LOCUS       NM_032233               2856 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens SET domain containing 3, actin N3(tau)-histidine
            methyltransferase (SETD3), transcript variant 1, mRNA.
ACCESSION   NM_032233
VERSION     NM_032233.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2856)
  AUTHORS   Gao,R., Yang,H. and Wang,Y.
  TITLE     SETD3 functions beyond histidine methylation
  JOURNAL   Life Sci 357, 123064 (2024)
   PUBMED   39299385
  REMARK    GeneRIF: SETD3 functions beyond histidine methylation.
            Review article
REFERENCE   2  (bases 1 to 2856)
  AUTHORS   Maas,M.N., Bilgin,N., Moesgaard,L., Hintzen,J.C.J., Drozak,A.,
            Drozak,J., Kongsted,J. and Mecinovic,J.
  TITLE     Examining prestructured beta-actin peptides as substrates of
            histidine methyltransferase SETD3
  JOURNAL   Sci Rep 14 (1), 26439 (2024)
   PUBMED   39488591
  REMARK    GeneRIF: Examining prestructured beta-actin peptides as substrates
            of histidine methyltransferase SETD3.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2856)
  AUTHORS   Gao,X., Wang,B., Zhu,K., Wang,L., Qin,B., Shang,K., Ding,W.,
            Wang,J. and Cui,S.
  TITLE     The EV71 2A protease occupies the central cleft of SETD3 and
            disrupts SETD3-actin interaction
  JOURNAL   Nat Commun 15 (1), 4176 (2024)
   PUBMED   38755176
  REMARK    GeneRIF: The EV71 2A protease occupies the central cleft of SETD3
            and disrupts SETD3-actin interaction.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2856)
  AUTHORS   Al-Fakhar,M.S.Q., Bilgin,N., Moesgaard,L., Witecka,A., Drozak,J.,
            Kongsted,J. and Mecinovic,J.
  TITLE     The Role of Trp79 in beta-Actin on Histidine Methyltransferase
            SETD3 Catalysis
  JOURNAL   Chembiochem 24 (21), e202300490 (2023)
   PUBMED   37581408
  REMARK    GeneRIF: The Role of Trp79 in beta-Actin on Histidine
            Methyltransferase SETD3 Catalysis.
REFERENCE   5  (bases 1 to 2856)
  AUTHORS   Wen,C., Li,Y., Huang,Y., Wang,N., He,S., Bao,M., Zhou,H. and Wu,L.
  TITLE     CircSETD3 mediates acquired resistance to gefitinib in non-small
            lung cancer cells by FXR1/ECT2 pathway
  JOURNAL   Int J Biochem Cell Biol 154, 106344 (2023)
   PUBMED   36503048
  REMARK    GeneRIF: CircSETD3 mediates acquired resistance to gefitinib in
            non-small lung cancer cells by FXR1/ECT2 pathway.
REFERENCE   6  (bases 1 to 2856)
  AUTHORS   Cooper,S.E., Hodimont,E. and Green,C.M.
  TITLE     A fluorescent bimolecular complementation screen reveals MAF1, RNF7
            and SETD3 as PCNA-associated proteins in human cells
  JOURNAL   Cell Cycle 14 (15), 2509-2519 (2015)
   PUBMED   26030842
  REMARK    GeneRIF: MAF1, RNF7 and SETD3 are identified as PCNA-associated
            proteins in human cells and given this interaction with PCNA, Maf1,
            RNF7, and SetD3 are potentially involved in DNA replication, DNA
            repair, or associated processes.
REFERENCE   7  (bases 1 to 2856)
  AUTHORS   Pires-Luis,A.S., Vieira-Coimbra,M., Vieira,F.Q., Costa-Pinheiro,P.,
            Silva-Santos,R., Dias,P.C., Antunes,L., Lobo,F., Oliveira,J.,
            Goncalves,C.S., Costa,B.M., Henrique,R. and Jeronimo,C.
  TITLE     Expression of histone methyltransferases as novel biomarkers for
            renal cell tumor diagnosis and prognostication
  JOURNAL   Epigenetics 10 (11), 1033-1043 (2015)
   PUBMED   26488939
  REMARK    GeneRIF: Results show that high expression levels of SMYD2, SETD3,
            and NO66 in renal cell tumors. Their low expression levels were
            significantly associated with shorter disease-specific and
            disease-free survival.
REFERENCE   8  (bases 1 to 2856)
  AUTHORS   Eom,G.H., Kim,K.B., Kim,J.H., Kim,J.Y., Kim,J.R., Kee,H.J.,
            Kim,D.W., Choe,N., Park,H.J., Son,H.J., Choi,S.Y., Kook,H. and
            Seo,S.B.
  TITLE     Histone methyltransferase SETD3 regulates muscle differentiation
  JOURNAL   J Biol Chem 286 (40), 34733-34742 (2011)
   PUBMED   21832073
REFERENCE   9  (bases 1 to 2856)
  AUTHORS   Tao,W.A., Wollscheid,B., O'Brien,R., Eng,J.K., Li,X.J.,
            Bodenmiller,B., Watts,J.D., Hood,L. and Aebersold,R.
  TITLE     Quantitative phosphoproteome analysis using a dendrimer conjugation
            chemistry and tandem mass spectrometry
  JOURNAL   Nat Methods 2 (8), 591-598 (2005)
   PUBMED   16094384
REFERENCE   10 (bases 1 to 2856)
  AUTHORS   Harrington,J.J., Sherf,B., Rundlett,S., Jackson,P.D., Perry,R.,
            Cain,S., Leventhal,C., Thornton,M., Ramachandran,R.,
            Whittington,J., Lerner,L., Costanzo,D., McElligott,K., Boozer,S.,
            Mays,R., Smith,E., Veloso,N., Klika,A., Hess,J., Cothren,K., Lo,K.,
            Offenbacher,J., Danzig,J. and Ducar,M.
  TITLE     Creation of genome-wide protein expression libraries using random
            activation of gene expression
  JOURNAL   Nat Biotechnol 19 (5), 440-445 (2001)
   PUBMED   11329013
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            CB988965.1, BX161471.1, AK026680.1 and BC037395.1.
            
            On Nov 23, 2018 this sequence version replaced NM_032233.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC142995.1, BX161471.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000331768.10/ ENSP00000327436.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-558               CB988965.1         58-615
            559-2042            BX161471.1         579-2062
            2043-2562           AK026680.1         1827-2346
            2563-2856           BC037395.1         2552-2845
FEATURES             Location/Qualifiers
     source          1..2856
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.2"
     gene            1..2856
                     /gene="SETD3"
                     /gene_synonym="C14orf154; hSETD3"
                     /note="SET domain containing 3, actin N3(tau)-histidine
                     methyltransferase"
                     /db_xref="GeneID:84193"
                     /db_xref="HGNC:HGNC:20493"
                     /db_xref="MIM:615671"
     exon            1..132
                     /gene="SETD3"
                     /gene_synonym="C14orf154; hSETD3"
                     /inference="alignment:Splign:2.1.0"
     exon            133..243
                     /gene="SETD3"
                     /gene_synonym="C14orf154; hSETD3"
                     /inference="alignment:Splign:2.1.0"
     CDS             141..1925
                     /gene="SETD3"
                     /gene_synonym="C14orf154; hSETD3"
                     /EC_number="2.1.1.85"
                     /note="isoform a is encoded by transcript variant 1; SET
                     domain-containing protein 3; histone-lysine
                     N-methyltransferase setd3; actin-histidine
                     N-methyltransferase; protein-L-histidine
                     N-tele-methyltransferase; SET domain containing 3, actin
                     histidine methyltransferase"
                     /codon_start=1
                     /product="actin-histidine N-methyltransferase isoform a"
                     /protein_id="NP_115609.2"
                     /db_xref="CCDS:CCDS9951.1"
                     /db_xref="GeneID:84193"
                     /db_xref="HGNC:HGNC:20493"
                     /db_xref="MIM:615671"
                     /translation="MGKKSRVKTQKSGTGATATVSPKEILNLTSELLQKCSSPAPGPG
                     KEWEEYVQIRTLVEKIRKKQKGLSVTFDGKREDYFPDLMKWASENGASVEGFEMVNFK
                     EEGFGLRATRDIKAEELFLWVPRKLLMTVESAKNSVLGPLYSQDRILQAMGNIALAFH
                     LLCERASPNSFWQPYIQTLPSEYDTPLYFEEDEVRYLQSTQAIHDVFSQYKNTARQYA
                     YFYKVIQTHPHANKLPLKDSFTYEDYRWAVSSVMTRQNQIPTEDGSRVTLALIPLWDM
                     CNHTNGLITTGYNLEDDRCECVALQDFRAGEQIYIFYGTRSNAEFVIHSGFFFDNNSH
                     DRVKIKLGVSKSDRLYAMKAEVLARAGIPTSSVFALHFTEPPISAQLLAFLRVFCMTE
                     EELKEHLLGDSAIDRIFTLGNSEFPVSWDNEVKLWTFLEDRASLLLKTYKTTIEEDKS
                     VLKNHDLSVRAKMAIKLRLGEKEILEKAVKSAAVNREYYRQQMEEKAPLPKYEESNLG
                     LLESSVGDSRLPLVLRNLEEEAGVQDALNIREAISKAKATENGLVNGENSIPNGTRSE
                     NESLNQESKRAVEDAKGSSSDSTAGVKE"
     exon            244..336
                     /gene="SETD3"
                     /gene_synonym="C14orf154; hSETD3"
                     /inference="alignment:Splign:2.1.0"
     exon            337..485
                     /gene="SETD3"
                     /gene_synonym="C14orf154; hSETD3"
                     /inference="alignment:Splign:2.1.0"
     exon            486..558
                     /gene="SETD3"
                     /gene_synonym="C14orf154; hSETD3"
                     /inference="alignment:Splign:2.1.0"
     exon            559..815
                     /gene="SETD3"
                     /gene_synonym="C14orf154; hSETD3"
                     /inference="alignment:Splign:2.1.0"
     exon            816..874
                     /gene="SETD3"
                     /gene_synonym="C14orf154; hSETD3"
                     /inference="alignment:Splign:2.1.0"
     exon            875..989
                     /gene="SETD3"
                     /gene_synonym="C14orf154; hSETD3"
                     /inference="alignment:Splign:2.1.0"
     exon            990..1064
                     /gene="SETD3"
                     /gene_synonym="C14orf154; hSETD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1231
                     /gene="SETD3"
                     /gene_synonym="C14orf154; hSETD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1317
                     /gene="SETD3"
                     /gene_synonym="C14orf154; hSETD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1318..1478
                     /gene="SETD3"
                     /gene_synonym="C14orf154; hSETD3"
                     /inference="alignment:Splign:2.1.0"
     exon            1479..2856
                     /gene="SETD3"
                     /gene_synonym="C14orf154; hSETD3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2840..2845
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SETD3"
                     /gene_synonym="C14orf154; hSETD3"
                     /note="hexamer: AAGAAA"
     polyA_site      2856
                     /gene="SETD3"
                     /gene_synonym="C14orf154; hSETD3"
                     /note="major polyA site"
ORIGIN      
        1 aggctgccgt cccgcccctc ccgtccggcc gccgccgccg ccaccgccgc caccgcctgg
       61 gggttggttg aggcggacgg cggggtccgg gccggagtac gtcgttcccg ctgcgctagg
      121 ggaagcgggc agtcagaaaa atgggtaaga agagtcgagt aaaaactcag aaatctggca
      181 ctggtgctac agcaactgtg tcaccaaagg aaatcttgaa cctgaccagt gagctgctgc
      241 agaaatgcag cagtccggcg cctggcccag gaaaagagtg ggaagagtat gtgcagatcc
      301 ggactctggt tgagaaaata cggaaaaagc aaaaaggtct gtccgttact tttgatggaa
      361 aaagagaaga ttactttcct gatctaatga aatgggcctc tgaaaatggg gcttctgtcg
      421 agggttttga aatggttaac ttcaaagaag agggctttgg tttgagagca acaagagata
      481 tcaaggcaga agaattgttt ttatgggttc cacgaaaatt gctaatgact gttgaatctg
      541 ctaaaaattc agtgttgggg cccttatatt ctcaagaccg aatccttcaa gccatgggaa
      601 acatcgcact ggcctttcat ttgctgtgtg agcgagccag ccctaactcc ttctggcagc
      661 cctatattca aaccctcccc agtgaatatg acactcctct ctactttgaa gaagatgaag
      721 ttcggtatct tcagtccaca caagctatac atgatgtctt cagccagtat aaaaacacag
      781 ctcgacagta cgcctacttc tataaagtca tccagaccca tcctcatgcc aacaaactac
      841 ccttgaagga ttctttcact tacgaggact acaggtgggc agtctcttct gttatgacga
      901 ggcaaaacca aattcccaca gaggatggtt cccgcgtgac cctggctctg attcctttat
      961 gggatatgtg taaccacacc aacggcctga tcactactgg ttacaacctg gaagatgacc
     1021 gctgtgagtg tgtggctctg caggattttc gggctggaga gcagatttac attttttatg
     1081 gcactcgatc caacgcagag tttgtgatcc acagtggttt tttctttgac aataactcac
     1141 acgacagagt gaaaataaag cttggagtga gtaaaagtga cagactctac gccatgaagg
     1201 ccgaggtctt ggctcgtgcc ggcatcccca cttccagtgt ttttgcattg cattttaccg
     1261 agccgcccat ctctgctcag cttttggctt ttctccgagt attctgtatg actgaagaag
     1321 aactgaaaga acacttgctg ggagacagcg ctattgatag aatcttcacc ttggggaact
     1381 cggaatttcc tgttagctgg gacaacgagg tcaaactttg gacatttctt gaagatagag
     1441 cctcacttct tttaaaaaca tataaaacaa ctattgagga agataaatcc gtcttgaaaa
     1501 accacgatct ttctgttcgt gcaaaaatgg ccatcaaatt gcgcttaggt gagaaagaga
     1561 ttttggaaaa agcagtaaag agtgcagctg tcaaccggga atactatcgc caacagatgg
     1621 aggaaaaggc tccgcttccc aaatatgaag agagtaacct tgggctgttg gagagcagcg
     1681 tgggggactc gaggctcccc ctggtcttga gaaacctcga ggaggaggct ggagtgcagg
     1741 atgccttgaa catcagagag gcaatcagca aagcaaaggc cacagaaaac gggcttgtaa
     1801 acggtgaaaa ctctatccct aatgggacca ggtccgaaaa tgaaagtctc aatcaagaaa
     1861 gtaaaagagc agttgaagac gccaaaggat cttcttcaga cagcactgct ggagttaagg
     1921 agtagctcga ggtgaagctg gatgggggat ccagtggagc aggagttgac ggacagtccg
     1981 ttcacatcgc tgtgtttcct tgttaacatt tttctttctg cagagaggaa gatatgtttt
     2041 tgctgcttta tataaaaatg gtttttttaa gttattttaa aaatctagct tccctttttg
     2101 attaagattg ccatcttgct tttaggcaaa acaaaccaat taacaaacaa ccacaagaaa
     2161 gggagaagag gtgcctgtgg gagattttgc agacctattg tgggtatagg tattttcttc
     2221 ctggggaaga attcagttcc cgtctcagct gtacttttgt gggcctgtca tcttgatgac
     2281 cagaatgaaa gcttgctctg cctcctgcca gccagaattg gtggcgggac ttggggatac
     2341 agcgtgaagg tggggaagtt gcacagcaga aaacagaatt gaagttggga aactctagag
     2401 tctgggcaaa atgtttggtt ttttctctta aaaaaaataa caccccatta ccaaaagaaa
     2461 aggtaaggtg gcaaccttat ttttaatagt ttgaaatgat gataatccta attatataaa
     2521 aatatatata taaacacaca tatatatagt gatttctaaa gatttgttta cttttgtgtt
     2581 ttgttttact gtactaagaa cttgtccttt ctccttgaat caaagtagga catgcatcat
     2641 cctcctaatt ttaaatgttg gctctgattt taaagtggtg catttgattc cagccttggt
     2701 aatggagagt ttgcaaacac acagcggccc acagcttcac gtggtggtgt gcagtgtgag
     2761 gcagctcctt ggctttcctg gttttcacaa caagctagag attttcaaag ctacactttt
     2821 gagtaaaaac ccttattaaa agaaaaacat gattaa
//
