LOCUS       NM_019605               5222 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens SERTA domain containing 4 (SERTAD4), transcript
            variant 1, mRNA.
ACCESSION   NM_019605
VERSION     NM_019605.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5222)
  AUTHORS   Chen,Y., Zheng,Y. and Liu,S.
  TITLE     KRAS mutation promotes the colonization of Fusobacterium nucleatum
            in colorectal cancer by down-regulating SERTAD4
  JOURNAL   J Cell Mol Med 28 (20), e70182 (2024)
   PUBMED   39462261
  REMARK    GeneRIF: KRAS mutation promotes the colonization of Fusobacterium
            nucleatum in colorectal cancer by down-regulating SERTAD4.
REFERENCE   2  (bases 1 to 5222)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   3  (bases 1 to 5222)
  AUTHORS   Kusano,S., Shiimura,Y. and Eizuru,Y.
  TITLE     I-mfa domain proteins specifically interact with SERTA domain
            proteins and repress their transactivating functions
  JOURNAL   Biochimie 93 (9), 1555-1564 (2011)
   PUBMED   21664411
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL035414.30, BP342499.1, BC012083.1 and AW340609.1.
            
            On Nov 23, 2018 this sequence version replaced NM_019605.4.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC012083.1, AK096381.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367012.4/ ENSP00000355979.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-6                 AL035414.30        14536-14541
            7-54                BP342499.1         1-48
            55-1519             BC012083.1         1-1465
            1520-5217           AL035414.30        24293-27990
            5218-5222           AW340609.1         5-9                 c
FEATURES             Location/Qualifiers
     source          1..5222
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.2"
     gene            1..5222
                     /gene="SERTAD4"
                     /gene_synonym="DJ667H12.2"
                     /note="SERTA domain containing 4"
                     /db_xref="GeneID:56256"
                     /db_xref="HGNC:HGNC:25236"
     exon            1..216
                     /gene="SERTAD4"
                     /gene_synonym="DJ667H12.2"
                     /inference="alignment:Splign:2.1.0"
     exon            217..408
                     /gene="SERTAD4"
                     /gene_synonym="DJ667H12.2"
                     /inference="alignment:Splign:2.1.0"
     CDS             234..1304
                     /gene="SERTAD4"
                     /gene_synonym="DJ667H12.2"
                     /note="isoform 1 is encoded by transcript variant 1; SERTA
                     domain-containing protein 4"
                     /codon_start=1
                     /product="SERTA domain-containing protein 4 isoform 1"
                     /protein_id="NP_062551.1"
                     /db_xref="CCDS:CCDS1494.1"
                     /db_xref="GeneID:56256"
                     /db_xref="HGNC:HGNC:25236"
                     /translation="MTLVLSMNRFCEPIVSEGAAEIAGYQTLWEADSYGGPSPPGPAQ
                     APLQGDRGAGPPLAGSHYRGISNPITTSKITYFKRKYVEEEDFHPPLSSCSHKTISIF
                     EERAHILYMSLEKLKFIDDPEVYLRRSVLINNLMKRIHGEIIMQNNWCFPACSFNGTS
                     AQEWFMAQDCPYRKRPRMAKEECEKFHACCFYQECGGHYLNLPLSVNANVGSASTAAS
                     SPSASSSSSSSSSSPPLPLPSCSRQVDFDVGSASIYKSDGQIPANEIFVTNVRSLGVQ
                     EKAKLNDEKANDDTNRDGGPLSHEPVGNDLAFECKGQFYDYFETGYNERNNVNESWKK
                     SLRKKEASPPSNKLCCSKGSKI"
     exon            409..524
                     /gene="SERTAD4"
                     /gene_synonym="DJ667H12.2"
                     /inference="alignment:Splign:2.1.0"
     exon            525..5222
                     /gene="SERTAD4"
                     /gene_synonym="DJ667H12.2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3056..3061
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERTAD4"
                     /gene_synonym="DJ667H12.2"
                     /note="hexamer: GATAAA"
     polyA_site      3087
                     /gene="SERTAD4"
                     /gene_synonym="DJ667H12.2"
                     /note="major polyA site"
     regulatory      5188..5193
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERTAD4"
                     /gene_synonym="DJ667H12.2"
                     /note="hexamer: AATAAA"
     polyA_site      5222
                     /gene="SERTAD4"
                     /gene_synonym="DJ667H12.2"
                     /note="major polyA site"
ORIGIN      
        1 attaccataa ccgtctgcag cgacggcggc gcagcgcccc agtcgcggcg gcgggacctg
       61 ccgggaccct tgcccgccgc gcacccgcag tcaccgccga gcgggcggcc gggccgggac
      121 ccgcgagtgt gcaccggcgg ccgggctggc gccgagccca gagcggacca gcagcagctc
      181 aagcgctgcg gccgccgcct ccccgctgac cccgcgatct gaggctgtca gagatgactc
      241 tggttctgtc catgaataga ttctgcgagc ccattgtctc ggaaggagct gctgaaattg
      301 ctgggtacca aacactatgg gaggctgaca gctacggagg cccaagcccc ccagggccag
      361 cacaagctcc tttgcaggga gaccggggag ctggtccccc actggcagga tcacattaca
      421 ggggaatttc aaatcctata acaacatcca agatcacata ctttaagagg aagtatgtgg
      481 aagaagagga ttttcaccca ccactcagca gctgtagcca taaaaccatc tcaatttttg
      541 aggaacgagc ccacatcctt tatatgtcct tagaaaagct aaagtttatc gatgatcctg
      601 aagtgtacct ccgaagatct gtccttataa acaatttgat gaaaaggatc catggagaaa
      661 ttatcatgca gaataactgg tgcttccctg cctgctcttt caatggcacc tctgcccaag
      721 agtggtttat ggctcaagac tgcccttacc gaaaacgacc acggatggcc aaagaggaat
      781 gtgaaaagtt tcatgcctgc tgcttttacc aagaatgtgg tggccactac ctaaatttac
      841 ccctttctgt caatgctaat gttggaagtg cctccactgc tgcctcctct ccctccgcct
      901 cttcttcctc ctcatcttcc tcttcctctc cccctttgcc tttaccgagt tgttcccgcc
      961 aggtggattt tgatgtaggt agtgcatcta tttacaagag tgatggccag atacctgcca
     1021 atgaaatctt tgtcactaat gtcagatcac ttggtgttca ggaaaaggcc aaattaaatg
     1081 atgagaaagc aaatgatgac accaacagag atggtggccc cctcagccac gaacctgtgg
     1141 gaaatgacct tgcttttgag tgcaaaggcc aattttatga ttattttgag accggatata
     1201 atgaaagaaa caatgtaaat gaatcttgga aaaagtcctt acggaaaaag gaggcttcac
     1261 caccaagtaa caaactgtgc tgcagcaaag gaagtaaaat atgagccatc ttctcaccga
     1321 actttgaagc atgcacagca tgatcagtta gctctcgtaa attttatttt gaatggattt
     1381 tgtagttttg tacaacagat aaaattatgc catgaacatg ccatgtcgtt ttaatgcctg
     1441 gagagcagat tgcgtaaaac atctgtatag caggcatcag cgagcttctt ataaatgtgg
     1501 tgatttttac caaggaaacg attgacttaa tgcttaaaag tatatcatag ttttcttacg
     1561 gaaaagatca gtagatgaga ttgggggaca atgtgccctt gcaatatttc cattgccccc
     1621 caaggagcct gtcactagct aagaaatttc tacatgtttg ccagttaatt agggagttat
     1681 ttggtaagca aatcaatata accagcaaag atacctgctt cttctatatg atacaatatt
     1741 ttttttaaat aaaagactaa agacagggag ctagatgaaa tggcttaatg gtgctgttaa
     1801 gtatttgtac ctaacagtct tgtgtgacag atgaaaatag gatgtaacat aatgaaacac
     1861 acctgtctag gggcggcaat caacagtctt acacagagag ggtattccct gcaagtttct
     1921 ggcttgcctg tgatgggtga tgaggctttt agagaggtgt tatacagggc gatttttggt
     1981 gccttacttt tatcttaatt tttgccaatg tgaaaattaa ggataaatca gagttacagc
     2041 agggatttaa caaacaggac aaaaaaaaaa aaaaaaaaaa aaccacaggg tggatcaata
     2101 tggtttggaa actgttaact ttgaactatt gtgttcagct tttgattcga catctctatt
     2161 ctttattttt gatgcccaat tgcttttgga ttcgccgttt tttcaatagg gatggaggaa
     2221 atgagagaga gagctgttag aaagcagcac gggctgctcg agcttttcta tggcaactgt
     2281 gtgttgctgg ggttggggtt ttctgggttt tgggttgttt tgttttgttt tcttgtccaa
     2341 tgaagttcac gaaccagtgg catgcattat acttttctct gttttgcatc atttcacttg
     2401 tttagattat aaaagcatgt gggtttttat atatgaactt tgctgttgat taagaagcac
     2461 aatgttaata aatgatgtgg tgatcaataa ggtttatctt aaagaatgta aagactttag
     2521 gtttttgaaa gttattttgg agaaatggga cttaatctat aatagttact atgtatttgg
     2581 tctacatttt ccaaataata tctttaactt gtacatttga aaagtgttca gagtggccct
     2641 cctaccatcc ttccttccac tccagccaac tcttcctgct aaactgtatt ccagtttcca
     2701 agtttactaa ttgacttggg cctgttcaaa taatacttca cagaaaccaa atgccaaacg
     2761 gaggaaataa gtaagccctc ccagtttctc caagataaag ctttttttat tattgctatt
     2821 aatattaaat ataggtctca ttcatacagt gtatgagtag gatcatttgg acaattgtcc
     2881 acaaagacca atttttaaaa cattttcttg tgttatagtt aaatagtcta gtaatgtttt
     2941 gtcctttatt ttcaatattt gataaacatt tgatgttcaa aacttagcta atagatgctt
     3001 gtatatgaat gtgttgtaat aaagtgaggt tttcttgata tatatttatt aagatgataa
     3061 aaattcatta agttttttaa attttaatgg ctattggcta tgtttctctt ttccattatt
     3121 ctctctcctt taaaaaactc aaaacatcta gaaactgtag tggatagtgg ccacacagga
     3181 gttttctaaa ttaaagagta ttttaaaatg ccaatctgac aggtgtttca gaatgatcct
     3241 agttcgtaag tttaagtttc tattgattaa gaagcacaat gttaatagat gatgtggtga
     3301 tcaataaggt tatgtctgaa agaatgtaaa gattttcctt tctggagtgt ctctgaaaaa
     3361 aattgtataa cacgaagcca taaatactga atcttagctg attgcattat gaactgtcaa
     3421 actgtgaaga tgacccatat gtaaacagtt ataacagcta cagattattg ctagtagcat
     3481 tccatacaat tccatattaa tgttcttagg agctaatatt tgataaaggg gaaagctagt
     3541 taaaaactaa ttaatttgtc aaatgtagca ttcttattat gagtgtaata tctcatggag
     3601 atttaaatat gaacgaaagg acttatcctt ctgcttttta aaagccccag cattactaga
     3661 tagtgttttt cttgaaggcc aaagctgtaa aatgacaaag ttggtgattt tcagcagcac
     3721 tcacctgagc tgtgagcgcc tgcacctgtt cggtagaacc cactagaatc acttctctgt
     3781 aggataagtg atgcctttga atccagcagc ataaaaatct gttcttttta gtcatcaagt
     3841 ttttgtttcc aggatatttc tagcattgca aaaaaaaatt tcttcaccaa acactaattc
     3901 ctaaacaccc atccaaacca caaaaattct cttgttagta ggcgagagtg ctaggacttc
     3961 ctgtgttcac ctcccatgca cccagcattg tcttttatgc atgagatatt ccattagatt
     4021 ttcctagagt ggccaggaca cccttcatag taagttatat ctcttaactg gattctatag
     4081 ttttatctcg agcaacttgg aaaagctaag acatcctcca cccacactgg tatctacgcg
     4141 cctggaagct gcaccttctc tcattgctgt gctctgcttt aaggaaaacc tgatatgaca
     4201 gaatcaagac tattaaaaga taaatgaggg gaaatcttca tttaagaaag ttgccttgct
     4261 ccccaagagt gcctttaatt gctattcccc taggcatctg ggtgcatatc attaatgaaa
     4321 tcattaacct ttgtctctgg tccttccttt ctaaaaacag cagattatag aaggtggtct
     4381 ggcaaaggga ttttcaaagg gcaaaagtct catcatcatc tttccactca aaatcctatt
     4441 attctacatt tcactttgca ggggtcctag ggacaggatt gcagggacag gggacatggg
     4501 aggaagacag aaaaattcaa aaccagcaga tgccactacc tggcaatgaa ttgaaaatta
     4561 ggggaaagca tctttggcgt gaccttttat taagacaaca gaaatttaga acattttaca
     4621 tgcttctttg ttaaatggtg aagcaaggga atgaaagtat ttatttttag agctcatagt
     4681 taactccatc aagacatggc tacccacccc tccagttatg aacttgtatt acagctccac
     4741 ttggtgactt cctttctgtg tatcaggagc agagcagagg acaacttgta gaagacatga
     4801 ccattaagag acatcaactt cgcaacaaat ataagacaag gatacaagga ttcctatgtg
     4861 atgcagctag gtttttatat ccttctaaca aatggtgagc aggagacttt tttggaaata
     4921 attagttgtg aaattccatt tttctgacag ccccttaaat ttgaagttat ttcatttgta
     4981 gttaaggtta tcacatccct gccaatttta ctagattttt tcagagacaa gcattcagca
     5041 tggcattagt aatgatggtt taaactaggt gcagaactgt cccatgaaga gaagaatgat
     5101 atcagtattt aaataataaa agaagagaca atgtatggtt tatagtgatt cattttaaga
     5161 ttgctgtatt ttgattttgt ggtttaaaat aaatgcatta aggatctttt aagttactac
     5221 aa
//
