKRGRKKPLSGNH
                     VQPPETMKCNTFIRQVKEEHGRHTDATVKVPFLKKCKEAGLLNYLLEEILDKVHSIPE
                     KLMDETTSESDYEEIGSALFDCRLFEDTFVNFQAAIEKKIHASQQRWQQLKEEIELLQ
                     DLKQTLCSFQENRDLMSSSTSISSLSY"
     exon            942..1067
                     /gene="SETDB2-PHF11"
                     /inference="alignment:Splign:2.1.0"
     exon            1068..1133
                     /gene="SETDB2-PHF11"
                     /inference="alignment:Splign:2.1.0"
     exon            1134..1230
                     /gene="SETDB2-PHF11"
                     /inference="alignment:Splign:2.1.0"
     exon            1231..1794
                     /gene="SETDB2-PHF11"
                     /inference="alignment:Splign:2.1.0"
     exon            1795..1911
                     /gene="SETDB2-PHF11"
                     /inference="alignment:Splign:2.1.0"
     exon            1912..2081
                     /gene="SETDB2-PHF11"
                     /inference="alignment:Splign:2.1.0"
     exon            2082..2307
                     /gene="SETDB2-PHF11"
                     /inference="alignment:Splign:2.1.0"
     exon            2308..2407
                     /gene="SETDB2-PHF11"
                     /inference="alignment:Splign:2.1.0"
     exon            2408..2501
                     /gene="SETDB2-PHF11"
                     /inference="alignment:Splign:2.1.0"
     exon            2502..2623
                     /gene="SETDB2-PHF11"
                     /inference="alignment:Splign:2.1.0"
     exon            2624..2731
                     /gene="SETDB2-PHF11"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..2865
                     /gene="SETDB2-PHF11"
                     /inference="alignment:Splign:2.1.0"
     exon            2866..2912
                     /gene="SETDB2-PHF11"
                     /inference="alignment:Splign:2.1.0"
     exon            2913..2977
                     /gene="SETDB2-PHF11"
                     /inference="alignment:Splign:2.1.0"
     exon            2978..3044
                     /gene="SETDB2-PHF11"
                     /inference="alignment:Splign:2.1.0"
     exon            3045..3176
                     /gene="SETDB2-PHF11"
                     /inference="alignment:Splign:2.1.0"
     exon            3177..3248
                     /gene="SETDB2-PHF11"
                     /inference="alignment:Splign:2.1.0"
     exon            3249..3714
                     /gene="SETDB2-PHF11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3695..3700
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SETDB2-PHF11"
                     /note="hexamer: AATAAA"
     polyA_site      3714
                     /gene="SETDB2-PHF11"
                     /note="major polyA site"
ORIGIN      
        1 ggaggttacg ccttccctca tccccggtag aggcagggcg ggactgttgt ggttgagatg
       61 aaggctagta aatggtgaag tacttcccgg ccagagggca cctgcgctcg ggaggtttgg
      121 gcggcttggc gtcggaggag agccccaccc gcggaggaac ccagccttgc caacggagct
      181 ggcggagctc actcctcagg tcaggcgggc ggcgtagaaa acgcagcgga gccaggtgaa
      241 accaaggcac cgccgtggct ggcccccgac agttcctcta gccgggaggt tggaggagct
      301 gaaaacgccg cggagccctc ggccgcccga gcaggggctg gaccccagcc cttgcagcct
      361 cccttctcct ggcacccaag tgcagtcctg gctgcagaag gggccgcggg cgcactgagt
      421 ttccaacctc catttcagcc tgtctgtctc agggtgcagc cttaatgaga ggtgattcct
      481 aagctgctgg gaacctgagg ttgtcaaagg ggcggcagga aatggacagc agtataaaac
      541 ccagaagcag aacttgaagg ttaaaccact agcccatttc acagaatgtt tcatccattt
      601 gtggaccaaa agatggagtt ggtttttatt tttaaaaaga taatgttaat gatctgatac
      661 cactacaaat atttacgtga gaagattcat ggacttgtct tttggttgga ctgtcactca
      721 tttctgaaag tttcttcagc cacaatttct atttgaaaat tcaagtatca aaggatacca
      781 ggtttagaat ggtataatga tgtattttgt ctgaggactg caaattttat agagaccaca
      841 gttggattcc agtgatattc tgcaatcaaa gtgatttgat aaacctaatt ttgaagcatt
      901 ttatatttat aagcgacatc aaaagatggg agaaaaaaat ggcgatgcaa aaactttctg
      961 gatggagcta gaagatgatg gaaaagtgga cttcattttt gaacaagtac aaaatgtgct
     1021 gcagtcactg aaacaaaaga tcaaagatgg gtctgccacc aataaagaat acatccaagc
     1081 aatgattcta gtgaatgaag caactataat taacagttca acatcaataa aggatcctat
     1141 gcctgtgact cagaaggaac aggaaaacaa atccaatgca tttccctcta catcatgtga
     1201 aaactccttt ccagaagact gtacatttct aacaacagaa aataaggaaa ttctctctct
     1261 tgaagataaa gttgtagact ttagagaaaa agactcatct tcgaatttat cttaccaaag
     1321 tcatgactgc tctggtgctt gtctgatgaa aatgccactg aacttgaagg gagaaaaccc
     1381 tctgcagctg ccaatcaaat gtcacttcca aagacgacat gcaaagacaa actctcattc
     1441 ttcagcactc cacgtgagtt ataaaacccc ttgtggaagg agtctacgaa acgtggagga
     1501 agtttttcgt tacctgcttg agacagagtg taacttttta tttacagata acttttcttt
     1561 caatacctat gttcagttgg ctcggaatta cccaaagcaa aaagaagttg tttctgatgt
     1621 ggatattagc aatggagtgg aatcagtgcc catttctttc tgtaatgaaa ttgacagtag
     1681 aaagctccca cagtttaagt acagaaagac tgtgtggcct cgagcatata atctaaccaa
     1741 cttttccagc atgtttactg attcctgtga ctgctctgag ggctgcatag acataacaaa
     1801 atgtgcatgt cttcaactga cagcaaggaa tgccaaaact tcccccttgt caagtgacaa
     1861 aataaccact ggatataaat ataaaagact acagagacag attcctactg gcatttatga
     1921 atgcagcctt ttgtgcaaat gtaatcgaca attgtgtcaa aaccgagttg tccaacatgg
     1981 tcctcaagtg aggttacagg tgttcaaaac tgagcagaag ggatggggtg tacgctgtct
     2041 agatgacatt gacagaggga catttgtttg catttattca ggaagattac taagcagagc
     2101 taacactgaa aaatcttatg gtattgatga aaacgggaga gatgagaata ctatgaaaaa
     2161 tatattttca aaaaagagga aattagaagt tgcatgttca gattgtgaag ttgaagttct
     2221 cccattagga ttggaaacac atcctagaac tgctaaaact gagaaatgtc caccaaagtt
     2281 cagtaataat cccaaggagc ttactgtgga aacgaaatat gataatattt caagaattca
     2341 atatcattca gttattagag atcctgaatc caagacagcc atttttcaac acaatgggaa
     2401 aaaaatggaa tttgtttcct cggagtctgt cactccagaa gataatgatg gatttaaacc
     2461 accccgagag catctgaact ctaaaaccaa gggagcacaa agtgtctttc aggttgcaga
     2521 aaagatggaa aaaaggacat gtgcactctg ccccaaagat gtcgaatata atgtcctata
     2581 ctttgcacaa tcagagaata tagctgctca tgagaattgt ttgctgtatt cttcaggact
     2641 tgtggaatgt gaggatcagg atccacttaa tcctgataga agttttgatg tggaatcagt
     2701 aaagaaagaa atccagagag gaaggaagtt gaaatgcaaa ttttgtcata aaagaggagc
     2761 caccgtggga tgtgatttaa aaaactgtaa caagaattac cactttttct gtgccaagaa
     2821 ggacgacgca gttccacagt ctgatggagt tcgaggaatt tataaactgc tttgccagca
     2881 acatgctcaa ttcccgatca tcgctcaaag tgctaaattt tcaggagtga aaagaaaaag
     2941 aggaaggaag aaacccctct caggcaatca tgtacagcca cccgaaacaa tgaaatgtaa
     3001 tacattcata agacaagtga aagaagagca tggcagacac acagatgcaa ctgtgaaagt
     3061 tccttttctt aagaaatgca aggaagcagg acttcttaat tacttacttg aagaaatatt
     3121 agacaaagtt cattcaattc cagaaaaact catggatgag actacttcag aatcagacta
     3181 tgaagaaatc gggagtgcac tttttgactg tagattgttc gaagacacat ttgtaaattt
     3241 tcaagcagca atagagaaaa aaattcatgc atctcaacaa aggtggcagc agttgaagga
     3301 agagattgag ctacttcagg acttaaaaca aaccttgtgc tcttttcaag aaaatagaga
     3361 tcttatgtca agttctacat caatatcatc cctgtcttat tagggattac cgtttcctaa
     3421 gccaagagtc atgtcaaatt gcaatcaggc tcaaaaccag agaccaggct gtgaaatcca
     3481 cacatcttta gaactagtcg tctcctcttg gcctcagcag ctcttccctg ttcttactgg
     3541 ttgacatttt gatcactctt tgcacactct tgtgtttttt gctcactgtc acattcccag
     3601 cacctagtat gctcagtaaa tgtttgtgga ataagtgcat aaaatgttct taacctttga
     3661 ttctacttac agcccatgat agcctcttag atataataaa tttggattat acta
//
