LOCUS       NM_001386375            1816 bp    mRNA    linear   PRI 24-OCT-2024
DEFINITION  Homo sapiens serpin family E member 3 (SERPINE3), transcript
            variant 1, mRNA.
ACCESSION   NM_001386375
VERSION     NM_001386375.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1816)
  AUTHORS   Indrischek,H., Hammer,J., Machate,A., Hecker,N., Kirilenko,B.,
            Roscito,J., Hans,S., Norden,C., Brand,M. and Hiller,M.
  TITLE     Vision-related convergent gene losses reveal SERPINE3's unknown
            role in the eye
  JOURNAL   Elife 11, e77999 (2022)
   PUBMED   35727138
  REMARK    GeneRIF: Vision-related convergent gene losses reveal SERPINE3's
            unknown role in the eye.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1816)
  AUTHORS   Lopez,S., Buil,A., Souto,J.C., Casademont,J., Martinez-Perez,A.,
            Almasy,L. and Soria,J.M.
  TITLE     A genome-wide association study in the genetic analysis of
            idiopathic thrombophilia project suggests sex-specific regulation
            of mitochondrial DNA levels
  JOURNAL   Mitochondrion 18, 34-40 (2014)
   PUBMED   25240745
REFERENCE   3  (bases 1 to 1816)
  AUTHORS   Heit,C., Jackson,B.C., McAndrews,M., Wright,M.W., Thompson,D.C.,
            Silverman,G.A., Nebert,D.W. and Vasiliou,V.
  TITLE     Update of the human and mouse SERPIN gene superfamily
  JOURNAL   Hum Genomics 7 (1), 22 (2013)
   PUBMED   24172014
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1816)
  AUTHORS   Dunham,A., Matthews,L.H., Burton,J., Ashurst,J.L., Howe,K.L.,
            Ashcroft,K.J., Beare,D.M., Burford,D.C., Hunt,S.E.,
            Griffiths-Jones,S., Jones,M.C., Keenan,S.J., Oliver,K., Scott,C.E.,
            Ainscough,R., Almeida,J.P., Ambrose,K.D., Andrews,D.T.,
            Ashwell,R.I., Babbage,A.K., Bagguley,C.L., Bailey,J., Bannerjee,R.,
            Barlow,K.F., Bates,K., Beasley,H., Bird,C.P., Bray-Allen,S.,
            Brown,A.J., Brown,J.Y., Burrill,W., Carder,C., Carter,N.P.,
            Chapman,J.C., Clamp,M.E., Clark,S.Y., Clarke,G., Clee,C.M.,
            Clegg,S.C., Cobley,V., Collins,J.E., Corby,N., Coville,G.J.,
            Deloukas,P., Dhami,P., Dunham,I., Dunn,M., Earthrowl,M.E.,
            Ellington,A.G., Faulkner,L., Frankish,A.G., Frankland,J.,
            French,L., Garner,P., Garnett,J., Gilbert,J.G., Gilson,C.J.,
            Ghori,J., Grafham,D.V., Gribble,S.M., Griffiths,C., Hall,R.E.,
            Hammond,S., Harley,J.L., Hart,E.A., Heath,P.D., Howden,P.J.,
            Huckle,E.J., Hunt,P.J., Hunt,A.R., Johnson,C., Johnson,D., Kay,M.,
            Kimberley,A.M., King,A., Laird,G.K., Langford,C.J., Lawlor,S.,
            Leongamornlert,D.A., Lloyd,D.M., Lloyd,C., Loveland,J.E.,
            Lovell,J., Martin,S., Mashreghi-Mohammadi,M., McLaren,S.J.,
            McMurray,A., Milne,S., Moore,M.J., Nickerson,T., Palmer,S.A.,
            Pearce,A.V., Peck,A.I., Pelan,S., Phillimore,B., Porter,K.M.,
            Rice,C.M., Searle,S., Sehra,H.K., Shownkeen,R., Skuce,C.D.,
            Smith,M., Steward,C.A., Sycamore,N., Tester,J., Thomas,D.W.,
            Tracey,A., Tromans,A., Tubby,B., Wall,M., Wallis,J.M., West,A.P.,
            Whitehead,S.L., Willey,D.L., Wilming,L., Wray,P.W., Wright,M.W.,
            Young,L., Coulson,A., Durbin,R., Hubbard,T., Sulston,J.E., Beck,S.,
            Bentley,D.R., Rogers,J. and Ross,M.T.
  TITLE     The DNA sequence and analysis of human chromosome 13
  JOURNAL   Nature 428 (6982), 522-528 (2004)
   PUBMED   15057823
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL137780.10.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14372080.893428.1,
                                           SRR18074967.3280127.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1968540,
                                           SAMEA1968968 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000681248.1/ ENSP00000506411.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-53                AL137780.10        37717-37769
            54-131              AL137780.10        38810-38887
            132-404             AL137780.10        39101-39373
            405-638             AL137780.10        42278-42511
            639-848             AL137780.10        45051-45260
            849-1047            AL137780.10        46239-46437
            1048-1148           AL137780.10        53069-53169
            1149-1235           AL137780.10        59304-59390
            1236-1319           AL137780.10        59836-59919
            1320-1816           AL137780.10        62265-62761
FEATURES             Location/Qualifiers
     source          1..1816
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="13"
                     /map="13q14.3"
     gene            1..1816
                     /gene="SERPINE3"
                     /note="serpin family E member 3"
                     /db_xref="GeneID:647174"
                     /db_xref="HGNC:HGNC:24774"
                     /db_xref="MIM:620989"
     exon            1..53
                     /gene="SERPINE3"
                     /inference="alignment:Splign:2.1.0"
     exon            54..131
                     /gene="SERPINE3"
                     /inference="alignment:Splign:2.1.0"
     exon            132..404
                     /gene="SERPINE3"
                     /inference="alignment:Splign:2.1.0"
     CDS             149..1363
                     /gene="SERPINE3"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; nexin-related serine protease inhibitor; Serpin
                     E3; serpin peptidase inhibitor, clade E (nexin,
                     plasminogen activator inhibitor type 1), member 3"
                     /codon_start=1
                     /product="serpin E3 isoform 1 precursor"
                     /protein_id="NP_001373304.1"
                     /db_xref="CCDS:CCDS91808.1"
                     /db_xref="GeneID:647174"
                     /db_xref="HGNC:HGNC:24774"
                     /db_xref="MIM:620989"
                     /translation="MPPFLITLFLFHSCCLRANGHLREGMTLLKTEFALHLYQSVAAC
                     RNETNFVISPAGVSLPLEILQFGAEGSTGQQLADALGYTVHDKRVKDFLHAVYATLPT
                     SSQGTEMELACSLFVQVGTPLSPCFVEHVSWWANSSLEPADLSEPNSTAIQTSEGASR
                     ETAGGGPSEGPGGWPWEQVSAAFAQLVLVSTMSFQGTWRKRFSSTDTQILPFTCAYGL
                     VLQVPMMHQTTEVNYGQFQDTAGHQVGVLELPYLGSAVSLFLVLPRDKDTPLSHIEPH
                     LTASTIHLWTTSLRRARMDVFLPRFRIQNQFNLKSILNSWGVTDLFDPLKANLKGISG
                     QDGFYVSEAIHKAKIEVLEEGTKASGATALLLLKRSRIPIFKADRPFIYFLREPNTGF
                     VFSIGRVSNPLD"
     exon            405..638
                     /gene="SERPINE3"
                     /inference="alignment:Splign:2.1.0"
     exon            639..848
                     /gene="SERPINE3"
                     /inference="alignment:Splign:2.1.0"
     exon            849..1047
                     /gene="SERPINE3"
                     /inference="alignment:Splign:2.1.0"
     exon            1048..1148
                     /gene="SERPINE3"
                     /inference="alignment:Splign:2.1.0"
     exon            1149..1235
                     /gene="SERPINE3"
                     /inference="alignment:Splign:2.1.0"
     exon            1236..1319
                     /gene="SERPINE3"
                     /inference="alignment:Splign:2.1.0"
     exon            1320..1816
                     /gene="SERPINE3"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 acccacaaga acagagtcga gcaaggaaac gtgcaacagt gatacaaaag tctggctttg
       61 ctaaagtcac acatccagta agtggccgaa gcagatcttc agacccacag tttggctgcc
      121 aaaggaccac agaaccctcc cagcctccat gccgcctttc ctgatcaccc tcttcctctt
      181 tcactcttgc tgcctccgag caaatggcca cctccgtgaa ggaatgacat tgctgaagac
      241 tgagtttgca cttcacctct accagagtgt ggccgcgtgt agaaatgaga cgaactttgt
      301 catctctcct gctggtgtgt ccctccccct ggagatcctg cagtttggag cagaagggag
      361 cactggtcag cagctggcag atgccctggg gtacactgtc catgacaaaa gggtgaaaga
      421 tttcttgcat gctgtttatg ccacactacc cacctccagc caaggcaccg agatggagct
      481 ggcctgcagc ctttttgtgc aagtgggaac gccactgtcc ccctgctttg tggagcacgt
      541 ctcctggtgg gctaacagca gcctggaacc agccgacctc agtgagccca atagcaccgc
      601 catccagact agcgaagggg cctccagaga gactgcaggt gggggcccca gtgagggccc
      661 tggtggctgg ccgtgggagc aagtcagtgc agcatttgct cagcttgtgc ttgtgagcac
      721 catgtccttc caaggcactt ggcgaaagag attctcctcc acagacacac agatcctgcc
      781 tttcacctgt gcctatggcc tcgtccttca ggtccccatg atgcaccaaa cgaccgaggt
      841 caactacggt cagttccagg acactgcagg ccatcaggtg ggggtgctgg agcttcctta
      901 cctgggaagt gcagtgagtc tgttcctggt gctgccccgt gacaaagaca cccccctgag
      961 ccacatcgag ccacacctca cagccagcac catccacctc tggaccacca gcctgaggag
     1021 agccaggatg gatgtgttcc tgcccaggtt taggatccaa aatcaattca acttaaaaag
     1081 cattttaaat tcttggggag tcaccgatct ttttgatcca ctcaaagcta acttgaaagg
     1141 aatttcaggc caagatggct tttatgtttc tgaagcaatc cacaaggcca agattgaagt
     1201 tttggaggaa ggcaccaagg catctggagc cacagctctg ttgttattga aaaggtctcg
     1261 gattcctatt tttaaagcag atcggccatt catctatttc ctgagagaac ctaacacagg
     1321 gtttgtcttc agtattggga gagtttcaaa tcccctagac taaatgcatg ttctccactt
     1381 tcatcaatgc ttttcttcat aaagttataa tttcattttg ctataccctt gaaatttaaa
     1441 aaaatgtctg ataaagtgta aaaagctaag ggtatgtgat tttcaatatt ataaacctaa
     1501 aaatacttca gtttttaaat gttataagtt tattttgcct actcttaatc caaatctatt
     1561 ttgaccttct tttctactgc ttacccccca aaccactaaa aggcacagca gtgatcatga
     1621 atggtgagtg agtcaggcca taagattgct tcctcagtac ggatactcta ggccatgttg
     1681 aattgagggt ggagaatgaa tagcgtggtt ttccttatcc tgtgaaactc aggggggatg
     1741 caaaatgagc aaagtcatct taaaggtgtt tcctttccat ttagcttata aataaaacag
     1801 agtttaagtg tgagaa
//
