LOCUS       NM_001080517            6931 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens SET domain containing 5 (SETD5), transcript variant 1,
            mRNA.
ACCESSION   NM_001080517 XM_926615
VERSION     NM_001080517.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6931)
  AUTHORS   Zaghi,M., Longo,F., Massimino,L., Rubio,A., Bido,S., Mazzara,P.G.,
            Bellini,E., Banfi,F., Podini,P., Maltecca,F., Zippo,A., Broccoli,V.
            and Sessa,A.
  TITLE     SETD5 haploinsufficiency affects mitochondrial compartment in
            neural cells
  JOURNAL   Mol Autism 14 (1), 20 (2023)
   PUBMED   37264456
  REMARK    GeneRIF: SETD5 haploinsufficiency affects mitochondrial compartment
            in neural cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 6931)
  AUTHORS   Li,M., Hou,Y., Zhang,Z., Zhang,B., Huang,T., Sun,A., Shao,G. and
            Lin,Q.
  TITLE     Structure, activity and function of the lysine methyltransferase
            SETD5
  JOURNAL   Front Endocrinol (Lausanne) 14, 1089527 (2023)
   PUBMED   36875494
  REMARK    GeneRIF: Structure, activity and function of the lysine
            methyltransferase SETD5.
            Review article
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 6931)
  AUTHORS   Yang,Z., Zhang,C., Liu,X., Che,N., Feng,Y. and Xuan,Y.
  TITLE     SETD5 Regulates Glycolysis in Breast Cancer Stem-Like Cells and
            Fuels Tumor Growth
  JOURNAL   Am J Pathol 192 (4), 712-721 (2022)
   PUBMED   35063407
  REMARK    GeneRIF: SETD5 Regulates Glycolysis in Breast Cancer Stem-Like
            Cells and Fuels Tumor Growth.
REFERENCE   4  (bases 1 to 6931)
  AUTHORS   Yang,Z., Zhang,C., Che,N., Feng,Y., Li,C. and Xuan,Y.
  TITLE     Su(var)3-9, Enhancer of Zeste, and Trithorax Domain-Containing 5
            Facilitates Tumor Growth and Pulmonary Metastasis through
            Up-Regulation of AKT1 Signaling in Breast Cancer
  JOURNAL   Am J Pathol 191 (1), 180-193 (2021)
   PUBMED   33129761
  REMARK    GeneRIF: Su(var)3-9, Enhancer of Zeste, and Trithorax
            Domain-Containing 5 Facilitates Tumor Growth and Pulmonary
            Metastasis through Up-Regulation of AKT1 Signaling in Breast
            Cancer.
REFERENCE   5  (bases 1 to 6931)
  AUTHORS   Chen,Q., Sun,Z., Li,J., Zhang,D., Guo,B. and Zhang,T.
  TITLE     SET Domain-Containing Protein 5 Enhances the Cell Stemness of
            Non-Small Cell Lung Cancer via the PI3K/Akt/mTOR Pathway
  JOURNAL   J Environ Pathol Toxicol Oncol 40 (2), 55-63 (2021)
   PUBMED   33822517
  REMARK    GeneRIF: SET Domain-Containing Protein 5 Enhances the Cell Stemness
            of Non-Small Cell Lung Cancer via the PI3K/Akt/mTOR Pathway.
REFERENCE   6  (bases 1 to 6931)
  AUTHORS   Kuechler,A., Zink,A.M., Wieland,T., Ludecke,H.J., Cremer,K.,
            Salviati,L., Magini,P., Najafi,K., Zweier,C., Czeschik,J.C.,
            Aretz,S., Endele,S., Tamburrino,F., Pinato,C., Clementi,M.,
            Gundlach,J., Maylahn,C., Mazzanti,L., Wohlleber,E., Schwarzmayr,T.,
            Kariminejad,R., Schlessinger,A., Wieczorek,D., Strom,T.M.,
            Novarino,G. and Engels,H.
  TITLE     Loss-of-function variants of SETD5 cause intellectual disability
            and the core phenotype of microdeletion 3p25.3 syndrome
  JOURNAL   Eur J Hum Genet 23 (6), 753-760 (2015)
   PUBMED   25138099
  REMARK    GeneRIF: SETD5 sequence variants contribute substantially to the
            microdeletion 3p25.3 phenotype.  SETD5 variants as a relatively
            frequent cause of intellectual disability.
REFERENCE   7  (bases 1 to 6931)
  AUTHORS   Poissonnier,L., Villain,G., Soncin,F. and Mattot,V.
  TITLE     miR126-5p repression of ALCAM and SetD5 in endothelial cells
            regulates leucocyte adhesion and transmigration
  JOURNAL   Cardiovasc Res 102 (3), 436-447 (2014)
   PUBMED   24562769
  REMARK    GeneRIF: miR126-5p is a functional, endothelial-enriched microRNA
            that participates in the control of leucocyte trafficking by
            regulating the expression of ALCAM and SetD5.
REFERENCE   8  (bases 1 to 6931)
  AUTHORS   Grozeva,D., Carss,K., Spasic-Boskovic,O., Parker,M.J., Archer,H.,
            Firth,H.V., Park,S.M., Canham,N., Holder,S.E., Wilson,M.,
            Hackett,A., Field,M., Floyd,J.A., Hurles,M. and Raymond,F.L.
  CONSRTM   UK10K Consortium
  TITLE     De novo loss-of-function mutations in SETD5, encoding a
            methyltransferase in a 3p25 microdeletion syndrome critical region,
            cause intellectual disability
  JOURNAL   Am J Hum Genet 94 (4), 618-624 (2014)
   PUBMED   24680889
  REMARK    GeneRIF: analysis provides sufficient evidence that rare de novo
            LoF mutations in SETD5 are a relatively frequent (0.7%) cause of
            intellectual disability
REFERENCE   9  (bases 1 to 6931)
  AUTHORS   Muzny,D.M., Scherer,S.E., Kaul,R., Wang,J., Yu,J., Sudbrak,R.,
            Buhay,C.J., Chen,R., Cree,A., Ding,Y., Dugan-Rocha,S., Gill,R.,
            Gunaratne,P., Harris,R.A., Hawes,A.C., Hernandez,J., Hodgson,A.V.,
            Hume,J., Jackson,A., Khan,Z.M., Kovar-Smith,C., Lewis,L.R.,
            Lozado,R.J., Metzker,M.L., Milosavljevic,A., Miner,G.R.,
            Morgan,M.B., Nazareth,L.V., Scott,G., Sodergren,E., Song,X.Z.,
            Steffen,D., Wei,S., Wheeler,D.A., Wright,M.W., Worley,K.C.,
            Yuan,Y., Zhang,Z., Adams,C.Q., Ansari-Lari,M.A., Ayele,M.,
            Brown,M.J., Chen,G., Chen,Z., Clendenning,J.,
            Clerc-Blankenburg,K.P., Chen,R., Chen,Z., Davis,C., Delgado,O.,
            Dinh,H.H., Dong,W., Draper,H., Ernst,S., Fu,G.,
            Gonzalez-Garay,M.L., Garcia,D.K., Gillett,W., Gu,J., Hao,B.,
            Haugen,E., Havlak,P., He,X., Hennig,S., Hu,S., Huang,W.,
            Jackson,L.R., Jacob,L.S., Kelly,S.H., Kube,M., Levy,R., Li,Z.,
            Liu,B., Liu,J., Liu,W., Lu,J., Maheshwari,M., Nguyen,B.V.,
            Okwuonu,G.O., Palmeiri,A., Pasternak,S., Perez,L.M., Phelps,K.A.,
            Plopper,F.J., Qiang,B., Raymond,C., Rodriguez,R.,
            Saenphimmachak,C., Santibanez,J., Shen,H., Shen,Y., Subramanian,S.,
            Tabor,P.E., Verduzco,D., Waldron,L., Wang,J., Wang,J., Wang,Q.,
            Williams,G.A., Wong,G.K., Yao,Z., Zhang,J., Zhang,X., Zhao,G.,
            Zhou,J., Zhou,Y., Nelson,D., Lehrach,H., Reinhardt,R., Naylor,S.L.,
            Yang,H., Olson,M., Weinstock,G. and Gibbs,R.A.
  TITLE     The DNA sequence, annotation and analysis of human chromosome 3
  JOURNAL   Nature 440 (7088), 1194-1198 (2006)
   PUBMED   16641997
REFERENCE   10 (bases 1 to 6931)
  AUTHORS   Robertson,N.G., Khetarpal,U., Gutierrez-Espeleta,G.A., Bieber,F.R.
            and Morton,C.C.
  TITLE     Isolation of novel and known genes from a human fetal cochlear cDNA
            library using subtractive hybridization and differential screening
  JOURNAL   Genomics 23 (1), 42-50 (1994)
   PUBMED   7829101
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC018506.5, AI243838.1,
            AK092046.1, CR627408.1 and AB051544.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 12, 2019 this sequence version replaced NM_001080517.2.
            
            Summary: This function of this gene has yet to be determined but
            based on sequence similarity to other SET domain proteins it may
            function as a histone methyltransferase. Mutations in this gene
            have been associated with an autosomal dominant form of
            intellectual disability. Alternative splicing results in multiple
            transcript variants encoding different isoforms. [provided by
            RefSeq, Jul 2017].
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000402198.7/ ENSP00000385852.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-157               AC018506.5         113087-113243       c
            158-285             AI243838.1         73-200
            286-610             AK092046.1         1-325
            611-866             CR627408.1         103-358
            867-5236            AB051544.1         576-4945
            5237-6931           AC018506.5         32704-34398         c
FEATURES             Location/Qualifiers
     source          1..6931
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.3"
     gene            1..6931
                     /gene="SETD5"
                     /gene_synonym="MRD23; SETD5A"
                     /note="SET domain containing 5"
                     /db_xref="GeneID:55209"
                     /db_xref="HGNC:HGNC:25566"
                     /db_xref="MIM:615743"
     exon            1..363
                     /gene="SETD5"
                     /gene_synonym="MRD23; SETD5A"
                     /inference="alignment:Splign:2.1.0"
     exon            364..423
                     /gene="SETD5"
                     /gene_synonym="MRD23; SETD5A"
                     /inference="alignment:Splign:2.1.0"
     exon            424..610
                     /gene="SETD5"
                     /gene_synonym="MRD23; SETD5A"
                     /inference="alignment:Splign:2.1.0"
     CDS             540..4868
                     /gene="SETD5"
                     /gene_synonym="MRD23; SETD5A"
                     /EC_number="2.1.1.359"
                     /EC_number="2.1.1.367"
                     /note="isoform 1 is encoded by transcript variant 1; SET
                     domain-containing protein 5; histone-lysine
                     N-methyltransferase SETD5"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase SETD5 isoform
                     1"
                     /protein_id="NP_001073986.1"
                     /db_xref="CCDS:CCDS46741.1"
                     /db_xref="GeneID:55209"
                     /db_xref="HGNC:HGNC:25566"
                     /db_xref="MIM:615743"
                     /translation="MSIAIPLGVTTSDTSYSDMAAGSDPESVEASPAVNEKSVYSTHN
                     YGTTQRHGCRGLPYATIIPRSDLNGLPSPVEERCGDSPNSEGETVPTWCPCGLSQDGF
                     LLNCDKCRGMSRGKVIRLHRRKQDNISGGDSSATESWDEELSPSTVLYTATQHTPTSI
                     TLTVRRTKPKKRKKSPEKGRAAPKTKKIKNSPSEAQNLDENTTEGWENRIRLWTDQYE
                     EAFTNQYSADVQNALEQHLHSSKEFVGKPTILDTINKTELACNNTVIGSQMQLQLGRV
                     TRVQKHRKILRAARDLALDTLIIEYRGKVMLRQQFEVNGHFFKKPYPFVLFYSKFNGV
                     EMCVDARTFGNDARFIRRSCTPNAEVRHMIADGMIHLCIYAVSAITKDAEVTIAFDYE
                     YSNCNYKVDCACHKGNRNCPIQKRNPNATELPLLPPPPSLPTIGAETRRRKARRKELE
                     MEQQNEASEENNDQQSQEVPEKVTVSSDHEEVDNPEEKPEEEKEEVIDDQENLAHSRR
                     TREDRKVEAIMHAFENLEKRKKRRDQPLEQSNSDVEITTTTSETPVGEETKTEAPESE
                     VSNSVSNVTIPSTPQSVGVNTRRSSQAGDIAAEKLVPKPPPAKPSRPRPKSRISRYRT
                     SSAQRLKRQKQANAQQAELSQAALEEGGSNSLVTPTEAGSLDSSGENRPLTGSDPTVV
                     SITGSHVNRAASKYPKTKKYLVTEWLNDKAEKQECPVECPLRITTDPTVLATTLNMLP
                     GLIHSPLICTTPKHYIRFGSPFIPERRRRPLLPDGTFSSCKKRWIKQALEEGMTQTSS
                     VPQETRTQHLYQSNENSSSSSICKDNADLLSPLKKWKSRYLMEQNVTKLLRPLSPVTP
                     PPPNSGSKSPQLATPGSSHPGEEECRNGYSLMFSPVTSLTTASRCNTPLQFELCHRKD
                     LDLAKVGYLDSNTNSCADRPSLLNSGHSDLAPHPSLGPTSETGFPSRSGDGHQTLVRN
                     SDQAFRTEFNLMYAYSPLNAMPRADGLYRGSPLVGDRKPLHLDGGYCSPAEGFSSRYE
                     HGLMKDLSRGSLSPGGERACEGVPSAPQNPPQRKKVSLLEYRKRKQEAKENSAGGGGD
                     SAQSKSKSAGAGQGSSNSVSDTGAHGVQGSSARTPSSPHKKFSPSHSSMSHLEAVSPS
                     DSRGTSSSHCRPQENISSRWMVPTSVERLREGGSIPKVLRSSVRVAQKGEPSPTWESN
                     ITEKDSDPADGEGPETLSSALSKGATVYSPSRYSYQLLQCDSPRTESQSLLQQSSSPF
                     RGHPTQSPGYSYRTTALRPGNPPSHGSSESSLSSTSYSSPAHPVSTDSLAPFTGTPGY
                     FSSQPHSGNSTGSNLPRRSCPSSAASPTLQGPSDSPTSDSVSQSSTGTLSSTSFPQNS
                     RSSLPSDLRTISLPSAGQSAVYQASRVSAVSNSQHYPHRGSGGVHQYRLQPLQGSGVK
                     TQTGLS"
     exon            611..716
                     /gene="SETD5"
                     /gene_synonym="MRD23; SETD5A"
                     /inference="alignment:Splign:2.1.0"
     exon            717..868
                     /gene="SETD5"
                     /gene_synonym="MRD23; SETD5A"
                     /inference="alignment:Splign:2.1.0"
     exon            869..927
                     /gene="SETD5"
                     /gene_synonym="MRD23; SETD5A"
                     /inference="alignment:Splign:2.1.0"
     exon            928..1106
                     /gene="SETD5"
                     /gene_synonym="MRD23; SETD5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1107..1349
                     /gene="SETD5"
                     /gene_synonym="MRD23; SETD5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1350..1498
                     /gene="SETD5"
                     /gene_synonym="MRD23; SETD5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1499..1616
                     /gene="SETD5"
                     /gene_synonym="MRD23; SETD5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1617..1726
                     /gene="SETD5"
                     /gene_synonym="MRD23; SETD5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1727..1979
                     /gene="SETD5"
                     /gene_synonym="MRD23; SETD5A"
                     /inference="alignment:Splign:2.1.0"
     exon            1980..2063
                     /gene="SETD5"
                     /gene_synonym="MRD23; SETD5A"
                     /inference="alignment:Splign:2.1.0"
     exon            2064..2321
                     /gene="SETD5"
                     /gene_synonym="MRD23; SETD5A"
                     /inference="alignment:Splign:2.1.0"
     exon            2322..2642
                     /gene="SETD5"
                     /gene_synonym="MRD23; SETD5A"
                     /inference="alignment:Splign:2.1.0"
     exon            2643..2885
                     /gene="SETD5"
                     /gene_synonym="MRD23; SETD5A"
                     /inference="alignment:Splign:2.1.0"
     exon            2886..3015
                     /gene="SETD5"
                     /gene_synonym="MRD23; SETD5A"
                     /inference="alignment:Splign:2.1.0"
     exon            3016..3263
                     /gene="SETD5"
                     /gene_synonym="MRD23; SETD5A"
                     /inference="alignment:Splign:2.1.0"
     exon            3264..3734
                     /gene="SETD5"
                     /gene_synonym="MRD23; SETD5A"
                     /inference="alignment:Splign:2.1.0"
     exon            3735..4036
                     /gene="SETD5"
                     /gene_synonym="MRD23; SETD5A"
                     /inference="alignment:Splign:2.1.0"
     exon            4037..4170
                     /gene="SETD5"
                     /gene_synonym="MRD23; SETD5A"
                     /inference="alignment:Splign:2.1.0"
     exon            4171..4259
                     /gene="SETD5"
                     /gene_synonym="MRD23; SETD5A"
                     /inference="alignment:Splign:2.1.0"
     exon            4260..6931
                     /gene="SETD5"
                     /gene_synonym="MRD23; SETD5A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      6894..6899
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SETD5"
                     /gene_synonym="MRD23; SETD5A"
                     /note="hexamer: AATAAA"
     regulatory      6912..6917
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SETD5"
                     /gene_synonym="MRD23; SETD5A"
                     /note="hexamer: AATAAT"
     polyA_site      6923
                     /gene="SETD5"
                     /gene_synonym="MRD23; SETD5A"
                     /note="major polyA site"
     polyA_site      6931
                     /gene="SETD5"
                     /gene_synonym="MRD23; SETD5A"
ORIGIN      
        1 agtggcgttt ccgctcgggc agcgggctga gtgagctgcc gccgccgccg ccgccgccgc
       61 cgccgccgcc gctgccgggg gaggggcggc cgccgcccgc ctgcgctcag agactcacgc
      121 agccccagtc ccgccagtcc gccaacacag tagtgccggc ccccctcttt ccctggccct
      181 gccccccctc cccgcctttg gctcgctccg cctttctgcc ccccaccccc acctcacggg
      241 tacgggccat tcccggccag gaaacgccgt ggcgccgcgt tgggcctaac tcgagtcctg
      301 ccgcctcccg ggagtgccgt gcgccgcagc ccgggcccag gccccggcag cgcctgggac
      361 aaggtcttca gaactactag cagataattt ggggggactt catattcaga agtctatata
      421 aaggattcct catgtccata acatgttgga tgaggctctg cagctcaccc ccactctcag
      481 agtggtcagt ctccattaat tggaccccgt gatttccaat ctctgctgtg ttggacgtca
      541 tgagcattgc aatccctctg ggagtcacca catcagatac atcctactca gatatggctg
      601 ctggatcaga ccctgaatct gtggaggcta gtccagcagt taatgagaag agcgtgtatt
      661 ccactcataa ttatgggacc actcagaggc atgggtgtcg aggactgcct tatgctacga
      721 tcatccctcg ttctgacctg aatggcctgc cgtcgcctgt agaggaacgc tgtggagaca
      781 gcccgaactc tgaaggagaa actgtaccta cctggtgtcc ttgtggtctt tctcaggatg
      841 gcttccttct caactgtgac aagtgcaggg gaatgagcag ggggaaggtt attagacttc
      901 atcggcggaa gcaggacaac atatcaggtg gggatagcag tgcaacagaa agctgggatg
      961 aggagctttc tccttccact gtgttgtata cagcaacaca gcacacacct acaagcatca
     1021 ccttaactgt tagaagaacc aaacccaaga agcggaaaaa gagtccagaa aagggtcgtg
     1081 cagcaccaaa gacgaagaaa atcaagaatt ctccctctga agcacagaat ttagatgaga
     1141 atacaactga gggctgggaa aatcggataa gactatggac tgaccagtat gaagaagctt
     1201 tcactaatca gtacagtgca gatgtacaga acgcgcttga acaacaccta cattctagca
     1261 aggaatttgt gggcaaacct actattttag acactattaa taagactgaa ttggcctgta
     1321 ataacacagt tattggttcc caaatgcagt tacagctggg aagagtcact cgtgttcaaa
     1381 agcaccggaa gatcctgagg gctgcaagag atttggcttt ggacactctt ataatagagt
     1441 atcgtgggaa agtcatgtta cgacagcaat ttgaggtcaa tgggcatttc ttcaaaaaac
     1501 catacccctt tgtgctcttc tactcaaaat tcaatggtgt agagatgtgt gtggatgccc
     1561 gtactttcgg taatgatgct cggttcatca gaagatcatg tacaccaaat gcagaggtgc
     1621 gacacatgat tgcagatggg atgattcacc tgtgcatcta tgctgtgtct gccatcacca
     1681 aggatgctga ggtcaccata gcatttgatt atgagtatag taactgtaat tataaagtgg
     1741 actgtgcctg tcacaaggga aaccggaatt gtcctataca aaaaaggaat cctaatgcta
     1801 cagaactgcc actcctacca cctcctccaa gcctacccac cattggagca gagactagac
     1861 gtagaaaagc acgacggaaa gagctagaga tggagcagca gaatgaggct tcagaggaga
     1921 ataatgacca gcaatcacaa gaagttccag aaaaagtaac tgtatccagt gatcatgagg
     1981 aagtagacaa tccagaagaa aaaccagaag aagagaaaga agaggttata gatgaccagg
     2041 agaacctagc tcatagcagg aggaccaggg aagatagaaa ggtagaagcc atcatgcatg
     2101 cttttgaaaa cttagagaaa agaaagaagc ggcgggatca gcccttggaa cagagcaact
     2161 ctgatgtaga gattactaca accacctcag agactcctgt tggtgaagag acaaaaactg
     2221 aagcccctga atctgaagtt agcaactctg tttcaaatgt taccatccca agcaccccac
     2281 agagtgttgg tgtgaatacc cggaggtctt cccaagcagg ggatattgct gcagaaaaac
     2341 tagtccccaa gccacctcca gcaaagcctt ctaggccccg gccgaagagt cgaatttctc
     2401 ggtacaggac cagttcagcc caaagactaa agcgtcagaa gcaggccaat gcacagcagg
     2461 cagaattgtc acaagctgcc ttggaagagg gaggaagtaa cagtttagta actcctactg
     2521 aagctggaag tctagacagt tcaggagaaa acaggccatt aacagggtct gacccaactg
     2581 tggtgtcaat tactggatcc catgtcaacc gtgctgcatc taaatacccc aaaaccaaaa
     2641 agtatctagt tacagaatgg ttgaatgaca aagcagagaa gcaagagtgc cctgttgagt
     2701 gccctttacg tatcacaacg gatccaactg tactggcaac gaccctaaac atgttaccag
     2761 gtcttatcca ttccccgtta atttgcacca cccccaaaca ctacattcgc tttggctcac
     2821 cctttatccc tgagagacgt cgaaggcccc ttctgcctga tggcacattc agctcctgta
     2881 agaagcgctg gataaaacaa gccttagaag aagggatgac tcaaacatca tctgtacccc
     2941 aagagactag aactcagcac ctataccaaa gcaatgagaa tagtagctct tctagtatct
     3001 gcaaagacaa tgcagacttg ttgagcccat taaagaaatg gaagtctcgc tatctgatgg
     3061 agcagaatgt caccaagtta cttcggcctc tgtctccagt cacaccaccc cctcccaatt
     3121 caggctcaaa gagtccccag ctggccacac ctggctcatc tcacccagga gaagaggagt
     3181 gtcgaaatgg atacagcctc atgttttcac cagtcacatc tcttactact gctagtcgct
     3241 gcaacactcc tctacagttt gagctttgtc accgaaaaga cctggatttg gcaaaagtag
     3301 gataccttga ctccaacact aacagctgtg ctgatagacc ttccctactc aactcaggtc
     3361 attctgacct ggctcctcat ccctccctcg gacccacttc tgagactggt ttcccaagca
     3421 gaagtggaga tggacatcag accctcgtga gaaactcaga ccaggcattt cggacagagt
     3481 tcaacttgat gtatgcctac tcccctttga atgctatgcc tcgagcagat ggactgtatc
     3541 gaggatctcc tctagtgggg gataggaagc ctttacattt ggatggggga tattgttccc
     3601 ctgcagaagg attttccagc agatatgaac atggcttaat gaaagacctc tctcgtggat
     3661 ccttgtcacc tggtggtgaa agggcctgtg aaggagtccc atctgccccc cagaacccac
     3721 cacagaggaa aaaagtatcc ctgctggagt accgaaaacg gaaacaagaa gctaaggaaa
     3781 attctgctgg tgggggaggt gactctgcac agagcaaaag caagtctgca ggagctgggc
     3841 aaggcagcag taactccgtt tccgacactg gtgcccatgg tgtgcaggga tcctcagccc
     3901 gaactccatc ttcccctcac aaaaaattct ccccatctca ttcctctatg tcccatttgg
     3961 aggcggtaag cccatcagat tccagaggca cttcttcatc tcactgcaga cctcaagaga
     4021 atatcagcag taggtggatg gttcccacat cagtagaacg actccgagaa ggagggagca
     4081 tccccaaggt cctccgaagc agcgtgaggg tggcccaaaa gggagagccc tctcccacat
     4141 gggagagtaa catcacagag aaagactcag accctgcaga tggagaaggc ccagagacat
     4201 taagctcagc actctctaaa ggagcaacag tttacagccc ttccagatac agctaccagc
     4261 tcctgcagtg tgatagtcct cggacagaat cacaaagcct ccttcagcag agttcctccc
     4321 ccttcagagg acatcctaca cagtctccag gatacagtta tcgaactact gcactgagac
     4381 ctggaaaccc cccctctcac ggttcttcag aatcatccct ctcttccacg tcctattcca
     4441 gccccgccca ccctgtgtcc acagactcgt tggccccatt tacggggaca ccagggtatt
     4501 ttagcagcca gccacattct ggaaacagca ctggcagcaa tcttccaagg aggagctgcc
     4561 cttctagtgc tgctagccct accctgcagg gaccctcaga ctcgccaacc tcagattcag
     4621 tttctcagtc cagcacagga actctgagtt ccacctcctt tcctcagaac tctaggtcgt
     4681 cattgccatc agacttacgg actatcagtc tgcccagtgc tgggcagtca gctgtctacc
     4741 aggcctccag ggtatctgcg gtttccaatt cacagcacta cccacaccgt gggagtgggg
     4801 gtgtgcacca gtaccgactc cagccactgc aagggtcagg agtcaagact cagacgggac
     4861 tttcctaggg cttctggatt tgggcaaaca gaactgaatg agcccatagc tgcttccttc
     4921 cagctgcctc tggaacctag gccgagcata ttgctgagga acggggggta caaggtgcca
     4981 gaggattggg tctggtggac aagaaacaag acttgtggtc acaattggcc tctggccttg
     5041 gagaaagctg taaatcttgt ctgaagcaga gactataaag aagtttctcc ctgctgtcaa
     5101 gggtacattg ttgacaagca aatggtgttt cggttagtaa cggttctaag tgcaatgagt
     5161 tgtgttgaag cctccgtctc ccatccttgc ctgtagcccg tagtcacttg tgcagtgagg
     5221 acatcttttt aaatttaaaa aaaaaaaaaa aaaaagtttt caaaggaaaa aaagttaaaa
     5281 gagccaatct caaagcccca agccatctga gtactgttag ggttttatgc acttaagaaa
     5341 aaaggtaggt atgtaaatgt tcatcctaag acaaccattc caaaagcagg tatctggcca
     5401 atgtgtgtcc accaagaata ctgtttatct ttgtcttaag atcaccaaga aataggcaag
     5461 gatagtaaag cttggaacct gcaccaactg gagggtgcct ggctctttga agaaaagctc
     5521 atggtcagct cttgattatt cgggagcaga ttatttgagt agattgtctg agcctccaac
     5581 tgttaccatc ctactccccc ttcccaagct atttcacagc tcagtaaccc atgaagtaag
     5641 tagacaagaa aaggaggaat gagacatgat ataggccaat tgcattgcta cttaccagct
     5701 tttggcaata aatttcatta ggaaggatac cgagtggttt gggaatgctt cgaattttat
     5761 tttttctact cccaattaat caggagttga tgatcccatg agcaggaccg cctccatgat
     5821 tggggagcat gcacttgtga ctgcagggta agagtgggaa gataggtttg tggagtggca
     5881 ccgacaggac tgtgattgtg tgtgggcctg ccccacattt ctctggggga tgcttatgtg
     5941 agagtgggcc cagtgaaaga gttaccaagc cacccacacc cctaacactg ttctggatga
     6001 gagatgagag cagaccggct tctccccatc agtgcattgt gcctgttgta cacccctgga
     6061 ggagccctgg agccagccca ggtggggtac acaatctttt taaattccat atggttgcca
     6121 gcttatttct ttcacttgtt tactgtaata tctggcgtgt ttttatttat ctaattttgt
     6181 attcagttat aaccatggta ggggtagtga atatatgaca ggtgtaatcc ctggtgctgc
     6241 agtggacctt cttttctttt ggacaagata atactgtgag tttccctcct tccttccctc
     6301 taatttgttt tccttttttc cccagcctct tgcatcccct tcttttctac cctgtcctac
     6361 aactatcata tgcacagtct tctctctttg tgtgtgactg ttacaaaatt tcacttttca
     6421 aaatcgaaat caggtgtttg ctcaaatgag gggagatttt tttttttttt ttttttttaa
     6481 atgctgagac ctcagcagag tacttttctt tttgttgttt cccccacaaa cccatcagtc
     6541 tgggagagca ttgggagtgg aaatcatgtt gcctgggatg ctggtttctt tgtatattat
     6601 ataaaacgta tgtaaatgtc tctccatttg ggctggggtt tgcattctcc ccttggctat
     6661 ttaaccaagg ggagaggcca gcgggcaggc ggccctcacc ctgcctggca cgtgcagaga
     6721 ccccagccac tctgtgtggg cagggtgctg tcaagaccag acctcttggg ggggtagggg
     6781 cgggggggtg gggggaactc ttggaaggga agaagtatca cttctttctc aagtggagtg
     6841 tttacacctt gctgtaacat ttgaactttc acaagagatg taataatttt gataataaaa
     6901 ttcttaacca taataatcat aaagttgaga a
//
