LOCUS       NM_002640               3321 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens serpin family B member 8 (SERPINB8), transcript
            variant 1, mRNA.
ACCESSION   NM_002640
VERSION     NM_002640.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3321)
  AUTHORS   Petersen,M., Lotke,R., Hopfensperger,K., Victoria,S., Haussmann,I.,
            Burster,T., Baldauf,H.M. and Sauter,D.
  TITLE     Inhibition of Infectious HIV-1 Production by Rerouting the Cellular
            Furin Inhibitor Serpin B8
  JOURNAL   J Virol 97 (6), e0029423 (2023)
   PUBMED   37272794
  REMARK    GeneRIF: Inhibition of Infectious HIV-1 Production by Rerouting the
            Cellular Furin Inhibitor Serpin B8.
REFERENCE   2  (bases 1 to 3321)
  AUTHORS   Ni,L., Li,P., Li,M., Huang,S. and Dang,N.
  TITLE     SERPINB8 and furin regulate ITGAX expression and affect the
            proliferation and invasion of melanoma cells
  JOURNAL   Exp Dermatol 32 (1), 24-29 (2023)
   PUBMED   36134483
  REMARK    GeneRIF: SERPINB8 and furin regulate ITGAX expression and affect
            the proliferation and invasion of melanoma cells.
REFERENCE   3  (bases 1 to 3321)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 3321)
  AUTHORS   Glavey,S.V., Naba,A., Manier,S., Clauser,K., Tahri,S., Park,J.,
            Reagan,M.R., Moschetta,M., Mishima,Y., Gambella,M., Rocci,A.,
            Sacco,A., O'Dwyer,M.E., Asara,J.M., Palumbo,A., Roccaro,A.M.,
            Hynes,R.O. and Ghobrial,I.M.
  TITLE     Proteomic characterization of human multiple myeloma bone marrow
            extracellular matrix
  JOURNAL   Leukemia 31 (11), 2426-2434 (2017)
   PUBMED   28344315
REFERENCE   5  (bases 1 to 3321)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   6  (bases 1 to 3321)
  AUTHORS   Dahlen,J.R., Foster,D.C. and Kisiel,W.
  TITLE     Expression, purification, and inhibitory properties of human
            proteinase inhibitor
  JOURNAL   Biochemistry 36 (48), 14874-14882 (1997)
   PUBMED   9402754
REFERENCE   7  (bases 1 to 3321)
  AUTHORS   Bartuski,A.J., Kamachi,Y., Schick,C., Overhauser,J. and
            Silverman,G.A.
  TITLE     Cytoplasmic antiproteinase 2 (PI8) and bomapin (PI10) map to the
            serpin cluster at 18q21.3
  JOURNAL   Genomics 43 (3), 321-328 (1997)
   PUBMED   9268635
REFERENCE   8  (bases 1 to 3321)
  AUTHORS   Hubberstey,A., Yu,G., Loewith,R., Lakusta,C. and Young,D.
  TITLE     Mammalian CAP interacts with CAP, CAP2, and actin
  JOURNAL   J Cell Biochem 61 (3), 459-466 (1996)
   PUBMED   8761950
REFERENCE   9  (bases 1 to 3321)
  AUTHORS   Sprecher,C.A., Morgenstern,K.A., Mathewes,S., Dahlen,J.R.,
            Schrader,S.K., Foster,D.C. and Kisiel,W.
  TITLE     Molecular cloning, expression, and partial characterization of two
            novel members of the ovalbumin family of serine proteinase
            inhibitors
  JOURNAL   J Biol Chem 270 (50), 29854-29861 (1995)
   PUBMED   8530382
REFERENCE   10 (bases 1 to 3321)
  AUTHORS   Huber,R. and Carrell,R.W.
  TITLE     Implications of the three-dimensional structure of alpha
            1-antitrypsin for structure and function of serpins
  JOURNAL   Biochemistry 28 (23), 8951-8966 (1989)
   PUBMED   2690952
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BQ435307.1, BX571754.1,
            L40377.1, BG611734.1, BE566411.1 and CA445967.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_002640.3.
            
            Summary: The protein encoded by this gene is a member of the
            ov-serpin family of serine protease inhibitors. The encoded protein
            is produced by platelets and can bind to and inhibit the function
            of furin, a serine protease involved in platelet functions. In
            addition, this protein has been found to enhance the mechanical
            stability of cell-cell adhesion in the skin, and defects in this
            gene have been associated with an autosomal-recessive form of
            exfoliative ichthyosis. [provided by RefSeq, Jan 2017].
            
            Transcript Variant: This variant (1) uses an alternate splice
            junction in the 5' UTR compared to variant 2. Variants 1, 2 and 10
            encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.205670.1, BX571754.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000397985.7/ ENSP00000381072.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-302               BQ435307.1         76-377
            303-1009            BX571754.1         263-969
            1010-1175           L40377.1           993-1158
            1176-1546           BX571754.1         1136-1506
            1547-2152           BX571754.1         1516-2121
            2153-2259           BG611734.1         195-301
            2260-2378           BX571754.1         2229-2347
            2379-2387           BE566411.1         29-37
            2388-3085           BX571754.1         2357-3054
            3086-3316           CA445967.1         21-251              c
            3317-3321           BX571754.1         3286-3290
FEATURES             Location/Qualifiers
     source          1..3321
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q22.1"
     gene            1..3321
                     /gene="SERPINB8"
                     /gene_synonym="C18orf53; CAP2; PI-8; PI8; PSS5"
                     /note="serpin family B member 8"
                     /db_xref="GeneID:5271"
                     /db_xref="HGNC:HGNC:8952"
                     /db_xref="MIM:601697"
     exon            1..90
                     /gene="SERPINB8"
                     /gene_synonym="C18orf53; CAP2; PI-8; PI8; PSS5"
                     /inference="alignment:Splign:2.1.0"
     exon            91..268
                     /gene="SERPINB8"
                     /gene_synonym="C18orf53; CAP2; PI-8; PI8; PSS5"
                     /inference="alignment:Splign:2.1.0"
     CDS             101..1225
                     /gene="SERPINB8"
                     /gene_synonym="C18orf53; CAP2; PI-8; PI8; PSS5"
                     /note="isoform a is encoded by transcript variant 1;
                     protease inhibitor 8 (ovalbumin type); serine (or
                     cysteine) proteinase inhibitor, clade B (ovalbumin),
                     member 8; cytoplasmic antiproteinase 2; serpin B8;
                     peptidase inhibitor 8; serpin peptidase inhibitor, clade B
                     (ovalbumin), member 8"
                     /codon_start=1
                     /product="serpin B8 isoform a"
                     /protein_id="NP_002631.3"
                     /db_xref="CCDS:CCDS11991.1"
                     /db_xref="GeneID:5271"
                     /db_xref="HGNC:HGNC:8952"
                     /db_xref="MIM:601697"
                     /translation="MDDLCEANGTFAISLFKILGEEDNSRNVFFSPMSISSALAMVFM
                     GAKGSTAAQMSQALCLYKDGDIHRGFQSLLSEVNRTGTQYLLRTANRLFGEKTCDFLP
                     DFKEYCQKFYQAELEELSFAEDTEECRKHINDWVAEKTEGKISEVLDAGTVDPLTKLV
                     LVNAIYFKGKWNEQFDRKYTRGMLFKTNEEKKTVQMMFKEAKFKMGYADEVHTQVLEL
                     PYVEEELSMVILLPDDNTDLAVVEKALTYEKFKAWTNSEKLTKSKVQVFLPRLKLEES
                     YDLEPFLRRLGMIDAFDEAKADFSGMSTEKNVPLSKVAHKCFVEVNEEGTEAAAATAV
                     VRNSRCSRMEPRFCADHPFLFFIRHHKTNCILFCGRFSSP"
     exon            269..406
                     /gene="SERPINB8"
                     /gene_synonym="C18orf53; CAP2; PI-8; PI8; PSS5"
                     /inference="alignment:Splign:2.1.0"
     exon            407..524
                     /gene="SERPINB8"
                     /gene_synonym="C18orf53; CAP2; PI-8; PI8; PSS5"
                     /inference="alignment:Splign:2.1.0"
     exon            525..667
                     /gene="SERPINB8"
                     /gene_synonym="C18orf53; CAP2; PI-8; PI8; PSS5"
                     /inference="alignment:Splign:2.1.0"
     exon            668..820
                     /gene="SERPINB8"
                     /gene_synonym="C18orf53; CAP2; PI-8; PI8; PSS5"
                     /inference="alignment:Splign:2.1.0"
     exon            821..3321
                     /gene="SERPINB8"
                     /gene_synonym="C18orf53; CAP2; PI-8; PI8; PSS5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1324..1329
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERPINB8"
                     /gene_synonym="C18orf53; CAP2; PI-8; PI8; PSS5"
                     /note="hexamer: AATAAA"
     polyA_site      1343
                     /gene="SERPINB8"
                     /gene_synonym="C18orf53; CAP2; PI-8; PI8; PSS5"
                     /note="major polyA site"
     regulatory      3291..3296
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERPINB8"
                     /gene_synonym="C18orf53; CAP2; PI-8; PI8; PSS5"
                     /note="hexamer: AATAAA"
     polyA_site      3321
                     /gene="SERPINB8"
                     /gene_synonym="C18orf53; CAP2; PI-8; PI8; PSS5"
ORIGIN      
        1 aatcaaggcg gacgtgaagc atctacaaag gaggaatagt caaagcagca gcggcggcgg
       61 cggcggcggc agcagcagca gcagcaggag accttctctg atggatgacc tctgtgaagc
      121 aaatggcact tttgccatca gcttatttaa aatattgggg gaagaggaca actcaagaaa
      181 cgtattcttc tctcccatga gcatctcctc tgccctggcc atggtcttca tgggggcaaa
      241 gggaagcact gcagcccaga tgtcccaggc actttgttta tacaaagacg gagatattca
      301 ccgaggtttc cagtcacttc tcagtgaagt taacagaact ggcactcagt acttgcttag
      361 aactgccaac agactctttg gagaaaagac gtgtgatttc cttccagact ttaaagaata
      421 ctgtcagaag ttctatcagg cagagctgga ggagttgtcc tttgctgaag acactgaaga
      481 gtgcaggaag catataaatg actgggtggc agagaagact gaaggtaaga tttcagaggt
      541 actggatgct gggacagtcg atcccctgac aaagctggtc cttgtgaatg ccatttattt
      601 caagggaaag tggaatgagc aatttgacag aaagtacaca aggggaatgc tctttaaaac
      661 caacgaggaa aaaaagacag tgcagatgat gtttaaggaa gctaagttta aaatggggta
      721 tgcggatgag gtacacaccc aggtcctgga gctgccctat gtggaagagg agctgagcat
      781 ggtcattctg cttcccgatg acaacacgga cctcgccgtg gtggaaaaag cacttacata
      841 tgagaaattc aaagcctgga caaattcaga aaagttgaca aaaagtaagg ttcaagtttt
      901 ccttcccaga ttaaagctgg aggagagtta tgacttggag cctttccttc gaagattagg
      961 aatgatcgat gcttttgacg aagccaaggc agacttttct ggaatgtcaa ctgagaagaa
     1021 tgtgcctctg tccaaggttg cccacaagtg cttcgtggag gtcaatgagg aaggcacaga
     1081 ggctgccgca gccactgctg tggtcaggaa ttcccggtgc agcagaatgg agccaagatt
     1141 ctgtgcagac cacccttttc ttttcttcat caggcaccac aaaaccaact gcatcttgtt
     1201 ctgtggcagg ttctcttctc cgtaaagagg agcaattgct gtacataccc tcctttcctt
     1261 ctacctatct tgccttaatt aacattccct gtgacctagt tggtgcagtg gcttgaatgc
     1321 caaaataaag cgtgtgcact ggatagtgtg tgaaagtctt tgctgaaagt tccagagcca
     1381 ttgagaataa ctgaggccgc agatgcatga aatttgggcc tgggaaggct atgctggttt
     1441 tggagtgttt ggggtgcctg ccattgcctc tgccttcacc taagtctgtg cccattgttt
     1501 caggggatct tatggagcat ctcagggctt caggagccag ccctcttcca tccgcccggc
     1561 tctgcccacc accactgcca ggctgaacag gggactagtg cccaggtgac actgcacaca
     1621 aagccaaggg caaaccctat agagtaaagc tgcagccacc ctgtgtctca tgtgcagctg
     1681 aaatagtgat ctgcttctgt cactgtcaca tagacagccc tgcatgcccc ctgtctcaca
     1741 cagtttgtaa tgaagacagc tccttctcat ctttccataa gcctgagata caagttcagg
     1801 gactcagcaa tgcactttag gactgagcta ggaggcaaat atctgaagct tgctatgctg
     1861 ttctttccat tccttttccc tctgaaacac acaaaatacc aaaggaactt acgcaacaca
     1921 ccactgagtc ctctaactaa tcatatgtgc tcagacacag ctcaagcaca ccccttagtt
     1981 aagaaagaac ctccatatac attaattttt ttctgcctaa aaataaaatt gcgttgtggc
     2041 agcaatttgg aaactacagc aaagtctcca aaaaaattga agtcacccac aattccaaca
     2101 cacagcaatc actgctgtta atagtgatat acatccttcc ctattatgtg tatgcaaata
     2161 gaaatttata agcattttac tacaagttaa tcatatcctt cagtagctta tttcttccct
     2221 tatgaaaaac ctcccttaag atctttccag gtcatcaatt tgatgtgcat agtattccac
     2281 tgtgtggctg gatttctata attgaatcta attttagaca gtttgagtaa ttaaaattat
     2341 ttctattaac aaataataga ttgctaataa tatatattat gctgttttgg atatactaaa
     2401 tatttgctca catccttaat atatttttta aaattcctaa caatagtact gttgagataa
     2461 aagttgagca cattttgaga cttcttccaa attggtccct agaaagttac actggtttgt
     2521 actctcactt atgtcactgt ttataccacc actgactgct gcctgcttta ttatttcttt
     2581 aatgagttgg actgaacagt ggttaatcct gactctgttt ttgactgaca gttaacagtt
     2641 acatgaacca ttcatattac agctcttact taaatttgac caagccagga tatatctgtt
     2701 aggccacatt catttaggga tcatgttttc caaagcaggt ttgggcaaaa ttaatccaca
     2761 ggactgaaag gtatacatct gtgagttttg ttctcacttc cacctctaat ttgaagaaca
     2821 ctttaattga cacagaatac atttcacata tttaacctct acaataagtt ctgacacatt
     2881 ttccatgaaa caaaccatcg ctatattcaa gataatgaac ctatctatca tactcccaaa
     2941 ttccttcttg catctttgta atttctcact cttccttctc cctctccccg tcccatccca
     3001 accactgatc tgctcaggca actaccaatc ttctttctgt cactatagat taatttgcat
     3061 ttttaaagaa atttacatac atggaaccat acatcatcta tgctttgtag tatgactcct
     3121 gtcactcagt acaattattt tgagattcat ttatgttatt gtatgtatca atagttcatc
     3181 ccttttattg gtaagtaaca tttttttgta taggtatacc atgatttgtt gatgaacaaa
     3241 tttacctgtt gatgaacatt tacgttgtta ccaagatttt tgctattgaa aataaagttt
     3301 ttatgaatat ttatatatat a
//
