LOCUS       NM_030648               6808 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens SET domain containing 7, histone lysine
            methyltransferase (SETD7), transcript variant 1, mRNA.
ACCESSION   NM_030648
VERSION     NM_030648.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6808)
  AUTHORS   Du,Y., Jiang,X., Zhang,Y., Ying,J. and Yi,Q.
  TITLE     Epigenetic mechanism of SET7/9-mediated histone methylation
            modification in high glucose-induced ferroptosis in retinal pigment
            epithelial cells
  JOURNAL   J Bioenerg Biomembr 56 (3), 297-309 (2024)
   PUBMED   38602631
  REMARK    GeneRIF: Epigenetic mechanism of SET7/9-mediated histone
            methylation modification in high glucose-induced ferroptosis in
            retinal pigment epithelial cells.
REFERENCE   2  (bases 1 to 6808)
  AUTHORS   Yang,Y., Xie,W., Qiao,X., Yang,J., Yao,D. and Zhu,D.
  TITLE     ZKSCAN5 activates LAPTM5 expression by recruiting SETD7 to promote
            metastasis in pancreatic ductal adenocarcinoma
  JOURNAL   Histol Histopathol 39 (6), 747-760 (2024)
   PUBMED   38018874
  REMARK    GeneRIF: ZKSCAN5 activates LAPTM5 expression by recruiting SETD7 to
            promote metastasis in pancreatic ductal adenocarcinoma.
REFERENCE   3  (bases 1 to 6808)
  AUTHORS   Zhang,J., Duan,B., Li,F., Jing,X., Li,R., Cai,S., Cao,L., Jiang,Q.,
            Zhou,J., Zhou,J., Qin,Y., Wang,X., Tong,D. and Huang,C.
  TITLE     SETD7 Promotes Cell Proliferation and Migration via
            Methylation-mediated TAF7 in Clear Cell Renal Cell Carcinoma
  JOURNAL   Int J Biol Sci 20 (8), 3008-3027 (2024)
   PUBMED   38904013
  REMARK    GeneRIF: SETD7 Promotes Cell Proliferation and Migration via
            Methylation-mediated TAF7 in Clear Cell Renal Cell Carcinoma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 6808)
  AUTHORS   Shi,Y., Wang,Z., Shao,Y., Guang,Q., Zhang,J., Liu,B., Wu,C.,
            Wang,Y. and Sui,P.
  TITLE     Combined SET7/9 and CDK4 inhibition act synergistically against
            osteosarcoma
  JOURNAL   Biochem Biophys Res Commun 708, 149808 (2024)
   PUBMED   38520914
  REMARK    GeneRIF: Combined SET7/9 and CDK4 inhibition act synergistically
            against osteosarcoma.
REFERENCE   5  (bases 1 to 6808)
  AUTHORS   Myadelets,D., Parfenyev,S., Vasileva,J., Shuvalov,O., Petukhov,A.,
            Fedorova,O., Barlev,N. and Daks,A.
  TITLE     Methyltransferase Set7/9 controls PARP1 expression and regulates
            cisplatin response of breast cancer cells
  JOURNAL   Biochem Biophys Res Commun 691, 149328 (2024)
   PUBMED   38043199
  REMARK    GeneRIF: Methyltransferase Set7/9 controls PARP1 expression and
            regulates cisplatin response of breast cancer cells.
REFERENCE   6  (bases 1 to 6808)
  AUTHORS   Kwon,T., Chang,J.H., Kwak,E., Lee,C.W., Joachimiak,A., Kim,Y.C.,
            Lee,J. and Cho,Y.
  TITLE     Mechanism of histone lysine methyl transfer revealed by the
            structure of SET7/9-AdoMet
  JOURNAL   EMBO J 22 (2), 292-303 (2003)
   PUBMED   12514135
REFERENCE   7  (bases 1 to 6808)
  AUTHORS   Jacobs,S.A., Harp,J.M., Devarakonda,S., Kim,Y., Rastinejad,F. and
            Khorasanizadeh,S.
  TITLE     The active site of the SET domain is constructed on a knot
  JOURNAL   Nat Struct Biol 9 (11), 833-838 (2002)
   PUBMED   12389038
  REMARK    Erratum:[Nat Struct Biol. 2003 Jun;10(7):578]
REFERENCE   8  (bases 1 to 6808)
  AUTHORS   Wilson,J.R., Jing,C., Walker,P.A., Martin,S.R., Howell,S.A.,
            Blackburn,G.M., Gamblin,S.J. and Xiao,B.
  TITLE     Crystal structure and functional analysis of the histone
            methyltransferase SET7/9
  JOURNAL   Cell 111 (1), 105-115 (2002)
   PUBMED   12372304
  REMARK    GeneRIF: crystal structure of human SET7/9 shows residues essential
            for catalytic activity with histone H3
REFERENCE   9  (bases 1 to 6808)
  AUTHORS   Nishioka,K., Chuikov,S., Sarma,K., Erdjument-Bromage,H.,
            Allis,C.D., Tempst,P. and Reinberg,D.
  TITLE     Set9, a novel histone H3 methyltransferase that facilitates
            transcription by precluding histone tail modifications required for
            heterochromatin formation
  JOURNAL   Genes Dev 16 (4), 479-489 (2002)
   PUBMED   11850410
REFERENCE   10 (bases 1 to 6808)
  AUTHORS   Wang,H., Cao,R., Xia,L., Erdjument-Bromage,H., Borchers,C.,
            Tempst,P. and Zhang,Y.
  TITLE     Purification and functional characterization of a histone H3-lysine
            4-specific methyltransferase
  JOURNAL   Mol Cell 8 (6), 1207-1217 (2001)
   PUBMED   11779497
  REMARK    GeneRIF: purification and functional characterization of a histone
            H3-lysine 4-specific methyltransferase
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC112236.3 and AC114743.4.
            
            On Aug 11, 2020 this sequence version replaced NM_030648.3.
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB051504.1, SRR11853565.22640.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000274031.8/ ENSP00000274031.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               AC112236.3         15860-15981         c
            123-252             AC112236.3         6682-6811           c
            253-454             AC114743.4         95853-96054         c
            455-644             AC114743.4         91719-91908         c
            645-726             AC114743.4         86042-86123         c
            727-844             AC114743.4         82965-83082         c
            845-1002            AC114743.4         80573-80730         c
            1003-6808           AC114743.4         68726-74531         c
FEATURES             Location/Qualifiers
     source          1..6808
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.1"
     gene            1..6808
                     /gene="SETD7"
                     /gene_synonym="KMT7; SET7; SET7/9; SET9"
                     /note="SET domain containing 7, histone lysine
                     methyltransferase"
                     /db_xref="GeneID:80854"
                     /db_xref="HGNC:HGNC:30412"
                     /db_xref="MIM:606594"
     exon            1..122
                     /gene="SETD7"
                     /gene_synonym="KMT7; SET7; SET7/9; SET9"
                     /inference="alignment:Splign:2.1.0"
     CDS             83..1183
                     /gene="SETD7"
                     /gene_synonym="KMT7; SET7; SET7/9; SET9"
                     /EC_number="2.1.1.364"
                     /note="isoform 1 is encoded by transcript variant 1; SET
                     domain-containing protein 7; histone H3-lysine 4-specific
                     methyltransferase; histone-lysine N-methyltransferase
                     SETD7; H3-K4-HMTase SETD7; lysine N-methyltransferase 7;
                     histone H3-K4 methyltransferase SETD7; SET domain
                     containing lysine methyltransferase 7; SET domain
                     containing 7, lysine methyltransferase"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase SETD7 isoform
                     1"
                     /protein_id="NP_085151.1"
                     /db_xref="CCDS:CCDS3748.1"
                     /db_xref="GeneID:80854"
                     /db_xref="HGNC:HGNC:30412"
                     /db_xref="MIM:606594"
                     /translation="MDSDDEMVEEAVEGHLDDDGLPHGFCTVTYSSTDRFEGNFVHGE
                     KNGRGKFFFFDGSTLEGYYVDDALQGQGVYTYEDGGVLQGTYVDGELNGPAQEYDTDG
                     RLIFKGQYKDNIRHGVCWIYYPDGGSLVGEVNEDGEMTGEKIAYVYPDERTALYGKFI
                     DGEMIEGKLATLMSTEEGRPHFELMPGNSVYHFDKSTSSCISTNALLPDPYESERVYV
                     AESLISSAGEGLFSKVAVGPNTVMSFYNGVRITHQEVDSRDWALNGNTLSLDEETVID
                     VPEPYNHVSKYCASLGHKANHSFTPNCIYDMFVHPRFGPIKCIRTLRAVEADEELTVA
                     YGYDHSPPGKSGPEAPEWYQVELKAFQATQQK"
     exon            123..252
                     /gene="SETD7"
                     /gene_synonym="KMT7; SET7; SET7/9; SET9"
                     /inference="alignment:Splign:2.1.0"
     exon            253..454
                     /gene="SETD7"
                     /gene_synonym="KMT7; SET7; SET7/9; SET9"
                     /inference="alignment:Splign:2.1.0"
     exon            455..644
                     /gene="SETD7"
                     /gene_synonym="KMT7; SET7; SET7/9; SET9"
                     /inference="alignment:Splign:2.1.0"
     exon            645..726
                     /gene="SETD7"
                     /gene_synonym="KMT7; SET7; SET7/9; SET9"
                     /inference="alignment:Splign:2.1.0"
     exon            727..844
                     /gene="SETD7"
                     /gene_synonym="KMT7; SET7; SET7/9; SET9"
                     /inference="alignment:Splign:2.1.0"
     exon            845..1002
                     /gene="SETD7"
                     /gene_synonym="KMT7; SET7; SET7/9; SET9"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..6808
                     /gene="SETD7"
                     /gene_synonym="KMT7; SET7; SET7/9; SET9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6788..6793
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SETD7"
                     /gene_synonym="KMT7; SET7; SET7/9; SET9"
                     /note="hexamer: ATTAAA"
     polyA_site      6808
                     /gene="SETD7"
                     /gene_synonym="KMT7; SET7; SET7/9; SET9"
                     /note="major polyA site"
ORIGIN      
        1 agagctcgct cagccgccgg gagcacccag agggacggga ggcagccgcg cagccccgag
       61 ctgggcagtg tccccagccg ccatggatag cgacgacgag atggtggagg aggcggtgga
      121 agggcacctg gacgatgacg gattaccgca cgggttctgc acagtcacct actcctccac
      181 agacagattt gaggggaact ttgttcacgg agaaaagaac ggacggggga agttcttctt
      241 ctttgatggc agcaccctgg aggggtatta tgtggatgat gccttgcagg gccagggagt
      301 ttacacttac gaagatgggg gagttctcca gggcacgtat gtagacggag agctgaacgg
      361 tccagcccag gaatatgaca cagatgggag actgatcttc aaggggcagt ataaagataa
      421 cattcgtcat ggagtgtgct ggatatatta cccagatgga ggaagccttg taggagaagt
      481 aaatgaagat ggggagatga ctggagagaa gatagcctat gtgtaccctg atgagaggac
      541 cgcactttat gggaaattta ttgatggaga gatgatagaa ggcaaactgg ctacccttat
      601 gtccactgaa gaagggaggc ctcactttga actgatgcct ggaaattcag tgtaccactt
      661 tgataagtcg acttcatctt gcatttctac caatgctctt cttccagatc cttatgaatc
      721 agaaagggtt tatgttgctg aatctcttat ttccagtgct ggagaaggac ttttttcaaa
      781 ggtagctgtg ggacctaata ctgttatgtc tttttataat ggagttcgaa ttacacacca
      841 agaggttgac agcagggact gggcccttaa tgggaacacc ctctcccttg atgaagaaac
      901 ggtcattgat gtgcctgagc cctataacca cgtatccaag tactgtgcct ccttgggaca
      961 caaggcaaat cactccttca ctccaaactg catctacgat atgtttgtcc acccccgttt
     1021 tgggcccatc aaatgcatcc gcaccctgag agcagtggag gccgatgaag agctcaccgt
     1081 tgcctatggc tatgaccaca gcccccccgg gaagagtggg cctgaagccc ctgagtggta
     1141 ccaggtggag ctgaaggcct tccaggccac ccagcaaaag tgaaaggcct ggctttgggg
     1201 ttcagagacc tggaatagaa acttggatct atgcactacg tttatctgac aatgggacaa
     1261 ccagggactg ctcatgctgt gacgtcacat cctctcacca tgcgttagca acgactttct
     1321 cgcatactaa ctaggtttga ctgtattact cataccagat ttaaaattag ctagccttgc
     1381 aacaacgtcc tactgagagg tattgtcgag catttgacat aagacagcgt gatgttcttt
     1441 ggtggttcaa gtctaaatct gtaccacatt cggagatgcc aaatgattag actgaaacag
     1501 ggaaacgggg tttttcagtc atttttagtc agtggttttt ccatagtgct tttttcctat
     1561 ggccagtgca aattgtgtta gcacacttgc atatgtgccg tattaagggt tgacaattac
     1621 tacatcttta ttctctaaat gtagtataat ttgcctttta acctttgatc tgtatcttgc
     1681 aatagaatgg ctttggtttt tttcttagta aataggagcc cacttctaaa gtcatttcac
     1741 ccctcagccc tattctcttt cttagatacc ctttacaaga gaaaacttcc aaatggattt
     1801 ttgcatcaat agcagtgtgt aggtctctct ggttctttct atatcatcat tttattatta
     1861 tgtcctaata taaagtactg gctcataggg ccagggtatt attatagaat attattctcg
     1921 catgtaaaca aagatatctt tgctttaaga tgtgagaaga aatgaattta ctttgtttgc
     1981 attaagttat ggaagagttg taatatatac tttaagaaag aagagaagaa aactagtatc
     2041 tctaagcggt aactatggca attttgcaat attttcagta gtgctagtaa ttttttcctc
     2101 cttgagtaca cattaaatgt acataacata gcgcggtcag gcttgtggca cagtgcattg
     2161 aattcaaaag tcaaacagca aatttgaatt ctaacagaat tcaaaaaaaa atttttttag
     2221 tcagtactac taaggcagac acactgatta ctaggtacaa atcaaacctt gatgctaaaa
     2281 ctcttcatca ttgtaatttc aaagcactta cctgcttcaa aacattgtaa actaagactg
     2341 aacacctgta tagtttaaaa gcaacactat caatagcatt tcagccattt tgccagccat
     2401 gtgtaatcac aactgcagaa ataaggagaa aacccctgtt tttttagttt agctaattag
     2461 atctgtaaca tcactgggat tgctctgaat gaatcctgag agttttgttt tttataagca
     2521 ccctcaccac atgccatagc tttgtctctt ttagacacct cgatgcagcg gctggaagga
     2581 ctggagagca gctgttgtgc tgatctgtag ctgtcagctg tgattcctgt cacctgagtc
     2641 agtttggtct ggaaagcgaa ggccttccaa gctgtagcag atagtgagct ccagctgatg
     2701 agagaaggct tcagtggaag aagagtgagg acataggcag aaggaagttt gctatttctt
     2761 gtcagttgca cattgcttta tgaagactac aacaaaagtg cttaatccca ggctgctcat
     2821 gactttcatt tcaggtggcc cttgggcaca ttgacagagt tgcccttccc ttctttgcaa
     2881 caccaggctt cctagagcac ccggttgcat gctttgcagc taggtggcag tggtttcagg
     2941 gagatccagt tggatccctg cttgaaagct taagccaatg gttcacccat gagaggaagt
     3001 tgtcagtgct tccaggaaga ttgcccacca aaggaactga atagttttta gatttaaagg
     3061 caccaggata gggtcactct tactctgtag aaagagaccg ttctatacac tgtgacggat
     3121 gggccagggc ctctggactt gcattctgat aggtgcttta atttaaatgt gcccaaaggg
     3181 agtgactgtc ttcaggagaa agatggcttg cattaacctc gatcaagtgg gttgtgcagc
     3241 caggtcaggg aatacggtca gggagaggat agtgctggtc atgcccccga tgcagctatg
     3301 ctctgaatga tttcattcct gagagtgata gcattctggt cctggctgca gtggggtaca
     3361 atttacgtcc taagtggggg ctactctaat tatcccattc aaatggaatt tttttcaaca
     3421 ttggatagaa ggaattgaag agttgtaagt agtgattagt ctgctaatca gttcttcaga
     3481 tgagatattg aatggtaaca ctctgagctt aaaactcagc agtgtgtctg tgacctccac
     3541 gcaaatcaga ggaagcaatg catccacgct gagcctcacc atgtcttcct cccaactctc
     3601 ttcatactct ctgtgtcttc cagctcttct ttctctggcc ggctctcttt cctcttctct
     3661 ctgcatatgt gagaacgcct gggcatcctg ggtaacagca gccccagctg ccctctcctg
     3721 ttccctgttc caagtcccct gcactgacct ttcttgagtc tctctggctc tgtgcatgtc
     3781 tttgggactc tgctcatctg gcttttcctc tgtgtgtgcc tctctgtttg cttatgtctc
     3841 tggctctgtc ttccccaccc ctcccctcac acacacacat actcccaaat gtaaggctct
     3901 gtggcaggtt ggaatcggag taaggcttga gattcactga gttctgtagg tagggaaaga
     3961 agtcaaggga gtggaggttc tataaggaat taacagctga ggacggaagg gtttgtttcc
     4021 cgtttgaacc taaacgcaag tggaaaagaa tactcagaat gtatttttct actttacatc
     4081 tgctggggaa ggaaatgtgt caggaagccg ctgcatctgg tcatttcatc gcatcagaat
     4141 cacagcagac gtggaagatt ccatgtggtg gggaataaag aaataacttt atgctctcct
     4201 gaaaaacagc gggagcctat gtgtgtgtgc gacactgtaa tctcaaggag attcactcag
     4261 agctgtctca gtccaactcc tgcatgacca gatcttccct tagcatcttt tctgtgatga
     4321 aatattatct tgtgttagag ttaggaatag gaactaacct gtaggagcat gtccccaaat
     4381 ggacatttga atggactaac aaaaacaact ggaaagactg aatttccgac acaaaggaat
     4441 gatgggatca aaaagaaagc agtgaggagt tcttgagtct tgtagtacct attcttattt
     4501 taacttgctt catccttgat ctacctgaga cactaagaag gaaattagtt ttccaagagc
     4561 tctttgaacc tgtctaggac tgtagttaaa cctatttgcc ctatgggggt tcttcacact
     4621 cgaaaaacta tttccttatc accaacgacc cacccagaaa ggccaatgag gccaaatgta
     4681 acaattttta acatttaaat ataactatta aaattgcatt aattgtgaac agtgaattaa
     4741 agggttgtct tctccaggag acagtatgtg gcacttttcg taaatttcat ttaatatata
     4801 aaaatttaaa tcactcactg caacatgcat ttaaaatctt ccaagaaggt agaggtatca
     4861 ttttctgttt tgctttgttt taaaacagtt gcctcaagct tctgtcttaa gagtagtgac
     4921 ttagaatcca gatatctttt gttttagaaa aacaagcaaa actatgttgc aagactgaca
     4981 gttgtaatgt ttatttgcca cagatcaaag gttcacaaag tatatcaaat ttacatctac
     5041 ttggggtacc ttgatagatt attattgttt ttcttttatc tttcccttca ggaatttgga
     5101 aactcgttgt cacttttttt aattttaaaa atactaaatt gtaatagttt tcttttgcca
     5161 aatgtgtgcg tacatattca aagcaatgaa actatttcaa gccatacaac cacaggggtg
     5221 ggaacccttt tcacaaattt taatgtgttt gtatgtaaat agatgtttgt atgaaatatt
     5281 ttcatgatag aatgaatata tttaaatgaa gttgaattat tccagtgcta cttaaacaca
     5341 ttacaaaaat tttggtgaga attatctgag tctattgaga tgtaatgcag atcaattttg
     5401 atttttaaaa atcaaaagcc tacaataact ctgactctca gcaacttcct cggcgttgtt
     5461 gcacctgacg tggagagagc tcgtaggctt ccccagtgcc tcagccgctt cctggtggaa
     5521 gttaggtgct aatggaggtg tgttcacctt ttagtgatat cactgcaggc ctttgagggg
     5581 cctgagagtg aatcagaggc attagagaca ccggtgcagt tatctggagc acaatttctt
     5641 tgcagggcag cagaatcaga agccagactt ggccatgtga acctcgaaac tcggtttccc
     5701 ggccgccatc aaccgccacc cttactgcct agtcacacac gtcagggagg ctgccctcag
     5761 tggagttggg gttgagaccc cagggtggga cttcacagtt ttgccagcaa tctctacctt
     5821 ctgacttctg cctcgcagag aggaaggaga ggggagcatc tggcaagggg cccatttctc
     5881 agcacagtac atttcctgtc tcagctctgg aagactatgc acccaagcac caaacttcca
     5941 accagagaga gagacgtcct ccgataacaa aaatccttgc ttcctctgtc tgtgacttta
     6001 cacacagttg ttcaaagttg ttaaatgtca agagtcaatc acatccctag gacatacctc
     6061 ccaactctcc tgactcttat gttattgaaa aaacaaacaa acaaaaactc ctttatgatg
     6121 atattcaact tgagtggggt tttttttcca ctttggtcct ggatataatg aaatgataca
     6181 tattaggata aattttcact gtgtatagta gcaatacgaa cacacatgcc aatgtatcaa
     6241 catatctact tggttacatt ttggtttatg ataattaacc ttgattcatg tattgggaag
     6301 ctacagggac tacgtaatac ctgcttatca cataggaaaa ttatgtccat gattctgagc
     6361 tcccttcttc aaaagtttcc tcctgggtgt tctatgttct ctctttatcc tgaaatacat
     6421 ttattaggtt gtgaggtatg ttgaagaagt agaagccagg ggtatgcttt cagcatttat
     6481 tgcaaccaaa agttaacccc atcacggtta acgagcatct ttggtctctt gtggaatttg
     6541 aactaaaact atgagcctta ttcaatatct ataattctat gattttttta aattatggga
     6601 aattaatgaa agatgtttac atgaataatg tttgccctta ctgtgttatg aatgagtttt
     6661 ttgtagtgtg tctgggtgca tgatgcaaga gagtaggaaa aatgtttctg aaacaaaact
     6721 tgacaaatat ttgtaatgaa agtaaattta aagattgcta taattgcgct atagaaacaa
     6781 tgcaagtatt aaacaaaata tacaatca
//
