LOCUS       NM_001366418            4418 bp    mRNA    linear   PRI 18-NOV-2024
DEFINITION  Homo sapiens SET domain bifurcated histone lysine methyltransferase
            1 (SETDB1), transcript variant 5, mRNA.
ACCESSION   NM_001366418 XM_005245641
VERSION     NM_001366418.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4418)
  AUTHORS   Xia,K., Hui,Y., Zhang,L., Qiu,Q., Zhong,J., Chen,H., Liu,X.,
            Wang,L. and Chen,Z.
  TITLE     SETDB1 targeting SESN2 regulates mitochondrial damage and oxidative
            stress in renal ischemia-reperfusion injury
  JOURNAL   BMC Biol 22 (1), 246 (2024)
   PUBMED   39443993
  REMARK    GeneRIF: SETDB1 targeting SESN2 regulates mitochondrial damage and
            oxidative stress in renal ischemia-reperfusion injury.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 4418)
  AUTHORS   Chang,Y.H., Yamamoto,K., Fujino,T., Wang,T.W., Sugimoto,E.,
            Zhang,W., Yabushita,T., Suzaki,K., Pietsch,E.C., Weir,B.A.,
            Crescenzo,R., Cowley,G.S., Attar,R., Philippar,U., Wunderlich,M.,
            Mizukawa,B., Zheng,Y., Enomoto,Y., Imai,Y., Kitamura,T. and
            Goyama,S.
  TITLE     SETDB1 suppresses NK cell-mediated immunosurveillance in acute
            myeloid leukemia with granulo-monocytic differentiation
  JOURNAL   Cell Rep 43 (8), 114536 (2024)
   PUBMED   39096901
REFERENCE   3  (bases 1 to 4418)
  AUTHORS   Kang,Y.K., Eom,J., Min,B. and Park,J.S.
  TITLE     SETDB1 deletion causes DNA demethylation and upregulation of
            multiple zinc-finger genes
  JOURNAL   Mol Biol Rep 51 (1), 778 (2024)
   PUBMED   38904842
  REMARK    GeneRIF: SETDB1 deletion causes DNA demethylation and upregulation
            of multiple zinc-finger genes.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4418)
  AUTHORS   Yang,W., Wei,Y., Wang,T., Xu,Y., Jin,X., Qian,H., Yang,S. and He,S.
  TITLE     Cytoplasmic localization of SETDB1-induced Warburg effect via
            c-MYC-LDHA axis enhances migration and invasion in breast carcinoma
  JOURNAL   Int J Mol Med 53 (4) (2024)
   PUBMED   38426579
  REMARK    GeneRIF: Cytoplasmic localization of SETDB1-induced Warburg effect
            via c-MYC-LDHA axis enhances migration and invasion in breast
            carcinoma.
REFERENCE   5  (bases 1 to 4418)
  AUTHORS   Hao,Y., Bai,X.Y., Huo,F. and Chen,X.B.
  TITLE     [Downregulation of SETDB1 suppresses epithelial mesenchymal
            transition and invasion and metastasis in oral cancer via SOX7
            methylation]
  JOURNAL   Shanghai Kou Qiang Yi Xue 33 (1), 30-35 (2024)
   PUBMED   38583021
  REMARK    GeneRIF: [Downregulation of SETDB1 suppresses epithelial
            mesenchymal transition and invasion and metastasis in oral cancer
            via SOX7 methylation].
REFERENCE   6  (bases 1 to 4418)
  AUTHORS   Ayyanathan,K., Lechner,M.S., Bell,P., Maul,G.G., Schultz,D.C.,
            Yamada,Y., Tanaka,K., Torigoe,K. and Rauscher,F.J. 3rd.
  TITLE     Regulated recruitment of HP1 to a euchromatic gene induces
            mitotically heritable, epigenetic gene silencing: a mammalian cell
            culture model of gene variegation
  JOURNAL   Genes Dev 17 (15), 1855-1869 (2003)
   PUBMED   12869583
REFERENCE   7  (bases 1 to 4418)
  AUTHORS   Yang,L., Mei,Q., Zielinska-Kwiatkowska,A., Matsui,Y.,
            Blackburn,M.L., Benedetti,D., Krumm,A.A., Taborsky,G.J. Jr. and
            Chansky,H.A.
  TITLE     An ERG (ets-related gene)-associated histone methyltransferase
            interacts with histone deacetylases 1/2 and transcription
            co-repressors mSin3A/B
  JOURNAL   Biochem J 369 (Pt 3), 651-657 (2003)
   PUBMED   12398767
REFERENCE   8  (bases 1 to 4418)
  AUTHORS   Schultz,D.C., Ayyanathan,K., Negorev,D., Maul,G.G. and
            Rauscher,F.J. 3rd.
  TITLE     SETDB1: a novel KAP-1-associated histone H3, lysine 9-specific
            methyltransferase that contributes to HP1-mediated silencing of
            euchromatic genes by KRAB zinc-finger proteins
  JOURNAL   Genes Dev 16 (8), 919-932 (2002)
   PUBMED   11959841
  REMARK    GeneRIF: Contributes to HP1-mediated silencing of euchromatic genes
            by KRAB zinc-finger proteins; KAP-1, SETDB1, H3-MeK9, and HP1 are
            enriched at promoter sequences of a euchromatic gene silenced by
            the KRAB-KAP-1 repression system
REFERENCE   9  (bases 1 to 4418)
  AUTHORS   Yang,L., Xia,L., Wu,D.Y., Wang,H., Chansky,H.A., Schubach,W.H.,
            Hickstein,D.D. and Zhang,Y.
  TITLE     Molecular cloning of ESET, a novel histone H3-specific
            methyltransferase that interacts with ERG transcription factor
  JOURNAL   Oncogene 21 (1), 148-152 (2002)
   PUBMED   11791185
REFERENCE   10 (bases 1 to 4418)
  AUTHORS   Harte,P.J., Wu,W., Carrasquillo,M.M. and Matera,A.G.
  TITLE     Assignment of a novel bifurcated SET domain gene, SETDB1, to human
            chromosome band 1q21 by in situ hybridization and radiation hybrids
  JOURNAL   Cytogenet Cell Genet 84 (1-2), 83-86 (1999)
   PUBMED   10343109
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL590133.32.
            
            On Oct 4, 2018 this sequence version replaced XM_005245641.4.
            
            Summary: This gene encodes a histone methyltransferase which
            regulates histone methylation, gene silencing, and transcriptional
            repression. This gene has been identified as a target for treatment
            in Huntington Disease, given that gene silencing and transcription
            dysfunction likely play a role in the disease pathogenesis.
            Alternatively spliced transcript variants of this gene have been
            described.[provided by RefSeq, Jun 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038197.719197.1,
                                           SRR1660805.205466.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000692827.1/ ENSP00000509425.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-155               AL590133.32        12556-12710
            156-426             AL590133.32        13897-14167
            427-578             AL590133.32        16160-16311
            579-613             AL590133.32        26133-26167
            614-713             AL590133.32        27522-27621
            714-839             AL590133.32        28756-28881
            840-1041            AL590133.32        29045-29246
            1042-1115           AL590133.32        30113-30186
            1116-1306           AL590133.32        31111-31301
            1307-1433           AL590133.32        33079-33205
            1434-1590           AL590133.32        35315-35471
            1591-1749           AL590133.32        35560-35718
            1750-2382           AL590133.32        36651-37283
            2383-2499           AL590133.32        37558-37674
            2500-2669           AL590133.32        45371-45540
            2670-3298           AL590133.32        46756-47384
            3299-3327           AL590133.32        48323-48351
            3328-3460           AL590133.32        48780-48912
            3461-3626           AL590133.32        49167-49332
            3627-3838           AL590133.32        49723-49934
            3839-3927           AL590133.32        50188-50276
            3928-4418           AL590133.32        50440-50930
FEATURES             Location/Qualifiers
     source          1..4418
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q21.3"
     gene            1..4418
                     /gene="SETDB1"
                     /gene_synonym="ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21"
                     /note="SET domain bifurcated histone lysine
                     methyltransferase 1"
                     /db_xref="GeneID:9869"
                     /db_xref="HGNC:HGNC:10761"
                     /db_xref="MIM:604396"
     exon            1..155
                     /gene="SETDB1"
                     /gene_synonym="ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21"
                     /inference="alignment:Splign:2.1.0"
     exon            156..426
                     /gene="SETDB1"
                     /gene_synonym="ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21"
                     /inference="alignment:Splign:2.1.0"
     CDS             167..4045
                     /gene="SETDB1"
                     /gene_synonym="ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21"
                     /EC_number="2.1.1.366"
                     /note="isoform 4 is encoded by transcript variant 5;
                     ERG-associated protein with a SET domain, ESET;
                     histone-lysine N-methyltransferase, H3lysine-9 specific 4;
                     lysine N-methyltransferase 1E; histone-lysine
                     N-methyltransferase SETDB1; histone H3-K9
                     methyltransferase 4; tudor domain containing 21; SET
                     domain bifurcated 1"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase SETDB1
                     isoform 4"
                     /protein_id="NP_001353347.1"
                     /db_xref="CCDS:CCDS91050.1"
                     /db_xref="GeneID:9869"
                     /db_xref="HGNC:HGNC:10761"
                     /db_xref="MIM:604396"
                     /translation="MSSLPGCIGLDAATATVESEEIAELQQAVVEELGISMEELRHFI
                     DEELEKMDCVQQRKKQLAELETWVIQKESEVAHVDQLFDDASRAVTNCESLVKDFYSK
                     LGLQYRDSSSEDESSRPTEIIEIPDEDDDVLSIDSGDAGSRTPKDQKLREAMAALRKS
                     AQDVQKFMDAVNKKSSSQDLHKGTLSQMSGELSKDGDLIVSMRILGKKRTKTWHKGTL
                     IAIQTVGPGKKYKVKFDNKGKSLLSGNHIAYDYHPPADKLYVGSRVVAKYKDGNQVWL
                     YAGIVAETPNVKNKLRFLIFFDDGYASYVTQSELYPICRPLKKTWEDIEDISCRDFIE
                     EYVTAYPNRPMVLLKSGQLIKTEWEGTWWKSRVEEVDGSLVRILFLDDKRCEWIYRGS
                     TRLEPMFSMKTSSASALEKKQGQLRTRPNMGAVRSKGPVVQYTQDLTGTGTQFKPVEP
                     PQPTAPPAPPFPPAPPLSPQAGDSESLESQLAQSRKQVAKKSTSFRPGSVGSGHSSPT
                     SPALSENVSGGKPGINQTYRSPLGSTASAPAPSALPAPPAPPVFHGMLERAPAEPSYR
                     APMEKLFYLPHVCSYTCLSRVRPMRNEQYRGKNPLLVPLLYDFRRMTARRRVNRKMGF
                     HVIYKTPCGLCLRTMQEIERYLFETGCDFLFLEMFCLDPYVLVDRKFQPYKPFYYILD
                     ITYGKEDVPLSCVNEIDTTPPPQVAYSKERIPGKGVFINTGPEFLVGCDCKDGCRDKS
                     KCACHQLTIQATACTPGGQINPNSGYQYKRLEECLPTGVYECNKRCKCDPNMCTNRLV
                     QHGLQVRLQLFKTQNKGWGIRCLDDIAKGSFVCIYAGKILTDDFADKEGLEMGDEYFA
                     NLDHIESVENFKEGYESDAPCSSDSSGVDLKDQEDGNSGTEDPEESNDDSSDDNFCKD
                     EDFSTSSVWRSYATRRQTRGQKENGLSETTSKDSHPPDLGPPHIPVPPSIPVGGCNPP
                     SSEETPKNKVASWLSCNSVSEGGFADSDSHSSFKTNEGGEGRAGGSRMEAEKASTSGL
                     GIKDEGDIKQAKKEDTDDRNKMSVVTESSRNYGYNPSPVKPEGLRRPPSKTSMHQSRR
                     LMASAQSNPDDVLTLSSSTESEGESGTSRKPTAGQTSATAVDSDDIQTISSGSEGDDF
                     EDKKNMTGPMKRQVAVKSTRGFALKSTHGIAIKSTNMASVDKGESAPVRKNTRQFYDG
                     EESCYIIDAKLEGNLGRYLNHSCSPNLFVQNVFVDTHDLRFPWVAFFASKRIRAGTEL
                     TWDYNYEVGSVEGKELLCCCGAIECRGRLL"
     exon            427..578
                     /gene="SETDB1"
                     /gene_synonym="ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21"
                     /inference="alignment:Splign:2.1.0"
     exon            579..613
                     /gene="SETDB1"
                     /gene_synonym="ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21"
                     /inference="alignment:Splign:2.1.0"
     exon            614..713
                     /gene="SETDB1"
                     /gene_synonym="ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21"
                     /inference="alignment:Splign:2.1.0"
     exon            714..839
                     /gene="SETDB1"
                     /gene_synonym="ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21"
                     /inference="alignment:Splign:2.1.0"
     exon            840..1041
                     /gene="SETDB1"
                     /gene_synonym="ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21"
                     /inference="alignment:Splign:2.1.0"
     exon            1042..1115
                     /gene="SETDB1"
                     /gene_synonym="ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21"
                     /inference="alignment:Splign:2.1.0"
     exon            1116..1306
                     /gene="SETDB1"
                     /gene_synonym="ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21"
                     /inference="alignment:Splign:2.1.0"
     exon            1307..1433
                     /gene="SETDB1"
                     /gene_synonym="ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21"
                     /inference="alignment:Splign:2.1.0"
     exon            1434..1590
                     /gene="SETDB1"
                     /gene_synonym="ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21"
                     /inference="alignment:Splign:2.1.0"
     exon            1591..1749
                     /gene="SETDB1"
                     /gene_synonym="ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21"
                     /inference="alignment:Splign:2.1.0"
     exon            1750..2382
                     /gene="SETDB1"
                     /gene_synonym="ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21"
                     /inference="alignment:Splign:2.1.0"
     exon            2383..2499
                     /gene="SETDB1"
                     /gene_synonym="ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21"
                     /inference="alignment:Splign:2.1.0"
     exon            2500..2669
                     /gene="SETDB1"
                     /gene_synonym="ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21"
                     /inference="alignment:Splign:2.1.0"
     exon            2670..3298
                     /gene="SETDB1"
                     /gene_synonym="ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21"
                     /inference="alignment:Splign:2.1.0"
     exon            3299..3327
                     /gene="SETDB1"
                     /gene_synonym="ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21"
                     /inference="alignment:Splign:2.1.0"
     exon            3328..3460
                     /gene="SETDB1"
                     /gene_synonym="ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21"
                     /inference="alignment:Splign:2.1.0"
     exon            3461..3626
                     /gene="SETDB1"
                     /gene_synonym="ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21"
                     /inference="alignment:Splign:2.1.0"
     exon            3627..3838
                     /gene="SETDB1"
                     /gene_synonym="ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21"
                     /inference="alignment:Splign:2.1.0"
     exon            3839..3927
                     /gene="SETDB1"
                     /gene_synonym="ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21"
                     /inference="alignment:Splign:2.1.0"
     exon            3928..4418
                     /gene="SETDB1"
                     /gene_synonym="ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4408..4413
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SETDB1"
                     /gene_synonym="ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21"
                     /note="hexamer: GATAAA"
     polyA_site      4418
                     /gene="SETDB1"
                     /gene_synonym="ESET; H3-K9-HMTase4; KG1T; KMT1E; TDRD21"
                     /note="major polyA site"
ORIGIN      
        1 gtttcttttg cttccccttc cctctttcac gcttcctccc ctccccctcc tcccttatcc
       61 cttcgctttc gctcttttcc gtcgaggccg acccctgagt tgtgagtctg gggtctggtt
      121 ggtgaaaaag agcccttgaa gctggaagac gggagaggac aaaagcatgt cttcccttcc
      181 tgggtgcatt ggtttggatg cagcaacagc tacagtggag tctgaagaga ttgcagagct
      241 gcaacaggca gtggttgagg aactgggtat ctctatggag gaacttcggc atttcatcga
      301 tgaggaactg gagaagatgg attgtgtaca gcaacgcaag aagcagctag cagagttaga
      361 gacatgggta atacagaaag aatctgaggt ggctcacgtt gaccaactct ttgatgatgc
      421 atccagggca gtgactaatt gtgagtcttt ggtgaaggac ttctactcca agctgggact
      481 acaataccgg gacagtagct ctgaggacga atcttcccgg cctacagaaa taattgagat
      541 tcctgatgaa gatgatgatg tcctcagtat tgattcaggt gatgctggga gcagaactcc
      601 aaaagaccag aagctccgtg aagctatggc tgccttaaga aagtcagctc aagatgttca
      661 gaagttcatg gatgctgtca acaagaagag cagttcccag gatctgcata aaggaacctt
      721 gagtcagatg tctggagaac taagcaaaga tggtgacctg atagtcagca tgcgaattct
      781 gggcaagaag agaactaaga cttggcacaa aggcaccctt attgccatcc agacagttgg
      841 gccagggaag aaatacaagg tgaaatttga caacaaagga aagagtctac tgtcggggaa
      901 ccatattgcc tatgattacc accctcctgc tgacaagctg tatgtgggca gtcgggtggt
      961 cgccaaatac aaagatggga atcaggtctg gctctatgct ggcattgtag ctgagacacc
     1021 aaacgtcaaa aacaagctca ggtttctcat tttctttgat gatggctatg cttcctatgt
     1081 cacacagtcg gaactgtatc ccatttgccg gccactgaaa aagacttggg aggacataga
     1141 agacatctcc tgccgtgact tcatagagga gtatgtcact gcctacccca accgccccat
     1201 ggtactgctc aagagtggcc agcttatcaa gactgagtgg gaaggcacgt ggtggaagtc
     1261 ccgagttgag gaggtggatg gcagcctagt caggatcctc ttcctggatg acaaaagatg
     1321 tgagtggatc tatcgaggct ctacacggct ggagcccatg ttcagcatga aaacatcctc
     1381 agcctctgca ctggagaaga agcaaggaca gctcaggaca cgtccaaata tgggtgctgt
     1441 gaggagcaaa ggccctgttg tccagtacac acaggatctg accggtactg gaacccagtt
     1501 caagccagtg gaacccccac agcctacagc tccacctgcc ccacctttcc cacctgctcc
     1561 acctctatcc ccccaagcag gtgacagtga aagcttggaa agccagcttg cccagtcacg
     1621 gaagcaggta gccaaaaaga gcacgtcctt tcgaccagga tctgtgggct ctggtcattc
     1681 ctcccctaca tctcctgcac tcagtgaaaa tgtctctggt gggaaacctg ggatcaacca
     1741 gacatataga tcacctttag gctccacagc ctctgcccca gcaccctcag cactcccggc
     1801 ccctccagca cccccagtct tccatggcat gctggagcgg gccccagcag agccctccta
     1861 ccgtgctccc atggagaagc ttttctactt acctcatgtc tgcagctata cctgtctgtc
     1921 tcgagtcaga cctatgagga atgagcagta ccggggcaag aaccctctgc tggtcccgtt
     1981 actatatgac ttccggcgga tgacagcccg gcgtcgagtt aaccgcaaga tgggctttca
     2041 tgttatctat aagacacctt gtggtctctg ccttcggaca atgcaggaga tagaacgcta
     2101 ccttttcgag actggctgtg acttcctctt cctggagatg ttctgtttgg atccatatgt
     2161 tcttgtggac cgaaagtttc agccctataa gcctttttac tatattttgg acatcactta
     2221 tgggaaggaa gatgttcccc tatcctgtgt caatgagatt gacacaaccc ctccacccca
     2281 ggtggcctac agcaaggaac gtatcccggg caagggtgtt ttcattaaca caggccctga
     2341 atttctggtt ggctgtgact gcaaggatgg gtgtcgggac aagtccaagt gtgcctgcca
     2401 tcaactaact atccaggcta cagcctgtac cccaggaggc caaatcaacc ctaactctgg
     2461 ctaccagtac aagagactag aagagtgtct acccacaggg gtatatgagt gtaacaaacg
     2521 ctgcaaatgt gacccaaaca tgtgcacaaa ccggttggtg caacatggac tacaagttcg
     2581 gctacagcta ttcaagacac agaacaaggg ctggggtatc cgctgcttgg atgacattgc
     2641 caaaggctct tttgtttgta tttatgcagg caaaatcctg acagatgact ttgcagacaa
     2701 ggagggtctg gaaatgggtg atgagtactt tgcaaatctg gaccatatcg agagcgtgga
     2761 gaacttcaaa gaaggatatg agagtgatgc cccctgttcc tctgacagca gtggtgtaga
     2821 cttgaaggac caggaagatg gcaacagcgg tacagaggac cctgaagagt ccaatgatga
     2881 tagctcagat gataacttct gtaaggatga ggacttcagc accagttcag tgtggcggag
     2941 ctatgctacc cggaggcaga cccggggcca gaaagagaac ggactctctg agacaacttc
     3001 caaggactcc caccccccag atcttggacc cccacatatt cctgttcctc cctcaatccc
     3061 tgtaggtggc tgcaatccac cttcctccga agagacaccc aagaacaagg tggcctcatg
     3121 gttgagctgc aatagtgtca gtgaaggtgg ttttgctgac tctgatagcc attcatcctt
     3181 caagactaat gaaggtgggg agggccgggc tgggggaagc cgaatggagg ctgagaaggc
     3241 ctccacctca ggactaggca tcaaggatga gggagacatc aaacaggcca agaaagagga
     3301 cactgacgac cgaaacaaga tgtcagtagt tactgaaagc tctcgaaatt acggttacaa
     3361 tccttctcct gtgaagcctg aaggacttcg ccgcccacct agtaagacta gtatgcatca
     3421 aagccgaaga ctcatggctt ctgctcagtc caaccctgat gatgtcctga cactgtccag
     3481 cagcacagaa agtgaggggg aaagtgggac cagccgaaag cccactgctg gtcagacttc
     3541 ggctacagcg gttgacagtg atgatatcca gaccatatcc tctggctctg aaggggatga
     3601 ctttgaggac aagaagaaca tgactggtcc aatgaagcgt caagtggcag taaaatcaac
     3661 ccgaggcttt gctcttaaat caacccatgg gattgcaatt aaatcaacca acatggcctc
     3721 tgtggacaag ggggagagcg cacctgttcg taagaacaca cgccaattct atgatggcga
     3781 ggagtcttgc tacatcattg atgccaagct tgaaggcaac ctgggccgct acctcaacca
     3841 cagttgcagc cccaacctgt ttgtccagaa tgtcttcgtg gatacccatg atcttcgctt
     3901 cccctgggtg gccttctttg ccagcaaaag aatccgggct gggacagaac ttacttggga
     3961 ctacaactac gaggtgggca gtgtggaagg caaggagcta ctctgttgct gtggggccat
     4021 tgaatgcaga ggacgtcttc tttagaggac agccttcttc ccaacccttc ttgaactgtc
     4081 gtttcctcag gaactgggtc ttcctgattg ttgaaccctg acccgaagtc tctgggctag
     4141 ctactccccc cagctcctag ttgatagaaa tgggggttct ggaccagatg atcccttcca
     4201 atgtggtgct agcaggcagg atcccttctc cacctccaaa ggccctaaag ggtggggaga
     4261 gatcaccact ctaacctcgg cctgacatcc ctcccatccc atatttgtcc aagtgttcct
     4321 gcttctaaca gactttgttc ttagaatgga gcctgtgtat ctactatctc cagtttgtat
     4381 tatttcttga aagtctttta acaatatgat aaaactaa
//
