LOCUS       NM_203344               1364 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens SERTA domain containing 3 (SERTAD3), transcript
            variant 2, mRNA.
ACCESSION   NM_203344
VERSION     NM_203344.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1364)
  AUTHORS   Sun,N., Li,C., Li,X.F., Deng,Y.Q., Jiang,T., Zhang,N.N., Zu,S.,
            Zhang,R.R., Li,L., Chen,X., Liu,P., Gold,S., Lu,N., Du,P., Wang,J.,
            Qin,C.F. and Cheng,G.
  TITLE     Type-IInterferon-Inducible SERTAD3 Inhibits Influenza A Virus
            Replication by Blocking the Assembly of Viral RNA Polymerase
            Complex
  JOURNAL   Cell Rep 33 (5), 108342 (2020)
   PUBMED   33147462
  REMARK    GeneRIF: Type-IInterferon-Inducible SERTAD3 Inhibits Influenza A
            Virus Replication by Blocking the Assembly of Viral RNA Polymerase
            Complex.
REFERENCE   2  (bases 1 to 1364)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1364)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1364)
  AUTHORS   Zhong,Q., Pevzner,S.J., Hao,T., Wang,Y., Mosca,R., Menche,J.,
            Taipale,M., Tasan,M., Fan,C., Yang,X., Haley,P., Murray,R.R.,
            Mer,F., Gebreab,F., Tam,S., MacWilliams,A., Dricot,A., Reichert,P.,
            Santhanam,B., Ghamsari,L., Calderwood,M.A., Rolland,T.,
            Charloteaux,B., Lindquist,S., Barabasi,A.L., Hill,D.E., Aloy,P.,
            Cusick,M.E., Xia,Y., Roth,F.P. and Vidal,M.
  TITLE     An inter-species protein-protein interaction network across vast
            evolutionary distance
  JOURNAL   Mol Syst Biol 12 (4), 865 (2016)
   PUBMED   27107014
  REMARK    Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1364)
  AUTHORS   Venkatesan,K., Rual,J.F., Vazquez,A., Stelzl,U., Lemmens,I.,
            Hirozane-Kishikawa,T., Hao,T., Zenkner,M., Xin,X., Goh,K.I.,
            Yildirim,M.A., Simonis,N., Heinzmann,K., Gebreab,F., Sahalie,J.M.,
            Cevik,S., Simon,C., de Smet,A.S., Dann,E., Smolyar,A.,
            Vinayagam,A., Yu,H., Szeto,D., Borick,H., Dricot,A., Klitgord,N.,
            Murray,R.R., Lin,C., Lalowski,M., Timm,J., Rau,K., Boone,C.,
            Braun,P., Cusick,M.E., Roth,F.P., Hill,D.E., Tavernier,J.,
            Wanker,E.E., Barabasi,A.L. and Vidal,M.
  TITLE     An empirical framework for binary interactome mapping
  JOURNAL   Nat Methods 6 (1), 83-90 (2009)
   PUBMED   19060904
REFERENCE   6  (bases 1 to 1364)
  AUTHORS   Darwish,H., Cho,J.M., Loignon,M. and Alaoui-Jamali,M.A.
  TITLE     Overexpression of SERTAD3, a putative oncogene located within the
            19q13 amplicon, induces E2F activity and promotes tumor growth
  JOURNAL   Oncogene 26 (29), 4319-4328 (2007)
   PUBMED   17260023
  REMARK    GeneRIF: Transduction of stably expressed human SERTAD3 induces
            cell transformation in vitro and tumor formation in mice via a
            transcription factor E2F-dependent mechanism.
REFERENCE   7  (bases 1 to 1364)
  AUTHORS   Watanabe-Fukunaga,R., Iida,S., Shimizu,Y., Nagata,S. and
            Fukunaga,R.
  TITLE     SEI family of nuclear factors regulates p53-dependent
            transcriptional activation
  JOURNAL   Genes Cells 10 (8), 851-860 (2005)
   PUBMED   16098148
REFERENCE   8  (bases 1 to 1364)
  AUTHORS   Hsu,S.I., Yang,C.M., Sim,K.G., Hentschel,D.M., O'Leary,E. and
            Bonventre,J.V.
  TITLE     TRIP-Br: a novel family of PHD zinc finger- and
            bromodomain-interacting proteins that regulate the transcriptional
            activity of E2F-1/DP-1
  JOURNAL   EMBO J 20 (9), 2273-2285 (2001)
   PUBMED   11331592
REFERENCE   9  (bases 1 to 1364)
  AUTHORS   Cho,J.M., Song,D.J., Bergeron,J., Benlimame,N., Wold,M.S. and
            Alaoui-Jamali,M.A.
  TITLE     RBT1, a novel transcriptional co-activator, binds the second
            subunit of replication protein A
  JOURNAL   Nucleic Acids Res 28 (18), 3478-3485 (2000)
   PUBMED   10982866
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC050643.2 and AW242302.1.
            
            On Nov 23, 2018 this sequence version replaced NM_203344.2.
            
            Summary: The protein encoded by this gene was identified in a yeast
            two-hybrid assay employing the second subunit of human replication
            protein A as bait. It is localized to the nucleus and its
            expression is significantly higher in cancer cell lines compared to
            normal cell lines. This protein has also been shown to be a strong
            transcriptional co-activator. Alternative splicing has been
            observed at this locus and two variants, both encoding the same
            protein, have been identified. [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same isoform.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC050643.2, SRR5189652.108586.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000322354.4/ ENSP00000325414.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1317              BC050643.2         41-1357
            1318-1364           AW242302.1         13-59               c
FEATURES             Location/Qualifiers
     source          1..1364
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..1364
                     /gene="SERTAD3"
                     /gene_synonym="RBT1"
                     /note="SERTA domain containing 3"
                     /db_xref="GeneID:29946"
                     /db_xref="HGNC:HGNC:17931"
                     /db_xref="MIM:612125"
     exon            1..121
                     /gene="SERTAD3"
                     /gene_synonym="RBT1"
                     /inference="alignment:Splign:2.1.0"
     exon            122..1364
                     /gene="SERTAD3"
                     /gene_synonym="RBT1"
                     /inference="alignment:Splign:2.1.0"
     CDS             128..718
                     /gene="SERTAD3"
                     /gene_synonym="RBT1"
                     /note="RPA-binding trans-activator; replication
                     protein-binding trans-activator"
                     /codon_start=1
                     /product="SERTA domain-containing protein 3"
                     /protein_id="NP_976219.1"
                     /db_xref="CCDS:CCDS12558.1"
                     /db_xref="GeneID:29946"
                     /db_xref="HGNC:HGNC:17931"
                     /db_xref="MIM:612125"
                     /translation="MVGGLKRKHSDLEEEEERWEWSPAGLQSYQQALLRISLDKVQRS
                     LGPRAPSLRRHVLIHNTLQQLQAALRLAPAPALPPEPLFLGEEDFSLSATIGSILREL
                     DTSMDGTEPPQNPVTPLGLQNEVPPQPDPVFLEALSSRYLGDSGLDDFFLDIDTSAVE
                     KEPARAPPEPPHNLFCAPGSWEWNELDHIMEIILGS"
     regulatory      1343..1348
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERTAD3"
                     /gene_synonym="RBT1"
                     /note="hexamer: AATAAA"
     polyA_site      1364
                     /gene="SERTAD3"
                     /gene_synonym="RBT1"
                     /note="major polyA site"
ORIGIN      
        1 agacggagag gccccgccga ggtgagcgag gctccaaccg gtcactggtg ggtcctggca
       61 ctggcgggtc gcaacgctgt gggcgttcca ggaggtggtc gtggcgaacc tggcagctgc
      121 gggcatcatg gtgggaggct tgaagaggaa acactctgat ttggaagagg aggaggagag
      181 gtgggagtgg agtccagcag gccttcagag ctaccagcaa gccctgctcc gcatctccct
      241 agacaaagtc cagcgcagcc tgggcccccg agcacccagc ctccgcaggc atgtcctcat
      301 ccataacacc ctccaacagc tgcaggctgc acttcgcctg gctcccgccc ctgccctgcc
      361 ccccgagccc ctcttcctgg gcgaggagga tttctccctg tcagccacca ttggctctat
      421 cctcagggag ctggacacct ccatggatgg gactgagccc cctcagaatc cagtgactcc
      481 ccttggcctc cagaatgaag tgccacccca gcctgatcca gtcttcttag aagctctgag
      541 ctcccggtac ttgggggact ctggcctgga tgacttcttt ctggacattg acacatctgc
      601 ggtagaaaag gagcctgcac gggccccacc agagcctcct cacaacctct tctgtgcccc
      661 aggttcttgg gagtggaatg aactggatca catcatggaa atcattctgg ggtcctaaaa
      721 ctgtgataga ggggatcgat ccttcctcat gtcatcttcg gtggcctgga tccctgaatg
      781 caactctggg tgtgtgtttt tgtgggggct cgaagcagtg actatggcct cctttgttcc
      841 catttcaggg ttccacaaac tgtcttgcat gtgtgtgtgt gtctggttac cccgaccttc
      901 tgtgaaggtg ggtcttcctg aattaattta tctattccaa atgccttaac gagactctgt
      961 ttctgggagt ctgattttcc acttacacat ttcttccacc tttcctgcta gttcccactc
     1021 ccctgtgacc actggggcct cagggaagat aaagaaagct gggcctgtcg aaggatgaca
     1081 gggatgtgct gccaggttgc tatagaaacc caggctctgc ctcttgcacc ttgagggggt
     1141 gggaggggct ggtgtcctcc ctccaggctg aaccccactt cctcggcagg accccagtct
     1201 cagcagcctc ctgatttcat aaccaggccg gaccacgtgc aatagggtgg aaaccaaact
     1261 gctccatgcc gggttattta aaagaaaggc agagtttgtg gtggcttttt tttttttttt
     1321 tggattgttt gtaatttttt taaataaaag tattttggaa ggag
//
