LOCUS       NM_014712               5991 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens SET domain containing 1A, histone lysine
            methyltransferase (SETD1A), mRNA.
ACCESSION   NM_014712 XM_049380
VERSION     NM_014712.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5991)
  AUTHORS   Hoshii,T., Kikuchi,S., Kujirai,T., Masuda,T., Ito,T., Yasuda,S.,
            Matsumoto,M., Rahmutulla,B., Fukuyo,M., Murata,T., Kurumizaka,H.
            and Kaneda,A.
  TITLE     BOD1L mediates chromatin binding and non-canonical function of H3K4
            methyltransferase SETD1A
  JOURNAL   Nucleic Acids Res 52 (16), 9463-9480 (2024)
   PUBMED   38989615
  REMARK    GeneRIF: BOD1L mediates chromatin binding and non-canonical
            function of H3K4 methyltransferase SETD1A.
REFERENCE   2  (bases 1 to 5991)
  AUTHORS   Colijn,M.A., Carrion,P., Poirier-Morency,G., Rogic,S., Torres,I.,
            Menon,M., Lisonek,M., Cook,C., DeGraaf,A., Thammaiah,S.P.,
            Neelakant,H., Willaeys,V., Leonova,O., White,R.F., Yip,S.,
            Mungall,A.J., MacLeod,P.M., Gibson,W.T., Sullivan,P.F., Honer,W.G.,
            Pavlidis,P. and Stowe,R.M.
  TITLE     SETD1A variant-associated psychosis: A systematic review of the
            clinical literature and description of two new cases
  JOURNAL   Prog Neuropsychopharmacol Biol Psychiatry 129, 110888 (2024)
   PUBMED   37918557
  REMARK    GeneRIF: SETD1A variant-associated psychosis: A systematic review
            of the clinical literature and description of two new cases.
            Review article
REFERENCE   3  (bases 1 to 5991)
  AUTHORS   Amin,H.M., Szabo,B., Abukhairan,R., Zeke,A., Kardos,J., Schad,E.
            and Tantos,A.
  TITLE     In Vivo and In Vitro Characterization of the RNA Binding Capacity
            of SETD1A (KMT2F)
  JOURNAL   Int J Mol Sci 24 (22), 16032 (2023)
   PUBMED   38003223
  REMARK    GeneRIF: In Vivo and In Vitro Characterization of the RNA Binding
            Capacity of SETD1A (KMT2F).
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5991)
  AUTHORS   Perlee,S., Kikuchi,S., Nakadai,T., Masuda,T., Ohtsuki,S.,
            Matsumoto,M., Rahmutulla,B., Fukuyo,M., Cifani,P., Kentsis,A.,
            Roeder,R.G., Kaneda,A. and Hoshii,T.
  TITLE     SETD1A function in leukemia is mediated through interaction with
            mitotic regulators BuGZ/BUB3
  JOURNAL   EMBO Rep 24 (10), e57108 (2023)
   PUBMED   37535603
  REMARK    GeneRIF: SETD1A function in leukemia is mediated through
            interaction with mitotic regulators BuGZ/BUB3.
REFERENCE   5  (bases 1 to 5991)
  AUTHORS   Chen,J., Xu,Z., Huang,H., Tang,Y., Shan,H. and Xiao,F.
  TITLE     SETD1A drives stemness by reprogramming the epigenetic landscape in
            hepatocellular carcinoma stem cells
  JOURNAL   JCI Insight 8 (18), e168375 (2023)
   PUBMED   37581938
  REMARK    GeneRIF: SETD1A drives stemness by reprogramming the epigenetic
            landscape in hepatocellular carcinoma stem cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5991)
  AUTHORS   Cho,Y.W., Hong,T., Hong,S., Guo,H., Yu,H., Kim,D., Guszczynski,T.,
            Dressler,G.R., Copeland,T.D., Kalkum,M. and Ge,K.
  TITLE     PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4
            methyltransferase complex
  JOURNAL   J Biol Chem 282 (28), 20395-20406 (2007)
   PUBMED   17500065
REFERENCE   7  (bases 1 to 5991)
  AUTHORS   Narayanan,A., Ruyechan,W.T. and Kristie,T.M.
  TITLE     The coactivator host cell factor-1 mediates Set1 and MLL1 H3K4
            trimethylation at herpesvirus immediate early promoters for
            initiation of infection
  JOURNAL   Proc Natl Acad Sci U S A 104 (26), 10835-10840 (2007)
   PUBMED   17578910
  REMARK    GeneRIF: HCF-1 was required for recruitment of the histone
            methyltransferases Set1 and MLL1, leading to histone H3K4
            trimethylation and transcriptional activation.
REFERENCE   8  (bases 1 to 5991)
  AUTHORS   Lee,J.H., Tate,C.M., You,J.S. and Skalnik,D.G.
  TITLE     Identification and characterization of the human Set1B histone
            H3-Lys4 methyltransferase complex
  JOURNAL   J Biol Chem 282 (18), 13419-13428 (2007)
   PUBMED   17355966
REFERENCE   9  (bases 1 to 5991)
  AUTHORS   Lee,J.H. and Skalnik,D.G.
  TITLE     CpG-binding protein (CXXC finger protein 1) is a component of the
            mammalian Set1 histone H3-Lys4 methyltransferase complex, the
            analogue of the yeast Set1/COMPASS complex
  JOURNAL   J Biol Chem 280 (50), 41725-41731 (2005)
   PUBMED   16253997
REFERENCE   10 (bases 1 to 5991)
  AUTHORS   Wysocka,J., Myers,M.P., Laherty,C.D., Eisenman,R.N. and Herr,W.
  TITLE     Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone
            H3-K4 methyltransferase are tethered together selectively by the
            cell-proliferation factor HCF-1
  JOURNAL   Genes Dev 17 (7), 896-911 (2003)
   PUBMED   12670868
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AB002337.2 and BC027450.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_014712.2.
            
            Summary: The protein encoded by this gene is a component of a
            histone methyltransferase (HMT) complex that produces mono-, di-,
            and trimethylated histone H3 at Lys4. Trimethylation of histone H3
            at lysine 4 (H3K4me3) is a chromatin modification known to
            generally mark the transcription start sites of active genes. The
            protein contains SET domains, a RNA recognition motif domain and is
            a member of the class V-like SAM-binding methyltransferase
            superfamily. [provided by RefSeq, Dec 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB002337.2, SRR9304718.128347.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262519.14/ ENSP00000262519.8
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5533              AB002337.2         461-5993
            5534-5675           BC027450.1         1594-1735
            5676-5987           AB002337.2         6136-6447
            5988-5991           BC027450.1         2048-2051
FEATURES             Location/Qualifiers
     source          1..5991
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p11.2"
     gene            1..5991
                     /gene="SETD1A"
                     /gene_synonym="EPEDD; EPEO2; KMT2F; NEDSID; Set1; Set1A"
                     /note="SET domain containing 1A, histone lysine
                     methyltransferase"
                     /db_xref="GeneID:9739"
                     /db_xref="HGNC:HGNC:29010"
                     /db_xref="MIM:611052"
     exon            1..211
                     /gene="SETD1A"
                     /gene_synonym="EPEDD; EPEO2; KMT2F; NEDSID; Set1; Set1A"
                     /inference="alignment:Splign:2.1.0"
     exon            212..376
                     /gene="SETD1A"
                     /gene_synonym="EPEDD; EPEO2; KMT2F; NEDSID; Set1; Set1A"
                     /inference="alignment:Splign:2.1.0"
     CDS             227..5350
                     /gene="SETD1A"
                     /gene_synonym="EPEDD; EPEO2; KMT2F; NEDSID; Set1; Set1A"
                     /EC_number="2.1.1.364"
                     /note="hSET1A; lysine N-methyltransferase 2F; SET
                     domain-containing protein 1A; set1/Ash2 histone
                     methyltransferase complex subunit SET1"
                     /codon_start=1
                     /product="histone-lysine N-methyltransferase SETD1A"
                     /protein_id="NP_055527.1"
                     /db_xref="CCDS:CCDS32435.1"
                     /db_xref="GeneID:9739"
                     /db_xref="HGNC:HGNC:29010"
                     /db_xref="MIM:611052"
                     /translation="MDQEGGGDGQKAPSFQWRNYKLIVDPALDPALRRPSQKVYRYDG
                     VHFSVNDSKYIPVEDLQDPRCHVRSKNRDFSLPVPKFKLDEFYIGQIPLKEVTFARLN
                     DNVRETFLKDMCRKYGEVEEVEILLHPRTRKHLGLARVLFTSTRGAKETVKNLHLTSV
                     MGNIIHAQLDIKGQQRMKYYELIVNGSYTPQTVPTGGKALSEKFQGSGAATETAESRR
                     RSSSDTAAYPAGTTAVGTPGNGTPCSQDTSFSSSRQDTPSSFGQFTPQSSQGTPYTSR
                     GSTPYSQDSAYSSSTTSTSFKPRRSENSYQDAFSRRHFSASSASTTASTAIAATTAAT
                     ASSSASSSSLSSSSSSSSSSSSSQFRSSDANYPAYYESWNRYQRHTSYPPRRATREEP
                     PGAPFAENTAERFPPSYTSYLPPEPSRPTDQDYRPPASEAPPPEPPEPGGGGGGGGPS
                     PEREEVRTSPRPASPARSGSPAPETTNESVPFAQHSSLDSRIEMLLKEQRSKFSFLAS
                     DTEEEEENSSMVLGARDTGSEVPSGSGHGPCTPPPAPANFEDVAPTGSGEPGATRESP
                     KANGQNQASPCSSGDDMEISDDDRGGSPPPAPTPPQQPPPPPPPPPPPPPYLASLPLG
                     YPPHQPAYLLPPRPDGPPPPEYPPPPPPPPHIYDFVNSLELMDRLGAQWGGMPMSFQM
                     QTQMLTRLHQLRQGKGLIAASAGPPGGAFGEAFLPFPPPQEAAYGLPYALYAQGQEGR
                     GAYSREAYHLPMPMAAEPLPSSSVSGEEARLPPREEAELAEGKTLPTAGTVGRVLAML
                     VQEMKSIMQRDLNRKMVENVAFGAFDQWWESKEEKAKPFQNAAKQQAKEEDKEKTKLK
                     EPGLLSLVDWAKSGGTTGIEAFAFGSGLRGALRLPSFKVKRKEPSEISEASEEKRPRP
                     STPAEEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFALDSEGEEASQES
                     SSEKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCSLYADSDGENDST
                     SDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPT
                     PAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEESPPSAPLRPPEPPAGPPAPAPR
                     PDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRKAPRGVE
                     RTIRNLPLDHASLVKSWPEEVSRGGRSRAGGRGRLTEEEEAEPGTEVDLAVLADLALT
                     PARRGLPALPAVEDSEATETSDEAERPRPLLSHILLEHNYALAVKPTPPAPALRPPEP
                     VPAPAALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEESSD
                     SSSSSDGEGALRRRSLRSHARRRRPPPPPPPPPPRAYEPRSEFEQMTILYDIWNSGLD
                     SEDMSYLRLTYERLLQQTSGADWLNDTHWVHHTITNLTTPKRKRRPQDGPREHQTGSA
                     RSEGYYPISKKEKDKYLDVCPVSARQLEGVDTQGTNRVLSERRSEQRRLLSAIGTSAI
                     MDSDLLKLNQLKFRKKKLRFGRSRIHEWGLFAMEPIAADEMVIEYVGQNIRQMVADMR
                     EKRYVQEGIGSSYLFRVDHDTIIDATKCGNLARFINHCCTPNCYAKVITIESQKKIVI
                     YSKQPIGVDEEITYDYKFPLEDNKIPCLCGTESCRGSLN"
     exon            377..472
                     /gene="SETD1A"
                     /gene_synonym="EPEDD; EPEO2; KMT2F; NEDSID; Set1; Set1A"
                     /inference="alignment:Splign:2.1.0"
     exon            473..743
                     /gene="SETD1A"
                     /gene_synonym="EPEDD; EPEO2; KMT2F; NEDSID; Set1; Set1A"
                     /inference="alignment:Splign:2.1.0"
     exon            744..865
                     /gene="SETD1A"
                     /gene_synonym="EPEDD; EPEO2; KMT2F; NEDSID; Set1; Set1A"
                     /inference="alignment:Splign:2.1.0"
     exon            866..1095
                     /gene="SETD1A"
                     /gene_synonym="EPEDD; EPEO2; KMT2F; NEDSID; Set1; Set1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1096..1945
                     /gene="SETD1A"
                     /gene_synonym="EPEDD; EPEO2; KMT2F; NEDSID; Set1; Set1A"
                     /inference="alignment:Splign:2.1.0"
     exon            1946..2731
                     /gene="SETD1A"
                     /gene_synonym="EPEDD; EPEO2; KMT2F; NEDSID; Set1; Set1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2732..2908
                     /gene="SETD1A"
                     /gene_synonym="EPEDD; EPEO2; KMT2F; NEDSID; Set1; Set1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2909..2996
                     /gene="SETD1A"
                     /gene_synonym="EPEDD; EPEO2; KMT2F; NEDSID; Set1; Set1A"
                     /inference="alignment:Splign:2.1.0"
     exon            2997..3154
                     /gene="SETD1A"
                     /gene_synonym="EPEDD; EPEO2; KMT2F; NEDSID; Set1; Set1A"
                     /inference="alignment:Splign:2.1.0"
     exon            3155..3242
                     /gene="SETD1A"
                     /gene_synonym="EPEDD; EPEO2; KMT2F; NEDSID; Set1; Set1A"
                     /inference="alignment:Splign:2.1.0"
     exon            3243..3584
                     /gene="SETD1A"
                     /gene_synonym="EPEDD; EPEO2; KMT2F; NEDSID; Set1; Set1A"
                     /inference="alignment:Splign:2.1.0"
     exon            3585..4634
                     /gene="SETD1A"
                     /gene_synonym="EPEDD; EPEO2; KMT2F; NEDSID; Set1; Set1A"
                     /inference="alignment:Splign:2.1.0"
     exon            4635..4807
                     /gene="SETD1A"
                     /gene_synonym="EPEDD; EPEO2; KMT2F; NEDSID; Set1; Set1A"
                     /inference="alignment:Splign:2.1.0"
     exon            4808..4918
                     /gene="SETD1A"
                     /gene_synonym="EPEDD; EPEO2; KMT2F; NEDSID; Set1; Set1A"
                     /inference="alignment:Splign:2.1.0"
     exon            4919..5038
                     /gene="SETD1A"
                     /gene_synonym="EPEDD; EPEO2; KMT2F; NEDSID; Set1; Set1A"
                     /inference="alignment:Splign:2.1.0"
     exon            5039..5176
                     /gene="SETD1A"
                     /gene_synonym="EPEDD; EPEO2; KMT2F; NEDSID; Set1; Set1A"
                     /inference="alignment:Splign:2.1.0"
     exon            5177..5991
                     /gene="SETD1A"
                     /gene_synonym="EPEDD; EPEO2; KMT2F; NEDSID; Set1; Set1A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5971..5976
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SETD1A"
                     /gene_synonym="EPEDD; EPEO2; KMT2F; NEDSID; Set1; Set1A"
                     /note="hexamer: ATTAAA"
     polyA_site      5991
                     /gene="SETD1A"
                     /gene_synonym="EPEDD; EPEO2; KMT2F; NEDSID; Set1; Set1A"
                     /note="major polyA site"
ORIGIN      
        1 gtcaaggtcc cgggccgcag catctagatc gtcgtggcga agccgactct ccgggggatg
       61 cggccaatct ccaagctccc tgggccgcaa cttccgagcc tcccagggcg ccggccgagg
      121 cgaagccgct accctcggcc ccgtgggtcc cccggcagcg cctgtggcga aagtgcgaat
      181 gcagaccctg tgcccgctgg gcctcgcgca gtgtaaatga gcaaagatgg atcaggaagg
      241 tgggggagat gggcagaagg ccccgagctt ccagtggcgg aactacaagc tcatcgtgga
      301 tcctgccttg gaccctgccc tgcgcaggcc ttctcagaag gtgtaccgct atgatggagt
      361 ccacttcagt gtcaacgact caaagtatat accagtcgaa gacctccaag acccccgttg
      421 ccatgtcagg tccaaaaaca gagacttttc cctcccagtc cctaagttta agctggacga
      481 gttctatatt ggacagattc cactgaagga agtgactttt gcaaggctga atgacaacgt
      541 gcgggagacc ttcctgaagg atatgtgccg taagtacggt gaggtggaag aggtagagat
      601 cctccttcac ccccgtacgc gcaagcacct gggcctggcc cgtgtgctct tcaccagcac
      661 tcggggcgcc aaggaaacgg tcaaaaacct ccaccttacc tccgtcatgg gcaacatcat
      721 ccatgcccag cttgacatca aaggacaaca acgaatgaaa tactatgaac taattgtcaa
      781 tggctcctac acccctcaga ctgtgcccac tgggggcaag gccctgagtg agaagttcca
      841 aggctcgggt gcagccactg agacggccga atcccgccgc cgctcttcct ctgacacagc
      901 tgcctaccca gcaggcacca ctgcggtggg cactcctggc aacggcaccc cctgctccca
      961 ggacacaagc ttctccagca gccgacaaga taccccatct tcctttggcc agttcacacc
     1021 tcagtcctcc caaggaaccc cctacacgtc tcggggcagc accccctact ctcaggactc
     1081 tgcctactcc agcagcacca cttcaacctc cttcaagccc cggcggtcag agaacagcta
     1141 ccaagatgcc ttttcccgcc gccacttctc tgcatcttca gcctccacaa ccgcctccac
     1201 ggccatcgcc gccaccactg cagccactgc ctcatcctcc gcctcttcct cctcattgtc
     1261 ctcgtcctcc tcgtcatcct cttcctcctc gtcctctcag tttcgtagtt ctgatgcaaa
     1321 ctacccagcg tattatgaaa gctggaatcg ctaccagcgc catacttcct acccaccacg
     1381 ccgggccaca cgggaggaac cccctggagc cccttttgct gaaaatacag ctgagcgctt
     1441 cccaccttct tacacctcct acctgccccc cgagcccagc cggcccaccg accaggacta
     1501 ccggcctcct gcctcagagg ctccaccccc ggagcctcca gaacctggtg gaggcggggg
     1561 tggaggaggg cccagccctg agagagaaga agttcggact tccccccgcc cagcctcccc
     1621 tgcccgctct ggctccccag ccccggagac caccaatgag agtgtgccct tcgcccagca
     1681 cagcagcctg gattcccgca tcgagatgct gctgaaggag cagcgctcca agttttcctt
     1741 cttggcctct gacacagagg aggaggaaga gaacagcagc atggtccttg gggccagaga
     1801 tacagggagt gaggtgcctt ctgggtcagg gcatgggccc tgcacacccc ctccggcccc
     1861 agctaatttt gaggatgtgg cacctacagg gagcggggag ccaggggcta cccgggagtc
     1921 tcccaaggca aatggacaga accaggcttc tccatgctct tctggagacg acatggagat
     1981 ctccgacgac gaccggggtg gctcaccccc tccggccccg acgccccctc agcagcctcc
     2041 gccacctccc cctcccccgc cgcctcctcc tccctacctg gcgtcccttc ctcttggtta
     2101 tcctccccac caacctgcct acctcctccc acccagacct gatgggccgc cgccccctga
     2161 gtacccccca cctcctccac cacccccgca catctatgac tttgtgaact ccttggagct
     2221 catggaccga cttggggctc agtggggagg gatgcccatg tccttccaga tgcagaccca
     2281 gatgttaact cggctccatc agctgcggca gggcaaggga ttgattgccg cctcagctgg
     2341 cccccccggt ggggcctttg gggaggcctt cctcccgttt ccacccccgc aggaggcagc
     2401 ctacggcttg ccgtatgctc tatatgcaca ggggcaggag ggcagagggg catactcacg
     2461 ggaggcctac cacctgccca tgccaatggc agccgagccc ctgccctcct cctcagtctc
     2521 gggagaggag gcccggctgc cacccaggga agaagcagag ctggcagagg gcaagaccct
     2581 cccgacagca ggcaccgtgg gccgtgtgct cgccatgctg gtccaggaga tgaagagcat
     2641 catgcagcga gacctcaacc gcaagatggt ggagaacgtg gccttcggag cctttgacca
     2701 gtggtgggag agcaaggagg agaaggccaa gccattccag aacgcggcca agcagcaagc
     2761 caaggaggag gataaagaga agacgaagct gaaggagcct ggcctgctgt ccctcgtgga
     2821 ctgggccaag agcgggggca ctacgggcat cgaggctttc gcctttgggt cagggctgag
     2881 aggggccctg cggctgcctt cattcaaggt aaagcggaaa gagccatcgg aaatttccga
     2941 ggccagtgag gaaaagaggc ctcgtccctc cactcctgct gaggaagatg aagacgaccc
     3001 tgaacaagag aaggaggctg gagagccagg acgtccgggg accaagcccc cgaagcggga
     3061 cgaagagcga ggcaagaccc agggcaagca ccgcaagtcc tttgctctgg acagcgaagg
     3121 ggaggaggca tcccaggagt cctcctcgga gaaggatgag gaggatgacg aggaagatga
     3181 ggaagatgaa gatcgagagg aagctgtgga taccacaaag aaggagacag aggtgtcgga
     3241 tggcgaggac gaggaaagcg attcgtcttc caaatgttct ctgtatgctg actcagatgg
     3301 cgaaaatgac agcacatcag actccgagag cagcagctct tccagctcct catcctcctc
     3361 ctcctcctcg tcctcatcct cctcgtcctc ttcatcctct gagtcctcct ctgaagatga
     3421 agaggaagag gagcggccag cagcccttcc ctcagcctcc ccgcccccca gagaagtccc
     3481 agtgcccacg ccagcacctg tggaggtgcc agtgccggaa agggttgcag gctccccagt
     3541 cacacccctg cccgaacagg aggcgtctcc agcaaggcct gcaggcccca cggaggagtc
     3601 accccccagt gcgcctctgc gtcccccaga accacctgct gggcccccgg cccctgcccc
     3661 acgccccgat gagcgtccct cttctcccat ccccctcctg cccccaccca agaaacgccg
     3721 gaaaactgtc tccttctctg ccatcgaggt ggtgccagcc ccggagcccc ctccagccac
     3781 accgccgcag gccaagtttc ccggcccagc ctcccgcaag gctccccggg gcgtggagcg
     3841 gaccatccgc aacctgcccc tggaccacgc atctctggtc aagagttggc ccgaggaggt
     3901 gtcccgagga ggccggagcc gggctggagg ccgaggccgc ctcaccgagg aagaggaggc
     3961 tgagccaggg acagaggtgg acctggcggt cctggccgac ctggccctga cccctgcccg
     4021 gcgcgggctg cctgccctgc ctgctgttga agactcagag gccacagaga catcggacga
     4081 ggccgagcgc cctaggcccc tgctcagcca catcctcctg gagcacaact atgccctggc
     4141 cgtcaagccc acgccccctg cgccagccct gcggcccccg gagccagtgc ccgcacccgc
     4201 cgccctcttc agttccccag ctgatgaggt cctggaggcc cccgaggtgg tggtggctga
     4261 ggcggaggag cccaagccgc agcaactgca gcagcagcgg gaggagggcg aagaggaggg
     4321 ggaggaagag ggggaggaag aggaggagga gtcctctgac agcagcagca gcagcgatgg
     4381 ggagggcgcc ctccggaggc gcagcctccg ctcccacgcc cggcgccgcc gccctccgcc
     4441 cccacccccg ccgccaccgc cccgcgccta cgagccacgc agtgagtttg aacagatgac
     4501 catcctgtat gacatttgga actcgggcct ggactcagag gacatgagtt acctgcggct
     4561 tacgtacgag cggctgctgc agcagacaag cggggctgac tggctcaacg acactcactg
     4621 ggtccatcac acaatcacca acctgaccac cccaaaacgc aagcggcggc cccaggatgg
     4681 gccccgggag caccagacag gctcagcccg cagcgaaggc tactacccca tcagcaagaa
     4741 ggagaaggac aagtacctgg acgtgtgccc agtctcggcc cggcagctgg agggcgtgga
     4801 cactcagggg acgaaccgcg tgctgtccga gcgccggtcc gagcagcggc ggctgctgag
     4861 cgccatcggt acctccgcca tcatggacag tgacctgctg aaactcaacc agctcaagtt
     4921 ccggaagaag aagctccgat ttggccggag ccggatccac gagtggggtc tgtttgccat
     4981 ggaacccatt gctgctgacg agatggtcat cgaatacgtg ggtcagaaca tccgtcagat
     5041 ggtggccgac atgcgggaga agcgctacgt gcaggagggc attggcagca gctacctgtt
     5101 ccgggtggac cacgacacca tcatcgatgc caccaagtgt ggcaacctgg ccagattcat
     5161 caaccactgc tgcacgccta actgctacgc caaggtcatc accatcgagt cccagaagaa
     5221 gatcgtgatc tactccaagc agcccattgg cgtggacgag gagatcacct acgactacaa
     5281 gttcccactg gaagacaaca agatcccgtg tctgtgtggc acagagagct gccggggctc
     5341 cctaaactga ggtggggcag gatgggtgcc cacaccccta tttattcccc ctggtgccct
     5401 gagctcccag caccccccca gccttagtgg gctcagcagg gcccacatgc ccccatctcc
     5461 aagcgtgggg ttgggggccc caagcccagc gagggagcct cagtccctgg aggcagcttc
     5521 tgcctctcct gtcacccctg cccaccaccc cctgattgtt tttctttgcg gagaagaagc
     5581 tgtaaatgtt ttgtagcagc cagcagctgt ttcctgtgga aacctggggt gccggcctgt
     5641 acagattctg tcctgggggg ctacacagtc ctcttgcttt gtgttaatgg ggacttcccc
     5701 ttacgccctg cgtgtacccc tccccagttt aggggtctct ggggcagtgg ccatgttctc
     5761 cccctggggg ggctctgcac ccccagtcct ggggactccg tgcctggaac cctgcctcat
     5821 ctgttcctgc cagaccctga gggtcaccct tccaccctgg tgtcactccc cggctcagcc
     5881 aggccaggat ggcggggtgg gtcccttttg ctgggctgga ctgtacatat gttaatagcg
     5941 caaacccgac gccacatttt tataattgtg attaaacttt attgtacaaa a
//
