LOCUS       NM_001307928            3738 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens serpin family B member 12 (SERPINB12), transcript
            variant 1, mRNA.
ACCESSION   NM_001307928 XM_011526247 XM_017026067
VERSION     NM_001307928.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3738)
  AUTHORS   Zheng,H.Z., Miao,X., Chang,J., Zhou,H., Zhang,J.J., Mo,H.M. and
            Jia,Q.
  TITLE     Smoking behavior associated upregulation of SERPINB12 promotes
            proliferation and metastasis via activating WNT signaling in NSCLC
  JOURNAL   J Cardiothorac Surg 19 (1), 141 (2024)
   PUBMED   38504347
  REMARK    GeneRIF: Smoking behavior associated upregulation of SERPINB12
            promotes proliferation and metastasis via activating WNT signaling
            in NSCLC.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3738)
  AUTHORS   Oliva,S., Laudadio,I., Fulci,V., Rossetti,D., Isoldi,S.,
            Stronati,L. and Carissimi,C.
  TITLE     SERPINB12 as a possible marker of steroid dependency in children
            with eosinophilic esophagitis: A pilot study
  JOURNAL   Dig Liver Dis 52 (2), 158-163 (2020)
   PUBMED   31653522
  REMARK    GeneRIF: SERPINB12 as a possible marker of steroid dependency in
            children with eosinophilic esophagitis: A pilot study.
REFERENCE   3  (bases 1 to 3738)
  AUTHORS   Chen,J. and Kuhn,L.A.
  TITLE     Deciphering the three-domain architecture in schlafens and the
            structures and roles of human schlafen12 and serpinB12 in
            transcriptional regulation
  JOURNAL   J Mol Graph Model 90, 59-76 (2019)
   PUBMED   31026779
  REMARK    GeneRIF: HSLFN12's partner hSerpinB12 may contribute to
            heterochromatin formation.
REFERENCE   4  (bases 1 to 3738)
  AUTHORS   Basson,M.D., Wang,Q., Chaturvedi,L.S., More,S., Vomhof-DeKrey,E.E.,
            Al-Marsoummi,S., Sun,K., Kuhn,L.A., Kovalenko,P. and Kiupel,M.
  TITLE     Schlafen 12 Interaction with SerpinB12 and Deubiquitylases Drives
            Human Enterocyte Differentiation
  JOURNAL   Cell Physiol Biochem 48 (3), 1274-1290 (2018)
   PUBMED   30045019
  REMARK    GeneRIF: SLFN12 regulates human enterocytic differentiation by a
            pathway involving SERPB12, the deubiquitylases, and Cdx2.
REFERENCE   5  (bases 1 to 3738)
  AUTHORS   Niehaus,J.Z., Miedel,M.T., Good,M., Wyatt,A.N., Pak,S.C.,
            Silverman,G.A. and Luke,C.J.
  TITLE     SERPINB12 Is a Slow-Binding Inhibitor of Granzyme A and Hepsin
  JOURNAL   Biochemistry 54 (45), 6756-6759 (2015)
   PUBMED   26497600
  REMARK    GeneRIF: SERPINB12 formed a covalent complex with GZMA and
            inhibited the enzyme with typical serpin slow-binding kinetics.
            SERPINB12 also inhibited Hepsin. SERPINB12 may function as an
            endogenous inhibitor of these peptidases.
REFERENCE   6  (bases 1 to 3738)
  AUTHORS   Niehaus,J.Z., Good,M., Jackson,L.E., Ozolek,J.A., Silverman,G.A.
            and Luke,C.J.
  TITLE     Human SERPINB12 Is an Abundant Intracellular Serpin Expressed in
            Most Surface and Glandular Epithelia
  JOURNAL   J Histochem Cytochem 63 (11), 854-865 (2015)
   PUBMED   26220980
  REMARK    GeneRIF: data suggest that SERPINB12, like some other intracellular
            serpins, may play a vital role in barrier function by providing
            protection of epithelial cells.
REFERENCE   7  (bases 1 to 3738)
  AUTHORS   Naba,A., Clauser,K.R., Whittaker,C.A., Carr,S.A., Tanabe,K.K. and
            Hynes,R.O.
  TITLE     Extracellular matrix signatures of human primary metastatic colon
            cancers and their metastases to liver
  JOURNAL   BMC Cancer 14, 518 (2014)
   PUBMED   25037231
  REMARK    Publication Status: Online-Only
REFERENCE   8  (bases 1 to 3738)
  AUTHORS   Heit,C., Jackson,B.C., McAndrews,M., Wright,M.W., Thompson,D.C.,
            Silverman,G.A., Nebert,D.W. and Vasiliou,V.
  TITLE     Update of the human and mouse SERPIN gene superfamily
  JOURNAL   Hum Genomics 7 (1), 22 (2013)
   PUBMED   24172014
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3738)
  AUTHORS   Askew,Y.S., Pak,S.C., Luke,C.J., Askew,D.J., Cataltepe,S.,
            Mills,D.R., Kato,H., Lehoczky,J., Dewar,K., Birren,B. and
            Silverman,G.A.
  TITLE     SERPINB12 is a novel member of the human ov-serpin family that is
            widely expressed and inhibits trypsin-like serine proteinases
  JOURNAL   J Biol Chem 276 (52), 49320-49330 (2001)
   PUBMED   11604408
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC090307.7.
            
            On or before Jun 20, 2020 this sequence version replaced
            XM_017026067.1, NM_001307928.1.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            CDS exon combination :: BC103885.1 [ECO:0000331]
            RNAseq introns       :: single sample supports all introns
                                    SAMEA2145893, SAMEA2147596 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            inferred exon combination :: based on alignments, homology
            MANE Ensembl match        :: ENST00000382768.2/ ENSP00000372218.1
            RefSeq Select criteria    :: based on manual assertion,
                                         conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-124               AC090307.7         79740-79863
            125-310             AC090307.7         93513-93698
            311-445             AC090307.7         95723-95857
            446-586             AC090307.7         96949-97089
            587-704             AC090307.7         98456-98573
            705-847             AC090307.7         101349-101491
            848-1015            AC090307.7         102816-102983
            1016-3738           AC090307.7         103978-106700
FEATURES             Location/Qualifiers
     source          1..3738
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.33"
     gene            1..3738
                     /gene="SERPINB12"
                     /gene_synonym="YUKOPIN"
                     /note="serpin family B member 12"
                     /db_xref="GeneID:89777"
                     /db_xref="HGNC:HGNC:14220"
                     /db_xref="MIM:615662"
     exon            1..124
                     /gene="SERPINB12"
                     /gene_synonym="YUKOPIN"
                     /inference="alignment:Splign:2.1.0"
     exon            125..310
                     /gene="SERPINB12"
                     /gene_synonym="YUKOPIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..1420
                     /gene="SERPINB12"
                     /gene_synonym="YUKOPIN"
                     /note="isoform 1 is encoded by transcript variant 1;
                     serine (or cysteine) proteinase inhibitor, clade B
                     (ovalbumin), member 12; serpin B12; serpin peptidase
                     inhibitor, clade B (ovalbumin), member 12"
                     /codon_start=1
                     /product="serpin B12 isoform 1"
                     /protein_id="NP_001294857.1"
                     /db_xref="CCDS:CCDS77194.1"
                     /db_xref="GeneID:89777"
                     /db_xref="HGNC:HGNC:14220"
                     /db_xref="MIM:615662"
                     /translation="MDSLVTANTKFCFDLFQEIGKDDRHKNIFFSPLSLSAALGMVRL
                     GARSDSAHQIDEVLHFNEFSQNESKEPDPCLKSNKQKVLADSSLEGQKKTTEPLDQQA
                     GSLNNESGLVSCYFGQLLSKLDRIKTDYTLSIANRLYGEQEFPICQEYLDGVIQFYHT
                     TIESVDFQKNPEKSRQEINFWVECQSQGKIKELFSKDAINAETVLVLVNAVYFKAKWE
                     TYFDHENTVDAPFCLNANENKSVKMMTQKGLYRIGFIEEVKAQILEMRYTKGKLSMFV
                     LLPSHSKDNLKGLEELERKITYEKMVAWSSSENMSEESVVLSFPRFTLEDSYDLNSIL
                     QDMGITDIFDETRADLTGISPSPNLYLSKIIHKTFVEVDENGTQAAAATGAVVSERSL
                     RSWVEFNANHPFLFFIRHNKTQTILFYGRVCSP"
     exon            311..445
                     /gene="SERPINB12"
                     /gene_synonym="YUKOPIN"
                     /inference="alignment:Splign:2.1.0"
     exon            446..586
                     /gene="SERPINB12"
                     /gene_synonym="YUKOPIN"
                     /inference="alignment:Splign:2.1.0"
     exon            587..704
                     /gene="SERPINB12"
                     /gene_synonym="YUKOPIN"
                     /inference="alignment:Splign:2.1.0"
     exon            705..847
                     /gene="SERPINB12"
                     /gene_synonym="YUKOPIN"
                     /inference="alignment:Splign:2.1.0"
     exon            848..1015
                     /gene="SERPINB12"
                     /gene_synonym="YUKOPIN"
                     /inference="alignment:Splign:2.1.0"
     exon            1016..3738
                     /gene="SERPINB12"
                     /gene_synonym="YUKOPIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3707..3712
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERPINB12"
                     /gene_synonym="YUKOPIN"
                     /note="hexamer: AATAAA"
     polyA_site      3738
                     /gene="SERPINB12"
                     /gene_synonym="YUKOPIN"
                     /note="major polyA site"
ORIGIN      
        1 gcctctcctt ataagttttc acaggctgta ggacttgcct ggttcctcct ctgctagatt
       61 gatttttgaa ttgactttat cagagcacag accttagctg gggacagccc tcactggctt
      121 ccagatcgtt ataagtttta caatggactc tcttgttaca gcaaacacca aattttgctt
      181 tgatcttttt caagagatag gcaaagatga tcgtcataaa aacatatttt tctctcccct
      241 gagcctctca gctgcccttg gtatggtacg cttgggtgct agaagtgaca gtgcacatca
      301 gattgatgag gtactacact tcaacgaatt ttcccagaat gaaagcaaag aacctgaccc
      361 ttgtctgaaa agcaacaaac aaaaagtgct ggctgacagc tctctggagg ggcagaaaaa
      421 aacgacagag cctctggatc agcaggctgg gtccttaaac aatgagagcg gactggtcag
      481 ctgctacttt gggcagcttc tctccaaatt agacaggatc aagactgatt acacactgag
      541 tattgccaac aggctttatg gagagcagga attcccaatc tgtcaggaat acttagatgg
      601 tgtgattcaa ttttaccaca cgacgattga aagtgttgat ttccaaaaaa accctgaaaa
      661 atccagacaa gagattaact tctgggttga atgtcaatcc caaggtaaaa tcaaggaact
      721 cttcagcaag gacgctatta atgctgagac tgtgctggta ctggtgaatg ctgtttactt
      781 caaggccaaa tgggaaacat actttgacca tgaaaacacg gtggatgcac ctttctgtct
      841 aaatgcgaat gaaaacaaga gtgtgaagat gatgacgcaa aaaggcctct acagaattgg
      901 cttcatagag gaggtgaagg cacagatcct ggaaatgagg tacaccaagg ggaagctcag
      961 catgttcgtg ctgctgccat ctcactctaa agataacctg aagggtctgg aagagcttga
     1021 aaggaaaatc acctatgaaa aaatggtggc ctggagcagc tcagaaaaca tgtcagaaga
     1081 atcggtggtc ctgtccttcc cccggttcac cctggaagac agctatgatc tcaattccat
     1141 tttacaagac atgggcatta cggatatctt tgatgaaacg agggctgatc ttactggaat
     1201 ctctccaagt cccaatttgt acttgtcaaa aattatccac aaaacctttg tggaggtgga
     1261 tgaaaacggt acccaggcag ctgcagccac tggggctgtt gtctcggaaa ggtcactacg
     1321 atcttgggtg gagtttaatg ccaaccaccc ttttctcttt ttcattagac acaacaaaac
     1381 ccaaaccatt ctcttttatg gcagggtctg ctctccttaa aaggggagca gtgtctagta
     1441 ctttggagct ggaggaaaat atcaatacaa tcttcccctg gcataagatg ggcatttgag
     1501 tttttggtaa tatctaaagc atctccttca tcctccagcc atcggcttgt gcttatcttg
     1561 atctttctgt caccctgtag cttattttca tctgagtctg ttagtattga agggctgttg
     1621 ttctctaccc taaactttca agcatataaa ttcaccctct gtgacctgaa ggtcaacaca
     1681 attcagaaca gtacctacct ccttttgaag gaatcctaaa agttcaggtc attagaccat
     1741 ttctaagaga tggcaaactc agaagccact ttaacatggg cagcaagaga acatgtttga
     1801 ctggaacgtg tttggaaact cagctctgtt tctggggtag tttgaccgga acgtgtttgg
     1861 aaactcagct ctgtttctgg gatagttatg attgtggtca tcactgggcg agatgccctg
     1921 tttcttcctt tgacagctac tgcatggaag atgtcctgtg aggtcttttc acctaggaca
     1981 aggcagggct tgggcgtatt taagtgatag ctcaaagatg tgtgactgcc ccaaccagca
     2041 ctcattttgc acagagcagg ggaatgatat ttgtcttgtg attttgacac tgacccagga
     2101 aagtggctag tggatttaga ggaggtttat ctcagttttc cttattgagt cccccaacat
     2161 tatcatcaaa cacttccctc tgtctctcct ccccctagct ccaagaattc ccacctgtgg
     2221 ctagctcctt ttatgcaccc agcacaggca ggtgtcaaga gaagtgctgc tggcattgtg
     2281 gacggctggc ctccgtatgc ccctctctct gccttctggc cacgtggagg ctggcctctg
     2341 tgtgcccctc tctctgcctt ctggccacgt ggaggctggc ctccgtgtgc ccctctctct
     2401 gccttctggc cacgtggact tttgtgtctt ccgagaggtc tcatgccaga ccacatggtg
     2461 acaacaggct tgagcctggg catggtgtcc atagcaatgc ttgttggctg ggcatgatgg
     2521 ctcatgcctg caatcccagc acttcttggg aggccgagtc aggtggatca cttgagtcca
     2581 ggagttcgag accagcctgg gcaacatatt gagaccctga ctctacaaaa aatacagaaa
     2641 ttagccgggc gtggtggtgt gcacctatag tcccagctac tcgggaggct gaggtgggaa
     2701 gatcacttga acccagggga tggaggctgc agtaagctga gatggcgcca ctgcactcca
     2761 gcctgggtga cagagcgaaa ccctgtctca aaaaacaaac aaacaaaaaa cccaaaaagc
     2821 caaaacaaaa cctgaaaccc ttgtcaagaa ggccattggg ctcatctcaa gctctagtct
     2881 actgaaggcc tgacctctga gtgttcctac tcgcggactc agggcctctg ttctctggtg
     2941 tggtaatctg agttcctaat ttctatctta gctgaatgtt ctgccatgac cactgacacg
     3001 tccaactcac atctctttgg agtcagtctc tttcctatcg aggtgggttt caggtcttgc
     3061 ttgcggctca gtttccttgg cccaccttgt ggctgtcctc ctcccagctg ccaccagtcg
     3121 ttcagtgtgg ccacgcagtt tttttgcaga aggcaggtga accacacctg ctcccatgct
     3181 agcctcctct tccttttctc acctacccca gtgatttctt tgtgctctga gagacaagtt
     3241 ccatgttctc catacaacct tctcattgtt gaagctcact tacgacctaa aacaatttga
     3301 cgttggtaac gtgaggcagt ttgaggcagt gccctatcca gaatgcatgt cccatgggtc
     3361 aaattaattt cagataacca aaaacttcat gtcccctgtg gttccttttg gggttgacgt
     3421 tttgggggct gtttccatgt ctgacttggc accactgccc gacacgtagc tggaaaccat
     3481 gacctatata taggcctgca ctgcccggca tttcttttgt tcttattctt ttacttggta
     3541 aacacatttt tttttcattt acatcgggat ttctcagatt ttgaagcatg agagggagaa
     3601 tgtatctatt tacaataatg aggaaaatta agaatcttaa atctttatgt aaatcagtaa
     3661 acattcttta ctaacctttg atttattaag aagtttcttc tgaatgaata aagcactttt
     3721 gttattagtt aaaatata
//
