LOCUS       NM_004155               4143 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens serpin family B member 9 (SERPINB9), mRNA.
ACCESSION   NM_004155
VERSION     NM_004155.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4143)
  AUTHORS   Huang,Y., Gong,M., Chen,H., Deng,C., Zhu,X., Lin,J., Huang,A.,
            Xu,Y., Tai,Y., Song,G., Xu,H., Hu,J., Feng,H., Tang,Q., Lu,J. and
            Wang,J.
  TITLE     Mass Spectrometry-Based Proteomics Identifies Serpin B9 as a Key
            Protein in Promoting Bone Metastases in Lung Cancer
  JOURNAL   Mol Cancer Res 22 (4), 402-414 (2024)
   PUBMED   38226993
  REMARK    GeneRIF: Mass Spectrometry-Based Proteomics Identifies Serpin B9 as
            a Key Protein in Promoting Bone Metastases in Lung Cancer.
REFERENCE   2  (bases 1 to 4143)
  AUTHORS   Anami,T., Ibe,Y., Li,L., Komohara,Y., Hirao,H., Harada,M., Yano,H.,
            Fujiwara,Y., Motoshima,T., Yatsuda,J., Hibi,T. and Kamba,T.
  TITLE     Overexpression of SerpinB9 in non-seminomatous germ cell tumors
  JOURNAL   Med Mol Morphol 57 (1), 68-75 (2024)
   PUBMED   37991604
  REMARK    GeneRIF: Overexpression of SerpinB9 in non-seminomatous germ cell
            tumors.
REFERENCE   3  (bases 1 to 4143)
  AUTHORS   Hirao,H., Adawy,A., Li,L., Yoshii,D., Yano,H., Fujiwara,Y.,
            Honda,M., Harada,M., Yamamoto,M., Komohara,Y. and Hibi,T.
  TITLE     The expression analysis of SerpinB9 in hepatoblastoma
            microenvironment
  JOURNAL   Pediatr Surg Int 40 (1), 55 (2024)
   PUBMED   38347163
  REMARK    GeneRIF: The expression analysis of SerpinB9 in hepatoblastoma
            microenvironment.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 4143)
  AUTHORS   Kimman,T., Slomp,A., Martens,A., Grabherr,S., Li,S., van Diest,E.,
            Meeldijk,J., Kuball,J., Minnema,M.C., Eldering,E., Bovenschen,N.,
            Sebestyen,Z. and Peperzak,V.
  TITLE     Serpin B9 controls tumor cell killing by CAR T cells
  JOURNAL   J Immunother Cancer 11 (3) (2023)
   PUBMED   36931661
  REMARK    GeneRIF: Serpin B9 controls tumor cell killing by CAR T cells.
REFERENCE   5  (bases 1 to 4143)
  AUTHORS   Kanamori,H., Krieg,S., Mao,C., Di Pippo,V.A., Wang,S.,
            Zajchowski,D.A. and Shapiro,D.J.
  TITLE     Proteinase inhibitor 9, an inhibitor of granzyme B-mediated
            apoptosis, is a primary estrogen-inducible gene in human liver
            cells
  JOURNAL   J Biol Chem 275 (8), 5867-5873 (2000)
   PUBMED   10681578
REFERENCE   6  (bases 1 to 4143)
  AUTHORS   Annand,R.R., Dahlen,J.R., Sprecher,C.A., De Dreu,P., Foster,D.C.,
            Mankovich,J.A., Talanian,R.V., Kisiel,W. and Giegel,D.A.
  TITLE     Caspase-1 (interleukin-1beta-converting enzyme) is inhibited by the
            human serpin analogue proteinase inhibitor 9
  JOURNAL   Biochem J 342 Pt 3 (Pt 3), 655-665 (1999)
   PUBMED   10477277
REFERENCE   7  (bases 1 to 4143)
  AUTHORS   Sun,J., Stephens,R., Mirza,G., Kanai,H., Ragoussis,J. and Bird,P.I.
  TITLE     A serpin gene cluster on human chromosome 6p25 contains PI6, PI9
            and ELANH2 which have a common structure almost identical to the
            18q21 ovalbumin serpin genes
  JOURNAL   Cytogenet Cell Genet 82 (3-4), 273-277 (1998)
   PUBMED   9858835
REFERENCE   8  (bases 1 to 4143)
  AUTHORS   Eyre,H.J., Sun,J., Sutherland,G.R. and Bird,P.
  TITLE     Chromosomal mapping of the gene (PI9) encoding the intracellular
            serpin proteinase inhibitor 9 to 6p25 by fluorescence in situ
            hybridization
  JOURNAL   Genomics 37 (3), 406-408 (1996)
   PUBMED   8938458
REFERENCE   9  (bases 1 to 4143)
  AUTHORS   Sun,J., Bird,C.H., Sutton,V., McDonald,L., Coughlin,P.B., De
            Jong,T.A., Trapani,J.A. and Bird,P.I.
  TITLE     A cytosolic granzyme B inhibitor related to the viral apoptotic
            regulator cytokine response modifier A is present in cytotoxic
            lymphocytes
  JOURNAL   J Biol Chem 271 (44), 27802-27809 (1996)
   PUBMED   8910377
REFERENCE   10 (bases 1 to 4143)
  AUTHORS   Sprecher,C.A., Morgenstern,K.A., Mathewes,S., Dahlen,J.R.,
            Schrader,S.K., Foster,D.C. and Kisiel,W.
  TITLE     Molecular cloning, expression, and partial characterization of two
            novel members of the ovalbumin family of serine proteinase
            inhibitors
  JOURNAL   J Biol Chem 270 (50), 29854-29861 (1995)
   PUBMED   8530382
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL133351.34, BC002538.2 and
            BX485378.1.
            
            On Nov 22, 2018 this sequence version replaced NM_004155.5.
            
            Summary: This gene encodes a member of the serine protease
            inhibitor family which are also known as serpins. The encoded
            protein belongs to a subfamily of intracellular serpins. This
            protein inhibits the activity of the effector molecule granzyme B.
            Overexpression of this protein may prevent cytotoxic T-lymphocytes
            from eliminating certain tumor cells. A pseudogene of this gene is
            found on chromosome 6. [provided by RefSeq, Mar 2012].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC002538.2, SRR1660805.99844.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2162568 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000380698.5/ ENSP00000370074.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-36                AL133351.34        39238-39273         c
            37-1363             BC002538.2         1-1327
            1364-4142           AL133351.34        23235-26013         c
            4143-4143           BX485378.1         31-31               c
FEATURES             Location/Qualifiers
     source          1..4143
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p25.2"
     gene            1..4143
                     /gene="SERPINB9"
                     /gene_synonym="CAP-3; CAP3; PI-9; PI9"
                     /note="serpin family B member 9"
                     /db_xref="GeneID:5272"
                     /db_xref="HGNC:HGNC:8955"
                     /db_xref="MIM:601799"
     exon            1..109
                     /gene="SERPINB9"
                     /gene_synonym="CAP-3; CAP3; PI-9; PI9"
                     /inference="alignment:Splign:2.1.0"
     exon            110..287
                     /gene="SERPINB9"
                     /gene_synonym="CAP-3; CAP3; PI-9; PI9"
                     /inference="alignment:Splign:2.1.0"
     CDS             120..1250
                     /gene="SERPINB9"
                     /gene_synonym="CAP-3; CAP3; PI-9; PI9"
                     /note="protease inhibitor 9 (ovalbumin type); serine (or
                     cysteine) proteinase inhibitor, clade B (ovalbumin),
                     member 9; serpin peptidase inhibitor, clade B, member 9;
                     serpin peptidase inhibitor, clade B (ovalbumin), member 9;
                     testicular tissue protein Li 180; peptidase inhibitor 9;
                     cytoplasmic antiproteinase 3"
                     /codon_start=1
                     /product="serpin B9"
                     /protein_id="NP_004146.1"
                     /db_xref="CCDS:CCDS4478.1"
                     /db_xref="GeneID:5272"
                     /db_xref="HGNC:HGNC:8955"
                     /db_xref="MIM:601799"
                     /translation="METLSNASGTFAIRLLKILCQDNPSHNVFCSPVSISSALAMVLL
                     GAKGNTATQMAQALSLNTEEDIHRAFQSLLTEVNKAGTQYLLRTANRLFGEKTCQFLS
                     TFKESCLQFYHAELKELSFIRAAEESRKHINTWVSKKTEGKIEELLPGSSIDAETRLV
                     LVNAIYFKGKWNEPFDETYTREMPFKINQEEQRPVQMMYQEATFKLAHVGEVRAQLLE
                     LPYARKELSLLVLLPDDGVELSTVEKSLTFEKLTAWTKPDCMKSTEVEVLLPKFKLQE
                     DYDMESVLRHLGIVDAFQQGKADLSAMSAERDLCLSKFVHKSFVEVNEEGTEAAAASS
                     CFVVAECCMESGPRFCADHPFLFFIRHNRANSILFCGRFSSP"
     exon            288..425
                     /gene="SERPINB9"
                     /gene_synonym="CAP-3; CAP3; PI-9; PI9"
                     /inference="alignment:Splign:2.1.0"
     exon            426..543
                     /gene="SERPINB9"
                     /gene_synonym="CAP-3; CAP3; PI-9; PI9"
                     /inference="alignment:Splign:2.1.0"
     exon            544..686
                     /gene="SERPINB9"
                     /gene_synonym="CAP-3; CAP3; PI-9; PI9"
                     /inference="alignment:Splign:2.1.0"
     exon            687..842
                     /gene="SERPINB9"
                     /gene_synonym="CAP-3; CAP3; PI-9; PI9"
                     /inference="alignment:Splign:2.1.0"
     exon            843..4143
                     /gene="SERPINB9"
                     /gene_synonym="CAP-3; CAP3; PI-9; PI9"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1474..1479
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERPINB9"
                     /gene_synonym="CAP-3; CAP3; PI-9; PI9"
                     /note="hexamer: ATTAAA"
     polyA_site      1497
                     /gene="SERPINB9"
                     /gene_synonym="CAP-3; CAP3; PI-9; PI9"
                     /note="major polyA site"
     regulatory      2916..2921
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERPINB9"
                     /gene_synonym="CAP-3; CAP3; PI-9; PI9"
                     /note="hexamer: AATAAA"
     polyA_site      2946
                     /gene="SERPINB9"
                     /gene_synonym="CAP-3; CAP3; PI-9; PI9"
     regulatory      4115..4120
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERPINB9"
                     /gene_synonym="CAP-3; CAP3; PI-9; PI9"
                     /note="hexamer: AATAAA"
     polyA_site      4143
                     /gene="SERPINB9"
                     /gene_synonym="CAP-3; CAP3; PI-9; PI9"
                     /note="major polyA site"
ORIGIN      
        1 gggagtccgc ggcgagcgca gcagcagggc cgggtcctgc gcctcggggg tcggcgtcca
       61 ggctcggagc gcggcacgga gacggcggca gcgctggact aggtggcagg ccctgcatca
      121 tggaaactct ttctaatgca agtggtactt ttgccatacg ccttttaaag atactgtgtc
      181 aagataaccc ttcgcacaac gtgttctgtt ctcctgtgag catctcctct gccctggcca
      241 tggttctcct aggggcaaag ggaaacaccg caacccagat ggcccaggca ctgtctttaa
      301 acacagagga agacattcat cgggctttcc agtcgcttct cactgaagtg aacaaggctg
      361 gcacacagta cctgctgaga acggccaaca ggctctttgg agagaaaact tgtcagttcc
      421 tctcaacgtt taaggaatcc tgtcttcaat tctaccatgc tgagctgaag gagctttcct
      481 ttatcagagc tgcagaagag tccaggaaac acatcaacac ctgggtctca aaaaagaccg
      541 aaggtaaaat tgaagagttg ttgccgggta gctcaattga tgcagaaacc aggctggttc
      601 ttgtcaatgc catctacttc aaaggaaagt ggaatgaacc gtttgacgaa acatacacaa
      661 gggaaatgcc ctttaaaata aaccaggagg agcaaaggcc agtgcagatg atgtatcagg
      721 aggccacgtt taagctcgcc cacgtgggcg aggtgcgcgc gcagctgctg gagctgccct
      781 acgccaggaa ggagctgagc ctgctggtgc tgctgcctga cgacggcgtg gagctcagca
      841 cggtggaaaa aagtctcact tttgagaaac tcacagcctg gaccaagcca gactgtatga
      901 agagtactga ggttgaagtt ctccttccaa aatttaaact acaagaggat tatgacatgg
      961 aatctgtgct tcggcatttg ggaattgttg atgccttcca acagggcaag gctgacttgt
     1021 cggcaatgtc agcggagaga gacctgtgtc tgtccaagtt cgtgcacaag agttttgtgg
     1081 aggtgaatga agaaggcacc gaggcagcgg cagcgtcgag ctgctttgta gttgcagagt
     1141 gctgcatgga atctggcccc aggttctgtg ctgaccaccc tttccttttc ttcatcaggc
     1201 acaacagagc caacagcatt ctgttctgtg gcaggttctc atcgccataa agggtgcact
     1261 taccgtgcac tcggccattt ccctcttcct gtgtccccag atccccacta cagctccaag
     1321 aggatgggcc tagaaagcca agtgcaaaga tgagggcaga ttctttacct gtctgccctc
     1381 atgatttgcc agcatgaatt catgatgctc cacactcgct tatgctactt aatcagaatc
     1441 ttgagaaaat agaccataat gattccctgt tgtattaaaa ttgcagtcca aatcccatag
     1501 gatggcaagc aaagttcttc tagaattcca catgcaattc actctggcga ccctgtgctt
     1561 tcctgacact gcgaatacat tccttaaccc gctgcctcag tggtaataaa tggtgctaga
     1621 tattgctact attttataga tttcctggtg cttagcctta taaaaaaggt tgtaaaatgt
     1681 acatttatat tttatctttt tttttttttt ttttctgaga cgcagtctgg ctctctgtcg
     1741 cccaggctgg agtgcagtgg ctcgatctcg gctcactgca agctccgcct cccgggttca
     1801 cgccattctc ctgcctcagc ctcccgagta gctgggacta caggcgcccg ccaccacgcc
     1861 cggctaattt tttgtatttt tagtagagac ggggtttcac cgtgttagcc aggatggtgt
     1921 cgatctcctg acctcgtgat ccacccgcct cggcctccca aagtgctggg attacaggct
     1981 tgagccaccg cgcccggcta tattttatct tttatctttt tctttgacat ttaccaatca
     2041 ccaagcatgc accaaacact gctttaggca ctggggacac aaaggggaca gagccatcct
     2101 cctttgacac ctggtcttca gttctgtgcc caacgtatat agttttgaca atgaccaggt
     2161 tggactgttt aatgtctttc aacttaccac gtaatcctct tgtagggatc acatctttct
     2221 ttatgatatt gtatttctct acctctaaca gtaaaaattc cattcaaccc ttaaagctca
     2281 cttcaaattc ttctttgaga agtttttcct ttctccgcaa ccagatgtac atatttgaac
     2341 tctctttgta cttggagggc acttctttcg tggtagttct tttattttta ttaatctctg
     2401 tatccttaga tagtcctcca acaaccaaag gttgggactc tgtcttacat atctgggtgc
     2461 ccctcatagt gcagtaataa gtaagttgat tatatacgag ctatgtaact tatatttttt
     2521 aatggttgga tatcactgag tttttttttt taagaatttt tttattgagg taaacttcac
     2581 ataacataaa attaactatt ttaaagtgag aagttcagtg ccacttagta ttgttaacaa
     2641 tgttgcataa ccaccacctt tatttaaagt tccaaaaaaa atgttctcct ctaaaaggaa
     2701 accccatccc attaagcaga tactctccat tccttccttc ctccagcccc cagcaaccac
     2761 caatctgctt tctgtctcta tggatttatc tattcttgct attttatata aattgaattg
     2821 tatgagacct tttgtgtctg gcttctttca cttagtacaa gtttttgaga tttatttaca
     2881 tagtagcatg tatcaacact tcatttttat ggccaaataa aattgtatta tgtgtttata
     2941 gcacaattta tttatccact cattcattga tggactttgg gttgtttctg acttttggct
     3001 attgggaata gtgctgctat gaatgtttgt gtacctgtat ttgtttgaat gcctattttg
     3061 cattctcttg ggtatatatc taggagtgga actgctgggt catatgttaa ttctatgttt
     3121 agctttttga ggaacagaca aactgttttc cacagcagtt gaaccattcc acattcccac
     3181 cagcaatgta tgagaattcc aatttctgtc cacttcctca ccaacactta ttattttcct
     3241 tttccttttt ttaaaaaaaa taagttatgg ccatcttagt gggtgtgaag tggtatctca
     3301 ttgtgttttt tatttgcatt tcctatgtaa tgagctagaa actaaagtac aaactagatg
     3361 ggacatccag tccctttgat agataatgct gagtaaaaaa tgagatgaaa gacatttgtt
     3421 tgtttttaga acacgagtga cagtttgtta aaaagcttta gaggaggaat gaaaacaaag
     3481 tgaagtacac ttagaaaagg gccaagtgga catcttggat gtcaagtgcc tagttcagta
     3541 tctttttttt tttttttttt ttttttgaga cagtgcctca ctctgtcacc caggctggag
     3601 tgtagtggca tgatctgggc tcactgcaac ctcctcctcc tggattcaag caattctctt
     3661 gcttcagcct cccaagtagc tgagactaca agcacccacc atcacaccca gctaattttg
     3721 tatttttcag tagagacggg gtttcgccac attggccgtg ttggtcttga actcctggcc
     3781 tcaagcgatc cgcctacctc agcctcccaa agtgctagga ttacaggcat aagccactga
     3841 gcccagccct agttcagtat cttttatgta aattacaaac atctgcaaca ttatgtatca
     3901 tatgcagata cttattgcat ttcttttatt agtggtgaaa gtgttctatg catttattgg
     3961 ctcttgaatt tcctcatcta tgaattgtca ttcatacacc tacttttctg cttcgttttt
     4021 acatatgtct ttgcctatta aagatattat ccctctgttt tatattttct ctcattcttg
     4081 tattgccttt taaattttgt tatgatgttt cattaataaa cagtgttttg ttttcctcta
     4141 taa
//
