LOCUS       NM_001353345            8557 bp    mRNA    linear   PRI 12-OCT-2024
DEFINITION  Homo sapiens SET domain containing 1B, histone lysine
            methyltransferase (SETD1B), mRNA.
ACCESSION   NM_001353345 XM_005253858
VERSION     NM_001353345.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 8557)
  AUTHORS   Portelinha,A., Wang,S., Parsa,S., Jiang,M., Gorelick,A.N.,
            Mohanty,S., Sharma,S., de Stanchina,E., Berishaj,M., Zhao,C.,
            Heward,J., Aryal,N.K., Tavana,O., Wen,J., Fitzgibbon,J., Dogan,A.,
            Younes,A., Melnick,A.M. and Wendel,H.G.
  TITLE     SETD1B mutations confer apoptosis resistance and BCL2 independence
            in B cell lymphoma
  JOURNAL   J Exp Med 221 (10) (2024)
   PUBMED   39235528
  REMARK    GeneRIF: SETD1B mutations confer apoptosis resistance and BCL2
            independence in B cell lymphoma.
REFERENCE   2  (bases 1 to 8557)
  AUTHORS   Tiwari,R., Viswanathan,L.G., Chowdary,R.M., Kenchaiah,R.,
            Asranna,A. and Sinha,S.
  TITLE     Phenotypic spectrum of SETD1B-related disorder: Myoclonic absence
            seizures and concurrent intellectual disability - Insights from two
            cases
  JOURNAL   Seizure 114, 57-60 (2024)
   PUBMED   38048716
  REMARK    GeneRIF: Phenotypic spectrum of SETD1B-related disorder: Myoclonic
            absence seizures and concurrent intellectual disability - Insights
            from two cases.
REFERENCE   3  (bases 1 to 8557)
  AUTHORS   Amin,H.M., Szabo,B., Abukhairan,R., Zeke,A., Kardos,J., Schad,E.
            and Tantos,A.
  TITLE     In Vivo and In Vitro Characterization of the RNA Binding Capacity
            of SETD1A (KMT2F)
  JOURNAL   Int J Mol Sci 24 (22), 16032 (2023)
   PUBMED   38003223
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 8557)
  AUTHORS   Bao,S. and Xu,C.
  TITLE     Molecular insight into the SETD1A/B N-terminal region and its
            interaction with WDR82
  JOURNAL   Biochem Biophys Res Commun 658, 136-140 (2023)
   PUBMED   37030068
  REMARK    GeneRIF: Molecular insight into the SETD1A/B N-terminal region and
            its interaction with WDR82.
REFERENCE   5  (bases 1 to 8557)
  AUTHORS   Weerts,M.J.A., Lanko,K., Guzman-Vega,F.J., Jackson,A.,
            Ramakrishnan,R., Cardona-Londono,K.J., Pena-Guerra,K.A., van
            Bever,Y., van Paassen,B.W., Kievit,A., van Slegtenhorst,M.,
            Allen,N.M., Kehoe,C.M., Robinson,H.K., Pang,L., Banu,S.H.,
            Zaman,M., Efthymiou,S., Houlden,H., Jarvela,I., Lauronen,L.,
            Maatta,T., Schrauwen,I., Leal,S.M., Ruivenkamp,C.A.L.,
            Barge-Schaapveld,D.Q.C.M., Peeters-Scholte,C.M.P.C.D.,
            Galehdari,H., Mazaheri,N., Sisodiya,S.M., Harrison,V., Sun,A.,
            Thies,J., Pedroza,L.A., Lara-Taranchenko,Y., Chinn,I.K.,
            Lupski,J.R., Garza-Flores,A., McGlothlin,J., Yang,L., Huang,S.,
            Wang,X., Jewett,T., Rosso,G., Lin,X., Mohammed,S., Merritt,J.L.
            2nd, Mirzaa,G.M., Timms,A.E., Scheck,J., Elting,M.W., Polstra,A.M.,
            Schenck,L., Ruzhnikov,M.R.Z., Vetro,A., Montomoli,M., Guerrini,R.,
            Koboldt,D.C., Mosher,T.M., Pastore,M.T., McBride,K.L., Peng,J.,
            Pan,Z., Willemsen,M., Koning,S., Turnpenny,P.D., de Vries,B.B.A.,
            Gilissen,C., Pfundt,R., Lees,M., Braddock,S.R., Klemp,K.C.,
            Vansenne,F., van Gijn,M.E., Quindipan,C., Deardorff,M.A.,
            Hamm,J.A., Putnam,A.M., Baud,R., Walsh,L., Lynch,S.A., Baptista,J.,
            Person,R.E., Monaghan,K.G., Crunk,A., Keller-Ramey,J., Reich,A.,
            Elloumi,H.Z., Alders,M., Kerkhof,J., McConkey,H., Haghshenas,S.,
            Maroofian,R., Sadikovic,B., Banka,S., Arold,S.T. and Barakat,T.S.
  CONSRTM   Genomics England Research Consortium
  TITLE     Delineating the molecular and phenotypic spectrum of the
            SETD1B-related syndrome
  JOURNAL   Genet Med 23 (11), 2122-2137 (2021)
   PUBMED   34345025
  REMARK    GeneRIF: Delineating the molecular and phenotypic spectrum of the
            SETD1B-related syndrome.
REFERENCE   6  (bases 1 to 8557)
  AUTHORS   Zhang,P., Lee,H., Brunzelle,J.S. and Couture,J.F.
  TITLE     The plasticity of WDR5 peptide-binding cleft enables the binding of
            the SET1 family of histone methyltransferases
  JOURNAL   Nucleic Acids Res 40 (9), 4237-4246 (2012)
   PUBMED   22266653
REFERENCE   7  (bases 1 to 8557)
  AUTHORS   Wu,M., Wang,P.F., Lee,J.S., Martin-Brown,S., Florens,L.,
            Washburn,M. and Shilatifard,A.
  TITLE     Molecular regulation of H3K4 trimethylation by Wdr82, a component
            of human Set1/COMPASS
  JOURNAL   Mol Cell Biol 28 (24), 7337-7344 (2008)
   PUBMED   18838538
REFERENCE   8  (bases 1 to 8557)
  AUTHORS   Lee,J.H. and Skalnik,D.G.
  TITLE     Wdr82 is a C-terminal domain-binding protein that recruits the
            Setd1A Histone H3-Lys4 methyltransferase complex to transcription
            start sites of transcribed human genes
  JOURNAL   Mol Cell Biol 28 (2), 609-618 (2008)
   PUBMED   17998332
REFERENCE   9  (bases 1 to 8557)
  AUTHORS   Lee,J.H., Tate,C.M., You,J.S. and Skalnik,D.G.
  TITLE     Identification and characterization of the human Set1B histone
            H3-Lys4 methyltransferase complex
  JOURNAL   J Biol Chem 282 (18), 13419-13428 (2007)
   PUBMED   17355966
REFERENCE   10 (bases 1 to 8557)
  AUTHORS   Roston,A. and Gibson,W.
  TITLE     SETD1B-Related Neurodevelopmental Disorder
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   36173874
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC084018.28 and AC079360.28.
            
            On or before Apr 2, 2020 this sequence version replaced
            XM_005253858.4, NM_001353345.1.
            
            Summary: SET1B is a component of a histone methyltransferase
            complex that produces trimethylated histone H3 at Lys4 (Lee et al.,
            2007 [PubMed 17355966]).[supplied by OMIM, Mar 2008].
            
            Sequence Note:.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038191.277522.1,
                                           SRR14038192.3135162.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000604567.6/ ENSP00000474253.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-225               AC084018.28        147179-147403
            226-413             AC084018.28        147894-148081
            414-512             AC084018.28        148288-148386
            513-783             AC084018.28        149005-149275
            784-896             AC084018.28        151378-151490
            897-2129            AC084018.28        152773-154005
            2130-2954           AC084018.28        157276-158100
            2955-3216           AC084018.28        160203-160464
            3217-3551           AC084018.28        160540-160874
            3552-3657           AC084018.28        160969-161074
            3658-4149           AC084018.28        162574-163065
            4150-5409           AC084018.28        165660-166919
            5410-5576           AC084018.28        168370-168536
            5577-5708           AC084018.28        170689-170820
            5709-5828           AC084018.28        170905-171024
            5829-5966           AC084018.28        171103-171240
            5967-8485           AC084018.28        173236-175754
            8486-8557           AC079360.28        2001-2072
FEATURES             Location/Qualifiers
     source          1..8557
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q24.31"
     gene            1..8557
                     /gene="SETD1B"
                     /gene_synonym="IDDSELD; KMT2G; Set1B"
                     /note="SET domain containing 1B, histone lysine
                     methyltransferase"
                     /db_xref="GeneID:23067"
                     /db_xref="HGNC:HGNC:29187"
                     /db_xref="MIM:611055"
     exon            1..225
                     /gene="SETD1B"
                     /gene_synonym="IDDSELD; KMT2G; Set1B"
                     /inference="alignment:Splign:2.1.0"
     exon            226..413
                     /gene="SETD1B"
                     /gene_synonym="IDDSELD; KMT2G; Set1B"
                     /inference="alignment:Splign:2.1.0"
     CDS             240..6140
                     /gene="SETD1B"
                     /gene_synonym="IDDSELD; KMT2G; Set1B"
                     /EC_number="2.1.1.364"
                     /note="lysine N-methyltransferase 2G; SET
                     domain-containing protein 1B"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase SETD1B"
                     /protein_id="NP_001340274.1"
                     /db_xref="CCDS:CCDS86338.1"
                     /db_xref="GeneID:23067"
                     /db_xref="HGNC:HGNC:29187"
                     /db_xref="MIM:611055"
                     /translation="MENSHPPHHHHQQPPPQPGPSGERRNHHWRSYKLMIDPALKKGH
                     HKLYRYDGQHFSLAMSSNRPVEIVEDPRVVGIWTKNKELELSVPKFKIDEFYVGPVPP
                     KQVTFAKLNDNIRENFLRDMCKKYGEVEEVEILYNPKTKKHLGIAKVVFATVRGAKDA
                     VQHLHSTSVMGNIIHVELDTKGETRMRFYELLVTGRYTPQTLPVGELDAVSPIVNETL
                     QLSDALKRLKDGGLSAGCGSGSSSVTPNSGGTPFSQDTAYSSCRLDTPNSYGQGTPLT
                     PRLGTPFSQDSSYSSRQPTPSYLFSQDPAVTFKARRHESKFTDAYNRRHEHHYVHNSP
                     AVTAVAGATAAFRGSSDLPFGAVGGTGGSSGPPFKAQPQDSATFAHTPPPAQATPAPG
                     FKSAFSPYQTPVAHFPPPPEEPTATAAFGARDSGEFRRAPAPPPLPPAEPLAKEKPGT
                     PPGPPPPDTNSMELGGRPTFGWSPEPCDSPGTPTLESSPAGPEKPHDSLDSRIEMLLK
                     EQRTKLLFLREPDSDTELQMEGSPISSSSSQLSPLAPFGTNSQPGFRGPTPPSSRPSS
                     TGLEDISPTPLPDSDEDEELDLGLGPRPPPEPGPPDPAGLLSQTAEVALDLVGDRTPT
                     SEKMDEGQQSSGEDMEISDDEMPSAPITSADCPKPMVVTPGAAAVAAPSVLAPTLPLP
                     PPPGFPPLPPPPPPPPPQPGFPMPPPLPPPPPPPPPAHPAVTVPPPPLPAPPGVPPPP
                     ILPPLPPFPPGLFPVMQVDMSHVLGGQWGGMPMSFQMQTQVLSRLMTGQGACPYPPFM
                     AAAAAAASAGLQFVNLPPYRGPFSLSNSGPGRGQHWPPLPKFDPSVPPPGYMPRQEDP
                     HKATVDGVLLVVLKELKAIMKRDLNRKMVEVVAFRAFDEWWDKKERMAKASLTPVKSG
                     EHKDEDRPKPKDRIASCLLESWGKGEGLGYEGLGLGIGLRGAIRLPSFKVKRKEPPDT
                     TSSGDQKRLRPSTSVDEEDEESERERDRDMADTPCELAKRDPKGVGVRRRPARPLELD
                     SGGEEDEKESLSASSSSSASSSSGSSTTSPSSSASDKEEEQESTEEEEEAEEEEEEEV
                     PRSQLSSSSTSSTSDKDDDDDDSDDRDESENDDEDTALSEASEKDEGDSDEEETVSIV
                     TSKAEATSSSESSESSEFESSSESSPSSSEDEEEVVAREEEEEEEEEEMVAEESMASA
                     GPEDFEQDGEEAALAPGAPAVDSLGMEEEVDIETEAVAPEERPSMLDEPPLPVGVEEP
                     ADSREPPEEPGLSQEGAMLLSPEPPAKEVEARPPLSPERAPEHDLEVEPEPPMMLPLP
                     LQPPLPPPRPPRPPSPPPEPETTDASHPSVPPEPLAEDHPPHTPGLCGSLAKSQSTET
                     VPATPGGEPPLSGGSSGLSLSSPQVPGSPFSYPAPSPSLSSGGLPRTPGRDFSFTPTF
                     SEPSGPLLLPVCPLPTGRRDERSGPLASPVLLETGLPLPLPLPLPLPLALPAVLRAQA
                     RAPTPLPPLLPAPLASCPPPMKRKPGRPRRSPPSMLSLDGPLVRPPAGAALGRELLLL
                     PGQPQTPVFPSTHDPRTVTLDFRNAGIPAPPPPLPPQPPPPPPPPPVEPTKLPFKELD
                     NQWPSEAIPPGPRGRDEVTEEYMELAKSRGPWRRPPKKRHEDLVPPAGSPELSPPQPL
                     FRPRSEFEEMTILYDIWNGGIDEEDIRFLCVTYERLLQQDNGMDWLNDTLWVYHPSTS
                     LSSAKKKKRDDGIREHVTGCARSEGFYTIDKKDKLRYLNSSRASTDEPPADTQGMSIP
                     AQPHASTRAGSERRSEQRRLLSSFTGSCDSDLLKFNQLKFRKKKLKFCKSHIHDWGLF
                     AMEPIAADEMVIEYVGQNIRQVIADMREKRYEDEGIGSSYMFRVDHDTIIDATKCGNF
                     ARFINHSCNPNCYAKVITVESQKKIVIYSKQHINVNEEITYDYKFPIEDVKIPCLCGS
                     ENCRGTLN"
     exon            414..512
                     /gene="SETD1B"
                     /gene_synonym="IDDSELD; KMT2G; Set1B"
                     /inference="alignment:Splign:2.1.0"
     exon            513..783
                     /gene="SETD1B"
                     /gene_synonym="IDDSELD; KMT2G; Set1B"
                     /inference="alignment:Splign:2.1.0"
     exon            784..896
                     /gene="SETD1B"
                     /gene_synonym="IDDSELD; KMT2G; Set1B"
                     /inference="alignment:Splign:2.1.0"
     exon            897..2129
                     /gene="SETD1B"
                     /gene_synonym="IDDSELD; KMT2G; Set1B"
                     /inference="alignment:Splign:2.1.0"
     exon            2130..2954
                     /gene="SETD1B"
                     /gene_synonym="IDDSELD; KMT2G; Set1B"
                     /inference="alignment:Splign:2.1.0"
     exon            2955..3216
                     /gene="SETD1B"
                     /gene_synonym="IDDSELD; KMT2G; Set1B"
                     /inference="alignment:Splign:2.1.0"
     exon            3217..3551
                     /gene="SETD1B"
                     /gene_synonym="IDDSELD; KMT2G; Set1B"
                     /inference="alignment:Splign:2.1.0"
     exon            3552..3657
                     /gene="SETD1B"
                     /gene_synonym="IDDSELD; KMT2G; Set1B"
                     /inference="alignment:Splign:2.1.0"
     exon            3658..4149
                     /gene="SETD1B"
                     /gene_synonym="IDDSELD; KMT2G; Set1B"
                     /inference="alignment:Splign:2.1.0"
     exon            4150..5409
                     /gene="SETD1B"
                     /gene_synonym="IDDSELD; KMT2G; Set1B"
                     /inference="alignment:Splign:2.1.0"
     exon            5410..5576
                     /gene="SETD1B"
                     /gene_synonym="IDDSELD; KMT2G; Set1B"
                     /inference="alignment:Splign:2.1.0"
     exon            5577..5708
                     /gene="SETD1B"
                     /gene_synonym="IDDSELD; KMT2G; Set1B"
                     /inference="alignment:Splign:2.1.0"
     exon            5709..5828
                     /gene="SETD1B"
                     /gene_synonym="IDDSELD; KMT2G; Set1B"
                     /inference="alignment:Splign:2.1.0"
     exon            5829..5966
                     /gene="SETD1B"
                     /gene_synonym="IDDSELD; KMT2G; Set1B"
                     /inference="alignment:Splign:2.1.0"
     exon            5967..8557
                     /gene="SETD1B"
                     /gene_synonym="IDDSELD; KMT2G; Set1B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      8505..8510
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SETD1B"
                     /gene_synonym="IDDSELD; KMT2G; Set1B"
                     /note="hexamer: ATTATA"
     regulatory      8519..8524
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SETD1B"
                     /gene_synonym="IDDSELD; KMT2G; Set1B"
                     /note="hexamer: TATAAA"
     polyA_site      8529
                     /gene="SETD1B"
                     /gene_synonym="IDDSELD; KMT2G; Set1B"
                     /note="major polyA site"
     regulatory      8535..8540
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SETD1B"
                     /gene_synonym="IDDSELD; KMT2G; Set1B"
                     /note="hexamer: AATATA"
     polyA_site      8540
                     /gene="SETD1B"
                     /gene_synonym="IDDSELD; KMT2G; Set1B"
                     /note="major polyA site"
     polyA_site      8557
                     /gene="SETD1B"
                     /gene_synonym="IDDSELD; KMT2G; Set1B"
                     /note="major polyA site"
ORIGIN      
        1 gtattgtggg atgtgcggct actgggagcc gagcctccgc cgccagccgc ctcccgggca
       61 gcagcagcag cagcggcggc ggcagcggca gcagctccgg gcccggcagc cgcggcggcg
      121 gcgccccccc ttcctggccc ccggtccggc cgccccggcc tcggctccct cgggggacac
      181 catgtactgg ctggcggcgc agggaggccg gcgcccggcg gggatgttgg gttaacggca
      241 tggagaacag tcaccccccc caccaccacc accagcagcc cccgccgcag cccggccctt
      301 cgggcgagag gaggaaccac cattggagaa gttacaagtt gatgattgac ccggctctga
      361 aaaaggggca tcataaactg taccgctacg atgggcagca tttcagcctg gcgatgtcca
      421 gcaaccgccc ggtggaaatt gtcgaagatc cccgggtcgt cgggatctgg accaaaaaca
      481 aggagctgga gctgtcggtg cccaaattca agatcgatga gttctacgtg ggcccggtgc
      541 ctccgaagca ggtgacattt gccaagctga atgataacat ccgtgaaaac ttcctgaggg
      601 acatgtgcaa gaagtatggg gaggtggagg aggtggagat tttgtacaac cccaagacca
      661 agaagcacct gggcatcgcc aaggtggtct ttgccacggt ccggggagcc aaggatgccg
      721 ttcagcactt gcacagcact tccgtcatgg gcaacattat ccacgtggag ctggacacca
      781 aaggggaaac ccgaatgcgg ttctatgaac tgttggtcac tggccgatac accccccaga
      841 ccctcccagt gggcgagctg gacgctgtct ctccaatcgt gaatgagacc ctgcagctgt
      901 cagatgccct gaagcgcctc aaggatggag gcctgtctgc aggctgtggc tccggctcct
      961 cctctgtcac ccccaatagc ggtgggacac ccttctccca ggacacagct tattccagct
     1021 gccgcctgga cacacccaac tcctatggac agggcacccc gctcacaccg cgcctgggca
     1081 cccctttctc acaggactcc agctactcca gccgccagcc cacaccctca tacctcttca
     1141 gccaggaccc tgcagtgacc ttcaaggccc ggcgccacga gagcaagttc acggacgcct
     1201 acaaccgccg ccacgaacat cattatgtac acaattctcc cgcggtcact gcggtggccg
     1261 gggccacagc cgctttccgg ggttcctcgg acctcccgtt cggagcagtc ggcggcactg
     1321 ggggcagcag cggtcccccg ttcaaggctc aaccacagga ttcagccaca tttgcccaca
     1381 ctccaccacc cgcccaagca acccctgctc ctggattcaa gtctgctttc tctccgtatc
     1441 agaccccagt ggcccacttc cctccacccc cggaagagcc caccgccaca gccgcttttg
     1501 gggcccgcga cagtggggag ttccggaggg caccggcgcc cccacccctg ccacctgctg
     1561 agcctctggc caaggagaag ccaggcacgc cacccggccc gccgcccccc gacaccaaca
     1621 gcatggagct gggcggccgg cccaccttcg gctggagtcc tgagccctgt gacagccctg
     1681 gcacgcccac gctggagtcg tcccctgcag ggccagagaa accccacgac agcctggact
     1741 cgcgcatcga gatgctgctg aaggagcagc gcaccaagct gctcttcctg agggagccgg
     1801 actcggacac cgagctgcag atggagggca gccccatctc ctcctcctcc tcccagctct
     1861 ccccactggc cccctttggc accaactccc agccaggctt ccggggcccc acgcccccct
     1921 cgtcacgccc ctccagcacc ggcctggagg atatcagccc aacacccctc ccagactccg
     1981 acgaggacga ggagctcgac ctgggccttg ggcctcggcc tccacctgag ccaggccccc
     2041 cggaccctgc tgggcttctg agccagacag ctgaggtggc cttggacctg gttggagaca
     2101 gaaccccgac ctcagagaag atggatgagg gccagcagtc ctcaggcgag gacatggaga
     2161 tctcggatga cgagatgccc tcggccccca tcaccagcgc tgactgcccc aagcccatgg
     2221 tggtgacccc aggagcggca gccgtggcag ccccttctgt gctagcccca accctgccgc
     2281 tgcccccgcc acctggcttc cccccgctgc cccccccacc accaccaccc ccaccgcagc
     2341 ctggcttccc catgccccca ccgctgcccc caccgccgcc cccaccccct ccagcccacc
     2401 ctgctgtgac agtgccccca ccacccttgc cagcgccgcc tggagtcccg cccccaccca
     2461 tcctgccacc actgcccccc tttccgccgg gcctgttccc tgtgatgcag gtggacatga
     2521 gccacgtgct gggtggccag tggggcggca tgcccatgtc cttccagatg caaacgcagg
     2581 tgctcagccg gctgatgacg ggccagggcg cctgccccta cccgcccttc atggccgctg
     2641 cggccgccgc tgcctcagct gggctccagt ttgtcaacct gccgccctac cggggcccct
     2701 tctccctgag caactccggc ccaggccgcg ggcagcactg gccaccactg cccaagtttg
     2761 acccgtcagt gcctccacca ggctacatgc cacgccagga ggacccacac aaagccacgg
     2821 tggatggcgt cctgctggtg gtcctcaaag aactcaaggc catcatgaag cgtgacctga
     2881 accgcaagat ggtggaagtg gtggctttcc gggcctttga cgagtggtgg gacaagaagg
     2941 agcggatggc caaggcctcg ctgaccccgg tgaagtcggg cgagcacaag gacgaggaca
     3001 ggccgaagcc caaggaccgc atcgcctcgt gcctgctgga gtcatggggc aagggcgagg
     3061 gcctgggcta cgagggcctg ggcctgggca ttgggctgcg tggggccatt cgcctgccct
     3121 ccttcaaggt caagaggaag gagccaccag acaccacctc atctggcgac cagaagcggc
     3181 tgcggccctc gacctctgtg gatgaggaag atgaagagtc cgagcgagag cgagaccggg
     3241 atatggcaga caccccctgt gagctcgcca agcgggaccc caagggcgtg ggtgtgcggc
     3301 ggcggccggc gcggcctctg gagctggaca gtggtgggga ggaggacgag aaggagtcat
     3361 tgtcggcgtc ctcgtcctca tccgcgtcat catcctcggg gtcctcaacc acctcaccct
     3421 cgtcctcggc ctccgacaag gaggaggaac aggagagcac cgaggaggaa gaggaggcgg
     3481 aggaggagga ggaggaggaa gtccccagga gccagctctc ctcctcctca acctcatcca
     3541 catcagataa ggatgacgac gatgacgaca gtgatgaccg ggacgagtct gagaacgatg
     3601 acgaggacac agccctgtca gaggcgagtg agaaggacga aggggactcg gatgaagagg
     3661 agacagtgag cattgtaacc tccaaggccg aagccacgtc gtccagtgag agttccgagt
     3721 cttctgagtt tgagtcaagc tccgagtcct cgccctcatc ctcggaggat gaggaggagg
     3781 tagtggccag ggaagaggag gaagaagagg aggaggagga gatggtggcc gaggaaagca
     3841 tggcttctgc aggccctgag gactttgagc aggacgggga ggaagcggct ctggccccgg
     3901 gggcacctgc agtggactcg ttgggcatgg aagaggaggt ggacatcgag actgaggctg
     3961 tggcccctga ggagcggccc tccatgctgg acgagccccc cttgcctgtg ggtgttgaag
     4021 agccagcgga ctccagggag ccgcctgagg aaccaggcct gagccaggaa ggggccatgt
     4081 tgctgtctcc agagccccct gccaaggagg tggaggctcg acccccattg tcccctgagc
     4141 gagctccaga acatgacctg gaagtggagc cggagccccc tatgatgctc cccttgccgc
     4201 tgcaaccacc attgccgccc ccacgaccac cccggccacc cagcccaccg ccggagcctg
     4261 agaccacaga tgcctcacac ccatctgtcc ctccggagcc ccttgccgag gaccaccccc
     4321 cgcatactcc aggcctctgt ggcagcctgg ccaagtcgca gagcacagag acggtgccag
     4381 ccacaccagg cggggagccc ccgctatcag ggggcagcag tggcctgtcc ctgagctctc
     4441 cgcaagtgcc cggcagcccc ttctcctacc cagccccgtc ccctagcttg agcagtgggg
     4501 gcctccctcg gacacctggc cgggacttca gcttcacacc caccttctcc gagcccagcg
     4561 ggcccttgct cctgcccgtc tgcccactcc ccactggccg acgcgatgaa cgctccgggc
     4621 ccctggcctc cccggtgctc ctggagacgg gcctgcccct ccctctgccc cttcccctgc
     4681 ccttgccctt ggcattgccc gccgtcttgc gggcccaggc tcgtgcgccc accccgctgc
     4741 cacccctgct gcccgccccc ctggcctctt gccctccccc aatgaagagg aagccgggcc
     4801 ggccccggcg atccccacca tctatgctct ccttggatgg gcccttggtc cgaccaccag
     4861 caggggccgc ccttggaagg gaactcctgc tcctgccggg ccagccacag acccccgtct
     4921 tccccagcac ccatgacccc cggacggtga ccctggactt ccggaacgcg gggatcccag
     4981 cccctccacc accccttccc ccccagccac ccccaccccc acctccccca cctgtagagc
     5041 ccaccaagct gccctttaag gagctagaca accagtggcc ctccgaggcc attcctccgg
     5101 gcccccgtgg gcgcgatgag gtcactgagg aatacatgga gttggccaag agccgggggc
     5161 cgtggcgccg gccacctaag aagcgccatg aggacctggt gccacctgcg ggctcgcccg
     5221 aactctcgcc accccagccc ctcttccggc cccgctcgga gtttgaggag atgaccatcc
     5281 tgtatgacat ctggaacggt ggcatcgatg aggaggacat ccgcttcctg tgtgtcacct
     5341 acgagcgact gctacagcag gacaatggca tggactggct taacgacacg ctctgggtct
     5401 accatccctc caccagcctc tcttcagcta agaagaagaa acgggacgat ggcatccgcg
     5461 agcacgtgac gggctgtgcc cgcagtgagg gcttctacac catcgacaag aaggacaagc
     5521 tcagatacct caacagcagc cgtgccagca ccgatgagcc ccccgcagac acccagggca
     5581 tgagcatccc agcacagccc cacgcctcca cccgggcagg ctcggagcgg cgttcggagc
     5641 agcgccgcct gctgtcctcc ttcactggca gctgtgacag tgacctgctc aagttcaacc
     5701 agctcaagtt ccggaagaaa aagctcaagt tctgcaagag ccacattcac gactggggct
     5761 tgttcgccat ggagcccatc gcggctgacg agatggtcat cgagtacgtg ggccagaata
     5821 tccgtcaggt gatcgcagac atgcgggaga agcgttatga ggacgagggc atcgggagca
     5881 gctacatgtt ccgggtggac catgacacca tcatcgacgc caccaagtgc ggcaacttcg
     5941 cgcgcttcat caaccacagc tgcaacccca actgctatgc caaggtgatc acggtggagt
     6001 cacagaagaa gatagtcatc tactcgaagc agcacattaa cgtcaatgag gagattacct
     6061 atgactataa gttccccatc gaggacgtca agatcccctg cctctgtggc tccgagaact
     6121 gccgggggac cctcaactag gccccggcac cagactcaaa ggatgtcagc cgtagccctg
     6181 ggactcccga gcgtggagcc cctggccccg gggcccggcc ccccgcgccc gcccccattt
     6241 caggtgctgt cctctaccca gcggccattc agggcctggc gccccacact accccctgga
     6301 gcccctggct ccggcccctc cgcgggaaag ggcttctctg tcgttcagcc cacgtctctc
     6361 tcattttaac aaacgcccct ttcaggattt ctgtttaact ccagcatcag cttctctctc
     6421 tccgtctctc ctcccctctc tctcttctct gtctcttctc tctcccacca tcaccctcgg
     6481 cctcttcctg tgaatgctgc tacgttgttt tgtcttctct atttttttcc tcgttgtgag
     6541 aaaagacatt taaccgttga aatgtgaagg tggaatcaga gaggggcccc gcgggggtct
     6601 gcagaggcct cagtgtggct gtgcgtggcc cgtgtcctgg aagccacccg gacctggacg
     6661 cagggccagg tgctgtggga aggatggagg cccccacggc cttgacctca gaacactacg
     6721 ccctgaaagc gcccctcact gcccgtgggc acagtgagga gaccccacac ctttccccac
     6781 ccgagctgca gcctgttcct tccccagagg cctggggcac cactgacccg gtggaccctg
     6841 atggagctaa gctgtcccag gcaggggtct ccgctctggg ctttccctgc cacctcacac
     6901 cccagcaccc cctaaacctt gggttcaatg tttactttct cattcggatg ccagcaacgc
     6961 gggagcctct cggaggcccc agtgcaggtg aggggcgctg agaacgcggg cagccactct
     7021 cttctgccct tgccttcgcc ctgggtggga cagggctccc aagggcaggc gggtccccca
     7081 gtcccgccat tacgggttgt cagaccgtct gcgtgtggca ttttttggct tataagcttc
     7141 acccactcac ccccaaccca caccccacat ccccctgccg gcagcccctc aacctaagaa
     7201 ggccagagca tatttatttt cggagggagc agattacttc tcccagagaa aggaaaatct
     7261 tggaaaagat ttaaaaacac aaatctaagc cttgacggtt tttttttccc ttttgacccc
     7321 cttcccatct cttcagaatt tattcccatg gctttttttt ttcttgtgcg tgtataaaat
     7381 caaaaggaag gggaaaaagg tttttgaagt tcagaaccaa cttctgtata tagaggctgc
     7441 cgcaaaggac tttctcttgg gaacattgtt tcttgtagaa acatgcggga agacattttt
     7501 tgctcatttc tttgtacttc caaaaaaaaa ggaaaaaaaa gacaaaagca agtccccccg
     7561 taccccagaa agcagaggag gcgtgtaaat aatttctgga aagtgactgt tgtgacccgg
     7621 agtcctcatc aagatgagcg cgctccatga gggagctgct cccaccctgc ggacgcaggc
     7681 ggccggagcc tctggtatct cagcttgtgt caagcttgtt atcatgtaaa ttctgtacaa
     7741 agaattgtta tttttctctt ttttgttgtt ggtggttttg ttgtgtgttt tttgttgttt
     7801 tttttttatt cctttccccc aggccctctc tatttgagac tgtgcccgcc ggtttcaaga
     7861 tcaaggaaat tggtggcaac aagacacaga tggggtacct gggcacagcg gcgaacttct
     7921 cttccgtttg cggttttctg cctaattgtg caactgagga aataatttat ttttcacatg
     7981 aggaaatgcg tagcttgtag agacggctga ttcaagttac atgtacagcc tccaaagggc
     8041 tgtctccatt ctgtcccctt cccataaaag aagtgggggt gttcgagaag accagggaag
     8101 ggacccttgc ctcacccctc cccctggcct caccttgctc ccagccatcg tgcccagtgt
     8161 taacctcggc tggccttcac taaggggact agacctccct ctccccagga gccccagccc
     8221 cagagtggtt tgcaataatc aagatatgtg tcgagtcatt tttctttcaa ctccctcatt
     8281 tttcattgaa caaatctctg cttttcaaga gttgggggtt tctgctattt tttgctttct
     8341 ctccctcccc ctgcaaagat gagaaccaat gagttttagg gatgtttgtg cgggtagact
     8401 ccatcatcca tatgtaactt gttttgaaga gaagtgtttc cgttgtgtgt cttgatgtaa
     8461 atatttgttc atatttttgt gaattcaata ctatgtacca ttgtattata gtaactttta
     8521 taaagcaaac cataaatata ctgacttttc ttacaga
//
