LOCUS       NM_013376               2084 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens SERTA domain containing 1 (SERTAD1), mRNA.
ACCESSION   NM_013376
VERSION     NM_013376.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2084)
  AUTHORS   Ha,J., Kim,M., Park,J.S., Lee,Y., Lee,J.Y., Shin,J.C., Seo,D.,
            Park,S.S., You,J., Jung,S.M., Kim,H.Y., Mizuno,S., Takahashi,S.,
            Kim,S.J. and Park,S.H.
  TITLE     SERTAD1 initiates NLRP3-mediated inflammasome activation through
            restricting NLRP3 polyubiquitination
  JOURNAL   Cell Rep 43 (2), 113752 (2024)
   PUBMED   38341852
  REMARK    GeneRIF: SERTAD1 initiates NLRP3-mediated inflammasome activation
            through restricting NLRP3 polyubiquitination.
REFERENCE   2  (bases 1 to 2084)
  AUTHORS   Kim,D.K., Weller,B., Lin,C.W., Sheykhkarimli,D., Knapp,J.J.,
            Dugied,G., Zanzoni,A., Pons,C., Tofaute,M.J., Maseko,S.B.,
            Spirohn,K., Laval,F., Lambourne,L., Kishore,N., Rayhan,A.,
            Sauer,M., Young,V., Halder,H., la Rosa,N.M., Pogoutse,O.,
            Strobel,A., Schwehn,P., Li,R., Rothballer,S.T., Altmann,M.,
            Cassonnet,P., Cote,A.G., Vergara,L.E., Hazelwood,I., Liu,B.B.,
            Nguyen,M., Pandiarajan,R., Dohai,B., Coloma,P.A.R., Poirson,J.,
            Giuliana,P., Willems,L., Taipale,M., Jacob,Y., Hao,T., Hill,D.E.,
            Brun,C., Twizere,J.C., Krappmann,D., Heinig,M., Falter,C., Aloy,P.,
            Demeret,C., Vidal,M., Calderwood,M.A., Roth,F.P. and
            Falter-Braun,P.
  TITLE     A proteome-scale map of the SARS-CoV-2-human contactome
  JOURNAL   Nat Biotechnol 41 (1), 140-149 (2023)
   PUBMED   36217029
REFERENCE   3  (bases 1 to 2084)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   4  (bases 1 to 2084)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2084)
  AUTHORS   Sandag,Z., Jung,S., Quynh,N.T.N., Myagmarjav,D., Anh,N.H., Le,D.T.,
            Lee,B.S., Mongre,R.K., Jo,T. and Lee,M.
  TITLE     Inhibitory Role of TRIP-Br1/XIAP in Necroptosis under
            Nutrient/Serum Starvation
  JOURNAL   Mol Cells 43 (3), 236-250 (2020)
   PUBMED   32050753
  REMARK    GeneRIF: Inhibitory Role of TRIP-Br1/XIAP in Necroptosis under
            Nutrient/Serum Starvation.
REFERENCE   6  (bases 1 to 2084)
  AUTHORS   Gupta,S., Takhar,P.P., Degenkolbe,R., Koh,C.H., Zimmermann,H.,
            Yang,C.M., Guan Sim,K., Hsu,S.I. and Bernard,H.U.
  TITLE     The human papillomavirus type 11 and 16 E6 proteins modulate the
            cell-cycle regulator and transcription cofactor TRIP-Br1
  JOURNAL   Virology 317 (1), 155-164 (2003)
   PUBMED   14675634
  REMARK    GeneRIF: interacts with low- and high-risk HPV11 and HPV16 E6
            proteins in yeast, in vitro and in mammalian cell cultures
REFERENCE   7  (bases 1 to 2084)
  AUTHORS   Hirose,T., Fujii,R., Nakamura,H., Aratani,S., Fujita,H.,
            Nakazawa,M., Nakamura,K., Nishioka,K. and Nakajima,T.
  TITLE     Regulation of CREB-mediated transcription by association of CDK4
            binding protein p34SEI-1 with CBP
  JOURNAL   Int J Mol Med 11 (6), 705-712 (2003)
   PUBMED   12736710
  REMARK    GeneRIF: p34SEI-1 strongly suppressed CREB-mediated transcription,
            and this suppression was overcome by excess amount of CBP
REFERENCE   8  (bases 1 to 2084)
  AUTHORS   Hsu,S.I., Yang,C.M., Sim,K.G., Hentschel,D.M., O'Leary,E. and
            Bonventre,J.V.
  TITLE     TRIP-Br: a novel family of PHD zinc finger- and
            bromodomain-interacting proteins that regulate the transcriptional
            activity of E2F-1/DP-1
  JOURNAL   EMBO J 20 (9), 2273-2285 (2001)
   PUBMED   11331592
REFERENCE   9  (bases 1 to 2084)
  AUTHORS   Sugimoto,M., Nakamura,T., Ohtani,N., Hampson,L., Hampson,I.N.,
            Shimamoto,A., Furuichi,Y., Okumura,K., Niwa,S., Taya,Y. and Hara,E.
  TITLE     Regulation of CDK4 activity by a novel CDK4-binding protein,
            p34(SEI-1)
  JOURNAL   Genes Dev 13 (22), 3027-3033 (1999)
   PUBMED   10580009
REFERENCE   10 (bases 1 to 2084)
  AUTHORS   Besley,G.T., Broadhead,D.M. and Lawlor,E.
  TITLE     Acid esterase deficiency: comparison of biochemical findings in
            infantile and adult forms
  JOURNAL   J Inherit Metab Dis 7 Suppl 2, 155-156 (1984)
   PUBMED   6434876
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK074652.1, AA928491.1 and AC010271.8.
            
            On Nov 22, 2018 this sequence version replaced NM_013376.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK222970.1, AK074652.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2142586, SAMEA2142853
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000357949.5/ ENSP00000350633.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-966               AK074652.1         34-999
            967-1172            AA928491.1         9-214               c
            1173-2084           AC010271.8         116962-117873       c
FEATURES             Location/Qualifiers
     source          1..2084
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19q13.2"
     gene            1..2084
                     /gene="SERTAD1"
                     /gene_synonym="SEI1; TRIP-Br1; TRIPBR1"
                     /note="SERTA domain containing 1"
                     /db_xref="GeneID:29950"
                     /db_xref="HGNC:HGNC:17932"
                     /db_xref="MIM:617850"
     exon            1..126
                     /gene="SERTAD1"
                     /gene_synonym="SEI1; TRIP-Br1; TRIPBR1"
                     /inference="alignment:Splign:2.1.0"
     exon            127..2084
                     /gene="SERTAD1"
                     /gene_synonym="SEI1; TRIP-Br1; TRIPBR1"
                     /inference="alignment:Splign:2.1.0"
     CDS             127..837
                     /gene="SERTAD1"
                     /gene_synonym="SEI1; TRIP-Br1; TRIPBR1"
                     /note="transcriptional regulator interacting with the
                     PHD-bromodomain 1; CDK4-binding protein p34SEI;
                     CDK4-binding protein p34SEI1; SEI-1; p34(SEI-1)"
                     /codon_start=1
                     /product="SERTA domain-containing protein 1"
                     /protein_id="NP_037508.2"
                     /db_xref="CCDS:CCDS12557.1"
                     /db_xref="GeneID:29950"
                     /db_xref="HGNC:HGNC:17932"
                     /db_xref="MIM:617850"
                     /translation="MLSKGLKRKREEEEEKEPLAVDSWWLDPGHTAVAQAPPAVASSS
                     LFDLSVLKLHHSLQQSEPDLRHLVLVVNTLRRIQASMAPAAALPPVPSPPAAPSVADN
                     LLASSDAALSASMASLLEDLSHIEGLSQAPQPLADEGPPGRSIGGAAPSLGALDLLGP
                     ATGCLLDDGLEGLFEDIDTSMYDNELWAPASEGLKPGPEDGPGKEEAPELDEAELDYL
                     MDVLVGTQALERPPGPGR"
     regulatory      1145..1150
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERTAD1"
                     /gene_synonym="SEI1; TRIP-Br1; TRIPBR1"
                     /note="hexamer: ATTAAA"
     polyA_site      1172
                     /gene="SERTAD1"
                     /gene_synonym="SEI1; TRIP-Br1; TRIPBR1"
                     /note="major polyA site"
     regulatory      2060..2065
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERTAD1"
                     /gene_synonym="SEI1; TRIP-Br1; TRIPBR1"
                     /note="hexamer: AATAAA"
     polyA_site      2084
                     /gene="SERTAD1"
                     /gene_synonym="SEI1; TRIP-Br1; TRIPBR1"
ORIGIN      
        1 agaactgcgt ctcgcgaccc aggcgcgggt ttccggagga cagccaacaa gcgatgctgc
       61 cgccgccgtt tcctgattgg ttgtgggtgg ctacctcttc gttctgattg gccgctagtg
      121 agcaagatgc tgagcaaggg tctgaagcgg aaacgggagg aggaggagga gaaggaacct
      181 ctggcagtcg actcctggtg gctagatcct ggccacacag cggtggcaca ggcacccccg
      241 gccgtggcct ctagctccct ctttgacctc tcagtgctca agctccacca cagcctgcag
      301 cagagtgagc cggacctgcg gcacctggtg ctggtcgtga acactctgcg gcgcatccag
      361 gcgtccatgg cacccgcggc tgccctgcca cctgtgccta gcccacctgc agcccccagt
      421 gtggctgaca acttactggc aagctcggac gctgcccttt cagcctccat ggccagcctc
      481 ctggaggacc tcagccacat tgagggcctg agtcaggctc cccaaccctt ggcagacgag
      541 gggccaccag gccgtagcat cgggggagca gcgcccagcc tgggtgcctt ggacctgctg
      601 ggcccagcca ctggctgtct actggacgat gggcttgagg gcctgtttga ggatattgac
      661 acctctatgt atgacaatga actttgggca ccagcctctg agggcctcaa accaggccct
      721 gaggatgggc cgggcaagga ggaagctccg gagctggacg aggccgaatt ggactacctc
      781 atggatgtgc tggtgggcac acaggcactg gagcgaccgc cggggccagg gcgctgagcc
      841 ctcgtgctgg aatggttgtc tggtatctga actgagcctg ctggctggac caactgtcct
      901 cgaaaagaca cagctggctt ccctagtaca gagaacaggg cttgggccac tttggagaga
      961 cagaatctag tcctgggcaa cttcacatcc gtcctcctgt ctcagggctg gcagggggag
     1021 cctggaatta ccccctagtg atggaatgac agggtctggt ggggactgaa ttccctggcc
     1081 ctggggtcat agcttgggct gttccttctc tgatacggga agagacccca atcagatttt
     1141 tcaaattaaa gccagtcctg ggaaatctca aatccgtgtg ctgctttgtc tctgggcaaa
     1201 tgtgaaggcg agataaaaac atcaaacatt ttattgggcg taggctgtgt acgaggcaca
     1261 gtttctaagc acgtcactgt gttaactcat ttaatcctat aacagcccta caagatcggt
     1321 agtattatca tccctatttt acaggtgaga aaaccaaggt tccaagatta tcacttgagg
     1381 tgggttttaa attatgaact tttttttttt tttttttgag atagggtctc gctctgtcac
     1441 ccaggttgaa gtacagtggt ctgatcatgg ctcactacag cctcaaactc ctgggctcaa
     1501 gcgatcctcc taccaggcca cttttttttt ttctttcttt tttttttaag acagattctt
     1561 actctgtcgc ccaggctgga gtgcagtggc gtgacttcgg ctcactgcaa cctccacctc
     1621 ccaggttcaa acgattctcc tgcctcggcc tcccaattag ctgggaccga ctaatttttt
     1681 atattttttg tagagacagg gtttcaccgt gttagccagg atggtcttca tcttctgacc
     1741 tcgtgatctg cctgcctcag cctcccaaag tgctgggatt acaggcgtga gccactgtgc
     1801 ctggcctttt tttttttttc ttaaatttta tttcttttct ttgctagcag gaagtcaagg
     1861 caacttttta aaaatgaaag caagtcctcg cctggagtct acctgtattt attgaggagc
     1921 gaaggggaga ttgctttcag aatggtcccg aaataaaaac acaaaacctg gaccctggac
     1981 agatcctctc caaggagccc tgagagtcgg ctctccagga aaatggggga ggaaaggggg
     2041 acaacagccc atttttaaaa ataaaattca ctcctggtct taaa
//
