LOCUS       NM_153706               1396 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens SET domain containing 9 (SETD9), transcript variant 1,
            mRNA.
ACCESSION   NM_153706
VERSION     NM_153706.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1396)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1396)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1396)
  AUTHORS   Puzone,R. and Pfeffer,U.
  TITLE     SNP variants at the MAP3K1/SETD9 locus 5q11.2 associate with
            somatic PIK3CA variants in breast cancers
  JOURNAL   Eur J Hum Genet 25 (3), 384-387 (2017)
   PUBMED   28029147
  REMARK    GeneRIF: SNP variants at the MAP3K1/SETD9 gene boundary associate
            with somatic PIK3CA variants in breast cancers.
REFERENCE   4  (bases 1 to 1396)
  AUTHORS   Petrossian,T.C. and Clarke,S.G.
  TITLE     Uncovering the human methyltransferasome
  JOURNAL   Mol Cell Proteomics 10 (1), M110.000976 (2011)
   PUBMED   20930037
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC036528.1 and AC008937.7.
            
            On May 17, 2019 this sequence version replaced NM_153706.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.371448.1, BC036528.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000285947.5/ ENSP00000285947.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-275               BC036528.1         324-598
            276-349             AC008937.7         22708-22781         c
            350-1233            BC036528.1         673-1556
            1234-1396           AC008937.7         16729-16891         c
FEATURES             Location/Qualifiers
     source          1..1396
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q11.2"
     gene            1..1396
                     /gene="SETD9"
                     /gene_synonym="C5orf35"
                     /note="SET domain containing 9"
                     /db_xref="GeneID:133383"
                     /db_xref="HGNC:HGNC:28508"
     exon            1..148
                     /gene="SETD9"
                     /gene_synonym="C5orf35"
                     /inference="alignment:Splign:2.1.0"
     CDS             51..950
                     /gene="SETD9"
                     /gene_synonym="C5orf35"
                     /note="isoform 1 is encoded by transcript variant 1; SET
                     domain-containing protein 9"
                     /codon_start=1
                     /product="SET domain-containing protein 9 isoform 1"
                     /protein_id="NP_714917.2"
                     /db_xref="CCDS:CCDS3972.1"
                     /db_xref="GeneID:133383"
                     /db_xref="HGNC:HGNC:28508"
                     /translation="MPGRLLRGLWQRWRRYKYRFVPWIALNLSHNPRTLRYVPEESKD
                     KVISDEDVLGTLLKVFQALFLNDFNKQSEILSMLPESVKSKYQDLLAVEHQGVKLLEN
                     RHQQQSTFKPEEILYKTLGFSVAQATSSLISAGKGVFVTKGLVPKGAVVSMYPGTVYQ
                     KYEPIFFQSIGNPFIFRCLDGVLIDGNDKGISKVVYRSCNGRDRLGPLKMSDSTWLTS
                     EIHNPLAVGQYVNNCSNDRAANVCYQEFDVPAVFPIELKQYLPNIAYSYDKQSPLRCV
                     VLVALRDINQGEELFSNYYTIVS"
     exon            149..516
                     /gene="SETD9"
                     /gene_synonym="C5orf35"
                     /inference="alignment:Splign:2.1.0"
     exon            517..640
                     /gene="SETD9"
                     /gene_synonym="C5orf35"
                     /inference="alignment:Splign:2.1.0"
     exon            641..756
                     /gene="SETD9"
                     /gene_synonym="C5orf35"
                     /inference="alignment:Splign:2.1.0"
     exon            757..862
                     /gene="SETD9"
                     /gene_synonym="C5orf35"
                     /inference="alignment:Splign:2.1.0"
     exon            863..1396
                     /gene="SETD9"
                     /gene_synonym="C5orf35"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1207..1212
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SETD9"
                     /gene_synonym="C5orf35"
                     /note="hexamer: ATTAAA"
     polyA_site      1233
                     /gene="SETD9"
                     /gene_synonym="C5orf35"
                     /note="major polyA site"
     regulatory      1363..1368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SETD9"
                     /gene_synonym="C5orf35"
                     /note="hexamer: AGTAAA"
     polyA_site      1396
                     /gene="SETD9"
                     /gene_synonym="C5orf35"
ORIGIN      
        1 ctcgatccgc cttccccgcg ccgtcctggt cacggccccg cggggcagcc atgcctggcc
       61 gtctgctgcg gggcctgtgg cagcgatggc gccgttacaa gtaccgcttc gttccctgga
      121 tcgcactgaa cctaagccac aacccgagga ccctccgata tgttccagag gaatccaaag
      181 acaaagttat ctcagatgaa gatgtcctag gaacattact gaaagttttc caggctctat
      241 tcttaaatga tttcaataaa caatcagaaa tcttgtctat gcttccagaa tctgttaaat
      301 caaaatatca agacctactg gcagttgaac atcaaggggt gaaactgctt gaaaacagac
      361 atcaacagca aagtaccttt aaaccagaag aaattcttta caagactttg ggtttcagtg
      421 ttgcccaagc aactagctca ttgatttctg ctggaaaagg tgtcttcgtt actaaaggat
      481 tggtaccaaa aggcgcagtc gtatctatgt atcctggtac agtatatcag aagtatgagc
      541 cgatcttttt ccagtccatt ggaaatccgt ttatttttag atgcctggat ggggtactca
      601 ttgatgggaa tgacaaaggg atatcaaaag ttgtgtacag atcttgcaat gggagggatc
      661 gactcggccc tttaaaaatg agtgatagta catggctaac gtcagaaatt cataaccctc
      721 tggctgtggg acagtatgtc aacaattgtt ccaatgacag agcagctaat gtctgttatc
      781 aggaatttga tgtgcctgca gttttcccta tagaactgaa gcagtatctt ccaaacattg
      841 cctacagcta tgacaaacaa agcccacttc gatgtgttgt tcttgtcgca cttagggaca
      901 tcaatcaagg agaagagctt ttttcaaact actacacaat tgtcagctaa ctctgtgaat
      961 cagaaattat taggttttct actcagctat taattctaag tgttttttgt taatcacttc
     1021 tctgagttct acctgtaaaa caaatatttt gagacttaat tggaatagga atttcttatg
     1081 tttttgttga tattatattt atgttccaat ttcatgataa aagctacttg cttcattaca
     1141 atttcaaatt tgtaatgcaa ttccaagttt aattggtttt cacctaaata cacaatagct
     1201 tattaaatta aaacctactc tttgaactta taatttcaat ttttcttttg tttattttgt
     1261 aagctctgtg gtggtttata aaattgtagc caggcatcag cagttcttgt agtactgctg
     1321 atgtgtacaa acttctgtaa aaactttatt tttacagaat tgagtaaaaa atacctattg
     1381 tgttgccatg agtaaa
//
