LOCUS       NP_006208                405 aa            linear   PRI 12-JUN-2024
DEFINITION  serpin I2 precursor [Homo sapiens].
ACCESSION   NP_006208
VERSION     NP_006208.1
DBSOURCE    REFSEQ: accession NM_006217.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 405)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (residues 1 to 405)
  AUTHORS   Fragoza,R., Das,J., Wierbowski,S.D., Liang,J., Tran,T.N., Liang,S.,
            Beltran,J.F., Rivera-Erick,C.A., Ye,K., Wang,T.Y., Yao,L., Mort,M.,
            Stenson,P.D., Cooper,D.N., Wei,X., Keinan,A., Schimenti,J.C.,
            Clark,A.G. and Yu,H.
  TITLE     Extensive disruption of protein interactions by genetic variants
            across the allele frequency spectrum in human populations
  JOURNAL   Nat Commun 10 (1), 4141 (2019)
   PUBMED   31515488
  REMARK    Publication Status: Online-Only
REFERENCE   3  (residues 1 to 405)
  AUTHORS   Heit,C., Jackson,B.C., McAndrews,M., Wright,M.W., Thompson,D.C.,
            Silverman,G.A., Nebert,D.W. and Vasiliou,V.
  TITLE     Update of the human and mouse SERPIN gene superfamily
  JOURNAL   Hum Genomics 7 (1), 22 (2013)
   PUBMED   24172014
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 405)
  AUTHORS   Hysi,P.G., Simpson,C.L., Fok,Y.K., Gerrelli,D., Webster,A.R.,
            Bhattacharya,S.S., Hammond,C.J., Sham,P.C. and Rahi,J.S.
  TITLE     Common polymorphisms in the SERPINI2 gene are associated with
            refractive error in the 1958 British Birth Cohort
  JOURNAL   Invest Ophthalmol Vis Sci 53 (1), 440-447 (2012)
   PUBMED   22110064
  REMARK    GeneRIF: The findings indicate that SERPINI2 is a promising
            candidate for further investigations of the genetic susceptibility
            to myopia.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 405)
  AUTHORS   Prakash,T., Sharma,V.K., Adati,N., Ozawa,R., Kumar,N., Nishida,Y.,
            Fujikake,T., Takeda,T. and Taylor,T.D.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
REFERENCE   6  (residues 1 to 405)
  AUTHORS   Farfsing,A., Engel,F., Seiffert,M., Hartmann,E., Ott,G.,
            Rosenwald,A., Stilgenbauer,S., Dohner,H., Boutros,M., Lichter,P.
            and Pscherer,A.
  TITLE     Gene knockdown studies revealed CCDC50 as a candidate gene in
            mantle cell lymphoma and chronic lymphocytic leukemia
  JOURNAL   Leukemia 23 (11), 2018-2026 (2009)
   PUBMED   19641524
REFERENCE   7  (residues 1 to 405)
  AUTHORS   Ragg,H.
  TITLE     The role of serpins in the surveillance of the secretory pathway
  JOURNAL   Cell Mol Life Sci 64 (21), 2763-2770 (2007)
   PUBMED   17668148
  REMARK    Review article
REFERENCE   8  (residues 1 to 405)
  AUTHORS   Chang,W.S., Chang,N.T., Lin,S.C., Wu,C.W. and Wu,F.Y.
  TITLE     Tissue-specific cancer-related serpin gene cluster at human
            chromosome band 3q26
  JOURNAL   Genes Chromosomes Cancer 29 (3), 240-255 (2000)
   PUBMED   10992299
REFERENCE   9  (residues 1 to 405)
  AUTHORS   Xiao,G., Liu,Y.E., Gentz,R., Sang,Q.A., Ni,J., Goldberg,I.D. and
            Shi,Y.E.
  TITLE     Suppression of breast cancer growth and metastasis by a serpin
            myoepithelium-derived serine proteinase inhibitor expressed in the
            mammary myoepithelial cells
  JOURNAL   Proc Natl Acad Sci U S A 96 (7), 3700-3705 (1999)
   PUBMED   10097100
REFERENCE   10 (residues 1 to 405)
  AUTHORS   Ozaki,K., Nagata,M., Suzuki,M., Fujiwara,T., Miyoshi,Y.,
            Ishikawa,O., Ohigashi,H., Imaoka,S., Takahashi,E. and Nakamura,Y.
  TITLE     Isolation and characterization of a novel human pancreas-specific
            gene, pancpin, that is down-regulated in pancreatic cancer cells
  JOURNAL   Genes Chromosomes Cancer 22 (3), 179-185 (1998)
   PUBMED   9624529
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC107311.8.
            
            Summary: The gene encodes a member of a family of proteins that
            acts as inhibitors of serine proteases. These proteins function in
            the regulation of a variety of physiological processes, including
            coagulation, fibrinolysis, development, malignancy, and
            inflammation. Expression of the encoded protein may be
            downregulated during pancreatic carcinogenesis. Alternative
            splicing results in multiple transcript variants for this gene.
            [provided by RefSeq, Jan 2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK226025.1, AB006423.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000264677.9/ ENSP00000264677.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..405
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q26.1"
     Protein         1..405
                     /product="serpin I2 precursor"
                     /note="serine (or cysteine) proteinase inhibitor, clade I
                     (pancpin), member 2; serine (or cysteine) proteinase
                     inhibitor, clade I (neuroserpin), member 2; serpin I2;
                     protease inhibitor 14; myoepithelium-derived serine
                     proteinase inhibitor; myoepithelium-derived serine
                     protease inhibitor; peptidase inhibitor 14;
                     pancreas-specific protein TSA2004; serpin peptidase
                     inhibitor, clade I (pancpin), member 2"
                     /calculated_mol_wt=44061
     sig_peptide     1..18
                     /note="/evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O75830.1)"
                     /calculated_mol_wt=2103
     mat_peptide     19..405
                     /product="Serpin I2. /id=PRO_0000032525"
                     /note="propagated from UniProtKB/Swiss-Prot (O75830.1)"
                     /calculated_mol_wt=44061
     Region          23..392
                     /region_name="serpinI2_pancpin"
                     /note="serpin family I member 2, pancpin; cd19576"
                     /db_xref="CDD:381042"
     Site            202
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O75830.1)"
     Site            207
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O75830.1)"
     Site            306
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (O75830.1)"
     Site            order(338..354,356..373)
                     /site_type="other"
                     /note="reactive center loop (RCL)"
                     /db_xref="CDD:381042"
     Site            357..358
                     /site_type="other"
                     /note="Reactive bond. /evidence=ECO:0000250; propagated
                     from UniProtKB/Swiss-Prot (O75830.1)"
     CDS             1..405
                     /gene="SERPINI2"
                     /gene_synonym="MEPI; PANCPIN; PI14; TSA2004"
                     /coded_by="NM_006217.6:51..1268"
                     /db_xref="CCDS:CCDS3200.1"
                     /db_xref="GeneID:5276"
                     /db_xref="HGNC:HGNC:8945"
                     /db_xref="MIM:605587"
ORIGIN      
        1 mdtiflwsll llffgsqasr csaqkntefa vdlyqevsls hkdniifspl gitlvlemvq
       61 lgakgkaqqq irqtlkqqet sageeffvlk sffsaisekk qeftfnlana lylqegftvk
      121 eqylhgnkef fqsaiklvdf qdakacaemi stwverktdg kikdmfsgee fgpltrlvlv
      181 naiyfkgdwk qkfrkedtql inftkkngst vkipmmkall rtkygyfses slnyqvlels
      241 ykgdefslii ilpaegmdie eveklitaqq ilkwlsemqe eeveislprf kveqkvdfkd
      301 vlyslnitei fsggcdlsgi tdssevyvsq vtqkvffein edgseaatst gihipvimsl
      361 aqsqfianhp flfimkhnpt esilfmgrvt npdtqeikgr dldsl
//
