LOCUS       NM_014454               5664 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens sestrin 1 (SESN1), transcript variant 1, mRNA.
ACCESSION   NM_014454
VERSION     NM_014454.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5664)
  AUTHORS   Gao,F., Zhang,B., Xiao,C., Sun,Z., Gao,Y., Liu,C., Dou,X., Tong,H.,
            Wang,R., Li,P. and Heng,L.
  TITLE     IGF2BP3 stabilizes SESN1 mRNA to mitigate oxidized low-density
            lipoprotein-induced oxidative stress and endothelial dysfunction in
            human umbilical vein endothelial cells by activating Nrf2 signaling
  JOURNAL   Prostaglandins Other Lipid Mediat 172, 106832 (2024)
   PUBMED   38460759
  REMARK    GeneRIF: IGF2BP3 stabilizes SESN1 mRNA to mitigate oxidized
            low-density lipoprotein-induced oxidative stress and endothelial
            dysfunction in human umbilical vein endothelial cells by activating
            Nrf2 signaling.
REFERENCE   2  (bases 1 to 5664)
  AUTHORS   Saffari,F., Momeni,A., Ramezani,M., Ansari,Y. and Moghbelinejad,S.
  TITLE     Metformin Caused Radiosensitivity of Breast Cancer Cells through
            the Expression Modulation of miR-21-5p/SESN1axis
  JOURNAL   Asian Pac J Cancer Prev 24 (11), 3715-3727 (2023)
   PUBMED   38019229
  REMARK    GeneRIF: Metformin Caused Radiosensitivity of Breast Cancer Cells
            through the Expression Modulation of miR-21-5p/SESN1axis.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5664)
  AUTHORS   Jing,Y., Zuo,Y., Sun,L., Yu,Z.R., Ma,S., Hu,H., Zhao,Q., Huang,D.,
            Zhang,W., Belmonte,J.C.I., Yu,Y., Qu,J., Liu,G.H. and Wang,S.
  TITLE     SESN1 is a FOXO3 effector that counteracts human skeletal muscle
            ageing
  JOURNAL   Cell Prolif 56 (5), e13455 (2023)
   PUBMED   37199024
  REMARK    GeneRIF: SESN1 is a FOXO3 effector that counteracts human skeletal
            muscle ageing.
REFERENCE   4  (bases 1 to 5664)
  AUTHORS   Zhang,C., Ren,L., Zhang,H., Yang,S., Deng,M., He,L., Cao,R.,
            Zhao,C. and Xia,J.
  TITLE     SESN1, negatively regulated by miR-377-3p, suppresses invasive
            growth of head and neck squamous cell carcinoma by interaction with
            SMAD3
  JOURNAL   Hum Cell 35 (4), 1100-1113 (2022)
   PUBMED   35622213
  REMARK    GeneRIF: SESN1, negatively regulated by miR-377-3p, suppresses
            invasive growth of head and neck squamous cell carcinoma by
            interaction with SMAD3.
REFERENCE   5  (bases 1 to 5664)
  AUTHORS   Budanov,A.V. and Karin,M.
  TITLE     p53 target genes sestrin1 and sestrin2 connect genotoxic stress and
            mTOR signaling
  JOURNAL   Cell 134 (3), 451-460 (2008)
   PUBMED   18692468
  REMARK    Erratum:[Cell. 2009 Jan 23;136(2):378]
REFERENCE   6  (bases 1 to 5664)
  AUTHORS   Wang,G., Jones,S.J., Marra,M.A. and Sadar,M.D.
  TITLE     Identification of genes targeted by the androgen and PKA signaling
            pathways in prostate cancer cells
  JOURNAL   Oncogene 25 (55), 7311-7323 (2006)
   PUBMED   16751804
REFERENCE   7  (bases 1 to 5664)
  AUTHORS   Budanov,A.V., Sablina,A.A., Feinstein,E., Koonin,E.V. and
            Chumakov,P.M.
  TITLE     Regeneration of peroxiredoxins by p53-regulated sestrins, homologs
            of bacterial AhpD
  JOURNAL   Science 304 (5670), 596-600 (2004)
   PUBMED   15105503
  REMARK    GeneRIF: results show that sestrins, a family of proteins whose
            expression is modulated by p53, are required for regeneration of
            peroxiredoxins containing Cys-SO(2)H
REFERENCE   8  (bases 1 to 5664)
  AUTHORS   Peeters,H., Debeer,P., Bairoch,A., Wilquet,V., Huysmans,C.,
            Parthoens,E., Fryns,J.P., Gewillig,M., Nakamura,Y., Niikawa,N., Van
            de Ven,W. and Devriendt,K.
  TITLE     PA26 is a candidate gene for heterotaxia in humans: identification
            of a novel PA26-related gene family in human and mouse
  JOURNAL   Hum Genet 112 (5-6), 573-580 (2003)
   PUBMED   12607115
  REMARK    GeneRIF: PA26 mutations are an infrequent cause of heterotaxia
            (situs inversus) in humans.
REFERENCE   9  (bases 1 to 5664)
  AUTHORS   Velasco-Miguel,S., Buckbinder,L., Jean,P., Gelbert,L., Talbott,R.,
            Laidlaw,J., Seizinger,B. and Kley,N.
  TITLE     PA26, a novel target of the p53 tumor suppressor and member of the
            GADD family of DNA damage and growth arrest inducible genes
  JOURNAL   Oncogene 18 (1), 127-137 (1999)
   PUBMED   9926927
REFERENCE   10 (bases 1 to 5664)
  AUTHORS   Buckbinder,L., Talbott,R., Seizinger,B.R. and Kley,N.
  TITLE     Gene regulation by temperature-sensitive p53 mutants:
            identification of p53 response genes
  JOURNAL   Proc Natl Acad Sci U S A 91 (22), 10640-10644 (1994)
   PUBMED   7938006
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL355305.9, AF033122.1 and
            AL390208.17.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jul 11, 2019 this sequence version replaced NM_014454.2.
            
            Summary: This gene encodes a member of the sestrin family. Sestrins
            are induced by the p53 tumor suppressor protein and play a role in
            the cellular response to DNA damage and oxidative stress. The
            encoded protein mediates p53 inhibition of cell growth by
            activating AMP-activated protein kinase, which results in the
            inhibition of the mammalian target of rapamycin protein. The
            encoded protein also plays a critical role in antioxidant defense
            by regenerating overoxidized peroxiredoxins, and the expression of
            this gene is a potential marker for exposure to radiation.
            Alternatively spliced transcript variants encoding multiple
            isoforms have been observed for this gene. [provided by RefSeq, Dec
            2010].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF033122.1, AK290157.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000436639.7/ ENSP00000393762.2
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-772               AL355305.9         57900-58671         c
            773-3227            AF033122.1         11-2465
            3228-3228           AL390208.17        60348-60348         c
            3229-3531           AF033122.1         2467-2769
            3532-5664           AL390208.17        57912-60044         c
FEATURES             Location/Qualifiers
     source          1..5664
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6q21"
     gene            1..5664
                     /gene="SESN1"
                     /gene_synonym="PA26; SEST1"
                     /note="sestrin 1"
                     /db_xref="GeneID:27244"
                     /db_xref="HGNC:HGNC:21595"
                     /db_xref="MIM:606103"
     exon            1..1052
                     /gene="SESN1"
                     /gene_synonym="PA26; SEST1"
                     /inference="alignment:Splign:2.1.0"
     CDS             774..2429
                     /gene="SESN1"
                     /gene_synonym="PA26; SEST1"
                     /EC_number="1.11.1.15"
                     /note="isoform 1 is encoded by transcript variant 1; p53
                     regulated PA26 nuclear protein; p53 activated gene 26"
                     /codon_start=1
                     /product="sestrin-1 isoform 1"
                     /protein_id="NP_055269.1"
                     /db_xref="CCDS:CCDS5070.1"
                     /db_xref="GeneID:27244"
                     /db_xref="HGNC:HGNC:21595"
                     /db_xref="MIM:606103"
                     /translation="MAEGENEVRWDGLCSRDSTTRETALENIRQTILRKTEYLRSVKE
                     TPHRPSDGLSNTESSDGLNKLLAHLLMLSKRCPFKDVREKSEFILKSIQELGIRIPRP
                     LGQGPSRFIPEKEILQVGSEDAQMHALFADSFAALGRLDNITLVMVFHPQYLESFLKT
                     QHYLLQMDGPLPLHYRHYIGIMAAARHQCSYLVNLHVNDFLHVGGDPKWLNGLENAPQ
                     KLQNLGELNKVLAHRPWLITKEHIEGLLKAEEHSWSLAELVHAVVLLTHYHSLASFTF
                     GCGISPEIHCDGGHTFRPPSVSNYCICDITNGNHSVDEMPVNSAENVSVSDSFFEVEA
                     LMEKMRQLQECRDEEEASQEEMASRFEIEKRESMFVFSSDDEEVTPARAVSRHFEDTS
                     YGYKDFSRHGMHVPTFRVQDYCWEDHGYSLVNRLYPDVGQLIDEKFHIAYNLTYNTMA
                     MHKDVDTSMLRRAIWNYIHCMFGIRYDDYDYGEINQLLDRSFKVYIKTVVCTPEKVTK
                     RMYDSFWRQFKHSEKVHVNLLLIEARMQAELLYALRAITRYMT"
     exon            1053..1118
                     /gene="SESN1"
                     /gene_synonym="PA26; SEST1"
                     /inference="alignment:Splign:2.1.0"
     exon            1119..1319
                     /gene="SESN1"
                     /gene_synonym="PA26; SEST1"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1502
                     /gene="SESN1"
                     /gene_synonym="PA26; SEST1"
                     /inference="alignment:Splign:2.1.0"
     exon            1503..1745
                     /gene="SESN1"
                     /gene_synonym="PA26; SEST1"
                     /inference="alignment:Splign:2.1.0"
     exon            1746..1893
                     /gene="SESN1"
                     /gene_synonym="PA26; SEST1"
                     /inference="alignment:Splign:2.1.0"
     exon            1894..2006
                     /gene="SESN1"
                     /gene_synonym="PA26; SEST1"
                     /inference="alignment:Splign:2.1.0"
     exon            2007..2197
                     /gene="SESN1"
                     /gene_synonym="PA26; SEST1"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2342
                     /gene="SESN1"
                     /gene_synonym="PA26; SEST1"
                     /inference="alignment:Splign:2.1.0"
     exon            2343..5664
                     /gene="SESN1"
                     /gene_synonym="PA26; SEST1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3509..3514
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SESN1"
                     /gene_synonym="PA26; SEST1"
                     /note="hexamer: AATAAA"
     polyA_site      3531
                     /gene="SESN1"
                     /gene_synonym="PA26; SEST1"
                     /note="major polyA site"
     regulatory      5639..5644
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SESN1"
                     /gene_synonym="PA26; SEST1"
                     /note="hexamer: AATAAA"
     polyA_site      5661
                     /gene="SESN1"
                     /gene_synonym="PA26; SEST1"
ORIGIN      
        1 gctccgcggc ccagcctggc gctcgaggat tgccagggcc gccctgtgcc ctctggctcg
       61 gcggtggtgg gcgagggctc agggatcgga gaagtagcgt cttcccgggg gtgccgaatt
      121 ggcggggctg ggggacgctt tttttcaccg ccgcccgccg agactacggc tgcccgagac
      181 tgccgccctc cgacagcgcc caagcctccg gccgctgcgg ccagtgggcc agggttcggc
      241 gagccttccc tgccggcgcc ggccggctgc tgaggcgctg ggaggagctg cggagggcgg
      301 ggactggtgt cggagaaggg gcggggtggg aacgccggag agaacccggt ggctgcacag
      361 acaaaaaagc cccgaatggc tggagggcgt tcagctgtta acagcctttt ggggcagagc
      421 acggatttga cagctccaca acgtgaggat atccactgac cccgcgagac ggaggagaac
      481 gcttccccga aattctctgc ccaccaaagc cagcgctgca aggttgcaac tttcaaactt
      541 tgtttttcca gaaagaagac tgccctttcg tgtacaagga gagggtgaga gggtgaccta
      601 gcttgtagat cggctgaagg caccagtggt tccaaatgtc acccagatgt gtgttttcat
      661 gacgatttga tttctctgat tttattttta catttttcat tttaaaaata caaagcaatt
      721 tttttggggc atgctgaaag gtaactgaag accgcaaagg aaaaactatt gtcatggctg
      781 aaggagagaa tgaagtgaga tgggatggac tctgcagcag agattcaact actagggaga
      841 cagcattgga aaacattagg caaaccattt tgaggaaaac cgagtatctt cgttcggtga
      901 aagaaacacc tcatcgtcca tcagacgggc tttcaaatac cgagtcttcg gatgggttga
      961 ataagctact tgctcatctg cttatgcttt ctaagaggtg tcccttcaaa gatgtgagag
     1021 agaaaagtga gtttattctg aagagcatcc aggaacttgg cattagaatt cctcgaccac
     1081 taggacaggg accaagcaga ttcatcccag aaaaggagat cctccaagtg gggagtgaag
     1141 acgcacagat gcatgcttta tttgcagatt cttttgctgc tttgggccgt ttggataaca
     1201 ttacgttagt gatggttttc cacccacaat atttagaaag tttcttaaaa actcagcact
     1261 atctactgca aatggatggg ccgttacccc tacattatcg tcactacatt ggaataatgg
     1321 ctgcggcaag acatcagtgc tcctacttag tgaacctgca tgtaaatgat ttccttcatg
     1381 ttggtgggga ccccaagtgg ctcaatggtt tagagaatgc tcctcaaaaa ctacagaatt
     1441 taggagaact taacaaagtg ttagcccata gaccttggct tattaccaaa gaacacattg
     1501 agggactttt aaaagctgaa gagcacagct ggtcccttgc ggaattggta catgcagtag
     1561 ttttactcac acactatcat tctcttgcct cattcacatt cggctgtgga atcagtccag
     1621 aaattcattg tgatggtggc cacacattca gacctccttc tgttagcaac tactgcatct
     1681 gtgacattac aaatggcaat cacagtgtgg atgagatgcc ggtcaactca gcagaaaatg
     1741 tttctgtaag tgattctttc tttgaggttg aagccctcat ggaaaagatg aggcagttac
     1801 aggaatgtcg agatgaagaa gaggcaagtc aggaagagat ggcttcacgt tttgaaatag
     1861 aaaaaagaga gagtatgttt gtcttctctt cagatgatga agaagttaca ccagcaagag
     1921 ctgtatctcg tcattttgag gatactagtt atggctataa agatttctct agacatggga
     1981 tgcatgttcc aacatttcgt gtccaggact attgctggga agatcatggt tattctttgg
     2041 taaatcgcct ttatccagat gtgggacagt tgattgatga aaaatttcac attgcttaca
     2101 atcttactta taatacaatg gcaatgcaca aagatgttga tacctcaatg cttagacggg
     2161 caatttggaa ctatattcac tgcatgtttg gaataagata tgatgattat gactatggtg
     2221 aaattaacca gctattggat cgtagcttta aagtttatat caaaactgtt gtttgcactc
     2281 ctgaaaaggt taccaaaaga atgtatgata gcttctggag gcagttcaag cactctgaga
     2341 aggttcatgt taatctgctt cttatagaag ctaggatgca agcagaactc ctttatgctc
     2401 tgagagccat tacccgctat atgacctgat gcctttcctt cattaaagat gattctggaa
     2461 tgatcagcag atatagtcta caagggggaa ggtactaagc cccaggacca atggtagaca
     2521 aaataattca gaaatccatt gtgccatgat tcctttagtt tctgctattt ttctgtggaa
     2581 aaccactgct ggcacaagca gtgactgttt ggcagcttca agtttagagc tgtgaagaca
     2641 ggctgccatt cacagtattt tgctttttga cagtacaaga tgctgtgtaa ctgttttaat
     2701 acagcaaata gtaactctcc aaatcctgtt gcttttatgt taaataagat aacaagaatt
     2761 ggagcatgca aagaatggga cttggataat gacttaagct ttatatgtaa agaattttag
     2821 aagatcttgg tgctgctatt cctgctggag gaatgaatag atggctgttt cagttaagct
     2881 attagtaata aaagtgaaca ttgctactat ctgagcctac atacataact tgtgtgattt
     2941 caaattaaac ttgcattatg tgttaatttt cttgcatcta aaaaagcata gaattcctac
     3001 tcacacagct cagcaacaac cattttgatg gtaacagtta atttctttca ttagtttttt
     3061 aaattcaggg ttctggatat taaattaaaa tggcattctt aaagattttc ttcaaaaagc
     3121 aatcctaaat gaaagtgtgt aaattataag aagctggcga tcttttgata tgctgtttca
     3181 caggatcctg acactggagg gcagctgtct tgtgcattac ttgtgtttcc agcaccaaag
     3241 ttgtgggaca tgttgctgta gactgctgcg cagtcctggg tgcattcagt ctctctgcct
     3301 ctgcctgcct cctggtcccc actttaaagg ctgtgcagct ccttaaataa taaagctgga
     3361 aaatattttt agtcgggtta tcaaatttga tttacaaaaa cgctaacttt gtttgaaatg
     3421 caaacaggtt tgaaaatatg tattaagtac tttgtattct ggaagcgtga attgcttttg
     3481 aagtctgtca gtattactgg tatttttaaa taaagaagaa tttttctcca attttatttg
     3541 ctgtctcaat ctcttaaaaa atcatgactt cactattagt aataattttg agtttctatc
     3601 tactttcata agccaagtac attcacactt aaatggcaaa acaacacttg aagccatttt
     3661 gaaacataca aagaggagtg gactttcttt agaatcttat ctgagaccat ttttatcttg
     3721 gaaatgactg gtatggccct atgcctgctc tcttttcaac tgttttagag ttccaataga
     3781 attttaagaa ttactaaaaa gaaggattca ttagggagag actacagaac aaaaaatgac
     3841 actcatcaga caagtagaaa tagctctaag tttaactgaa gctgttgtga tgataactct
     3901 gttagttact cctcaaaaca tttattgagc tcaatctagt gcctgcctac aaatgtatgg
     3961 ggtagtgtgg aagtaggggt tgggaaggat caattttgaa cagaggtggt acctgtcctc
     4021 aaggatattt actctcatga gaagacaaga ctataacctt agctaggaat agagtattat
     4081 tatcttcaat atgttttata tttaaagaaa cttacttata agtgcattac tcattgaata
     4141 tgcatcatgc ctttgtcctc ttctgcctgc tgctgagttc tctcaccaga gcaatacaat
     4201 tgaacccaag aagatagtta aaattttact tatcccattt ctgctctttg ttcctcctct
     4261 tgaaaataca aaatttctag tagagattct aatcagcagt agagtgatca caaaacaaga
     4321 tcaactagaa tgcatttagt ccactggaac ttataatcac ttagaaattg aaatcaaaat
     4381 tttaatgagt taaaaaatat gtttatacct aaagtaataa aagtgcatgt gatacaaagt
     4441 taatgtttca atgccttcca tttagcaggt gcttcctgtt ggagtgtttt ctcaaaacta
     4501 aacacacagg atttctaatg ttactatata atctttgaaa ccagtagttt ccaaaataat
     4561 tagggaaggt acattacact ggggatatca aaaccttccc caaccagagg aaaattttct
     4621 tctaaaataa tcatgagaag atttctggtt gagggtccca ggattcaaga gttaaaatct
     4681 tgagttgttt tggccgtatt tgggaaaatt ttttattagg ccaaacttta tcatctctaa
     4741 gaatgagatt gattttgata cagaccacca ggagataagt agataagtaa aacttgttgg
     4801 ataagcactt tttatcaata tactctgaaa ttttattagc atattcatat atgtgaatat
     4861 catacatgaa tcagaaatgt tactagcata tttgtatatg tgaatatcat atatgaatca
     4921 tcatactagt tttttgctaa cactggtaga tgggagtaat gtcagcaaga tgatggactt
     4981 gggaactcca cgtcctcatt ctcccagaga cgctgagtta acaatatatg ggccagaata
     5041 tctttgtgag aactctagaa accaattggg aaactgcagc atttaggcaa atgcaaagcc
     5101 aggaaaaggc cgcaccaaaa ggctaggaaa gtttgtggat tttgctcacc ctagctcttc
     5161 cccagcagag gatggtgtga tcaagaggaa gcataaattc agcaaagttg taggatacaa
     5221 agtcagcaca caaaaatcag ttgtatttct atacactaac aatgaatgat ccaaaaaaat
     5281 ttaacaattc catttacaat aggatcaaaa agaataaaat acttaggaat aaacctaacc
     5341 aaggggatat gtgatggctg aatgtttgtg tcttccccta catttgtatg ttgatgtatg
     5401 ttgtatgctg aaatgtaatc ctcaatgtgg tgatattaaa aaagtaggcc tttgggaggt
     5461 gataagatca agagggctct gctctcatga atgggattag tgccctttaa tagaggtctg
     5521 gggagctccc cttctaccat gaaaggacac agctagagtg tgccatctgt gaggaagaaa
     5581 acactcacta ggcactaaat ccttgatatc ggacttccca gcctccaaaa ctgtgagcaa
     5641 taaatttctg ttatctataa atta
//
