LOCUS       NM_006919               1707 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens serpin family B member 3 (SERPINB3), mRNA.
ACCESSION   NM_006919
VERSION     NM_006919.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1707)
  AUTHORS   Martini,A., Turato,C., Cannito,S., Quarta,S., Biasiolo,A.,
            Ruvoletto,M., Novo,E., Marafatto,F., Guerra,P., Tonon,M.,
            Clemente,N., Bocca,C., Piano,S.S., Guido,M., Gregori,D., Parola,M.,
            Angeli,P. and Pontisso,P.
  TITLE     The polymorphic variant of SerpinB3 (SerpinB3-PD) is associated
            with faster cirrhosis decompensation
  JOURNAL   Aliment Pharmacol Ther 59 (3), 380-392 (2024)
   PUBMED   37990490
  REMARK    GeneRIF: The polymorphic variant of SerpinB3 (SerpinB3-PD) is
            associated with faster cirrhosis decompensation.
REFERENCE   2  (bases 1 to 1707)
  AUTHORS   Ohara,Y., Tang,W., Liu,H., Yang,S., Dorsey,T.H., Cawley,H.,
            Moreno,P., Chari,R., Guest,M.R., Azizian,A., Gaedcke,J.,
            Ghadimi,M., Hanna,N., Ambs,S. and Hussain,S.P.
  TITLE     SERPINB3-MYC axis induces the basal-like/squamous subtype and
            enhances disease progression in pancreatic cancer
  JOURNAL   Cell Rep 42 (12), 113434 (2023)
   PUBMED   37980563
  REMARK    GeneRIF: SERPINB3-MYC axis induces the basal-like/squamous subtype
            and enhances disease progression in pancreatic cancer.
REFERENCE   3  (bases 1 to 1707)
  AUTHORS   Novo,E., Cappon,A., Villano,G., Quarta,S., Cannito,S., Bocca,C.,
            Turato,C., Guido,M., Maggiora,M., Protopapa,F., Sutti,S.,
            Provera,A., Ruvoletto,M., Biasiolo,A., Foglia,B., Albano,E.,
            Pontisso,P. and Parola,M.
  TITLE     SerpinB3 as a Pro-Inflammatory Mediator in the Progression of
            Experimental Non-Alcoholic Fatty Liver Disease
  JOURNAL   Front Immunol 13, 910526 (2022)
   PUBMED   35874657
  REMARK    GeneRIF: SerpinB3 as a Pro-Inflammatory Mediator in the Progression
            of Experimental Non-Alcoholic Fatty Liver Disease.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1707)
  AUTHORS   Luke,C.J., Markovina,S., Good,M., Wight,I.E., Thomas,B.J.,
            Linneman,J.M., Lanik,W.E., Koroleva,O., Coffman,M.R., Miedel,M.T.,
            Gong,Q., Andress,A., Campos Guerrero,M., Wang,S., Chen,L.,
            Beatty,W.L., Hausmann,K.N., White,F.V., Fitzpatrick,J.A.J.,
            Orvedahl,A., Pak,S.C. and Silverman,G.A.
  TITLE     Lysoptosis is an evolutionarily conserved cell death pathway
            moderated by intracellular serpins
  JOURNAL   Commun Biol 5 (1), 47 (2022)
   PUBMED   35022507
  REMARK    GeneRIF: Lysoptosis is an evolutionarily conserved cell death
            pathway moderated by intracellular serpins.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1707)
  AUTHORS   Ran,C., Sun,J., Qu,Y. and Long,N.
  TITLE     Clinical value of MRI, serum SCCA, and CA125 levels in the
            diagnosis of lymph node metastasis and para-uterine infiltration in
            cervical cancer
  JOURNAL   World J Surg Oncol 19 (1), 343 (2021)
   PUBMED   34886853
  REMARK    GeneRIF: Clinical value of MRI, serum SCCA, and CA125 levels in the
            diagnosis of lymph node metastasis and para-uterine infiltration in
            cervical cancer.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1707)
  AUTHORS   Schick,C., Pemberton,P.A., Shi,G.P., Kamachi,Y., Cataltepe,S.,
            Bartuski,A.J., Gornstein,E.R., Bromme,D., Chapman,H.A. and
            Silverman,G.A.
  TITLE     Cross-class inhibition of the cysteine proteinases cathepsins K, L,
            and S by the serpin squamous cell carcinoma antigen 1: a kinetic
            analysis
  JOURNAL   Biochemistry 37 (15), 5258-5266 (1998)
   PUBMED   9548757
REFERENCE   7  (bases 1 to 1707)
  AUTHORS   Schneider,S.S., Schick,C., Fish,K.E., Miller,E., Pena,J.C.,
            Treter,S.D., Hui,S.M. and Silverman,G.A.
  TITLE     A serine proteinase inhibitor locus at 18q21.3 contains a tandem
            duplication of the human squamous cell carcinoma antigen gene
  JOURNAL   Proc Natl Acad Sci U S A 92 (8), 3147-3151 (1995)
   PUBMED   7724531
REFERENCE   8  (bases 1 to 1707)
  AUTHORS   Suminami,Y., Kishi,F., Sekiguchi,K. and Kato,H.
  TITLE     Squamous cell carcinoma antigen is a new member of the serine
            protease inhibitors
  JOURNAL   Biochem Biophys Res Commun 181 (1), 51-58 (1991)
   PUBMED   1958219
REFERENCE   9  (bases 1 to 1707)
  AUTHORS   Mino-Miyagawa,N., Kimura,Y. and Hamamoto,K.
  TITLE     Tumor-antigen 4. Its immunohistochemical distribution and tissue
            and serum concentrations in squamous cell carcinoma of the lung and
            esophagus
  JOURNAL   Cancer 66 (7), 1505-1512 (1990)
   PUBMED   2208001
REFERENCE   10 (bases 1 to 1707)
  AUTHORS   Mino,N., Iio,A. and Hamamoto,K.
  TITLE     Availability of tumor-antigen 4 as a marker of squamous cell
            carcinoma of the lung and other organs
  JOURNAL   Cancer 62 (4), 730-734 (1988)
   PUBMED   2840187
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB229922.1, U19556.1 and AK222746.1.
            
            On Nov 22, 2018 this sequence version replaced NM_006919.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK222746.1, AK222753.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1966682,
                                           SAMEA1968189 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000283752.10/ ENSP00000283752.5
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-498               DB229922.1         93-590
            499-1324            U19556.1           454-1279
            1325-1707           AK222746.1         1325-1707
FEATURES             Location/Qualifiers
     source          1..1707
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.33"
     gene            1..1707
                     /gene="SERPINB3"
                     /gene_synonym="HsT1196; SCC; SCCA-1; SCCA-PD; SCCA1;
                     SSCA1; T4-A"
                     /note="serpin family B member 3"
                     /db_xref="GeneID:6317"
                     /db_xref="HGNC:HGNC:10569"
                     /db_xref="MIM:600517"
     exon            1..48
                     /gene="SERPINB3"
                     /gene_synonym="HsT1196; SCC; SCCA-1; SCCA-PD; SCCA1;
                     SSCA1; T4-A"
                     /inference="alignment:Splign:2.1.0"
     exon            49..239
                     /gene="SERPINB3"
                     /gene_synonym="HsT1196; SCC; SCCA-1; SCCA-PD; SCCA1;
                     SSCA1; T4-A"
                     /inference="alignment:Splign:2.1.0"
     CDS             75..1247
                     /gene="SERPINB3"
                     /gene_synonym="HsT1196; SCC; SCCA-1; SCCA-PD; SCCA1;
                     SSCA1; T4-A"
                     /note="squamous cell carcinoma antigen 1; serine (or
                     cysteine) proteinase inhibitor, clade B (ovalbumin),
                     member 3; protein T4-A; serpin peptidase inhibitor, clade
                     B (ovalbumin), member 3"
                     /codon_start=1
                     /product="serpin B3"
                     /protein_id="NP_008850.1"
                     /db_xref="CCDS:CCDS11987.1"
                     /db_xref="GeneID:6317"
                     /db_xref="HGNC:HGNC:10569"
                     /db_xref="MIM:600517"
                     /translation="MNSLSEANTKFMFDLFQQFRKSKENNIFYSPISITSALGMVLLG
                     AKDNTAQQIKKVLHFDQVTENTTGKAATYHVDRSGNVHHQFQKLLTEFNKSTDAYELK
                     IANKLFGEKTYLFLQEYLDAIKKFYQTSVESVDFANAPEESRKKINSWVESQTNEKIK
                     NLIPEGNIGSNTTLVLVNAIYFKGQWEKKFNKEDTKEEKFWPNKNTYKSIQMMRQYTS
                     FHFASLEDVQAKVLEIPYKGKDLSMIVLLPNEIDGLQKLEEKLTAEKLMEWTSLQNMR
                     ETRVDLHLPRFKVEESYDLKDTLRTMGMVDIFNGDADLSGMTGSRGLVLSGVLHKAFV
                     EVTEEGAEAAAATAVVGFGSSPTSTNEEFHCNHPFLFFIRQNKTNSILFYGRFSSP"
     exon            240..296
                     /gene="SERPINB3"
                     /gene_synonym="HsT1196; SCC; SCCA-1; SCCA-PD; SCCA1;
                     SSCA1; T4-A"
                     /inference="alignment:Splign:2.1.0"
     exon            297..425
                     /gene="SERPINB3"
                     /gene_synonym="HsT1196; SCC; SCCA-1; SCCA-PD; SCCA1;
                     SSCA1; T4-A"
                     /inference="alignment:Splign:2.1.0"
     exon            426..543
                     /gene="SERPINB3"
                     /gene_synonym="HsT1196; SCC; SCCA-1; SCCA-PD; SCCA1;
                     SSCA1; T4-A"
                     /inference="alignment:Splign:2.1.0"
     exon            544..686
                     /gene="SERPINB3"
                     /gene_synonym="HsT1196; SCC; SCCA-1; SCCA-PD; SCCA1;
                     SSCA1; T4-A"
                     /inference="alignment:Splign:2.1.0"
     exon            687..842
                     /gene="SERPINB3"
                     /gene_synonym="HsT1196; SCC; SCCA-1; SCCA-PD; SCCA1;
                     SSCA1; T4-A"
                     /inference="alignment:Splign:2.1.0"
     exon            843..1707
                     /gene="SERPINB3"
                     /gene_synonym="HsT1196; SCC; SCCA-1; SCCA-PD; SCCA1;
                     SSCA1; T4-A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1685..1690
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERPINB3"
                     /gene_synonym="HsT1196; SCC; SCCA-1; SCCA-PD; SCCA1;
                     SSCA1; T4-A"
                     /note="hexamer: AATAAA"
     polyA_site      1707
                     /gene="SERPINB3"
                     /gene_synonym="HsT1196; SCC; SCCA-1; SCCA-PD; SCCA1;
                     SSCA1; T4-A"
                     /note="major polyA site"
ORIGIN      
        1 agacacacat agcctctctg cccacctctg cttcctctag gaacacagga gttccagatc
       61 acatcgagtt caccatgaat tcactcagtg aagccaacac caagttcatg ttcgacctgt
      121 tccaacagtt cagaaaatca aaagagaaca acatcttcta ttcccctatc agcatcacat
      181 cagcattagg gatggtcctc ttaggagcca aagacaacac tgcacaacag attaagaagg
      241 ttcttcactt tgatcaagtc acagagaaca ccacaggaaa agctgcaaca tatcatgttg
      301 ataggtcagg aaatgttcat caccagtttc aaaagcttct gactgaattc aacaaatcca
      361 ctgatgcata tgagctgaag atcgccaaca agctcttcgg agaaaaaacg tatctatttt
      421 tacaggaata tttagatgcc atcaagaaat tttaccagac cagtgtggaa tctgttgatt
      481 ttgcaaatgc tccagaagaa agtcgaaaga agattaactc ctgggtggaa agtcaaacga
      541 atgaaaaaat taaaaaccta attcctgaag gtaatattgg cagcaatacc acattggttc
      601 ttgtgaacgc aatctatttc aaagggcagt gggagaagaa atttaataaa gaagatacta
      661 aagaggaaaa attttggcca aacaagaata catacaagtc catacagatg atgaggcaat
      721 acacatcttt tcattttgcc tcgctggagg atgtacaggc caaggtcctg gaaataccat
      781 acaaaggcaa agatctaagc atgattgtgt tgctgccaaa tgaaatcgat ggtctccaga
      841 agcttgaaga gaaactcact gctgagaaat tgatggaatg gacaagtttg cagaatatga
      901 gagagacacg tgtcgattta cacttacctc ggttcaaagt ggaagagagc tatgacctca
      961 aggacacgtt gagaaccatg ggaatggtgg atatcttcaa tggggatgca gacctctcag
     1021 gcatgaccgg gagccgcggt ctcgtgctat ctggagtcct acacaaggcc tttgtggagg
     1081 ttacagagga gggagcagaa gctgcagctg ccaccgctgt agtaggattc ggatcatcac
     1141 ctacttcaac taatgaagag ttccattgta atcacccttt cctattcttc ataaggcaaa
     1201 ataagaccaa cagcatcctc ttctatggca gattctcatc cccgtagatg caattagtct
     1261 gtcactccat ttggaaaatg ttcacctgca gatgttctgg taaactgatt gctggcaaca
     1321 acagattctc ttggctcata tttcttttct ttctcatctt gatgatgatc gtcatcatca
     1381 agaatttaat gattaaaata gcatgccttt ctctctttct cttaataagc ccacatataa
     1441 atgtactttt tcttccagaa aaattctcct tgaggaaaaa tgtccaaaat aagatgaatc
     1501 acttaatacc gtatcttcta aatttgaaat ataattctgt ttgtgacctg ttttaaatga
     1561 accaaaccaa atcatacttt ttctttgaat ttagcaacct agaaacacac atttctttga
     1621 atttaggtga tacctaaatc cttcttatgt ttctaaattt tgtgattcta taaaacacat
     1681 catcaataaa atagtgacat aaaatca
//
