LOCUS       NM_002974               1707 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens serpin family B member 4 (SERPINB4), transcript
            variant 1, mRNA.
ACCESSION   NM_002974
VERSION     NM_002974.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1707)
  AUTHORS   Chuang,T.P., Lai,W.Y., Gabre,J.L., Lind,D.E., Umapathy,G.,
            Bokhari,A.A., Bergman,B., Kristenson,L., Thoren,F.B., Le,A.,
            Doebele,R.C., Van den Eynden,J., Palmer,R.H. and Hallberg,B.
  TITLE     ALK fusion NSCLC oncogenes promote survival and inhibit NK cell
            responses via SERPINB4 expression
  JOURNAL   Proc Natl Acad Sci U S A 120 (8), e2216479120 (2023)
   PUBMED   36791109
  REMARK    GeneRIF: ALK fusion NSCLC oncogenes promote survival and inhibit NK
            cell responses via SERPINB4 expression.
REFERENCE   2  (bases 1 to 1707)
  AUTHORS   Oka,K., Miyagawa,T., Suga,H., Miyagaki,T., Mizuno,Y., Kamijo,H.,
            Hisamoto,T., Omori,I., Boki,H., Oka,T., Takahashi-Shishido,N.,
            Sugaya,M. and Sato,S.
  TITLE     Increased expression of squamous cell carcinoma antigen 1 and 2 in
            mycosis fungoides and Sezary syndrome
  JOURNAL   Eur J Dermatol 32 (4), 464-470 (2022)
   PUBMED   36301759
  REMARK    GeneRIF: Increased expression of squamous cell carcinoma antigen 1
            and 2 in mycosis fungoides and Sezary syndrome', trans 'Increased
            expression of squamous cell carcinoma antigen 1 and 2 in mycosis
            fungoides and Sezary syndrome.
REFERENCE   3  (bases 1 to 1707)
  AUTHORS   Makita,E., Sugawara,D., Kuroda,S., Itabashi,K., Hirakubo,Y.,
            Nonaka,K. and Ichihashi,K.
  TITLE     Differences in Thymus and Activation-Regulated Chemokine and
            Squamous Cell Carcinoma Antigen 2 Levels in Food Protein-Induced
            Enterocolitis Syndrome and Atopic Dermatitis
  JOURNAL   Int Arch Allergy Immunol 183 (9), 967-974 (2022)
   PUBMED   35537383
  REMARK    GeneRIF: Differences in Thymus and Activation-Regulated Chemokine
            and Squamous Cell Carcinoma Antigen 2 Levels in Food
            Protein-Induced Enterocolitis Syndrome and Atopic Dermatitis.
REFERENCE   4  (bases 1 to 1707)
  AUTHORS   Derakhshan,S., Poosti,A., Razavi,A.E., Moosavi,M.A., Mahdavi,N.,
            Naieni,F.B., Hesari,K.K. and Rahpeima,A.
  TITLE     Evaluation of squamous cell carcinoma antigen 1 expression in oral
            squamous cell carcinoma (tumor cells and peritumoral T-lymphocytes)
            and verrucous carcinoma and comparison with normal oral mucosa
  JOURNAL   J Appl Oral Sci 29, e20210374 (2021)
   PUBMED   34878006
  REMARK    GeneRIF: Evaluation of squamous cell carcinoma antigen 1 expression
            in oral squamous cell carcinoma (tumor cells and peritumoral
            T-lymphocytes) and verrucous carcinoma and comparison with normal
            oral mucosa.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1707)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   6  (bases 1 to 1707)
  AUTHORS   Cataltepe,S., Gornstein,E.R., Schick,C., Kamachi,Y., Chatson,K.,
            Fries,J., Silverman,G.A. and Upton,M.P.
  TITLE     Co-expression of the squamous cell carcinoma antigens 1 and 2 in
            normal adult human tissues and squamous cell carcinomas
  JOURNAL   J Histochem Cytochem 48 (1), 113-122 (2000)
   PUBMED   10653592
REFERENCE   7  (bases 1 to 1707)
  AUTHORS   Sakaguchi,Y., Kishi,F., Murakami,A., Suminami,Y. and Kato,H.
  TITLE     Structural analysis of human SCC antigen 2 promoter
  JOURNAL   Biochim Biophys Acta 1444 (1), 111-116 (1999)
   PUBMED   9931463
REFERENCE   8  (bases 1 to 1707)
  AUTHORS   Bartuski,A.J., Kamachi,Y., Schick,C., Massa,H., Trask,B.J. and
            Silverman,G.A.
  TITLE     A murine ortholog of the human serpin SCCA2 maps to chromosome 1
            and inhibits chymotrypsin-like serine proteinases
  JOURNAL   Genomics 54 (2), 297-306 (1998)
   PUBMED   9828132
REFERENCE   9  (bases 1 to 1707)
  AUTHORS   Barnes,R.C. and Worrall,D.M.
  TITLE     Identification of a novel human serpin gene; cloning sequencing and
            expression of leupin
  JOURNAL   FEBS Lett 373 (1), 61-65 (1995)
   PUBMED   7589435
REFERENCE   10 (bases 1 to 1707)
  AUTHORS   Schneider,S.S., Schick,C., Fish,K.E., Miller,E., Pena,J.C.,
            Treter,S.D., Hui,S.M. and Silverman,G.A.
  TITLE     A serine proteinase inhibitor locus at 18q21.3 contains a tandem
            duplication of the human squamous cell carcinoma antigen gene
  JOURNAL   Proc Natl Acad Sci U S A 92 (8), 3147-3151 (1995)
   PUBMED   7724531
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC017401.1 and BU676816.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On May 17, 2019 this sequence version replaced NM_002974.3.
            
            Summary: The protein encoded by this gene is a member of the serpin
            family of serine protease inhibitors. The encoded protein is highly
            expressed in many tumor cells and can inactivate granzyme M, an
            enzyme that kills tumor cells. This protein, along with serpin B3,
            can be processed into smaller fragments that aggregate to form an
            autoantigen in psoriasis, probably by causing chronic inflammation.
            [provided by RefSeq, Jan 2017].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017401.1, SRR5189658.84724.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2156670 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341074.10/ ENSP00000343445.5
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1698              BC017401.1         4-1701
            1699-1707           BU676816.1         18-26               c
FEATURES             Location/Qualifiers
     source          1..1707
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.33"
     gene            1..1707
                     /gene="SERPINB4"
                     /gene_synonym="LEUPIN; PI11; SCCA-2; SCCA1; SCCA2"
                     /note="serpin family B member 4"
                     /db_xref="GeneID:6318"
                     /db_xref="HGNC:HGNC:10570"
                     /db_xref="MIM:600518"
     exon            1..48
                     /gene="SERPINB4"
                     /gene_synonym="LEUPIN; PI11; SCCA-2; SCCA1; SCCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            49..239
                     /gene="SERPINB4"
                     /gene_synonym="LEUPIN; PI11; SCCA-2; SCCA1; SCCA2"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1247
                     /gene="SERPINB4"
                     /gene_synonym="LEUPIN; PI11; SCCA-2; SCCA1; SCCA2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine (or cysteine) proteinase inhibitor, clade B
                     (ovalbumin), member 4; squamous cell carcinoma antigen 2;
                     protease inhibitor (leucine-serpin); serpin B4;
                     SCCA2/SCCA1 fusion protein; squamous cell carcinoma
                     antigen 1; peptidase inhibitor 11; serpin peptidase
                     inhibitor, clade B (ovalbumin), member 4"
                     /codon_start=1
                     /product="serpin B4 isoform 1"
                     /protein_id="NP_002965.1"
                     /db_xref="CCDS:CCDS11986.1"
                     /db_xref="GeneID:6318"
                     /db_xref="HGNC:HGNC:10570"
                     /db_xref="MIM:600518"
                     /translation="MNSLSEANTKFMFDLFQQFRKSKENNIFYSPISITSALGMVLLG
                     AKDNTAQQISKVLHFDQVTENTTEKAATYHVDRSGNVHHQFQKLLTEFNKSTDAYELK
                     IANKLFGEKTYQFLQEYLDAIKKFYQTSVESTDFANAPEESRKKINSWVESQTNEKIK
                     NLFPDGTIGNDTTLVLVNAIYFKGQWENKFKKENTKEEKFWPNKNTYKSVQMMRQYNS
                     FNFALLEDVQAKVLEIPYKGKDLSMIVLLPNEIDGLQKLEEKLTAEKLMEWTSLQNMR
                     ETCVDLHLPRFKMEESYDLKDTLRTMGMVNIFNGDADLSGMTWSHGLSVSKVLHKAFV
                     EVTEEGVEAAAATAVVVVELSSPSTNEEFCCNHPFLFFIRQNKTNSILFYGRFSSP"
     exon            240..296
                     /gene="SERPINB4"
                     /gene_synonym="LEUPIN; PI11; SCCA-2; SCCA1; SCCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            297..425
                     /gene="SERPINB4"
                     /gene_synonym="LEUPIN; PI11; SCCA-2; SCCA1; SCCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            426..543
                     /gene="SERPINB4"
                     /gene_synonym="LEUPIN; PI11; SCCA-2; SCCA1; SCCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            544..686
                     /gene="SERPINB4"
                     /gene_synonym="LEUPIN; PI11; SCCA-2; SCCA1; SCCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            687..842
                     /gene="SERPINB4"
                     /gene_synonym="LEUPIN; PI11; SCCA-2; SCCA1; SCCA2"
                     /inference="alignment:Splign:2.1.0"
     exon            843..1707
                     /gene="SERPINB4"
                     /gene_synonym="LEUPIN; PI11; SCCA-2; SCCA1; SCCA2"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agacacacac agcctctctg cccacctctg cttcctctag gaacacagga gttccagatc
       61 acatcgagtt caccatgaat tcactcagtg aagccaacac caagttcatg ttcgatctgt
      121 tccaacagtt cagaaaatca aaagagaaca acatcttcta ttcccctatc agcatcacat
      181 cagcattagg gatggtcctc ttaggagcca aagacaacac tgcacaacaa attagcaagg
      241 ttcttcactt tgatcaagtc acagagaaca ccacagaaaa agctgcaaca tatcatgttg
      301 ataggtcagg aaatgttcat caccagtttc aaaagcttct gactgaattc aacaaatcca
      361 ctgatgcata tgagctgaag atcgccaaca agctcttcgg agaaaagacg tatcaatttt
      421 tacaggaata tttagatgcc atcaagaaat tttaccagac cagtgtggaa tctactgatt
      481 ttgcaaatgc tccagaagaa agtcgaaaga agattaactc ctgggtggaa agtcaaacga
      541 atgaaaaaat taaaaaccta tttcctgatg ggactattgg caatgatacg acactggttc
      601 ttgtgaacgc aatctatttc aaagggcagt gggagaataa atttaaaaaa gaaaacacta
      661 aagaggaaaa attttggcca aacaagaata catacaaatc tgtacagatg atgaggcaat
      721 acaattcctt taattttgcc ttgctggagg atgtacaggc caaggtcctg gaaataccat
      781 acaaaggcaa agatctaagc atgattgtgc tgctgccaaa tgaaatcgat ggtctgcaga
      841 agcttgaaga gaaactcact gctgagaaat tgatggaatg gacaagtttg cagaatatga
      901 gagagacatg tgtcgattta cacttacctc ggttcaaaat ggaagagagc tatgacctca
      961 aggacacgtt gagaaccatg ggaatggtga atatcttcaa tggggatgca gacctctcag
     1021 gcatgacctg gagccacggt ctctcagtat ctaaagtcct acacaaggcc tttgtggagg
     1081 tcactgagga gggagtggaa gctgcagctg ccaccgctgt agtagtagtc gaattatcat
     1141 ctccttcaac taatgaagag ttctgttgta atcacccttt cctattcttc ataaggcaaa
     1201 ataagaccaa cagcatcctc ttctatggca gattctcatc cccatagatg caattagtct
     1261 gtcactccat ttagaaaatg ttcacctaga ggtgttctgg taaactgatt gctggcaaca
     1321 acagattctc ttggctcata tttcttttct atctcatctt gatgatgata gtcatcatca
     1381 agaatttaat gattaaaata gcatgccttt ctctctttct cttaataagc ccacatataa
     1441 atgtactttt ccttccagaa aaatttccct tgaggaaaaa tgtccaagat aagatgaatc
     1501 atttaatacc gtgtcttcta aatttgaaat ataattctgt ttctgacctg ttttaaatga
     1561 accaaaccaa atcatacttt ctcttcaaat ttagcaacct agaaacacac atttctttga
     1621 atttaggtga tacctaaatc cttcttatgt ttctaaattt tgtgattcta taaaacacat
     1681 catcaataaa ataatgacat aaaatca
//
