LOCUS       NM_015559               9909 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens SET binding protein 1 (SETBP1), transcript variant 1,
            mRNA.
ACCESSION   NM_015559
VERSION     NM_015559.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9909)
  AUTHORS   Oyler,H.O., Hudac,C.M., Chung,W.K., Green Synder,L., Robertson,S.,
            Srivastava,S. and Geye,T.
  TITLE     SETBP1 haploinsufficiency and related disorders clinical and
            neurobehavioral phenotype study
  JOURNAL   Clin Genet 106 (4), 448-461 (2024)
   PUBMED   38923504
  REMARK    GeneRIF: SETBP1 haploinsufficiency and related disorders clinical
            and neurobehavioral phenotype study.
REFERENCE   2  (bases 1 to 9909)
  AUTHORS   Crespiatico,I., Zaghi,M., Mastini,C., D'Aliberti,D., Mauri,M.,
            Mercado,C.M., Fontana,D., Spinelli,S., Crippa,V., Inzoli,E.,
            Manghisi,B., Civettini,I., Ramazzotti,D., Sangiorgio,V.,
            Gengotti,M., Brambilla,V., Aroldi,A., Banfi,F., Barone,C.,
            Orsenigo,R., Riera,L., Riminucci,M., Corsi,A., Breccia,M.,
            Morotti,A., Cilloni,D., Roccaro,A., Sacco,A., Stagno,F.,
            Serafini,M., Mottadelli,F., Cazzaniga,G., Pagni,F., Chiarle,R.,
            Azzoni,E., Sessa,A., Gambacorti-Passerini,C., Elli,E.M., Mologni,L.
            and Piazza,R.
  TITLE     First-hit SETBP1 mutations cause a myeloproliferative disorder with
            bone marrow fibrosis
  JOURNAL   Blood 143 (14), 1399-1413 (2024)
   PUBMED   38194688
  REMARK    GeneRIF: First-hit SETBP1 mutations cause a myeloproliferative
            disorder with bone marrow fibrosis.
            Erratum:[Blood. 2024 Jun 27;143(26):2810. doi:
            10.1182/blood.2024025290.. PMID: 38935362]
REFERENCE   3  (bases 1 to 9909)
  AUTHORS   Alesi,V., Genovese,S., Roberti,M.C., Sallicandro,E., Di Tommaso,S.,
            Loddo,S., Orlando,V., Pompili,D., Calacci,C., Mei,V.,
            Pisaneschi,E., Faggiano,M.V., Morgia,A., Mammi,C., Astrea,G.,
            Battini,R., Priolo,M., Dentici,M.L., Milone,R. and Novelli,A.
  TITLE     Structural rearrangements as a recurrent pathogenic mechanism for
            SETBP1 haploinsufficiency
  JOURNAL   Hum Genomics 18 (1), 29 (2024)
   PUBMED   38520002
  REMARK    GeneRIF: Structural rearrangements as a recurrent pathogenic
            mechanism for SETBP1 haploinsufficiency.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9909)
  AUTHORS   Whitlock,J.H., Wilk,E.J., Howton,T.C., Clark,A.D. and
            Lasseigne,B.N.
  TITLE     The landscape of SETBP1 gene expression and transcription factor
            activity across human tissues
  JOURNAL   PLoS One 19 (1), e0296328 (2024)
   PUBMED   38165902
  REMARK    GeneRIF: The landscape of SETBP1 gene expression and transcription
            factor activity across human tissues.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 9909)
  AUTHORS   Vaquerizas,J.M., Kummerfeld,S.K., Teichmann,S.A. and Luscombe,N.M.
  TITLE     A census of human transcription factors: function, expression and
            evolution
  JOURNAL   Nat Rev Genet 10 (4), 252-263 (2009)
   PUBMED   19274049
  REMARK    Review article
REFERENCE   6  (bases 1 to 9909)
  AUTHORS   Ott,M.G., Schmidt,M., Schwarzwaelder,K., Stein,S., Siler,U.,
            Koehl,U., Glimm,H., Kuhlcke,K., Schilz,A., Kunkel,H., Naundorf,S.,
            Brinkmann,A., Deichmann,A., Fischer,M., Ball,C., Pilz,I.,
            Dunbar,C., Du,Y., Jenkins,N.A., Copeland,N.G., Luthi,U., Hassan,M.,
            Thrasher,A.J., Hoelzer,D., von Kalle,C., Seger,R. and Grez,M.
  TITLE     Correction of X-linked chronic granulomatous disease by gene
            therapy, augmented by insertional activation of MDS1-EVI1, PRDM16
            or SETBP1
  JOURNAL   Nat Med 12 (4), 401-409 (2006)
   PUBMED   16582916
  REMARK    GeneRIF: Correction of X-linked chronic granulomatous disease by
            gene therapy was augmented by insertional activation of SETBP1.
REFERENCE   7  (bases 1 to 9909)
  AUTHORS   Anderson,N.L., Polanski,M., Pieper,R., Gatlin,T., Tirumalai,R.S.,
            Conrads,T.P., Veenstra,T.D., Adkins,J.N., Pounds,J.G., Fagan,R. and
            Lobley,A.
  TITLE     The human plasma proteome: a nonredundant list developed by
            combination of four separate sources
  JOURNAL   Mol Cell Proteomics 3 (4), 311-326 (2004)
   PUBMED   14718574
REFERENCE   8  (bases 1 to 9909)
  AUTHORS   Minakuchi,M., Kakazu,N., Gorrin-Rivas,M.J., Abe,T., Copeland,T.D.,
            Ueda,K. and Adachi,Y.
  TITLE     Identification and characterization of SEB, a novel protein that
            binds to the acute undifferentiated leukemia-associated protein SET
  JOURNAL   Eur J Biochem 268 (5), 1340-1351 (2001)
   PUBMED   11231286
REFERENCE   9  (bases 1 to 9909)
  AUTHORS   Duis,J. and van Bon,B.W.M.
  TITLE     Schinzel-Giedion Syndrome
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   38452171
REFERENCE   10 (bases 1 to 9909)
  AUTHORS   Morgan,A., Srivastava,S., Duis,J. and van Bon,B.
  TITLE     SETBP1 Haploinsufficiency Disorder
  JOURNAL   (in) Adam MP, Feldman J, Mirzaa GM, Pagon RA, Wallace SE and
            Amemiya A (Eds.);
            GENEREVIEWS(R);
            (1993)
   PUBMED   34807554
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BG433843.1, BC146776.1,
            AC105074.5, BQ641251.1 and AC090376.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 11, 2018 this sequence version replaced NM_015559.2.
            
            Summary: This gene encodes a protein which contains a several
            motifs including a ski homology region and a SET-binding region in
            addition to three nuclear localization signals. The encoded protein
            has been shown to bind the SET nuclear oncogene which is involved
            in DNA replication. Mutations in this gene are associated with
            Schinzel-Giedion midface retraction syndrome. Multiple transcript
            variants encoding different isoforms have been found for this gene.
            [provided by RefSeq, Aug 2011].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (a). Variants 1, 3 and 4
            all encode isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data because no single transcript was available
            for the full length of the gene. The extent of this transcript is
            supported by transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC146776.1, AB007897.2 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000649279.2/ ENSP00000497406.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                BG433843.1         2-11
            11-3606             BC146776.1         1-3596
            3607-3607           AC105074.5         61410-61410         c
            3608-4130           BC146776.1         3598-4120
            4131-4728           BQ641251.1         217-814
            4729-9909           AC090376.6         150444-155624       c
FEATURES             Location/Qualifiers
     source          1..9909
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q12.3"
     gene            1..9909
                     /gene="SETBP1"
                     /gene_synonym="MRD29; SEB"
                     /note="SET binding protein 1"
                     /db_xref="GeneID:26040"
                     /db_xref="HGNC:HGNC:15573"
                     /db_xref="MIM:611060"
     exon            1..134
                     /gene="SETBP1"
                     /gene_synonym="MRD29; SEB"
                     /inference="alignment:Splign:2.1.0"
     exon            135..792
                     /gene="SETBP1"
                     /gene_synonym="MRD29; SEB"
                     /inference="alignment:Splign:2.1.0"
     CDS             307..5097
                     /gene="SETBP1"
                     /gene_synonym="MRD29; SEB"
                     /note="isoform a is encoded by transcript variant 1;
                     SET-binding protein"
                     /codon_start=1
                     /product="SET-binding protein isoform a"
                     /protein_id="NP_056374.2"
                     /db_xref="CCDS:CCDS11923.2"
                     /db_xref="GeneID:26040"
                     /db_xref="HGNC:HGNC:15573"
                     /db_xref="MIM:611060"
                     /translation="MESRETLSSSRQRGGESDFLPVSSAKPPAAPGCAGEPLLSTPGP
                     GKGIPVGGERMEPEEEDELGSGRDVDSNSNADSEKWVAGDGLEEQEFSIKEANFTEGS
                     LKLKIQTTKRAKKPPKNLENYICPPEIKITIKQSGDQKVSRAGKNSKATKEEERSHSK
                     KKLLTASDLAASDLKGFQPQAYERPQKHSTLHYDTGLPQDFTGDTLKPKHQQKSSSQN
                     HMDWSTNSDSGPVTQNCFISPESGRETASTSKIPALEPVASFAKAQGKKGSAGNTWSQ
                     LSNNNKDLLLGGVAPSPSSHSSPAPPSSSAECNGLQPLVDQDGGGTKEPPEPPTVGSK
                     KKSSKKDVISQTIPNPDLDWVKNAQKAFDNTEGKREGYSADSAQEASPARQNVSSASN
                     PENDSSHVRITIPIKAPSLDPTNHKRKKRQSIKAVVEKIMPEKALASGITMSSEVVNR
                     ILSNSEGNKKDPRVPKLSKMIENESPSVGLETGGNAEKVIPGGVSKPRKPPMVMTPPT
                     CTDHSPSRKLPEIQHPKFAAKRRWTCSKPKPSTMLREAVMATSDKLMLEPPSAYPITP
                     SSPLYTNTDSLTVITPVKKKRGRPKKQPLLTVETIHEGTSTSPVSPISREFPGTKKRK
                     RRRNLAKLAQLVPGEDKPMSEMKFHKKVGKLGVLDKKTIKTINKMKTLKRKNILNQIL
                     SCSSSVALKAKAPPETSPGAAAIESKLGKQINVSKRGTIYIGKKRGRKPRAELPPPSE
                     EPKTAIKHPRPVSSQPDVPAVPSNFQSLVASSPAAMHPLSTQLGGSNGNLSPASTETN
                     FSELKTMPNLQPISALPTKTQKGIHSGTWKLSPPRLMANSPSHLCEIGSLKEITLSPV
                     SESHSEETIPSDSGIGTDNNSTSDQAEKSSESRRRYSFDFCSLDNPEAIPSDTSTKNR
                     HGHRQKHLIVDNFLAHESLKKPKHKRKRKSLQNRDDLQFLADLEELITKFQVFRISHR
                     SYTFYHENPYPSIFRINFDHYYPVPYIQYDPLLYLRRTSDLKSKKKRGRPAKTNDTMT
                     KVPFLQGFSYPIPSGSYYAPYGMPYTSMPMMNLGYYGQYPAPLYLSHTLGAASPFMRP
                     TVPPPQFHTNSHVKMSGAAKHKAKHGVHLQGPVSMGLGDMQPSLNPPKVGSASLSSGR
                     LHKRKHKHKHKHKEDRILGTHDNLSGLFAGKATGFSSHILSERLSSADKELPLVSEKN
                     KHKEKQKHQHSEAGHKASKNNFEVDTLSTLSLSDAQHWTQAKEKGDLSSEPVDSCTKR
                     YSGSGGDGGSTRSENLDVFSEMNPSNDKWDSDVSGSKRRSYEGFGTYREKDIQAFKMN
                     RKERSSYDSSMSPGMPSPHLKVDQTAVHSKNEGSVPTMMTRKKPAAVDSVTIPPAPVL
                     SLLAASAATSDAVGSSLKKRFKRREIEAIQCEVRKMCNYTKILSTKKNLDHVNKILKA
                     KRLQRQSKTGNNFVKKRRGRPRKQPTQFDEDSRDQMPVLEKCIDLPSKRGQKPSLSPL
                     VLEPAASQDTIMATIEAVIHMAREAPPLPPPPPPPLPPPPPPPLPPPPPLPKTPRGGK
                     RKHKPQAPAQPPQQSPPQQPLPQEEEVKAKRQRKSRGSESEVLP"
     exon            793..846
                     /gene="SETBP1"
                     /gene_synonym="MRD29; SEB"
                     /inference="alignment:Splign:2.1.0"
     exon            847..4306
                     /gene="SETBP1"
                     /gene_synonym="MRD29; SEB"
                     /inference="alignment:Splign:2.1.0"
     exon            4307..4477
                     /gene="SETBP1"
                     /gene_synonym="MRD29; SEB"
                     /inference="alignment:Splign:2.1.0"
     exon            4478..9909
                     /gene="SETBP1"
                     /gene_synonym="MRD29; SEB"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9885..9890
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SETBP1"
                     /gene_synonym="MRD29; SEB"
                     /note="hexamer: ATTAAA"
     polyA_site      9909
                     /gene="SETBP1"
                     /gene_synonym="MRD29; SEB"
                     /note="major polyA site"
ORIGIN      
        1 gtaacttgca ggttaagtgg agctagagag ctacattgta acctagttgg atttttttgg
       61 ggggggaatg tatcagaatc taacgtgtcg ttaatagaaa gaagaacagg caagaagtgg
      121 tccagccggc gaagttgcag atctgatctc ttctgaacac ctcatcgtgt ctccatccct
      181 gggaatctga ccctagcaac tggaccactt tgttcttgga attttgggtg tcctcttttc
      241 tcacctttcc cttttccctt ttccccttcc ccctcctgag aactccggaa gactgtagag
      301 attgtcatgg agtccaggga aaccttaagc agctcccggc aaagaggggg cgagtcagac
      361 ttcctgccgg tctcctcagc caagccccca gctgctcctg gctgtgcagg agaacctttg
      421 ctctccactc caggacctgg gaaggggatc ccggtgggcg gagagcgcat ggagccagag
      481 gaggaggatg aactaggctc agggcgggat gtggattcca actccaacgc ggacagtgag
      541 aaatgggtgg caggagatgg tttggaagag caggaatttt ctatcaagga ggcaaacttc
      601 acagagggaa gtctgaagct aaagattcag accacaaagc gggctaagaa acccccaaag
      661 aatttggaga actatatatg tccacctgag atcaagatca ccatcaagca gtctggggac
      721 cagaaggtgt cccgtgctgg aaaaaatagc aaagccacga aggaggaaga aagaagccac
      781 tccaaaaaga agctcctcac agccagtgac cttgcagcca gtgacctcaa aggatttcag
      841 ccacaggctt acgagaggcc ccagaaacat tcaactctcc attatgacac gggcctccca
      901 caggacttca ccggtgacac cttaaaacca aagcaccagc aaaaaagcag cagccagaac
      961 cacatggact ggtccaccaa ctctgacagc ggacccgtca ctcagaattg cttcatcagt
     1021 ccagagtctg gcagagaaac tgcaagcacc agcaagatcc ccgctcttga gcccgtggct
     1081 tcctttgcaa aggcccaggg taagaaaggc agtgcaggga acacgtggag tcagttgtct
     1141 aacaataaca aagatctgct cttgggaggt gtggctccat ccccaagcag ccacagctca
     1201 ccagccccac ccagcagctc tgctgagtgc aacgggcttc agcccttggt ggatcaagat
     1261 ggaggaggta caaaggagcc cccagaacca cctacggtgg gcagcaagaa aaagtccagt
     1321 aaaaaagatg tgataagtca gaccatacca aacccagacc tggattgggt caagaatgcc
     1381 cagaaagcat ttgacaatac agaagggaaa agggaaggtt attccgcaga tagtgcccaa
     1441 gaggcatcac cagccaggca gaacgtgagt tctgccagta atcctgaaaa tgactcaagt
     1501 catgtccgga ttactatccc catcaaggca ccctctctgg atccaaccaa ccataagagg
     1561 aaaaaaagac agtccattaa agcggtggtg gaaaagatca tgccagagaa agccttggct
     1621 tctggaatca ccatgagcag tgaagtagtt aacaggatac tttccaactc tgaggggaat
     1681 aagaaggatc cccgtgtccc taagttgagt aaaatgatag agaatgagtc cccctcagtt
     1741 ggccttgaaa ctggtggaaa tgctgagaaa gttatcccag gaggtgtgtc taagccgcgg
     1801 aagccaccca tggtcatgac acctccaacg tgcacagatc actctccatc cagaaagctg
     1861 ccagaaatcc agcatccaaa atttgctgca aaacgaaggt ggacttgcag caaaccaaaa
     1921 cctagcacca tgcttcgaga ggcagttatg gccacctctg ataaactgat gctggagccc
     1981 ccgtctgcat atcccatcac cccatccagc cctctctaca ccaacacaga cagtcttact
     2041 gtgatcactc cagtcaaaaa gaagcgggga cgaccaaaga agcagccttt gctcacagtc
     2101 gagacgattc atgagggaac ttccaccagc cccgtcagtc ccatcagccg agagtttcct
     2161 ggcactaaga aaagaaagcg acgacgcaat ttagcgaagt tggcccagct agtgccggga
     2221 gaggacaaac ccatgagcga gatgaaattt cacaagaaag ttggaaagct cggcgtgttg
     2281 gataagaaga ccatcaaaac tatcaataag atgaagacac tcaagaggaa aaacatcttg
     2341 aatcagatct tgtcctgttc cagcagcgtt gctctgaagg caaaagctcc cccagagacc
     2401 agccctgggg cagcagccat tgaaagcaaa ctgggcaagc agattaatgt cagcaagagg
     2461 ggaaccatct acattggcaa gaagcggggc aggaagccaa gagcagagct gccaccccca
     2521 tccgaagaac ccaaaacagc catcaagcac cccaggcctg tttctagcca gccggatgtt
     2581 ccagccgtgc cttccaactt tcagtcactt gtggcgtctt caccagcagc tatgcaccca
     2641 ctttcaacac agttaggtgg gtccaatggc aacctgagcc ctgccagcac tgaaaccaat
     2701 ttttcagagt tgaaaactat gccaaatctc cagcccatca gtgctcttcc aaccaaaacc
     2761 caaaagggaa tacacagtgg aacctggaag ctgtctccac ccagactgat ggccaactcc
     2821 ccttcacacc tgtgcgagat tggctcccta aaggaaatca cgctgtcccc tgtgagcgag
     2881 tcccacagtg aggagacgat ccccagcgac agcggcattg ggacagacaa caacagcact
     2941 tctgaccaag cggagaagag ctcagaatcc cgaaggaggt actcttttga tttctgctcc
     3001 ctggacaacc cggaggccat tccgtccgac accagcacaa agaaccggca tggccaccgg
     3061 caaaagcatc tcattgtgga caactttctg gcccacgaaa gcctcaagaa gccaaagcac
     3121 aagaggaaac ggaaaagcct gcaaaaccgc gatgacctcc agtttctggc agacctggag
     3181 gagctaatca ccaagttcca agtgttcaga atctcccacc ggagttacac cttctaccac
     3241 gagaatccat atcccagcat ttttcggatt aattttgatc actattaccc ggtgccatat
     3301 atccagtatg acccgttgct ctatcttcgt aggacttcag acttgaagtc aaagaagaag
     3361 cgtggtaggc ctgcaaaaac caatgacacc atgacaaagg tgcctttttt acaagggttc
     3421 agctacccta ttcccagtgg aagttactat gcaccctatg gaatgcctta cacatcaatg
     3481 cctatgatga accttggtta ttacggtcag tacccagctc ctttgtacct atcgcacacg
     3541 cttggagcag cttccccatt catgaggcca acagtgccac cacctcagtt ccacacaaac
     3601 tcccacgtaa agatgtccgg tgcagctaag cataaagcca agcatggagt acacctgcag
     3661 ggacctgtta gcatgggcct tggtgacatg cagccttctc tgaaccctcc caaggtaggc
     3721 agtgccagtc tgtccagtgg tcggctccat aagaggaaac acaaacacaa gcataagcac
     3781 aaggaagacc ggatcctagg gacccatgac aacctgagtg gtctttttgc aggcaaagcc
     3841 acaggcttct ccagccacat cctgagcgag cggctgagta gcgcagacaa agagctcccg
     3901 ctggtgagtg agaagaacaa gcataaggag aaacagaagc accagcacag cgaagccggc
     3961 cacaaagctt ctaagaacaa ctttgaggtg gacaccctgt ctacactgtc actttccgac
     4021 gcccagcatt ggacacaggc caaggaaaaa ggagacttga gcagtgagcc tgtggactca
     4081 tgcacgaaaa gatactctgg cagtggcggg gatggtggca gcacgagatc agagaacctg
     4141 gacgtgttca gtgaaatgaa cccttcgaat gacaagtggg acagtgacgt gagtgggagt
     4201 aaaaggagga gctatgaagg ctttggaacg tacagggaaa aggacatcca agccttcaag
     4261 atgaaccgca aggagagaag ttcttatgac tcctccatgt ctccagggat gccaagtccc
     4321 cacttaaaag tggaccagac agcagtgcat agtaagaacg aaggctcagt gcccaccatg
     4381 atgaccagga agaagccagc cgcagttgac agtgttacaa ttccaccagc cccagtgtta
     4441 tctctccttg ctgcatctgc agcaacgtcg gatgcagtcg gctcctccct gaagaagagg
     4501 ttcaagcggc gggagatcga agccatccag tgcgaagtgc ggaagatgtg caactacacc
     4561 aagatcctgt ccaccaagaa gaacctggac cacgtgaaca agatcctgaa ggccaagcgg
     4621 ctgcagagac aatcaaaaac aggcaacaac ttcgtgaaga agaggcgcgg gcgtcccagg
     4681 aagcagccca cccagttcga tgaggactcc agagaccaaa tgccggtgct ggaaaaatgc
     4741 atcgacctgc ccagcaaaag aggccagaag cccagcctga gcccgctggt gctggagccc
     4801 gccgccagcc aagacaccat catggccacc atcgaggcgg tcatccacat ggcccgggag
     4861 gcgccgcccc tgcccccgcc accgccgccg cccctgccgc caccgccgcc accacccctg
     4921 cccccgccac cccctctacc caagaccccc cgaggcggaa agaggaaaca caaaccgcag
     4981 gcccccgctc agcccccaca gcagtcgccc ccgcagcagc cccttcccca ggaagaggag
     5041 gtgaaagcca aaaggcagag gaagtcccga gggagtgaga gcgaggtcct tccctagggc
     5101 gggtctgggc gtctgcacct ggggcctagg gaactgacac gtgggaagcg cagtgagccg
     5161 gggcgggggc ggaatccccc gctgcaggga cacccacgcc cttctctcca gaagccgggc
     5221 aggcagaatc cggccagacg acggggctga gccatcagga gctcttggga aagcaaagca
     5281 gggagacacc ttcagaagaa gcttgtctga gcttcaccgc agctcccacc acgcggcgct
     5341 tcagtacggc tggatcctcc gcaggcgagc ggaaggcccc caggaggagc aggctggtgg
     5401 cactctcctg acctcacgct gccaaggtgc gccctcgact cccgatttca tttgctggcc
     5461 aggaaaatcg aaagggaaac accctcaatt aggaaacatt ccaaggggag aaaagctgca
     5521 aattgctcaa ctggcattgc tgtaacccgt tccatttaat tggtttttat ttcttttgat
     5581 tttcaagctc tgctaagctt tggggtacca acgtcatctt caggtgacct gaatctttcc
     5641 cttaaccgta cagtttctcg atggaattgt gtgatcagaa ggtggaattc tagtgatagg
     5701 cgacctcaga cccgcattca tgttctgtgt gcctcttcta ttgcacatac actgattttt
     5761 agcattgtct attcctattt ttcctttgcc cattgtactt ccatatatct tttcattaac
     5821 ttacttgctg cctttttttt ttcttggtac acatttaaat aaagtaatcc ttaacctgtg
     5881 ctgtaaagtt cacccttggc atgctgttcc aagaacctgg gtttgaatcc caatcgttgt
     5941 gaaacatact cagtattgat aaaacctttt taataagtga tgcagagcag ccaaggatat
     6001 gttgacccag atgtcaacca ggctattttt atacttaaaa catgtcagca gagcataggc
     6061 agaataaaat ggtttaaata ccccacagca aatagagtaa ctgacaaacc accaaaaact
     6121 gaaaccccag acccaccaga aagacaagtg tctagcaatg ccttggtacc tgatcttttt
     6181 cattcaaata attgtcatag gttgttcaaa aaaaaaaaaa aaaaggaaac aaaaacacaa
     6241 tagaagtcca ttatcccttg ataattattt cttaaaagca aatgggagta agtgttctta
     6301 tctggaaaaa taaataaata aaatgctcaa agggtatcac cacttcaatt ttatcaagcc
     6361 accttggaca aagtatccaa attgtggttg ccttaataaa ctaaaacatt attgtacata
     6421 atgtaattat aaatctatca gtctgcatgg atgcaaactg tgtgtgacaa atcgtctttt
     6481 aaatggtcaa tttcagctgt acatttctca tccaagttgt actctagcca ttggtttagc
     6541 gtggacagat actccatctc tattatccat ttccacagcc caaataaaat atgttaagca
     6601 ggctcagaat gaatatgaag aattccattt ccgtagatgt tttctaaaag tcagattgtg
     6661 gaaatttcaa ataagtattt tcaatttcct ccctcactcc ctcttacctt ccccaagaca
     6721 tcaaacacct ggcatggtag attatagaaa gagacactga gagagagaat taaattttct
     6781 aatgggaatt agaatatctg gtttacctcc aaattaagtt tctttacagg aagttgggac
     6841 cagctggaaa ttgtattatc atttcggaac acaatattac ttccttagag agagatggat
     6901 ttttgttggc aacataaaag aataagtgat ggggtatcta tgtgagtaaa tttttaaatt
     6961 ccaagttaat atgcttgcaa acattactgc tgcgttatgg caccaagagt tggttgaaat
     7021 tacccacgta gtcatactcc tgtgctctgt caccatggac ttcacatcat ttgctgccca
     7081 ctagttcaat cgcatttaat cctagcaata tgtaagttta aaggactgca ttcccctcta
     7141 ctttaaagct tatatcctag atactcagtt tgtgaccttg gttgaccttt ggcatttcac
     7201 gcaagttgaa cagcaaaatc aaagcagcca tttttaattc gtcattccca agccctatct
     7261 gagtggttcc aaagtcacct gagaggaagg tttaaattag tccctctcac cccaccattg
     7321 ctataaaaca gcaacgtttt cattccaatt cagccataaa gaggtttctc ttcttactgg
     7381 gttttgaaat catttccttt tttctttcgt ttgcccttct tccttcctgt gttgtactat
     7441 ctctccaacc acgtctataa gcagactcaa tcttcttgca gaggaagatg agctggcact
     7501 ctgcaaactt ctttaataag gacccaaagt ttacttgaca ttaacctcta gtaggtgaga
     7561 aattccaaaa aagctttggg gtacattaga atttccaaag ctctgaaaga tatttcagga
     7621 gatttaacag cagagttgca acttacacgt gaattctggt ctatagtggt catgtgagtt
     7681 aaattcgaat cctctacttg tatgacccta ggaatagatt ggaatactgc agaggaccaa
     7741 agctgaggca tgctaaacag ctgcttggag gtggaagcaa gttcagtcac ctactcagct
     7801 tcctctctcc accacccagt tcctccctca gtatcacatt atttttttct tctgcttttc
     7861 attaacctaa ctcatctcat cagtacaacc attttcttat tctctaacta cccccaattc
     7921 ctttagcctc tccccacctg tccaaactca gctcagccgt gggccaatgc agcttacaga
     7981 cggttgcaga gctaggaaga aaacccagct ctcccaaccc tgatcgtgga ggtctctggc
     8041 cccccaacac tgccttctgg gggctgcatt tttttttttt ttttgagaag aggtcttttg
     8101 ggatgcatgg tgctccacat acagcttcac aaaatatttc attataagag aaaccccttg
     8161 atttttattt ctttttcttt tgttttctgg attacctgcc ttcagtaagc agatgcagac
     8221 ccacttgtaa ggagtctggt tagtgatgag aaaaggatga aatctagata caaaagtcac
     8281 cttgaaggtg atgatggatc tttaatccac ttgactaagt gtctggaaga gctacttgct
     8341 cttccacccc tcatctcaaa tgagaggagc agaagtttaa cttcctcaaa tagcccagct
     8401 ctggctaaaa cccaaagaag aaaggtcaaa ggaagggaaa gcatgtcagg ggctggtttg
     8461 tgacttggca ggaccaggaa acagcagcca ctgacagccc agagaaggtg actaagggct
     8521 ggcagaagat tagaatgtta atttggctgc tgtccggact aggaggccat gttcaatggc
     8581 agtcagaatt tgtgttctgc gcattgctgg gtctataaat atgataagca agtggtgaca
     8641 gaattatagt ataaggtgat gtactacatg cagatcataa aggctttggt tttaagactt
     8701 aagtagaaaa tccctctcct agcttattac ccaacaatat tcagataatg agcttttgga
     8761 gaatatcttt ttcctatcac tagaaagatt tacctgggaa ctgtctaaag tctacacaca
     8821 tatttccaaa gcctttaaat accaactgca gcatggagag agaggggtgg cagaagctga
     8881 aatgcctcaa aagccattta agtgttacgt tgcaggattt tcagtccttc tcgttatgta
     8941 aaagtagata aatatagacg ttattctcaa cactacccta tagtatcaca gtggtccaaa
     9001 tgccagagct tacagataat gtcatcacag tgcctagaaa ctcgaactgt aatatatcgt
     9061 agcattttct tggtgtttct taaagtttct ttccacaata caaggtcctc tctgcctctt
     9121 gtttcttgga gagttcaccc cactgatgag tcttccttcc ctgttggact cagtcatttg
     9181 gggaacagtc ttagaagcac atatcaacca aggaagaaac ttcctggata tctattgccc
     9241 acttgcccag gtctaataaa cactaaaggg gggaaattga aaggagctgc caactggtca
     9301 acgtggaagg gcggttccac cctagattgg tgtctttctt tttcttcctt tttttaaaaa
     9361 aaatctattt cttaaataat aataaatgca catgatgtgt taaatatgta catatatatt
     9421 tcaaaagaaa aaatggggca caagattgtc ttacaagtcg tgctggctaa tttttagttt
     9481 gtattcataa gtggttttta aaagcctttt ttaaagtgta atttgcatgt tctactttga
     9541 ttgtatgtaa acatatttta gaacaaaaaa tgtatttgta ttttattgaa tatagaggca
     9601 agaaaattgt acattgtttg aaatgttctt tttgtaacag tttttattca taaagcattt
     9661 ttgtacattt aaaatgaaca tggacttgct gttatttgag gcgtagatac atctagcatg
     9721 cttactgtca tgctcctcca tggtcttaga tgttgggttt taaacatttt tttctaaaag
     9781 aaagctcagt cttttccgct accagatcag gttagcacag tatagagcac ttaactatta
     9841 aaaaaaaaaa gttaatccta ttcatatgtt attcattgtg tgaaattaaa gacattcaat
     9901 tcagtctaa
//
