LOCUS       NM_144665               9563 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens sestrin 3 (SESN3), transcript variant 1, mRNA.
ACCESSION   NM_144665
VERSION     NM_144665.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 9563)
  AUTHORS   Livneh,I., Fabre,B., Goldhirsh,G., Lulu,C., Zinger,A., Shammai
            Vainer,Y., Kaduri,M., Dahan,A., Ziv,T., Schroeder,A.,
            Ben-Neriah,Y., Zohar,Y., Cohen-Kaplan,V. and Ciechanover,A.
  TITLE     Inhibition of nucleo-cytoplasmic proteasome translocation by the
            aromatic amino acids or silencing Sestrin3-their sensing
            mediator-is tumor suppressive
  JOURNAL   Cell Death Differ 31 (10), 1242-1254 (2024)
   PUBMED   39266717
  REMARK    GeneRIF: Inhibition of nucleo-cytoplasmic proteasome translocation
            by the aromatic amino acids or silencing Sestrin3-their sensing
            mediator-is tumor suppressive.
REFERENCE   2  (bases 1 to 9563)
  AUTHORS   Luu,D., Shah,T., Sakharkar,P. and Min,D.I.
  TITLE     Genetic variations in a Sestrin2/Sestrin3/mTOR Axis and development
            of new-onset diabetes after kidney transplantation
  JOURNAL   Transpl Immunol 81, 101947 (2023)
   PUBMED   37918578
  REMARK    GeneRIF: Genetic variations in a Sestrin2/Sestrin3/mTOR Axis and
            development of new-onset diabetes after kidney transplantation.
REFERENCE   3  (bases 1 to 9563)
  AUTHORS   Chen,Y., Huang,T., Yu,Z., Yu,Q., Wang,Y., Hu,J., Shi,J. and Yang,G.
  TITLE     The functions and roles of sestrins in regulating human diseases
  JOURNAL   Cell Mol Biol Lett 27 (1), 2 (2022)
   PUBMED   34979914
  REMARK    GeneRIF: The functions and roles of sestrins in regulating human
            diseases.
            Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 9563)
  AUTHORS   Zhang,L., Ren,R., Yang,X., Ge,Y., Zhang,X. and Yuan,H.
  TITLE     Oncogenic role of early growth response-1 in liver cancer through
            the regulation of the microRNA-675/sestrin 3 and the
            Wnt/beta-catenin signaling pathway
  JOURNAL   Bioengineered 12 (1), 5305-5322 (2021)
   PUBMED   34409922
  REMARK    GeneRIF: Oncogenic role of early growth response-1 in liver cancer
            through the regulation of the microRNA-675/sestrin 3 and the
            Wnt/beta-catenin signaling pathway.
REFERENCE   5  (bases 1 to 9563)
  AUTHORS   Waterhouse,M., Pennisi,S., Pfeifer,D., Deuter,M., von Bubnoff,N.,
            Scherer,F., Strussmann,T., Wehr,C., Duyster,J., Bertz,H., Finke,J.
            and Duque-Afonso,J.
  TITLE     Colon and liver tissue damage detection using methylated SESN3 and
            PTK2B genes in circulating cell-free DNA in patients with acute
            graft-versus-host disease
  JOURNAL   Bone Marrow Transplant 56 (2), 327-333 (2021)
   PUBMED   33082554
  REMARK    GeneRIF: Colon and liver tissue damage detection using methylated
            SESN3 and PTK2B genes in circulating cell-free DNA in patients with
            acute graft-versus-host disease.
            Erratum:[Bone Marrow Transplant. 2021 Oct;56(10):2616. doi:
            10.1038/s41409-021-01405-8.. PMID: 34413471]
REFERENCE   6  (bases 1 to 9563)
  AUTHORS   Hagenbuchner,J., Kuznetsov,A., Hermann,M., Hausott,B., Obexer,P.
            and Ausserlechner,M.J.
  TITLE     FOXO3-induced reactive oxygen species are regulated by BCL2L11
            (Bim) and SESN3
  JOURNAL   J Cell Sci 125 (Pt 5), 1191-1203 (2012)
   PUBMED   22349704
REFERENCE   7  (bases 1 to 9563)
  AUTHORS   Chen,C.C., Jeon,S.M., Bhaskar,P.T., Nogueira,V., Sundararajan,D.,
            Tonic,I., Park,Y. and Hay,N.
  TITLE     FoxOs inhibit mTORC1 and activate Akt by inducing the expression of
            Sestrin3 and Rictor
  JOURNAL   Dev Cell 18 (4), 592-604 (2010)
   PUBMED   20412774
  REMARK    GeneRIF: FoxOs inhibit mTORC1 and activate Akt by inducing the
            expression of Sestrin3 and Rictor
REFERENCE   8  (bases 1 to 9563)
  AUTHORS   Nogueira,V., Park,Y., Chen,C.C., Xu,P.Z., Chen,M.L., Tonic,I.,
            Unterman,T. and Hay,N.
  TITLE     Akt determines replicative senescence and oxidative or oncogenic
            premature senescence and sensitizes cells to oxidative apoptosis
  JOURNAL   Cancer Cell 14 (6), 458-470 (2008)
   PUBMED   19061837
REFERENCE   9  (bases 1 to 9563)
  AUTHORS   Kopnin,P.B., Agapova,L.S., Kopnin,B.P. and Chumakov,P.M.
  TITLE     Repression of sestrin family genes contributes to oncogenic
            Ras-induced reactive oxygen species up-regulation and genetic
            instability
  JOURNAL   Cancer Res 67 (10), 4671-4678 (2007)
   PUBMED   17510393
REFERENCE   10 (bases 1 to 9563)
  AUTHORS   Peeters,H., Debeer,P., Bairoch,A., Wilquet,V., Huysmans,C.,
            Parthoens,E., Fryns,J.P., Gewillig,M., Nakamura,Y., Niikawa,N., Van
            de Ven,W. and Devriendt,K.
  TITLE     PA26 is a candidate gene for heterotaxia in humans: identification
            of a novel PA26-related gene family in human and mouse
  JOURNAL   Hum Genet 112 (5-6), 573-580 (2003)
   PUBMED   12607115
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AP000787.5, AK096300.1 and
            AF086251.1.
            
            On May 17, 2019 this sequence version replaced NM_144665.3.
            
            Summary: This gene encodes a member of the sestrin family of
            stress-induced proteins. The encoded protein reduces the levels of
            intracellular reactive oxygen species induced by activated Ras
            downstream of RAC-alpha serine/threonine-protein kinase (Akt) and
            FoxO transcription factor. The protein is required for normal
            regulation of blood glucose, insulin resistance and plays a role in
            lipid storage in obesity. Alternative splicing results in multiple
            transcript variants. [provided by RefSeq, Oct 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803611.239775.1,
                                           SRR1660809.197020.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2467150, SAMN03267756
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000536441.7/ ENSP00000441927.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-120               AP000787.5         111629-111748       c
            121-2107            AK096300.1         1-1987
            2108-2145           AF086251.1         534-571
            2146-9563           AP000787.5         46059-53476         c
FEATURES             Location/Qualifiers
     source          1..9563
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q21"
     gene            1..9563
                     /gene="SESN3"
                     /gene_synonym="SEST3"
                     /note="sestrin 3"
                     /db_xref="GeneID:143686"
                     /db_xref="HGNC:HGNC:23060"
                     /db_xref="MIM:607768"
     exon            1..420
                     /gene="SESN3"
                     /gene_synonym="SEST3"
                     /inference="alignment:Splign:2.1.0"
     CDS             343..1821
                     /gene="SESN3"
                     /gene_synonym="SEST3"
                     /note="isoform 1 is encoded by transcript variant 1"
                     /codon_start=1
                     /product="sestrin-3 isoform 1"
                     /protein_id="NP_653266.2"
                     /db_xref="CCDS:CCDS8303.1"
                     /db_xref="GeneID:143686"
                     /db_xref="HGNC:HGNC:23060"
                     /db_xref="MIM:607768"
                     /translation="MNRGGGSPSAAANYLLCTNCRKVLRKDKRIRVSQPLTRGPSAFI
                     PEKEVVQANTVDERTNFLVEEYSTSGRLDNITQVMSLHTQYLESFLRSQFYMLRMDGP
                     LPLPYRHYIAIMAAARHQCSYLINMHVDEFLKTGGIAEWLNGLEYVPQRLKNLNEINK
                     LLAHRPWLITKEHIQKLVKTGENNWSLPELVHAVVLLAHYHALASFVFGSGINPERDP
                     EISNGFRLISVNNFCVCDLANDNNIENASLSGSNFGIVDSLSELEALMERMKRLQEER
                     EDEEASQEEMSTRFEKEKKESLFVVSGDTFHSFPHSDFEDDMIITSDVSRYIEDPGFG
                     YEDFARRGEEHLPTFRAQDYTWENHGFSLVNRLYSDIGHLLDEKFRMVYNLTYNTMAT
                     HEDVDTTMLRRALFNYVHCMFGIRYDDYDYGEVNQLLERSLKVYIKTVTCYPERTTKR
                     MYDSYWRQFKHSEKVHVNLLLMEARMQAELLYALRAITRHLT"
     exon            421..486
                     /gene="SESN3"
                     /gene_synonym="SEST3"
                     /inference="alignment:Splign:2.1.0"
     exon            487..684
                     /gene="SESN3"
                     /gene_synonym="SEST3"
                     /inference="alignment:Splign:2.1.0"
     exon            685..867
                     /gene="SESN3"
                     /gene_synonym="SEST3"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1104
                     /gene="SESN3"
                     /gene_synonym="SEST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1105..1279
                     /gene="SESN3"
                     /gene_synonym="SEST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1280..1398
                     /gene="SESN3"
                     /gene_synonym="SEST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1399..1589
                     /gene="SESN3"
                     /gene_synonym="SEST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1590..1734
                     /gene="SESN3"
                     /gene_synonym="SEST3"
                     /inference="alignment:Splign:2.1.0"
     exon            1735..9563
                     /gene="SESN3"
                     /gene_synonym="SEST3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      9510..9515
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SESN3"
                     /gene_synonym="SEST3"
                     /note="hexamer: AATAAA"
     polyA_site      9536
                     /gene="SESN3"
                     /gene_synonym="SEST3"
                     /note="major polyA site"
ORIGIN      
        1 gcactgaggc gctgcggcgg cggtggtggc ggtggcagcg gtggcggctg ctcgtcctag
       61 cctggcgggg gcgggggtct ggaagatggg ggcgggtgga acaacgggcc ggtgaggagc
      121 agccgccgcc gtctccgccg tcgctggggc agctgccgcg gtggtcgcct ctggcagtgc
      181 cgctagcttt caggcagtcg cctctcctcc cgacatcccg ccttgaggag gctgaggcgg
      241 aatcgcggct ggcggcgggg ggacggaccg gccctgcagt ggccgcagtg acagcccgga
      301 cccggccctc cgcccgctct cgcctcggcg cccgcagcca cgatgaaccg gggcggcggc
      361 agcccgtcgg ccgccgccaa ctacctgctc tgtaccaact gccggaaagt gctgcggaag
      421 gataaaagaa tcagagtgtc tcaacccttg acaagaggac caagtgcctt tattccagag
      481 aaggaagttg tccaagcaaa cacagtggat gaacgtacta actttcttgt ggaagaatac
      541 tctacatccg gtcgtctgga caacatcaca caggtcatga gtttacacac tcagtacctg
      601 gagtctttct tgcggagcca gttttacatg ttgcgcatgg atggtcccct tcctctacca
      661 tacaggcact atattgcaat aatggctgca gctagacatc agtgttctta cttaataaac
      721 atgcatgtgg atgaattttt aaagactgga ggtattgctg agtggttgaa tggtttggaa
      781 tatgtgccac aaagactgaa aaatcttaat gaaattaata agctgctagc acatcgacct
      841 tggctgatca caaaagagca cattcagaaa cttgtcaaaa ctggagaaaa taattggtct
      901 ctgcctgaac tggtacatgc tgtggtcctc ctggcacatt atcatgcttt ggcaagcttt
      961 gtttttggta gtggtatcaa tccagagaga gatccagaaa tctccaatgg attcaggcta
     1021 atatcagtca acaatttctg cgtttgtgat cttgctaatg acaacaacat agagaatgca
     1081 tctctttcag gcagcaactt tgggattgtg gattctctaa gtgagctaga ggccttaatg
     1141 gaaaggatga aaagacttca agaagaaagg gaagatgaag aggcgtctca agaagaaatg
     1201 agcactcgtt ttgaaaagga gaagaaagaa agtctttttg tggtctctgg agatactttt
     1261 cattcatttc ctcattcaga ttttgaggat gacatgatta taacatctga tgtctctcga
     1321 tatattgaag accctggttt tgggtatgaa gactttgcca gacgaggaga agagcatttg
     1381 ccaacattcc gagctcagga ctatacctgg gaaaatcatg ggttctccct ggtgaacaga
     1441 ctttattctg acattggaca tcttcttgat gaaaagtttc ggatggtcta caatctcaca
     1501 tataacacta tggccaccca tgaggatgtt gacacaacca tgctgcgcag agctttattt
     1561 aactatgttc actgtatgtt tggaatcagg tatgatgact atgattatgg agaagttaat
     1621 caattacttg aaagaagcct gaaggtttac attaagacag tgacctgcta tcctgagaga
     1681 actacaaaac gcatgtatga tagttactgg cggcagttca aacactcaga aaaagttcat
     1741 gtcaatctac ttttaatgga agcacgaatg caagctgaac ttctttatgc tcttcgtgcc
     1801 ataactcggc atttgacctg aagtatcacc caaggaaaat gtcatacatg tgtaaagacc
     1861 tttcacataa gataaacatt gaagctattt gtgatatagc atcaaaaatt attcagttct
     1921 ctagtgtcaa agtttagccg tttgtttttt tttttttgtt ttttgcggct gtaatgtgca
     1981 atgatgtgtt ttattttcct tgatgcttaa cattactaac aattgcaaaa ataatactga
     2041 ggagcactac tttgcattgt ttgtagttgg agttttggat actgatcata aatcatgaat
     2101 ctggcgtatt aatgcttaac ttcagcgcct ttgggttgtg tgtatgtgta ttttttctcc
     2161 ccccaccccg cccttttttt tttaagaata aggacaagtg cttacaatct gctcaagcaa
     2221 ttgtttttca gatattggaa ttcagcaaag agtgacctct ctggccattc taaaacttta
     2281 atgttgtgtc ctaaatctgg tggaggaaaa gcatgcgctg ttgaaccaag ctgctcactg
     2341 gacacatatt tgtgtcccca ggagattatt tgtcaggcac tgttttttat ttgtttgttt
     2401 gttcatttat tgttgtttta ctgctattgg cgataacatg aaatgtgata cagctattgc
     2461 ccataattta atgtgaaatt aatcatgatg aattctatag catgctactg aaatgccaaa
     2521 ttcagctatt ttctttctct tctaaaatgg aagtttcagt tttccatatc agatgtatat
     2581 aagtggaatt ataacacaat cctatcactg acagtaatcc tcagtcacct taaataatca
     2641 gtgctcacag tgctgcttac agttcattta gttggcacat ataaacctgt acccacacaa
     2701 gactgaccaa aaattttctt tgcacatttt tcctttctca tagttttttt ctatatttcg
     2761 ttaagcaaag gaaggttaat atgcctattt ttcctgttag gcttttagaa attattttcc
     2821 atgacttttg ttcttataat aggttagaca gtttattttt caaaggtaaa aattgtgttt
     2881 ctatgcatta atgtgattga actacaaaaa cagagtgcaa tatgttcaaa aaatactcaa
     2941 ctaaactttc cccctgtcat atcactgcaa aagtgtcctt ttaaacagag ccataaagaa
     3001 atttttttca aatttcttta ttgcacaggc ttttttcagt tttacctttc tgggattgaa
     3061 caatgttcct ttcataatgc caaagcattc ccttccccag aaaaatctcc ttggacaact
     3121 ggtttaaaaa cgttattaag tcatagggga ggaataagcg gccaaaaagt cacatttttg
     3181 cattggttta cgttgcttga ttagactatc ttcagagagc acattatgtg tttatagctt
     3241 taatttgtat tatgtcaatg aaccagtgaa gtgcctaaag agatgcttac aactatccag
     3301 taggacacaa ctgcactgct ttttaaacac tttttggtta gttaagggtg acttgaattg
     3361 tacacataca tgctaatttt tgaaaactta tccatttttc atagtaaata atatagataa
     3421 aattttctgt tagagttccc gcaaatattt cattttagac ttacttgtga tataagattt
     3481 aacttttctt ttgtgaaaga atcgtgaact agtgtttcat gaaatcattt tcctcttcca
     3541 tttatcatcc tcctctggta caatatattg ggttgctttc ttttagattt tgttccagat
     3601 aggaaaacaa atatgactgt atacttatta acataaggta gttctgcatt tttggattcc
     3661 aggatcctgt ttgaaatctt ccatgtgagg aaaaaattac taatattttt aaagacaggg
     3721 tggtttattt aaagagatta ttcagagaac ttgtgccata tctcgtctgt tttattgcat
     3781 atgccatatg ttaactttta ttcaatatta cattatgtag atatgtaata caaagaaaat
     3841 atttaggaga atggcaaaac acaaatggca acataaatgt ccatttgact tacctaactt
     3901 cacaactttc aagttgagga tgtcatttat tcttgaattt gtttttttac tagatgcttt
     3961 caattaatag ccctatattt ttgtgcaggc gaactgtata acaggataaa aaatgatttg
     4021 tatgtattga aaaggaggag aaattctcac agaacaccat atgagcttta gaccaaaagg
     4081 ggaaacaagg tttaagtaac taaaatggcc acttagtttg tgtttatttt tttccctgga
     4141 aatgtaagta gttggagttt aggctatgga aatattagtg cctttaatag atctctttcc
     4201 ttgcaaagtt tctttttagc tcagcattga tctatcttat caataggaaa ataagttgac
     4261 ttggaactat aaacaaaaac aacaccatat atttatgaac ctcagtgaac cagcctagaa
     4321 aaattgactt ctgcaggtgc taaagcacct actaatacgc agcatgcaca gcatttcagg
     4381 ttgtgaatac cattttacaa cgagtttgct gttaactctc tttatccaat gcaaacttga
     4441 aattctgatg cggttttcca gggtggtatt ttttcagagt attgaattta ctatttagta
     4501 atttatagta tagcttttta tattaaaatg tgatattttt aaaagagata tctggttcaa
     4561 ttggtataat gacgtgatta tgcaatatgc tgatctacac cttgcgctca cattgtgcca
     4621 aacttaaatg tgcaagtgta cgtgagaaaa gcacatgtga atgtgaattc tttaattctt
     4681 tgcttattat gttaaaatta gtcttcatag tccactgatg tgtatgcttg aataatgtct
     4741 atttactttg gaatttcaag atttccagct tcaatggtaa tttataattt ctcagatcac
     4801 cttaagaaat attgagatac tctcccacct gaaaataatc tgttctttaa cccacctgac
     4861 tatgggagta gccaggcagg tgcctcactg gcttcttcag acgaggcttc ctcaggtgga
     4921 tatatgacta ttaggggaaa agaggctttt gagacagctt attacctcct tccccttttt
     4981 gaactaagta cattgtctca gtcccagtat gaatttgtcc catttggggt atttttaaaa
     5041 taaaagatgg ctaacatgga atctggggca tagccttggc ctttaattat ggttgtaagc
     5101 ccaaataatg gcagagaaac acagggctgt ttttacaaca gaaaactcaa tataagtttt
     5161 atataagaat cctataaaat ttgaaccaga gctcctattt agttgttata atgtctccta
     5221 aagatcttaa atgcttctaa aagctaatta ttattccaga gcaacttttt ccttttcccc
     5281 cttataaagt ttttttttaa atccaaaatc ttagatttct gtgccacagc aaaataaaat
     5341 gatcaacaat taaagatctg tacttaaaat agtacaccat ttttagtgga gggagggtgc
     5401 atgcctatat gatggtaaga ttcttttgaa ctctaaggac aattcctcat ggaaaaaata
     5461 aatttcagtg catattataa aaatgatttg cactgtgtta gcaaaataag gtgttttagg
     5521 ttgtatttta aagacaattc taaatcattt ctctggaaag caagacctta aattcttctc
     5581 tttaatagaa ctgcttttat gcaaagagat ggtcttaaca tggactaaac agtacataac
     5641 aataatgttt gttatgtaaa tagtatatca catttgctta gtagcacaat tcaacagcag
     5701 gctgaaagtc gtggctcctc tgctcagatt gagttttaag ttacctaatt tatgtaatca
     5761 gaatctattc taggtggccg tcaacgtaaa ctgtgtttcc ctattatatc cctctggaga
     5821 ctgagaatca aattaaatag tctttcttca aagcagtact gtaacatgaa tgtatttatc
     5881 tcagtcaaca gaacttatat gcccactgta tgtggagctt atttcaatgc taatttggct
     5941 tagttagcag acctagaatc tgcccaggtg agacctagaa caaaaatagc tggggtgaaa
     6001 tggataagag aggtagaggt atatgtcaag gcagagccct atgaggaagg aagagttttc
     6061 aaagaatatg aggaacatag tgctgagagt gtggctgcct tcagcaccgt acacctaatc
     6121 tagagaaaat atttcccatg tgggaggtcc tgtctgcatt cagtccaccc ttttctgcct
     6181 gcttcttcct ccaagtgcct caacctctac atgctcactc tcctcccctt ccctcagccc
     6241 atcttggtct aagcagcttt cacaatccaa accaaacatc accagccacc cgctgataag
     6301 tcaccagcat ttactttcct gagttacttt ttctccattc attgagacta tggattcatc
     6361 ccaactcctt ctaaatccct caaccatcca gctatatttt ggctaacctt tgccctagac
     6421 actctaccag atgttaatgc agtatcaagt gtaaattgtg tcaccctatt ctgttctacc
     6481 cttttccctg ctgccgaaat atcttgctct cctctacctc atccccaaag agcctataaa
     6541 ttcagagtat ccaacctttt catggattca ctcactgttg ttcagtaata caacttccat
     6601 attttaaata aatcataaaa gatttttgcc ttctatcaaa gtaggaaact ttatatttat
     6661 acatgataca gaaattgaac tatttctatc gttcagaatt tagcatataa caggatttta
     6721 aagtgattga attgccatcc taacttggat ttgtattagg ttatgaatga atactgttgt
     6781 tagtccaagc tatttgaatg taaagttaaa attctccagc aatccagaat gacttgtaac
     6841 ccttcagtgg aatgggaaat ttctggtatg caaatagggt ggtgttccag acatttgttt
     6901 tattggtggt gtttgggcct tgaaacacat ttctaataga atgacatatg gcaaagggta
     6961 tttagatggt cctatgggat cacagaagcc catatgattt aaaatataga taaaataaca
     7021 caaaattggg tacataaggg tttaaccagg ctttcctggg ttagactaag cctctaacct
     7081 ctgttcctat cctgttctta tgggaggaaa aaaaatgttc catgggatga aaagaaaatg
     7141 cattgacttt gtagtcttta ttctcctagc cgcacttcgg gtatatccag aaggaagagg
     7201 aaatgcaaag aggaagaaga tgtaatagtt cttctctcca gctaggtgca cttgaggttg
     7261 ttcataaatg taaaattatg tcaggtttct aacatgggac actgcacaca gttgtctgac
     7321 ctgatgaacc atcccatttg aaagtataga ttattattat ttcttgtagt atttggttgt
     7381 tttccatctc attcatgaac aactcaacct gatagtagta tccaataaat gcctttcagg
     7441 gctcaggaat gaattgacat cctagttaag aaatgagact taataatgga gactgaatga
     7501 ggcggtttgt attaaattat atgccatgaa gtgttcattt tagctttaac ctaattatga
     7561 ctgtaccacc atgaagtaca gaatgaaaaa ttatatatat gggggggaaa cagaatgaat
     7621 atctgattct tttgaatgct tgtggaaatc tttgagatcg tgcagggcat accacaaaat
     7681 agcctttaga acagataccc aattttacag ttcataggac aacatcaaac attagtaagt
     7741 ctaaataaga tgaatagaat ttttgttatg taaattttgc tagaacagtc tattttcttg
     7801 cacccctcaa gttaacctct taaaaaaatg aatgtataat ttctaccgaa agaatatcag
     7861 agagaatctc tctggcctat agtgttaaaa tattgttcac aaatcctgat tagttaagtg
     7921 catacattat gaaacttaca gaataaaact tattatacat ctctttctta aattaatatc
     7981 tttacacatt ttcaactggc tccccaagtc tgataaggaa ggattaaaag aaaaaagaaa
     8041 tgtattagtt gggtggccaa ggagtttcct ttgtaatgtt gagagacttc cgctttctga
     8101 atttcgctgg ttctctaagg taaaagagtt aaatagtacc cttgttcacc aaggaaagtg
     8161 atccaaacta tatatctagt gcagatattt cctttgcatt atttagtctt ctctggagag
     8221 aaaatacagt ttccccttcc tctttctctt cacatttact cttttcaacc caaaataaga
     8281 gacatagaaa gcaaaccaca gccagtttgg catcttctca gtgctactag tataggcaca
     8341 tacacataca cagtctcagc aaggttataa agaaccctgt caggtccact tgcaacatgg
     8401 ccttgctact tggattagct cctttaagcc tgaaaataac tttcctggtc atggaagaac
     8461 tggacgcatc ttttaactta tgaaatagaa gttgaacttg aaaactcttt ttaaaaaatc
     8521 ctggttttgc aggacagcta cataatgaat gtatatatta agactgtagc tgaattgcac
     8581 atgaaatcag attgccaact tcttgacttt caatgttaga catttatcct taagttgtga
     8641 gcgatatatg tagcatgctg tgaaatgtct gttatagctc tttaattcat cagtattaat
     8701 acagaattat catttgcgtt tcttggtact ttttattcaa tgtaatcaga agctgtgatg
     8761 ttttgccttt gtagtcctgt gctttgttac tgtaattttt tttttttttt tacgaagcac
     8821 gtgactggac taatgtaagg cagatgacgt gatctttaag actgctatat atatcagtct
     8881 cttactctat aaggttttaa attagaataa gcttttatca aatagataat tgatgcaatt
     8941 taggattcac gcaagtttca gtgtcaaatg gcggtcttat agtttcaatt ctgaaaatag
     9001 caaacttaat aaacagccac tttaaacttg ttctggcaaa ccagaccctg ctgtagatat
     9061 agtctaaggt agttaaccat ataagccttt tcaactctta atgccctcca catgaatcag
     9121 cagttaagaa ggttctagaa cccatgaaag cttttgtatg tattactagg ttttgttttt
     9181 cttatgtttg ctgattttac agttctgact aaagctgacc taaatggatc agtttatgtg
     9241 taatattcta gtgctttaat gactcttttt ttctttggag ggagggtaac attatttgga
     9301 cagatgcaga aggaactgtt agtgagtcaa gacaaacaca tctgaaataa aggaactgtg
     9361 tattaacatg ttaacaattc ataactgcac tttttatgac attttgaaaa tctatttata
     9421 ggtacagaac aatgggtttt gttaaactgt atcacattta tacttgcaga aatttatttc
     9481 attgttatta gtaggaattt tattggttca ataaaattgg caaaactgaa caccaatcat
     9541 ttgcctactt tgtttatact gga
//
