LOCUS       NM_002639               2586 bp    mRNA    linear   PRI 08-OCT-2024
DEFINITION  Homo sapiens serpin family B member 5 (SERPINB5), mRNA.
ACCESSION   NM_002639
VERSION     NM_002639.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2586)
  AUTHORS   Liu,B.X., Xie,Y., Zhang,J., Zeng,S., Li,J., Tao,Q., Yang,J.,
            Chen,Y. and Zeng,C.
  TITLE     SERPINB5 promotes colorectal cancer invasion and migration by
            promoting EMT and angiogenesis via the TNF-alpha/NF-kappaB pathway
  JOURNAL   Int Immunopharmacol 131, 111759 (2024)
   PUBMED   38460302
  REMARK    GeneRIF: SERPINB5 promotes colorectal cancer invasion and migration
            by promoting EMT and angiogenesis via the TNF-alpha/NF-kappaB
            pathway.
REFERENCE   2  (bases 1 to 2586)
  AUTHORS   Rathod,M., Franz,H., Beyersdorfer,V., Wanuske,M.T.,
            Leal-Fischer,K., Hanns,P., Studle,C., Zimmermann,A., Buczak,K.,
            Schinner,C. and Spindler,V.
  TITLE     DPM1 modulates desmosomal adhesion and epidermal differentiation
            through SERPINB5
  JOURNAL   J Cell Biol 223 (4) (2024)
   PUBMED   38477878
  REMARK    GeneRIF: DPM1 modulates desmosomal adhesion and epidermal
            differentiation through SERPINB5.
REFERENCE   3  (bases 1 to 2586)
  AUTHORS   Elkady,N. and Allam,D.M.
  TITLE     The Role of Galectin3, Tubulinbeta, and Maspin in Promoting Tumor
            Budding in Colorectal Carcinoma and Their Clinical Implications
  JOURNAL   Appl Immunohistochem Mol Morphol 32 (3), 143-150 (2024)
   PUBMED   38251657
  REMARK    GeneRIF: The Role of Galectin3, Tubulinbeta, and Maspin in
            Promoting Tumor Budding in Colorectal Carcinoma and Their Clinical
            Implications.
REFERENCE   4  (bases 1 to 2586)
  AUTHORS   Hong,L., Chen,M., Huang,M., Chen,W., Abudukeremu,X., She,F. and
            Chen,Y.
  TITLE     FOXA2 suppresses gallbladder carcinoma cell migration, invasion,
            and epithelial-mesenchymal transition by targeting SERPINB5
  JOURNAL   Environ Toxicol 39 (2), 708-722 (2024)
   PUBMED   37665156
  REMARK    GeneRIF: FOXA2 suppresses gallbladder carcinoma cell migration,
            invasion, and epithelial-mesenchymal transition by targeting
            SERPINB5.
REFERENCE   5  (bases 1 to 2586)
  AUTHORS   Wu,J., Liu,Y., Wang,W., Wang,H. and Zhang,H.
  TITLE     Effect of Maspin Gene Methylation Induced by Specific shRNA
            Sequences on the Proliferation of Oral Squamous Cell Carcinoma HN13
            Cells
  JOURNAL   Cell Mol Biol (Noisy-le-grand) 69 (4), 70-74 (2023)
   PUBMED   37329546
  REMARK    GeneRIF: Effect of Maspin Gene Methylation Induced by Specific
            shRNA Sequences on the Proliferation of Oral Squamous Cell
            Carcinoma HN13 Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2586)
  AUTHORS   Pemberton,P.A., Tipton,A.R., Pavloff,N., Smith,J., Erickson,J.R.,
            Mouchabeck,Z.M. and Kiefer,M.C.
  TITLE     Maspin is an intracellular serpin that partitions into secretory
            vesicles and is present at the cell surface
  JOURNAL   J Histochem Cytochem 45 (12), 1697-1706 (1997)
   PUBMED   9389773
REFERENCE   7  (bases 1 to 2586)
  AUTHORS   Sager,R., Sheng,S., Pemberton,P. and Hendrix,M.J.
  TITLE     Maspin. A tumor suppressing serpin
  JOURNAL   Adv Exp Med Biol 425, 77-88 (1997)
   PUBMED   9433491
  REMARK    Review article
REFERENCE   8  (bases 1 to 2586)
  AUTHORS   Pemberton,P.A., Wong,D.T., Gibson,H.L., Kiefer,M.C.,
            Fitzpatrick,P.A., Sager,R. and Barr,P.J.
  TITLE     The tumor suppressor maspin does not undergo the stressed to
            relaxed transition or inhibit trypsin-like serine proteases.
            Evidence that maspin is not a protease inhibitory serpin
  JOURNAL   J Biol Chem 270 (26), 15832-15837 (1995)
   PUBMED   7797587
REFERENCE   9  (bases 1 to 2586)
  AUTHORS   Schneider,S.S., Schick,C., Fish,K.E., Miller,E., Pena,J.C.,
            Treter,S.D., Hui,S.M. and Silverman,G.A.
  TITLE     A serine proteinase inhibitor locus at 18q21.3 contains a tandem
            duplication of the human squamous cell carcinoma antigen gene
  JOURNAL   Proc Natl Acad Sci U S A 92 (8), 3147-3151 (1995)
   PUBMED   7724531
REFERENCE   10 (bases 1 to 2586)
  AUTHORS   Zou,Z., Anisowicz,A., Hendrix,M.J., Thor,A., Neveu,M., Sheng,S.,
            Rafidi,K., Seftor,E. and Sager,R.
  TITLE     Maspin, a serpin with tumor-suppressing activity in human mammary
            epithelial cells
  JOURNAL   Science 263 (5146), 526-529 (1994)
   PUBMED   8290962
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC036176.8.
            
            On Nov 23, 2018 this sequence version replaced NM_002639.4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189658.204898.1, U04313.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000382771.9/ ENSP00000372221.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-88                AC036176.8         51678-51765         c
            89-263              AC036176.8         44127-44301         c
            264-401             AC036176.8         41640-41777         c
            402-519             AC036176.8         39259-39376         c
            520-662             AC036176.8         35628-35770         c
            663-830             AC036176.8         29436-29603         c
            831-2586            AC036176.8         23638-25393         c
FEATURES             Location/Qualifiers
     source          1..2586
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.33"
     gene            1..2586
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /note="serpin family B member 5"
                     /db_xref="GeneID:5268"
                     /db_xref="HGNC:HGNC:8949"
                     /db_xref="MIM:154790"
     exon            1..88
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /inference="alignment:Splign:2.1.0"
     exon            89..263
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /inference="alignment:Splign:2.1.0"
     CDS             96..1223
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /note="protease inhibitor 5 (maspin); serine (or cysteine)
                     proteinase inhibitor, clade B (ovalbumin), member 5; PI-5;
                     peptidase inhibitor 5; serpin peptidase inhibitor, clade B
                     (ovalbumin), member 5"
                     /codon_start=1
                     /product="serpin B5"
                     /protein_id="NP_002630.2"
                     /db_xref="CCDS:CCDS32839.1"
                     /db_xref="GeneID:5268"
                     /db_xref="HGNC:HGNC:8949"
                     /db_xref="MIM:154790"
                     /translation="MDALQLANSAFAVDLFKQLCEKEPLGNVLFSPICLSTSLSLAQV
                     GAKGDTANEIGQVLHFENVKDVPFGFQTVTSDVNKLSSFYSLKLIKRLYVDKSLNLST
                     EFISSTKRPYAKELETVDFKDKLEETKGQINNSIKDLTDGHFENILADNSVNDQTKIL
                     VVNAAYFVGKWMKKFSESETKECPFRVNKTDTKPVQMMNMEATFCMGNIDSINCKIIE
                     LPFQNKHLSMFILLPKDVEDESTGLEKIEKQLNSESLSQWTNPSTMANAKVKLSIPKF
                     KVEKMIDPKACLENLGLKHIFSEDTSDFSGMSETKGVALSNVIHKVCLEITEDGGDSI
                     EVPGARILQHKDELNADHPFIYIIRHNKTRNIIFFGKFCSP"
     exon            264..401
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /inference="alignment:Splign:2.1.0"
     exon            402..519
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /inference="alignment:Splign:2.1.0"
     exon            520..662
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /inference="alignment:Splign:2.1.0"
     exon            663..830
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /inference="alignment:Splign:2.1.0"
     exon            831..2586
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2565..2570
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /note="hexamer: AATAAA"
     polyA_site      2586
                     /gene="SERPINB5"
                     /gene_synonym="maspin; PI5"
                     /note="major polyA site"
ORIGIN      
        1 agacacggtc gcctccacat ccaggtcttt gtgctcctcg cttgcctgtt ccttttccac
       61 gcattttcca ggataactgt gactccaggc ccgcaatgga tgccctgcaa ctagcaaatt
      121 cggcttttgc cgttgatctg ttcaaacaac tatgtgaaaa ggagccactg ggcaatgtcc
      181 tcttctctcc aatctgtctc tccacctctc tgtcacttgc tcaagtgggt gctaaaggtg
      241 acactgcaaa tgaaattgga caggttcttc attttgaaaa tgtcaaagat gtaccctttg
      301 gatttcaaac agtaacatcg gatgtaaaca aacttagttc cttttactca ctgaaactaa
      361 tcaagcggct ctacgtagac aaatctctga atctttctac agagttcatc agctctacga
      421 agagaccgta tgcaaaggaa ttggaaactg ttgacttcaa agataaattg gaagaaacga
      481 aaggtcagat caacaactca attaaggatc tcacagatgg ccactttgag aacattttag
      541 ctgacaacag tgtgaacgac cagaccaaaa tccttgtggt taatgctgcc tactttgttg
      601 gcaagtggat gaagaaattt tctgaatcag aaacaaaaga atgtcctttc agagtcaaca
      661 agacagacac caaaccagtg cagatgatga acatggaggc cacgttctgt atgggaaaca
      721 ttgacagtat caattgtaag atcatagagc ttccttttca aaataagcat ctcagcatgt
      781 tcatcctact acccaaggat gtggaggatg agtccacagg cttggagaag attgaaaaac
      841 aactcaactc agagtcactg tcacagtgga ctaatcccag caccatggcc aatgccaagg
      901 tcaaactctc cattccaaaa tttaaggtgg aaaagatgat tgatcccaag gcttgtctgg
      961 aaaatctagg gctgaaacat atcttcagtg aagacacatc tgatttctct ggaatgtcag
     1021 agaccaaggg agtggcccta tcaaatgtta tccacaaagt gtgcttagaa ataactgaag
     1081 atggtgggga ttccatagag gtgccaggag cacggatcct gcagcacaag gatgaattga
     1141 atgctgacca tccctttatt tacatcatca ggcacaacaa aactcgaaac attattttct
     1201 ttggcaaatt ctgttctcct taagtggcat agcccatgtt aagtcctccc tgacttttct
     1261 gtggatgccg atttctgtaa actctgcatc cagagattca ttttctagat acaataaatt
     1321 gctaatgttg ctggatcagg aagccgccag tacttgtcat atgtagcctt cacacagata
     1381 gacctttttt ttttttccaa ttctatcttt tgtttccttt tttcccataa gacaatgaca
     1441 tacgctttta atgaaaagga atcacgttag aggaaaaata tttattcatt atttgtcaaa
     1501 ttgtccgggg tagttggcag aaatacagtc ttccacaaag aaaattccta taaggaagat
     1561 ttggaagctc ttcttcccag cactatgctt tccttctttg ggatagagaa tgttccagac
     1621 attctcgctt ccctgaaaga ctgaagaaag tgtagtgcat gggacccacg aaactgccct
     1681 ggctccagtg aaacttgggc acatgctcag gctactatag gtccagaagt ccttatgtta
     1741 agccctggca ggcaggtgtt tattaaaatt ctgaattttg gggattttca aaagataata
     1801 ttttacatac actgtatgtt atagaacttc atggatcaga tctggggcag caccctataa
     1861 atcaacacct taatatgctg caacaaaatg tagaatattc agacaaaatg gatacataaa
     1921 gactaagtag cccataaggg gtcaaaattt gctgccaaat gcgtatgcca ccaacttaca
     1981 aaaacacttc gttcgcagag cttttcagat tgtggaatgt tggataagga attatagacc
     2041 tctagtagct gaaatgcaag accccaagag gaagttcaga tcttaatata aattcacttt
     2101 catttttgat agctgtccca tctggtcatt tggttggcac tagactggtg gcaggggctt
     2161 ctagctgact tgcacaggga ttctcacaat agccgatatc agaatttgtg ttgaaggaac
     2221 ttgtctcttc atctaatatg atagcgggaa aaggagagga aactactgcc tttagaaaat
     2281 ataagtaaag tgattaaagt gctcacgtta ccttgacaca tagtttttca gtctatgggt
     2341 ttagttactt tagatggcaa gcatgtaact tatattaata gtaatttgta aagttggttg
     2401 gataagctat ccgtgttgca ggttcatgga ttacttctct ataaaaaata tgtatttacc
     2461 aaaaattttg tgacattcct tctcccatct cttccttgac ctgcattgta aataggttct
     2521 tcttgttctg agattcaata ttgaattttt cctatgctat tgacaataaa atattattga
     2581 actaca
//
