LOCUS       NM_014755               5549 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens SERTA domain containing 2 (SERTAD2), mRNA.
ACCESSION   NM_014755 XM_376059
VERSION     NM_014755.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5549)
  AUTHORS   Chen,Y., Jie,X., Xing,B., Wu,Z., Yang,X., Rao,X., Xu,Y., Zhou,D.,
            Dong,X., Zhang,T., Yang,K., Li,Z. and Wu,G.
  TITLE     REV1 promotes lung tumorigenesis by activating the Rad18/SERTAD2
            axis
  JOURNAL   Cell Death Dis 13 (2), 110 (2022)
   PUBMED   35115490
  REMARK    GeneRIF: REV1 promotes lung tumorigenesis by activating the
            Rad18/SERTAD2 axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5549)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 5549)
  AUTHORS   Liew,C.W., Boucher,J., Cheong,J.K., Vernochet,C., Koh,H.J.,
            Mallol,C., Townsend,K., Langin,D., Kawamori,D., Hu,J., Tseng,Y.H.,
            Hellerstein,M.K., Farmer,S.R., Goodyear,L., Doria,A., Bluher,M.,
            Hsu,S.I. and Kulkarni,R.N.
  TITLE     Ablation of TRIP-Br2, a regulator of fat lipolysis, thermogenesis
            and oxidative metabolism, prevents diet-induced obesity and insulin
            resistance
  JOURNAL   Nat Med 19 (2), 217-226 (2013)
   PUBMED   23291629
  REMARK    GeneRIF: TRIP-Br2, modulates fat storage through simultaneous
            regulation of lipolysis, thermogenesis and oxidative metabolism.
REFERENCE   4  (bases 1 to 5549)
  AUTHORS   Fox,C.S., Liu,Y., White,C.C., Feitosa,M., Smith,A.V.,
            Heard-Costa,N., Lohman,K., Johnson,A.D., Foster,M.C.,
            Greenawalt,D.M., Griffin,P., Ding,J., Newman,A.B., Tylavsky,F.,
            Miljkovic,I., Kritchevsky,S.B., Launer,L., Garcia,M.,
            Eiriksdottir,G., Carr,J.J., Gudnason,V., Harris,T.B., Cupples,L.A.
            and Borecki,I.B.
  CONSRTM   GIANT Consortium; MAGIC Consortium; GLGC Consortium
  TITLE     Genome-wide association for abdominal subcutaneous and visceral
            adipose reveals a novel locus for visceral fat in women
  JOURNAL   PLoS Genet 8 (5), e1002695 (2012)
   PUBMED   22589738
REFERENCE   5  (bases 1 to 5549)
  AUTHORS   Cheong,J.K., Gunaratnam,L., Zang,Z.J., Yang,C.M., Sun,X.,
            Nasr,S.L., Sim,K.G., Peh,B.K., Rashid,S.B., Bonventre,J.V.,
            Salto-Tellez,M. and Hsu,S.I.
  TITLE     TRIP-Br2 promotes oncogenesis in nude mice and is frequently
            overexpressed in multiple human tumors
  JOURNAL   J Transl Med 7, 8 (2009)
   PUBMED   19152710
  REMARK    GeneRIF: TRIP-Br2 is frequently overexpressed in both cancer cell
            lines and multiple human tumors.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5549)
  AUTHORS   Cheong,J.K., Gunaratnam,L. and Hsu,S.I.
  TITLE     CRM1-mediated nuclear export is required for 26 S
            proteasome-dependent degradation of the TRIP-Br2 proto-oncoprotein
  JOURNAL   J Biol Chem 283 (17), 11661-11676 (2008)
   PUBMED   18316374
  REMARK    GeneRIF: CRM1-mediated nuclear export may be required for the
            proper execution of ubiquitin-proteasome-dependent degradation of
            TRIP-Br2
REFERENCE   7  (bases 1 to 5549)
  AUTHORS   Watanabe-Fukunaga,R., Iida,S., Shimizu,Y., Nagata,S. and
            Fukunaga,R.
  TITLE     SEI family of nuclear factors regulates p53-dependent
            transcriptional activation
  JOURNAL   Genes Cells 10 (8), 851-860 (2005)
   PUBMED   16098148
REFERENCE   8  (bases 1 to 5549)
  AUTHORS   Hsu,S.I., Yang,C.M., Sim,K.G., Hentschel,D.M., O'Leary,E. and
            Bonventre,J.V.
  TITLE     TRIP-Br: a novel family of PHD zinc finger- and
            bromodomain-interacting proteins that regulate the transcriptional
            activity of E2F-1/DP-1
  JOURNAL   EMBO J 20 (9), 2273-2285 (2001)
   PUBMED   11331592
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC007365.3 and BQ017415.1.
            
            On Nov 23, 2018 this sequence version replaced NM_014755.2.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660807.408695.1, D50917.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA2144835
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000313349.3/ ENSP00000326933.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 AC007365.3         125891-125891
            2-294               AC007365.3         125892-126184
            295-5021            AC007365.3         142929-147655
            5022-5549           BQ017415.1         18-545              c
FEATURES             Location/Qualifiers
     source          1..5549
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="2"
                     /map="2p14"
     gene            1..5549
                     /gene="SERTAD2"
                     /gene_synonym="Sei-2; TRIP-Br2; TRIPBR2"
                     /note="SERTA domain containing 2"
                     /db_xref="GeneID:9792"
                     /db_xref="HGNC:HGNC:30784"
                     /db_xref="MIM:617851"
     exon            1..294
                     /gene="SERTAD2"
                     /gene_synonym="Sei-2; TRIP-Br2; TRIPBR2"
                     /inference="alignment:Splign:2.1.0"
     exon            295..5549
                     /gene="SERTAD2"
                     /gene_synonym="Sei-2; TRIP-Br2; TRIPBR2"
                     /inference="alignment:Splign:2.1.0"
     CDS             299..1243
                     /gene="SERTAD2"
                     /gene_synonym="Sei-2; TRIP-Br2; TRIPBR2"
                     /note="transcriptional regulator interacting with the
                     PHS-bromodomain 2; transcriptional regulator interacting
                     with the PHD-bromodomain 2"
                     /codon_start=1
                     /product="SERTA domain-containing protein 2"
                     /protein_id="NP_055570.1"
                     /db_xref="CCDS:CCDS33210.1"
                     /db_xref="GeneID:9792"
                     /db_xref="HGNC:HGNC:30784"
                     /db_xref="MIM:617851"
                     /translation="MLGKGGKRKFDEHEDGLEGKIVSPCDGPSKVSYTLQRQTIFNIS
                     LMKLYNHRPLTEPSLQKTVLINNMLRRIQEELKQEGSLRPMFTPSSQPTTEPSDSYRE
                     APPAFSHLASPSSHPCDLGSTTPLEACLTPASLLEDDDDTFCTSQAMQPTAPTKLSPP
                     ALLPEKDSFSSALDEIEELCPTSTSTEAATAATDSVKGTSSEAGTQKLDGPQESRADD
                     SKLMDSLPGNFEITTSTGFLTDLTLDDILFADIDTSMYDFDPCTSSSGTASKMAPVSA
                     DDLLKTLAPYSSQPVTPSQPFKMDLTELDHIMEVLVGS"
     regulatory      5530..5535
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERTAD2"
                     /gene_synonym="Sei-2; TRIP-Br2; TRIPBR2"
                     /note="hexamer: AATAAA"
     polyA_site      5549
                     /gene="SERTAD2"
                     /gene_synonym="Sei-2; TRIP-Br2; TRIPBR2"
                     /note="major polyA site"
ORIGIN      
        1 actcctgcac ggcgagtgct ggagcacgac gtaccgctcg ctcggtcagg gcgccccctc
       61 cgcccgcctc ctgcttcctc ctccgctgcc tgccgccgcc gcctccacca ttgtataatg
      121 ctcggggcgc gcaggcagag aacggcggag tcttagcttc agcctcgcct gctgcccgct
      181 ccccggcgcc accctcgggc ccctggagcg gggcactccg catggagcgg gagtagctga
      241 ggagtgggcg gaaacccctc ctgatgcgtt agttcccagg tggagctgca tgtgatatat
      301 gttgggtaaa ggaggaaaac ggaagtttga tgagcatgaa gatgggctgg aaggcaaaat
      361 cgtgtctccc tgtgacggtc catccaaggt gtcttacacc ttacagcgcc agactatctt
      421 caacatttcc cttatgaaac tctataacca caggcccctg acagagccca gcttgcaaaa
      481 gaccgtttta attaacaaca tgttgaggcg gatccaggag gaactcaaac aggaaggcag
      541 cctgaggccc atgttcaccc cctcctccca gcccaccacc gagcccagcg acagctaccg
      601 agaggccccg ccggccttca gccacctggc gtccccgtcc tcccacccct gcgacctcgg
      661 aagcactacg cccctggagg cctgcctcac cccggcctca ctgctcgagg acgacgatga
      721 cacgttttgc acctcccagg ccatgcagcc cacggctccc accaaactgt cacctccagc
      781 cctcttgcca gaaaaggaca gtttctcctc tgccttggac gagatcgagg agctctgtcc
      841 cacatctacc tccacagagg cggccacggc tgcgactgac agtgtgaaag ggacctccag
      901 cgaggctggc acccagaaac tcgacggtcc tcaagagagc cgcgcagatg actcaaaact
      961 gatggactct ctgcctggga attttgaaat aacgacgtcc acgggtttcc tgacagactt
     1021 gaccctggat gacatcctgt ttgctgacat tgatacgtcc atgtatgatt ttgacccctg
     1081 cacttcctca tcagggacag cctcaaaaat ggcccctgtg tctgccgacg acctcctcaa
     1141 aactctggct ccttacagca gtcagcctgt caccccaagt cagcctttca aaatggacct
     1201 cacagagctg gaccacatca tggaggtgct tgttgggtcc taagacccag ggacccagcg
     1261 actatgccca cccagacccc agagcgttcc cataaccctg acagttctcc acactgtgca
     1321 tgcacccttg cttgcctttt tcagagaaaa agaaaatttt acaacaggat cacactagtt
     1381 tttgctttga gcagagttgg agtgccttca tccaagtatg accactttta atacactttt
     1441 ttgagtggtt cctcagagac ctactaccct ggtataggaa agaatccatt tgaagacaat
     1501 gttgcaatgt tgaatgacaa aaataaacag ttcaagtgaa gcacaaggat taagttggaa
     1561 aagctgtaaa ttgcatgtgc atatttgtct attttttcta taagttttat tgcaagaggt
     1621 aaagaagaaa actatatata tatatcttat ttagataatc tcagtacctt ttctggcatt
     1681 tttgccctgt ataggttgac ttggcaattc ggccttttta gaggcattaa ctactcctcg
     1741 taagtgttgc atttacatgg ctgtttagaa aactgctgcc caaatttatt ttatattttt
     1801 gtacagattc tgcagtttat gatattgttt ttctaaaaac aaatgctgtt tatacatatg
     1861 agatagctat tttgatagga tttgctcaca tagttcctgc aaacttcaga tgtacaagtt
     1921 gcacttgtac ttttatagag ttgtaatgtt ttatatgtgt atggtgcaag agaaaattgg
     1981 atcaaatcaa tctgcagttg atgtccccaa atgcaaacac aggcacacac atgcacacac
     2041 ccataaacac acacacagtg ctttaagaaa gggccaggtg atatcacacc caaatttcac
     2101 aagcactgac cccctggcac caacacccgc cagtactgtg acttccaaag ccagagccac
     2161 atgtgctcat caaacttgca ttaagcagtt ggcgggagat ggctgtggag ctgggggttt
     2221 aagtgatggt tctcttttgc tccctctttt gagggtaaag ctactgtctt tcttaagagt
     2281 gtatttatgc caagtttgcg cttttaattg tttttatttt gttttttaat gaaaacccag
     2341 atctttcctt tttggcataa tttttatgat gacctgaaat tttacatccg aacaaaattt
     2401 tacatccgaa aagcaaccaa cttcttcatg gaactcagcc ctgttgcaat gcttagggcc
     2461 cttaaagaag aaaatctccc cagaaggcat ccatcatgtt gcttaattgt cttctgcagc
     2521 ttcctttccc tagagctttc cctgtgttgc taagagctga aaatggcatc ttcgtgatca
     2581 ccacagtgag cttggctcgc ctcggccggc ccgggatgca ctcttacaac atgtgtgact
     2641 cttgaacctg gagttcatca cattacgtca cagcttccca tctggttgct ttcctgagtc
     2701 agctacttca cacttgtcaa ggctgtttta ccccaaaact cagacaggac tttctatgca
     2761 tgttttccct cctcccccca attccccccc ccatcacctt atctcccagg acacacttga
     2821 gaagtagctt tttattccta gtggtgtaca tttaatttta aaaaggttgc aatgtatcat
     2881 gcttgttgcc gaaactgttt atggccttct tgtttcagtt ttttcttttc ttccaatggt
     2941 actttagctg ttgagtgcag gttacaacct atattgttat gcagatggct tctttaggaa
     3001 taacttttat atttatttaa aaatttttaa attatgggat gttttgttgt tgttgttgtc
     3061 tttgttgttg gtcatttgtc aatattcagt caccaattct gctcacttct tgccatggat
     3121 aaaattgggt ctttctggct aattaaaaaa gacaacttta taaaatggca ctttaagcaa
     3181 gccatagtta gttttatttt tgtaatgcac atggcaaagc aaagacgttt gtgatgaagg
     3241 aactgctcat ctaagcaaaa gatttgagta tgatatgata aaggctttct acattctaat
     3301 ttactttttc cccccacttg aatgtgtttt aaaggctaat tatcagctca gtagagcagt
     3361 gagaaactga tcaaattgca cttgttctcc tacaagcaac ctccacgcag acacctcgta
     3421 ctgctacagg tgtgtcattt cctttaatag gaccagggac catgtaactg aggtgagggt
     3481 tgtagtagat gcttccagtg tcagtatgcc tgttaatttt aagagcttcc ctttcttgca
     3541 gagaacaagt ctgcccagat tccatgcttt ctataactgg aggacctggc aaacctgccg
     3601 catgctgcac acatctacct acgtacacat atacaatagt attgatgatt ctgaacaata
     3661 acagggtaaa acagttggtt tgccattgtt aaaaactgat ttacagtaac ttacaacaac
     3721 tgtacttttg ttggattagc aaatcatgtg tttaaacaaa tcccatatgt tgggcaacag
     3781 ttcaaataag cacggagaag tgttgcccaa acttggttct ctgactctta tgtatttgta
     3841 aggctgggct tcaaaatcaa aacaaaaacc ccaaaaacag caggcaaatg ctttttaact
     3901 ctgacaccgt tgccataaat ccctgatact caaagtctaa caagaaagac atggaaaatt
     3961 agcagcccat tttcagaaag atcaaaatga tctagggttc taattgcttt tgcatcctat
     4021 tcttacaaag tgatgtccca acagggaaca gtaggagctg gagtgggatc tccaagtccc
     4081 agtttgagtg tgggatgtgc ttccagcagt gccttccctt tatgaaagac atcacatggc
     4141 atccagggcc aggcaggcag cttgaggtgc ctttacgaga aaaccgagct ggggctggga
     4201 gaggacagtt attgacactg atgtgcaatg aagtgacaag atgagagcag aatcgtaaga
     4261 gctttgaatt tgaagtgagt ttttttcccc ccataagtta tttattcctt ttttctgtgt
     4321 aaatatattt attttactgt ggagcgctaa catctggatc gtaacatgtg cagaatgtat
     4381 ggtaggaatg tattctcttg taggaatgta aatctgtatt aaaagggggt ccaagccagg
     4441 cccccaggtc ttctcattgt atgcacagtc cgcattcatt tttactcttc tctaatatgg
     4501 gtctatttga aatatgcaaa aggtatgagg aatgttttaa tacctccaaa tttttaagaa
     4561 aagcatcaaa gggttgatat tttttaaagt ttttttagta gcactttctc tggatgacag
     4621 aaggagcaac cacatgggca cccttgttca taccaaaggg tgagcagtgg ccagagcctc
     4681 ctctgcacct ctcgagtgtc tttaccaatt gagcttttta tcgccatagc cccttggagt
     4741 gccccagctg ccctgaggtc aatcaaggaa aatttcttaa tgaaataagc tccaaagagc
     4801 caaagtatca acttacagat cgtttttaaa gcttaaattt atgaaccacc tttgtggtaa
     4861 acaatgaatt atgaataccg cagggcagcc ttcttaaatg acaaatgtaa aaaaaaaaaa
     4921 aaaaaagact ctacttcgtg cagcaattgc tactctatac gaattgtctt aatttgaaaa
     4981 ccttgctgtt acaaattgga cctttataca ttttctgaaa acaatgaaaa gagtatattt
     5041 aaccttttct ggctgtaaat ggttaccttc ctgtaactgc cccgcacctg gaggcatgga
     5101 gttgtgtgca tcctgcttat gtacaattgt tttcagtgtt tctaagaatg agtctgaatg
     5161 gttcttgaaa attagccagg atcaaatgct attgcagaca aagccaataa aaagttggac
     5221 ttcttttggg gataacaagt tttggaagag aaatgcaggc catatgtgcg catgaccgag
     5281 attttgaaaa aagatgtaca tagtgacatg tttggtgcat ggtttttgag gagggctttt
     5341 gtcaaaaagg aggtataacc tttcccccac agacctgaga gctgtgcctt ttctatgcaa
     5401 tattacagac gttacatcgg aacccagatg gctgtattca catgtaggtt tgggctgtaa
     5461 tctaaacaat tggacagatt aaatgtacat ggaaatgagc agtcttactt ttgtagtttt
     5521 atattataca ataaacagtt aaaagatga
//
