LOCUS       NM_002575               1906 bp    mRNA    linear   PRI 12-NOV-2024
DEFINITION  Homo sapiens serpin family B member 2 (SERPINB2), transcript
            variant 2, mRNA.
ACCESSION   NM_002575
VERSION     NM_002575.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1906)
  AUTHORS   Tziastoudi,M., Pissas,G., Golfinopoulos,S., Filippidis,G.,
            Poulianiti,C., Tsironi,E.E., Dardiotis,E., Eleftheriadis,T. and
            Stefanidis,I.
  TITLE     Serpin Family B Member 2 Polymorphisms in Patients with Diabetic
            Kidney Disease: An Association Study
  JOURNAL   Int J Mol Sci 25 (20), 10906 (2024)
   PUBMED   39456691
  REMARK    GeneRIF: Serpin Family B Member 2 Polymorphisms in Patients with
            Diabetic Kidney Disease: An Association Study.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1906)
  AUTHORS   Shome,D., Al-Jamea,L., Woodman,A., Salem,A.H., Bakhiet,M., Taha,S.,
            Sandhu,A.K., Al-Yami,F.S., Waheed,K.B., Elnagi,E.A., Almish,M. and
            Quiambao,J.V.
  TITLE     Plasminogen activator inhibitor-2 and impaired fibrinolysis in
            pregnancy and sickle cell anemia
  JOURNAL   Arch Gynecol Obstet 309 (6), 2447-2458 (2024)
   PUBMED   37401942
  REMARK    GeneRIF: Plasminogen activator inhibitor-2 and impaired
            fibrinolysis in pregnancy and sickle cell anemia.
REFERENCE   3  (bases 1 to 1906)
  AUTHORS   Cirillo,F., Spinelli,A., Talia,M., Scordamaglia,D., Santolla,M.F.,
            Grande,F., Rizzuti,B., Maggiolini,M., Gerard,C. and Lappano,R.
  TITLE     Estetrol/GPER/SERPINB2 transduction signaling inhibits the motility
            of triple-negative breast cancer cells
  JOURNAL   J Transl Med 22 (1), 450 (2024)
   PUBMED   38741146
  REMARK    GeneRIF: Estetrol/GPER/SERPINB2 transduction signaling inhibits the
            motility of triple-negative breast cancer cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1906)
  AUTHORS   Wang,X., Nie,X., Xu,G., Gao,J., Wang,B., Yang,J. and Song,G.
  TITLE     miR-450b promotes cell migration and invasion by inhibiting
            SERPINB2 in oral squamous cell carcinoma
  JOURNAL   Oral Dis 30 (2), 376-389 (2024)
   PUBMED   36251494
  REMARK    GeneRIF: miR-450b promotes cell migration and invasion by
            inhibiting SERPINB2 in oral squamous cell carcinoma.
REFERENCE   5  (bases 1 to 1906)
  AUTHORS   Chen,Z., Wei,Y., Zheng,Y., Zhu,H., Teng,Q., Lin,X., Wu,F. and
            Zhou,F.
  TITLE     SERPINB2, an Early Responsive Gene to Epigallocatechin Gallate,
            Inhibits Migration and Promotes Apoptosis in Esophageal Cancer
            Cells
  JOURNAL   Cells 11 (23), 3852 (2022)
   PUBMED   36497110
  REMARK    GeneRIF: SERPINB2, an Early Responsive Gene to Epigallocatechin
            Gallate, Inhibits Migration and Promotes Apoptosis in Esophageal
            Cancer Cells.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1906)
  AUTHORS   Rasmussen,H.H., van Damme,J., Puype,M., Gesser,B., Celis,J.E. and
            Vandekerckhove,J.
  TITLE     Microsequences of 145 proteins recorded in the two-dimensional gel
            protein database of normal human epidermal keratinocytes
  JOURNAL   Electrophoresis 13 (12), 960-969 (1992)
   PUBMED   1286667
REFERENCE   7  (bases 1 to 1906)
  AUTHORS   Estreicher,A., Muhlhauser,J., Carpentier,J.L., Orci,L. and
            Vassalli,J.D.
  TITLE     The receptor for urokinase type plasminogen activator polarizes
            expression of the protease to the leading edge of migrating
            monocytes and promotes degradation of enzyme inhibitor complexes
  JOURNAL   J Cell Biol 111 (2), 783-792 (1990)
   PUBMED   2166055
REFERENCE   8  (bases 1 to 1906)
  AUTHORS   Ellis,V., Wun,T.C., Behrendt,N., Ronne,E. and Dano,K.
  TITLE     Inhibition of receptor-bound urokinase by plasminogen-activator
            inhibitors
  JOURNAL   J Biol Chem 265 (17), 9904-9908 (1990)
   PUBMED   2161846
REFERENCE   9  (bases 1 to 1906)
  AUTHORS   Samia,J.A., Alexander,S.J., Horton,K.W., Auron,P.E., Byers,M.G.,
            Shows,T.B. and Webb,A.C.
  TITLE     Chromosomal organization and localization of the human urokinase
            inhibitor gene: perfect structural conservation with ovalbumin
  JOURNAL   Genomics 6 (1), 159-167 (1990)
   PUBMED   2303256
REFERENCE   10 (bases 1 to 1906)
  AUTHORS   Schwartz,B.S., Monroe,M.C. and Bradshaw,J.D.
  TITLE     Endotoxin-induced production of plasminogen activator inhibitor by
            human monocytes is autonomous and can be inhibited by lipid X
  JOURNAL   Blood 73 (8), 2188-2195 (1989)
   PUBMED   2471561
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC012609.1, AC072051.8 and CD366374.1.
            
            On Nov 22, 2018 this sequence version replaced NM_002575.2.
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: M18082.1, BC012609.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1966682, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000299502.9/ ENSP00000299502.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-582               BC012609.1         5-586
            583-610             AC072051.8         32504-32531         c
            611-753             AC072051.8         28466-28608         c
            754-918             AC072051.8         27780-27944         c
            919-1873            AC072051.8         26493-27447         c
            1874-1906           CD366374.1         17-49               c
FEATURES             Location/Qualifiers
     source          1..1906
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.33-q22.1"
     gene            1..1906
                     /gene="SERPINB2"
                     /gene_synonym="HsT1201; PAI; PAI-2; PAI2; PLANH2"
                     /note="serpin family B member 2"
                     /db_xref="GeneID:5055"
                     /db_xref="HGNC:HGNC:8584"
                     /db_xref="MIM:173390"
     exon            1..66
                     /gene="SERPINB2"
                     /gene_synonym="HsT1201; PAI; PAI-2; PAI2; PLANH2"
                     /inference="alignment:Splign:2.1.0"
     exon            67..243
                     /gene="SERPINB2"
                     /gene_synonym="HsT1201; PAI; PAI-2; PAI2; PLANH2"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1323
                     /gene="SERPINB2"
                     /gene_synonym="HsT1201; PAI; PAI-2; PAI2; PLANH2"
                     /note="plasminogen activator inhibitor, type II
                     (arginine-serpin); serine (or cysteine) proteinase
                     inhibitor, clade B (ovalbumin), member 2; monocyte
                     Arg-serpin; urokinase inhibitor; placental plasminogen
                     activator inhibitor; serpin B2; serpin peptidase
                     inhibitor, clade B (ovalbumin), member 2;
                     plasminogen-activator inhibitor"
                     /codon_start=1
                     /product="plasminogen activator inhibitor 2"
                     /protein_id="NP_002566.1"
                     /db_xref="CCDS:CCDS11989.1"
                     /db_xref="GeneID:5055"
                     /db_xref="HGNC:HGNC:8584"
                     /db_xref="MIM:173390"
                     /translation="MEDLCVANTLFALNLFKHLAKASPTQNLFLSPWSISSTMAMVYM
                     GSRGSTEDQMAKVLQFNEVGANAVTPMTPENFTSCGFMQQIQKGSYPDAILQAQAADK
                     IHSSFRSLSSAINASTGNYLLESVNKLFGEKSASFREEYIRLCQKYYSSEPQAVDFLE
                     CAEEARKKINSWVKTQTKGKIPNLLPEGSVDGDTRMVLVNAVYFKGKWKTPFEKKLNG
                     LYPFRVNSAQRTPVQMMYLREKLNIGYIEDLKAQILELPYAGDVSMFLLLPDEIADVS
                     TGLELLESEITYDKLNKWTSKDKMAEDEVEVYIPQFKLEEHYELRSILRSMGMEDAFN
                     KGRANFSGMSERNDLFLSEVFHQAMVDVNEEGTEAAAGTGGVMTGRTGHGGPQFVADH
                     PFLFLIMHKITNCILFFGRFSSP"
     exon            244..363
                     /gene="SERPINB2"
                     /gene_synonym="HsT1201; PAI; PAI-2; PAI2; PLANH2"
                     /inference="alignment:Splign:2.1.0"
     exon            364..492
                     /gene="SERPINB2"
                     /gene_synonym="HsT1201; PAI; PAI-2; PAI2; PLANH2"
                     /inference="alignment:Splign:2.1.0"
     exon            493..610
                     /gene="SERPINB2"
                     /gene_synonym="HsT1201; PAI; PAI-2; PAI2; PLANH2"
                     /inference="alignment:Splign:2.1.0"
     exon            611..753
                     /gene="SERPINB2"
                     /gene_synonym="HsT1201; PAI; PAI-2; PAI2; PLANH2"
                     /inference="alignment:Splign:2.1.0"
     exon            754..918
                     /gene="SERPINB2"
                     /gene_synonym="HsT1201; PAI; PAI-2; PAI2; PLANH2"
                     /inference="alignment:Splign:2.1.0"
     exon            919..1906
                     /gene="SERPINB2"
                     /gene_synonym="HsT1201; PAI; PAI-2; PAI2; PLANH2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1883..1888
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERPINB2"
                     /gene_synonym="HsT1201; PAI; PAI-2; PAI2; PLANH2"
                     /note="hexamer: AATAAA"
     polyA_site      1906
                     /gene="SERPINB2"
                     /gene_synonym="HsT1201; PAI; PAI-2; PAI2; PLANH2"
                     /note="major polyA site"
ORIGIN      
        1 gtaacaactc tcagaggagc attgcccgtc agacagcaac tcagagaata accagagaac
       61 aaccagattg aaacaatgga ggatctttgt gtggcaaaca cactctttgc cctcaattta
      121 ttcaagcatc tggcaaaagc aagccccacc cagaacctct tcctctcccc atggagcatc
      181 tcgtccacca tggccatggt ctacatgggc tccaggggca gcaccgaaga ccagatggcc
      241 aaggtgcttc agtttaatga agtgggagcc aatgcagtta cccccatgac tccagagaac
      301 tttaccagct gtgggttcat gcagcagatc cagaagggta gttatcctga tgcgattttg
      361 caggcacaag ctgcagataa aatccattca tccttccgct ctctcagctc tgcaatcaat
      421 gcatccacag ggaattattt actggaaagt gtcaataagc tgtttggtga gaagtctgcg
      481 agcttccggg aagaatatat tcgactctgt cagaaatatt actcctcaga accccaggca
      541 gtagacttcc tagaatgtgc agaagaagct agaaaaaaga ttaattcctg ggtcaagact
      601 caaaccaaag gcaaaatccc aaacttgtta cctgaaggtt ctgtagatgg ggataccagg
      661 atggtcctgg tgaatgctgt ctacttcaaa ggaaagtgga aaactccatt tgagaagaaa
      721 ctaaatgggc tttatccttt ccgtgtaaac tcggctcagc gcacacctgt acagatgatg
      781 tacttgcgtg aaaagctaaa cattggatac atagaagacc taaaggctca gattctagaa
      841 ctcccatatg ctggagatgt tagcatgttc ttgttgcttc cagatgaaat tgccgatgtg
      901 tccactggct tggagctgct ggaaagtgaa ataacctatg acaaactcaa caagtggacc
      961 agcaaagaca aaatggctga agatgaagtt gaggtataca taccccagtt caaattagaa
     1021 gagcattatg aactcagatc cattctgaga agcatgggca tggaggacgc cttcaacaag
     1081 ggacgggcca atttctcagg gatgtcggag aggaatgacc tgtttctttc tgaagtgttc
     1141 caccaagcca tggtggatgt gaatgaggag ggcactgaag cagccgctgg cacaggaggt
     1201 gttatgacag ggagaactgg acatggaggc ccacagtttg tggcagatca tccttttctt
     1261 tttcttatta tgcataagat aaccaactgc attttatttt tcggcagatt ttcctcaccc
     1321 taaaactaag cgtgctgctt ctgcaaaaga tttttgtaga tgagctgtgt gcctcagaat
     1381 tgctatttca aattgccaaa aatttagaga tgttttctac atatttctgc tcttctgaac
     1441 aacttctgct acccactaaa taaaaacaca gaaataatta gacaattgtc tattataaca
     1501 tgacaaccct attaatcatt tggtcttcta aaatgggatc atgcccattt agattttcct
     1561 tactatcagt ttatttttat aacattaact tttactttgt tatttattat tttatataat
     1621 ggtgagtttt taaattattg ctcactgcct atttaatgta gctaataaag ttatagaagc
     1681 agatgatctg ttaatttcct atctaataaa tgcctttaat tgttctcata atgaagaata
     1741 agtaggtatc cctccatgcc cttctgtaat aaatatctgg aaaaaacatt aaacaatagg
     1801 caaatatatg ttatgtgcat ttctagaaat acataacaca tatatatgtc tgtatcttat
     1861 attcaattgc aagtatataa taaataaacc tgcttccaaa caacaa
//
