LOCUS       NM_031459               3462 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens sestrin 2 (SESN2), mRNA.
ACCESSION   NM_031459
VERSION     NM_031459.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3462)
  AUTHORS   Xia,K., Hui,Y., Zhang,L., Qiu,Q., Zhong,J., Chen,H., Liu,X.,
            Wang,L. and Chen,Z.
  TITLE     SETDB1 targeting SESN2 regulates mitochondrial damage and oxidative
            stress in renal ischemia-reperfusion injury
  JOURNAL   BMC Biol 22 (1), 246 (2024)
   PUBMED   39443993
  REMARK    GeneRIF: SETDB1 targeting SESN2 regulates mitochondrial damage and
            oxidative stress in renal ischemia-reperfusion injury.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3462)
  AUTHORS   Zheng,T., Zhang,D., Fu,Q., Wang,M., Cheng,Z., Cao,Y., Wang,L.,
            Liu,J. and Zhao,Y.
  TITLE     DNA methylation-driven gene FAM3D promotes colorectal cancer growth
            via the ATF4-SESN2-mTORC1 pathway
  JOURNAL   Aging (Albany NY) 16 (19), 12866-12892 (2024)
   PUBMED   39388305
  REMARK    GeneRIF: DNA methylation-driven gene FAM3D promotes colorectal
            cancer growth via the ATF4-SESN2-mTORC1 pathway.
REFERENCE   3  (bases 1 to 3462)
  AUTHORS   Sun,D., Cui,H., Rong,L., Ma,T., Li,X., Ye,Z. and Li,Z.
  TITLE     Sestrin2 Protects Human Lens Epithelial Cells (HLECs) Against
            Apoptosis in Cataracts Formation: Interaction Between Endoplasmic
            Reticulum (ER) Stress and Oxidative Stress (OS) is Involved
  JOURNAL   Curr Eye Res 49 (9), 949-960 (2024)
   PUBMED   38780907
  REMARK    GeneRIF: Sestrin2 Protects Human Lens Epithelial Cells (HLECs)
            Against Apoptosis in Cataracts Formation: Interaction Between
            Endoplasmic Reticulum (ER) Stress and Oxidative Stress (OS) is
            Involved.
REFERENCE   4  (bases 1 to 3462)
  AUTHORS   Zhang,L.L., Ding,K., Liao,S.S., Zhang,Y.G., Liao,H.Y., Chen,R. and
            Meng,Q.T.
  TITLE     Sestrin2 reduces ferroptosis via the Keap1/Nrf2 signaling pathway
            after intestinal ischemia-reperfusion
  JOURNAL   Free Radic Biol Med 214, 115-128 (2024)
   PUBMED   38331008
  REMARK    GeneRIF: Sestrin2 reduces ferroptosis via the Keap1/Nrf2 signaling
            pathway after intestinal ischemia-reperfusion.
REFERENCE   5  (bases 1 to 3462)
  AUTHORS   Tian,X. and Wei,J.
  TITLE     Sestrin 2 protects human lens epithelial cells from oxidative
            stress and apoptosis induced by hydrogen peroxide by regulating the
            mTOR/Nrf2 pathway
  JOURNAL   Int J Immunopathol Pharmacol 38, 3946320241234741 (2024)
   PUBMED   38379215
  REMARK    GeneRIF: Sestrin 2 protects human lens epithelial cells from
            oxidative stress and apoptosis induced by hydrogen peroxide by
            regulating the mTOR/Nrf2 pathway.
REFERENCE   6  (bases 1 to 3462)
  AUTHORS   Budanov,A.V. and Karin,M.
  TITLE     p53 target genes sestrin1 and sestrin2 connect genotoxic stress and
            mTOR signaling
  JOURNAL   Cell 134 (3), 451-460 (2008)
   PUBMED   18692468
  REMARK    Erratum:[Cell. 2009 Jan 23;136(2):378]
REFERENCE   7  (bases 1 to 3462)
  AUTHORS   Budanov,A.V., Sablina,A.A., Feinstein,E., Koonin,E.V. and
            Chumakov,P.M.
  TITLE     Regeneration of peroxiredoxins by p53-regulated sestrins, homologs
            of bacterial AhpD
  JOURNAL   Science 304 (5670), 596-600 (2004)
   PUBMED   15105503
  REMARK    GeneRIF: results show that sestrins, a family of proteins whose
            expression is modulated by p53, are required for regeneration of
            peroxiredoxins containing Cys-SO(2)H
REFERENCE   8  (bases 1 to 3462)
  AUTHORS   Peeters,H., Debeer,P., Bairoch,A., Wilquet,V., Huysmans,C.,
            Parthoens,E., Fryns,J.P., Gewillig,M., Nakamura,Y., Niikawa,N., Van
            de Ven,W. and Devriendt,K.
  TITLE     PA26 is a candidate gene for heterotaxia in humans: identification
            of a novel PA26-related gene family in human and mouse
  JOURNAL   Hum Genet 112 (5-6), 573-580 (2003)
   PUBMED   12607115
REFERENCE   9  (bases 1 to 3462)
  AUTHORS   Budanov,A.V., Shoshani,T., Faerman,A., Zelin,E., Kamer,I.,
            Kalinski,H., Gorodin,S., Fishman,A., Chajut,A., Einat,P.,
            Skaliter,R., Gudkov,A.V., Chumakov,P.M. and Feinstein,E.
  TITLE     Identification of a novel stress-responsive gene Hi95 involved in
            regulation of cell viability
  JOURNAL   Oncogene 21 (39), 6017-6031 (2002)
   PUBMED   12203114
REFERENCE   10 (bases 1 to 3462)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DB094914.1, BC013304.2 and
            AK025640.1.
            
            On Nov 23, 2018 this sequence version replaced NM_031459.4.
            
            Summary: This gene encodes a member of the sestrin family of
            PA26-related proteins. The encoded protein may function in the
            regulation of cell growth and survival. This protein may be
            involved in cellular response to different stress conditions.
            [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY123223.1, SRR1660803.54785.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000253063.4/ ENSP00000253063.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-420               DB094914.1         67-486
            421-2434            BC013304.2         415-2428
            2435-3462           AK025640.1         1127-2154
FEATURES             Location/Qualifiers
     source          1..3462
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.3"
     gene            1..3462
                     /gene="SESN2"
                     /gene_synonym="HI95; SES2; SEST2"
                     /note="sestrin 2"
                     /db_xref="GeneID:83667"
                     /db_xref="HGNC:HGNC:20746"
                     /db_xref="MIM:607767"
     exon            1..420
                     /gene="SESN2"
                     /gene_synonym="HI95; SES2; SEST2"
                     /inference="alignment:Splign:2.1.0"
     CDS             331..1773
                     /gene="SESN2"
                     /gene_synonym="HI95; SES2; SEST2"
                     /EC_number="1.11.1.15"
                     /note="hypoxia induced gene 95; hypoxia-induced"
                     /codon_start=1
                     /product="sestrin-2"
                     /protein_id="NP_113647.1"
                     /db_xref="CCDS:CCDS321.1"
                     /db_xref="GeneID:83667"
                     /db_xref="HGNC:HGNC:20746"
                     /db_xref="MIM:607767"
                     /translation="MIVADSECRAELKDYLRFAPGGVGDSGPGEEQRESRARRGPRGP
                     SAFIPVEEVLREGAESLEQHLGLEALMSSGRVDNLAVVMGLHPDYFTSFWRLHYLLLH
                     TDGPLASSWRHYIAIMAAARHQCSYLVGSHMAEFLQTGGDPEWLLGLHRAPEKLRKLS
                     EINKLLAHRPWLITKEHIQALLKTGEHTWSLAELIQALVLLTHCHSLSSFVFGCGILP
                     EGDADGSPAPQAPTPPSEQSSPPSRDPLNNSGGFESARDVEALMERMQQLQESLLRDE
                     GTSQEEMESRFELEKSESLLVTPSADILEPSPHPDMLCFVEDPTFGYEDFTRRGAQAP
                     PTFRAQDYTWEDHGYSLIQRLYPEGGQLLDEKFQAAYSLTYNTIAMHSGVDTSVLRRA
                     IWNYIHCVFGIRYDDYDYGEVNQLLERNLKVYIKTVACYPEKTTRRMYNLFWRHFRHS
                     EKVHVNLLLLEARMQAALLYALRAITRYMT"
     exon            421..486
                     /gene="SESN2"
                     /gene_synonym="HI95; SES2; SEST2"
                     /inference="alignment:Splign:2.1.0"
     exon            487..684
                     /gene="SESN2"
                     /gene_synonym="HI95; SES2; SEST2"
                     /inference="alignment:Splign:2.1.0"
     exon            685..867
                     /gene="SESN2"
                     /gene_synonym="HI95; SES2; SEST2"
                     /inference="alignment:Splign:2.1.0"
     exon            868..1080
                     /gene="SESN2"
                     /gene_synonym="HI95; SES2; SEST2"
                     /inference="alignment:Splign:2.1.0"
     exon            1081..1231
                     /gene="SESN2"
                     /gene_synonym="HI95; SES2; SEST2"
                     /inference="alignment:Splign:2.1.0"
     exon            1232..1350
                     /gene="SESN2"
                     /gene_synonym="HI95; SES2; SEST2"
                     /inference="alignment:Splign:2.1.0"
     exon            1351..1541
                     /gene="SESN2"
                     /gene_synonym="HI95; SES2; SEST2"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1686
                     /gene="SESN2"
                     /gene_synonym="HI95; SES2; SEST2"
                     /inference="alignment:Splign:2.1.0"
     exon            1687..3462
                     /gene="SESN2"
                     /gene_synonym="HI95; SES2; SEST2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3433..3438
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SESN2"
                     /gene_synonym="HI95; SES2; SEST2"
                     /note="hexamer: AATAAA"
     polyA_site      3462
                     /gene="SESN2"
                     /gene_synonym="HI95; SES2; SEST2"
                     /note="major polyA site"
ORIGIN      
        1 gctggcagtt ccgcggcggg gatgctgagg agcgctgggt ccgggagcag ccctggcccc
       61 tgcggacttc cgaggccgtg aaaacccctg cgctgcggcc cttcccaggc ccccgaggcc
      121 gttcgccgtt cccgaagccc gactggggga agagtccagc accaaagcgg ccgttctcgg
      181 attccggagc gttctggagc cccgagagac gccccggggt tctagaagct ccccggcggc
      241 gcccagtccc ggcttcattc gggcgtccct ccgaaaccca ctcgggtgca cgggtcgtcg
      301 gcgagccgcg accgggtcct ggcgcgcacc atgatcgtgg cggactccga gtgccgcgca
      361 gagctcaagg actacctgcg gttcgccccg ggcggcgtcg gcgactcggg ccccggagag
      421 gagcagaggg agagccgggc tcggcgaggc cctcgagggc ccagcgcctt catccccgtg
      481 gaggaggtcc ttcgggaggg ggctgagagc ctcgagcagc acctggggct ggaggcactg
      541 atgtcctctg ggcgagtaga caacctggca gtggtgatgg gcctgcaccc tgactacttt
      601 accagcttct ggcgcctgca ctacctgctg ctgcacacgg atggtccctt ggccagctcc
      661 tggcgccact acattgccat catggctgcc gcccgccatc agtgttctta cctggtaggc
      721 tcccacatgg ccgagtttct gcagactggt ggtgaccctg agtggctgct gggcctccac
      781 cgggcccccg agaagctgcg caaactcagc gagatcaaca agttgctggc gcatcggcca
      841 tggctcatca ccaaggaaca catccaggcc ttgctgaaga ccggcgagca cacttggtcc
      901 ctggccgagc tcattcaggc tctggtcctg ctcacccact gccactcgct ctcctccttc
      961 gtgtttggct gtggcatcct ccctgagggg gatgcagatg gcagccctgc cccccaggca
     1021 cctacacccc ctagtgaaca gagcagcccc ccaagcaggg acccgttgaa caactctggg
     1081 ggctttgagt ctgcccgcga cgtggaggcg ctgatggagc gcatgcagca gctgcaggag
     1141 agcctgctgc gggatgaggg gacgtcccag gaggagatgg agagccgctt tgagctggag
     1201 aagtcagaga gcctgctggt gaccccctca gctgacatcc tggagccctc tccacaccca
     1261 gacatgctgt gctttgtgga agaccctact ttcggatatg aggacttcac tcggagaggg
     1321 gctcaggcac cccctacctt ccgggcccag gattatacct gggaagacca tggctactcg
     1381 ctgatccagc ggctttaccc tgagggtggg cagctgctgg atgagaagtt ccaggcagcc
     1441 tatagcctca cctacaatac catcgccatg cacagtggtg tggacacctc cgtgctccgc
     1501 agggccatct ggaactatat ccactgcgtc tttggcatca gatatgatga ctatgattat
     1561 ggggaggtga accagctcct ggagcggaac ctcaaggtct atatcaagac agtggcctgc
     1621 tacccagaga agaccacccg aagaatgtac aacctcttct ggaggcactt ccgccactca
     1681 gagaaggtcc acgtgaactt gctgctcctg gaggcgcgca tgcaagccgc tctgctgtac
     1741 gccctccgtg ccatcacccg ctacatgacc tgactcctga gcaggacctg ggcccggttc
     1801 agctccccac aaggacttct ctgtctggag acagccccag acccttttgt gtcccatgcc
     1861 caccctcccc acgctgcagt gggcttgtgt gtgatgtgca gtcccgaagc cacaccctcc
     1921 cttttcctca ctggaatgga cagttcattg cactgactct gggatctcag ccctgctcct
     1981 gggagctgga agagcacttg gagatcctaa gggaccacac ccttcctcct tcccctgccc
     2041 acagaggcag agggcacagg aaagaagccg ggccaagctc ggaattaatg tgccacaagt
     2101 gttgtggcct tcctgaactg ggaagtccct ggctggcccc cgggggagag gggcaaatgc
     2161 ctccgggact gacactccag gcagctttgc cttctctccc ctgtcatttc cagatttcat
     2221 tacctcctac ttgccattca cccatcaatg tgaaagtcag ggtcacagct ggtctgtgtg
     2281 tccagttccc taaaagcctg ttctgttggg cagcctgagg ctgttgcccg aatcctagtt
     2341 cagttttttg acttcctttg ccctttttcc cttttctcca tgcttaatgg tgtgaggcgt
     2401 caggagagag gccaagtaca taaaaaaaaa aaaagcagat tatctctaga gagtttgagc
     2461 ctttgctggt cacattgcct tctgaagagg agggagtatt agattataaa tcctctttat
     2521 tttggtcctt tatgcttgag gttccaacct ggagccacag tgtgtgagag gaggaggaga
     2581 gggagaattc tgttctccca gagctgcacc tgcctcgcag aggccagcac cccactctcc
     2641 tgcctccagt ggccctgccg cagatgtctc ccaaaaagtt gagcctttct agatggctta
     2701 ggtggcacca tggctcagca ggaggggcgg gaggcaccag ggttcttgtt tggaccctgc
     2761 ccctgggcca tggccaggtg accatggcta cattgccaaa cctctgactg ccacagctgc
     2821 agactgagag ggtgggtctg agtccccaca atgtctgaag ctgcccctgg gattctcagg
     2881 ccaacctgcc aacagcaagc ggattttctt gcaagatcag ggaccccatt tctgcagcca
     2941 gtgtctcctg ggtgccttct gaggactccc acccccatcc cagtatctca tctgtcccct
     3001 ctcctggggc ttaagtgggt tgcttccagg cagaagcagc caaggaccga ttccaggcac
     3061 tttctgtagc aaatgactgt gaattacgac ttctcttgcc cttcttctag cagtctgtgc
     3121 ctcctctctg accagtttgg agggcactga agaaaggcaa gggccgtgct gctgctgggc
     3181 ggggcaggag aggagcctgg ccagtgtgcc acattaaata cccgtgcagg cgcggagaag
     3241 caaccggcac ccccttccgg cctgaaagcc ctccctgcaa gaaggtgtgc aggagagaag
     3301 aggccccggc atggggatct gggttctaga gggcatgtga tgactgtaaa tgttcactgg
     3361 gtgggtaggg agtggtatcc agtgttcaag tgcagaaatc tttggctttg ctaccagttc
     3421 catatgatga gaaataaacg ttcgctgagg ttttgtttca ta
//
