LOCUS       NM_003011               2927 bp    mRNA    linear   PRI 07-MAY-2024
DEFINITION  Homo sapiens SET nuclear proto-oncogene (SET), transcript variant
            2, mRNA.
ACCESSION   NM_003011
VERSION     NM_003011.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2927)
  AUTHORS   Chen,J., Jiao,Z., Liu,Y., Zhang,M. and Wang,D.
  TITLE     USP7 interacts with and destabilizes oncoprotein SET
  JOURNAL   Biochem Biophys Res Commun 709, 149818 (2024)
   PUBMED   38555840
  REMARK    GeneRIF: USP7 interacts with and destabilizes oncoprotein SET.
REFERENCE   2  (bases 1 to 2927)
  AUTHORS   Xu,W., Yao,H., Wu,Z., Yan,X., Jiao,Z., Liu,Y., Zhang,M. and Wang,D.
  TITLE     Oncoprotein SET-associated transcription factor ZBTB11 triggers
            lung cancer metastasis
  JOURNAL   Nat Commun 15 (1), 1362 (2024)
   PUBMED   38355937
  REMARK    GeneRIF: Oncoprotein SET-associated transcription factor ZBTB11
            triggers lung cancer metastasis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2927)
  AUTHORS   Xu,H., Wu,D., Xiao,M., Lei,Y., Lei,Y., Yu,X. and Shi,S.
  TITLE     PP2A complex disruptor SET prompts widespread hypertranscription of
            growth-essential genes in the pancreatic cancer cells
  JOURNAL   Sci Adv 10 (4), eadk6633 (2024)
   PUBMED   38277454
  REMARK    GeneRIF: PP2A complex disruptor SET prompts widespread
            hypertranscription of growth-essential genes in the pancreatic
            cancer cells.
REFERENCE   4  (bases 1 to 2927)
  AUTHORS   Kohyanagi,N., Kitamura,N., Ikeda,S., Shibutani,S., Sato,K. and
            Ohama,T.
  TITLE     PP2A inhibitor SET promotes mTORC1 and Bmi1 signaling through Akt
            activation and maintains the colony-formation ability of cancer
            cells
  JOURNAL   J Biol Chem 300 (1), 105584 (2024)
   PUBMED   38141761
  REMARK    GeneRIF: PP2A inhibitor SET promotes mTORC1 and Bmi1 signaling
            through Akt activation and maintains the colony-formation ability
            of cancer cells.
REFERENCE   5  (bases 1 to 2927)
  AUTHORS   Kou,F., Wu,L., Zheng,Y., Yi,Y., Ji,Z., Huang,Z., Guo,S. and Yang,L.
  TITLE     HMGB1/SET/HAT1 complex-mediated SASH1 repression drives glycolysis
            and metastasis in lung adenocarcinoma
  JOURNAL   Oncogene 42 (46), 3407-3421 (2023)
   PUBMED   37794134
  REMARK    GeneRIF: HMGB1/SET/HAT1 complex-mediated SASH1 repression drives
            glycolysis and metastasis in lung adenocarcinoma.
REFERENCE   6  (bases 1 to 2927)
  AUTHORS   Nagata,K., Kawase,H., Handa,H., Yano,K., Yamasaki,M., Ishimi,Y.,
            Okuda,A., Kikuchi,A. and Matsumoto,K.
  TITLE     Replication factor encoded by a putative oncogene, set, associated
            with myeloid leukemogenesis
  JOURNAL   Proc Natl Acad Sci U S A 92 (10), 4279-4283 (1995)
   PUBMED   7753797
REFERENCE   7  (bases 1 to 2927)
  AUTHORS   Adachi,Y., Pavlakis,G.N. and Copeland,T.D.
  TITLE     Identification of in vivo phosphorylation sites of SET, a nuclear
            phosphoprotein encoded by the translocation breakpoint in acute
            undifferentiated leukemia
  JOURNAL   FEBS Lett 340 (3), 231-235 (1994)
   PUBMED   8131851
REFERENCE   8  (bases 1 to 2927)
  AUTHORS   Vaesen,M., Barnikol-Watanabe,S., Gotz,H., Awni,L.A., Cole,T.,
            Zimmermann,B., Kratzin,H.D. and Hilschmann,N.
  TITLE     Purification and characterization of two putative HLA class II
            associated proteins: PHAPI and PHAPII
  JOURNAL   Biol Chem Hoppe Seyler 375 (2), 113-126 (1994)
   PUBMED   8192856
REFERENCE   9  (bases 1 to 2927)
  AUTHORS   Adachi,Y., Pavlakis,G.N. and Copeland,T.D.
  TITLE     Identification and characterization of SET, a nuclear
            phosphoprotein encoded by the translocation break point in acute
            undifferentiated leukemia
  JOURNAL   J Biol Chem 269 (3), 2258-2262 (1994)
   PUBMED   8294483
REFERENCE   10 (bases 1 to 2927)
  AUTHORS   von Lindern,M., van Baal,S., Wiegant,J., Raap,A., Hagemeijer,A. and
            Grosveld,G.
  TITLE     Can, a putative oncogene associated with myeloid leukemogenesis,
            may be activated by fusion of its 3' half to different genes:
            characterization of the set gene
  JOURNAL   Mol Cell Biol 12 (8), 3346-3355 (1992)
   PUBMED   1630450
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL356481.16, CA392072.1,
            AK223556.1, BP343325.1, CN408133.1 and BQ774097.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_003011.3.
            
            Summary: The protein encoded by this gene inhibits acetylation of
            nucleosomes, especially histone H4, by histone acetylases (HAT).
            This inhibition is most likely accomplished by masking histone
            lysines from being acetylated, and the consequence is to silence
            HAT-dependent transcription. The encoded protein is part of a
            complex localized to the endoplasmic reticulum but is found in the
            nucleus and inhibits apoptosis following attack by cytotoxic T
            lymphocytes. This protein can also enhance DNA replication of the
            adenovirus genome. Several transcript variants encoding different
            isoforms have been found for this gene. [provided by RefSeq, Oct
            2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.124742.1, M93651.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322030.13/ ENSP00000318012.9
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AL356481.16        169858-169865
            9-35                CA392072.1         1-27
            36-1285             AK223556.1         1-1250
            1286-1729           BP343325.1         135-578
            1730-2436           CN408133.1         50-756
            2437-2927           BQ774097.1         18-508              c
FEATURES             Location/Qualifiers
     source          1..2927
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q34.11"
     gene            1..2927
                     /gene="SET"
                     /gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; MRD58;
                     PHAPII; TAF-I; TAF-IBETA"
                     /note="SET nuclear proto-oncogene"
                     /db_xref="GeneID:6418"
                     /db_xref="HGNC:HGNC:10760"
                     /db_xref="MIM:600960"
     exon            1..434
                     /gene="SET"
                     /gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; MRD58;
                     PHAPII; TAF-I; TAF-IBETA"
                     /inference="alignment:Splign:2.1.0"
     CDS             362..1195
                     /gene="SET"
                     /gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; MRD58;
                     PHAPII; TAF-I; TAF-IBETA"
                     /note="isoform 2 is encoded by transcript variant 2; SET
                     translocation (myeloid leukemia-associated); protein
                     phosphatase type 2A inhibitor; Template-Activating
                     Factor-I, chromatin remodelling factor; inhibitor of
                     granzyme A-activated DNase; HLA-DR-associated protein II;
                     inhibitor-2 of protein phosphatase-2A; phosphatase 2A
                     inhibitor I2PP2A; SET nuclear oncogene"
                     /codon_start=1
                     /product="protein SET isoform 2"
                     /protein_id="NP_003002.2"
                     /db_xref="CCDS:CCDS6907.1"
                     /db_xref="GeneID:6418"
                     /db_xref="HGNC:HGNC:10760"
                     /db_xref="MIM:600960"
                     /translation="MSAPAAKVSKKELNSNHDGADETSEKEQQEAIEHIDEVQNEIDR
                     LNEQASEEILKVEQKYNKLRQPFFQKRSELIAKIPNFWVTTFVNHPQVSALLGEEDEE
                     ALHYLTRVEVTEFEDIKSGYRIDFYFDENPYFENKVLSKEFHLNESGDPSSKSTEIKW
                     KSGKDLTKRSSQTQNKASRKRQHEEPESFFTWFTDHSDAGADELGEVIKDDIWPNPLQ
                     YYLVPDMDDEEGEGEEDDDDDEEEEGLEDIDEEGDEDEGEEDEDDDEGEEGEEDEGED
                     D"
     exon            435..492
                     /gene="SET"
                     /gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; MRD58;
                     PHAPII; TAF-I; TAF-IBETA"
                     /inference="alignment:Splign:2.1.0"
     exon            493..635
                     /gene="SET"
                     /gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; MRD58;
                     PHAPII; TAF-I; TAF-IBETA"
                     /inference="alignment:Splign:2.1.0"
     exon            636..739
                     /gene="SET"
                     /gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; MRD58;
                     PHAPII; TAF-I; TAF-IBETA"
                     /inference="alignment:Splign:2.1.0"
     exon            740..853
                     /gene="SET"
                     /gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; MRD58;
                     PHAPII; TAF-I; TAF-IBETA"
                     /inference="alignment:Splign:2.1.0"
     exon            854..1024
                     /gene="SET"
                     /gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; MRD58;
                     PHAPII; TAF-I; TAF-IBETA"
                     /inference="alignment:Splign:2.1.0"
     exon            1025..1171
                     /gene="SET"
                     /gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; MRD58;
                     PHAPII; TAF-I; TAF-IBETA"
                     /inference="alignment:Splign:2.1.0"
     exon            1172..2927
                     /gene="SET"
                     /gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; MRD58;
                     PHAPII; TAF-I; TAF-IBETA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2047..2052
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SET"
                     /gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; MRD58;
                     PHAPII; TAF-I; TAF-IBETA"
                     /note="hexamer: ACTAAA"
     polyA_site      2064
                     /gene="SET"
                     /gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; MRD58;
                     PHAPII; TAF-I; TAF-IBETA"
                     /note="major polyA site"
     regulatory      2899..2904
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SET"
                     /gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; MRD58;
                     PHAPII; TAF-I; TAF-IBETA"
                     /note="hexamer: AATAAA"
     polyA_site      2927
                     /gene="SET"
                     /gene_synonym="2PP2A; I2PP2A; IGAAD; IPP2A2; MRD58;
                     PHAPII; TAF-I; TAF-IBETA"
ORIGIN      
        1 ccctcgccgt aggaggaggt ggaggaggag gcggctcggg agagcgagca gcgagctggc
       61 tggatcgccg agcgcgagtg agggagccga gccgcccgcc gccgccgcct ccgcctcccc
      121 tccgcgaaca ggagcccggg ccggggcccg gcacgccgcc ccagcccgtc cctcggcgtc
      181 aggccgcgag ggtagcgcgc gcgagcgagc gagggggagg gagagcgagc gagcgccggg
      241 aggaggcggc cggaccgagc gggcgcccgc gcgtgtggcg tgaggggaag ccgcttgccc
      301 gcccccttcg ccttcccttc tctccccctc cccgctcccc ccccgaccgc ggagcagcac
      361 catgtcggcg ccggcggcca aagtcagtaa aaaggagctc aactccaacc acgacggggc
      421 cgacgagacc tcagaaaaag aacagcaaga agcgattgaa cacattgatg aagtacaaaa
      481 tgaaatagac agacttaatg aacaagccag tgaggagatt ttgaaagtag aacagaaata
      541 taacaaactc cgccaaccat tttttcagaa gaggtcagaa ttgatcgcca aaatcccaaa
      601 tttttgggta acaacatttg tcaaccatcc acaagtgtct gcactgcttg gggaggaaga
      661 tgaagaggca ctgcattatt tgaccagagt tgaagtgaca gaatttgaag atattaaatc
      721 aggttacaga atagattttt attttgatga aaatccttac tttgaaaata aagttctctc
      781 caaagaattt catctgaatg agagtggtga tccatcttcg aagtccaccg aaatcaaatg
      841 gaaatctgga aaggatttga cgaaacgttc gagtcaaacg cagaataaag ccagcaggaa
      901 gaggcagcat gaggaaccag agagcttctt tacctggttt actgaccatt ctgatgcagg
      961 tgctgatgag ttaggagagg tcatcaaaga tgatatttgg ccaaacccat tacagtacta
     1021 cttggttccc gatatggatg atgaagaagg agaaggagaa gaagatgatg atgatgatga
     1081 agaggaggaa ggattagaag atattgacga agaaggggat gaggatgaag gtgaagaaga
     1141 tgaagatgat gatgaagggg aggaaggaga ggaggatgaa ggagaagatg actaaataga
     1201 acactgatgg attccaacct tccttttttt aaattttctc cagtccctgg gagcaagttg
     1261 cagtcttttt tttttttttt tttttttttc cctcttgtgc tcagtcgccc tgttcttgag
     1321 gtctcttttc tctactccat ggttctcaat ttatttgggg ggaaatacct tgagcagaat
     1381 acaatgggaa aagagtctct acccctttct gttcgaagtt catttttatc ccttcctgtc
     1441 tgaacaaaaa ctgtatggaa tcaacaccac cgagctctgt gggaaaaaag aaaaacctgc
     1501 tcccttcgct ctgctggaag ctggagggtg ctaggcccct gtgtagtagt gcatagaatt
     1561 ctagcttttt tcctcctttc tctgtatatt gggctcagag agtacactgt gtctctatgt
     1621 gaatatggac agttagcatt taccaacatg tatctgtcta ctttctcttg tttaaaaaaa
     1681 gaaaaaaaaa cttaaaaaaa tggggttata gaaggtcagc aaagggtggg tttgagatgt
     1741 ttgggtgggt taagtgggca ttttgacaac atggcttctc ctttggcatg tttaattgtg
     1801 atatttgaca gacatccttg cagtttaaga tgacactttt aaaataaatt ctctcctaat
     1861 gatgacttga gccctgccac tcaatgggag aatcagcaga acctgtagga tcttatttgg
     1921 aattgacatt ctctattgta attttgttcc tgtttatttt taaattttct ttttgtttca
     1981 ctggaaagga aagatgatgc tcagttttaa acgttaaaag tgtacaagtt gctttgttac
     2041 aataaaacta aatgtgtaca caaaggattt gatgcttttc tctcagcata ggtatgctta
     2101 ctatgacctt ccaagtttga cttgtataac atcactgtca aactttgtca ccctaacttc
     2161 gtattttttg atacgcactt tgcaggatga cctcagggct atgtggattg agtaatggga
     2221 tttgaatcaa tgtattaata tctccatagc tgggaaacgt gggttcaatt tgccattggt
     2281 ttctgaaagt attcacatca tttgggatac cagatagctc aatactctct gagtacattg
     2341 tgcccttgat ttttatctcc aagtggcagt ttttaaaatt ggccttttac ctggatataa
     2401 attaattgtg cctgccacca ccatccaaca gacctggtgc tctaatgcca agttatacac
     2461 gggacagttg ctggcatgtc ttcattggct atataaaatg tggccaagaa gataggctct
     2521 cagtaagaag tctgatggtg agcagtaact gtccctgctt tctggtataa agctctcaaa
     2581 tgtgaccatg tgaatctggg tgggataatg gactcagctc tgtctgctca atgccattgt
     2641 gcagagaagc accctaatgc ataagctttt taatgctgta aaatatagtc gctgaaatta
     2701 aatgccactt tttcagaggt gaattaatgg acagtctggt gaacttcaaa agctttttga
     2761 tgtataaaac ttgataaatg gaactattcc atcaataggc aaaagtgtaa caacctatct
     2821 agatggatag tatgtaattt ctgcacaggt ctctgtttag taaatacatc actgtatacc
     2881 gatcaggaat cttgctccaa taaaggaaca taaagatttt ttttgga
//
