LOCUS       NM_001370475            1735 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens serpin family B member 11 (SERPINB11), transcript
            variant 4, mRNA.
ACCESSION   NM_001370475 XM_011526251
VERSION     NM_001370475.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1735)
  AUTHORS   Heit,C., Jackson,B.C., McAndrews,M., Wright,M.W., Thompson,D.C.,
            Silverman,G.A., Nebert,D.W. and Vasiliou,V.
  TITLE     Update of the human and mouse SERPIN gene superfamily
  JOURNAL   Hum Genomics 7 (1), 22 (2013)
   PUBMED   24172014
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1735)
  AUTHORS   Lim,W., Kim,J.H., Ahn,S.E., Jeong,W., Kim,J., Bazer,F.W., Han,J.Y.
            and Song,G.
  TITLE     Avian SERPINB11 gene: a marker for ovarian endometrioid cancer in
            chickens
  JOURNAL   Exp Biol Med (Maywood) 237 (2), 150-159 (2012)
   PUBMED   22289513
  REMARK    GeneRIF: SERPINB11 has a role in ovarian endometrioid carcinoma in
            chickens and human
REFERENCE   3  (bases 1 to 1735)
  AUTHORS   Seixas,S., Ivanova,N., Ferreira,Z., Rocha,J. and Victor,B.L.
  TITLE     Loss and gain of function in SERPINB11: an example of a gene under
            selection on standing variation, with implications for
            host-pathogen interactions
  JOURNAL   PLoS One 7 (2), e32518 (2012)
   PUBMED   22393410
  REMARK    GeneRIF: SERPINB11 is a gene under selection on standing variation,
            with roles in host-pathogen interactions
REFERENCE   4  (bases 1 to 1735)
  AUTHORS   Askew,D.J., Cataltepe,S., Kumar,V., Edwards,C., Pace,S.M.,
            Howarth,R.N., Pak,S.C., Askew,Y.S., Bromme,D., Luke,C.J.,
            Whisstock,J.C. and Silverman,G.A.
  TITLE     SERPINB11 is a new noninhibitory intracellular serpin. Common
            single nucleotide polymorphisms in the scaffold impair
            conformational change
  JOURNAL   J Biol Chem 282 (34), 24948-24960 (2007)
   PUBMED   17562709
  REMARK    GeneRIF: SERPINB11 is a new noninhibitory intracellular serpin
REFERENCE   5  (bases 1 to 1735)
  AUTHORS   Denoeud,F., Kapranov,P., Ucla,C., Frankish,A., Castelo,R.,
            Drenkow,J., Lagarde,J., Alioto,T., Manzano,C., Chrast,J., Dike,S.,
            Wyss,C., Henrichsen,C.N., Holroyd,N., Dickson,M.C., Taylor,R.,
            Hance,Z., Foissac,S., Myers,R.M., Rogers,J., Hubbard,T., Harrow,J.,
            Guigo,R., Gingeras,T.R., Antonarakis,S.E. and Reymond,A.
  TITLE     Prominent use of distal 5' transcription start sites and discovery
            of a large number of additional exons in ENCODE regions
  JOURNAL   Genome Res 17 (6), 746-759 (2007)
   PUBMED   17567994
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC069356.6 and KF459701.1.
            
            On May 8, 2019 this sequence version replaced XM_011526251.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK292775.1, AY739645.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2144335, SAMEA2147975
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000544088.6/ ENSP00000441497.1
            polymorphic pseudogene :: PMID: 22393410
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                AC069356.6         70149-70195         c
            48-230              AC069356.6         62794-62976         c
            231-290             AC069356.6         61761-61820         c
            291-419             KF459701.1         103-231             c
            420-537             AC069356.6         57003-57120         c
            538-680             AC069356.6         53000-53142         c
            681-836             AC069356.6         52169-52324         c
            837-1735            AC069356.6         49262-50160         c
FEATURES             Location/Qualifiers
     source          1..1735
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q21.33"
     gene            1..1735
                     /gene="SERPINB11"
                     /gene_synonym="EPIPIN; SERPIN11"
                     /note="serpin family B member 11"
                     /db_xref="GeneID:89778"
                     /db_xref="HGNC:HGNC:14221"
                     /db_xref="MIM:615682"
     exon            1..47
                     /gene="SERPINB11"
                     /gene_synonym="EPIPIN; SERPIN11"
                     /inference="alignment:Splign:2.1.0"
     exon            48..230
                     /gene="SERPINB11"
                     /gene_synonym="EPIPIN; SERPIN11"
                     /inference="alignment:Splign:2.1.0"
     CDS             63..1241
                     /gene="SERPINB11"
                     /gene_synonym="EPIPIN; SERPIN11"
                     /note="isoform a is encoded by transcript variant 4;
                     serine (or cysteine) proteinase inhibitor, clade B
                     (ovalbumin), member 11; serpin B11; serpin peptidase
                     inhibitor, clade B (ovalbumin), member 11"
                     /codon_start=1
                     /product="serpin B11 isoform a"
                     /protein_id="NP_001357404.1"
                     /db_xref="GeneID:89778"
                     /db_xref="HGNC:HGNC:14221"
                     /db_xref="MIM:615682"
                     /translation="MGSLSTANVEFCLDVFKELNSNNIGDNIFFSSLSLLYALSMVLL
                     GARGETEEQLEKVLHFSHTVDSLKPGFKDSPKCSQAGRIHSEFGVEFSQINQPDSNCT
                     LSIANRLYGTKTMAFHQQYLSCSEKWYQARLQTVDFEQSTEETRKTINAWVENKTNGK
                     VANLFGKSTIDPSSVMVLVNAIYFKGQWQNKFQVRETVKSPFQLSEGKNVTVEMMYQI
                     GTFKLAFVKEPQMQVLELPYVNNKLSMIILLPVGIANLKQIEKQLNSGTFHEWTSSSN
                     MMEREVEVHLPRFKLETKYELNSLLKSLGVTDLFNQVKADLSGMSPTKGLYLSKAIHK
                     SYLDVSEEGTEAAAATGDSIAVKSLPMRAQFKANHPFLFFIRHTHTNTILFCGKLASP
                     "
     exon            231..290
                     /gene="SERPINB11"
                     /gene_synonym="EPIPIN; SERPIN11"
                     /inference="alignment:Splign:2.1.0"
     exon            291..419
                     /gene="SERPINB11"
                     /gene_synonym="EPIPIN; SERPIN11"
                     /inference="alignment:Splign:2.1.0"
     exon            420..537
                     /gene="SERPINB11"
                     /gene_synonym="EPIPIN; SERPIN11"
                     /inference="alignment:Splign:2.1.0"
     exon            538..680
                     /gene="SERPINB11"
                     /gene_synonym="EPIPIN; SERPIN11"
                     /inference="alignment:Splign:2.1.0"
     exon            681..836
                     /gene="SERPINB11"
                     /gene_synonym="EPIPIN; SERPIN11"
                     /inference="alignment:Splign:2.1.0"
     exon            837..1735
                     /gene="SERPINB11"
                     /gene_synonym="EPIPIN; SERPIN11"
                     /inference="alignment:Splign:2.1.0"
ORIGIN      
        1 agtctaactt gccactctgt gaacttcact actggaaagc aacaaaggca gtcggcataa
       61 aaatgggttc tctcagcaca gctaacgttg aattttgcct tgatgtgttc aaagagctga
      121 acagtaacaa cataggagat aacatcttct tttcttcgct gagtctgctt tatgctctaa
      181 gcatggtcct ccttggtgcc aggggagaga ctgaagagca attggagaag gtgcttcatt
      241 ttagtcatac tgtagactca ttaaaaccag ggttcaagga ctcacctaag tgcagccaag
      301 ctggaagaat tcattccgag tttggtgtcg aattctctca aatcaaccag ccagactcta
      361 actgtaccct cagcattgcc aacaggctct acgggacaaa gacgatggca tttcatcagc
      421 aatatttaag ctgttctgag aaatggtatc aagccaggtt gcaaactgtg gattttgaac
      481 agtctacaga agaaacgagg aaaacgatta atgcttgggt tgaaaataaa actaatggaa
      541 aagtcgcaaa tctctttgga aagagcacaa ttgacccttc atctgtaatg gtcctggtga
      601 atgccatata tttcaaagga caatggcaaa ataaatttca agtaagagag acagttaaaa
      661 gtccttttca gctaagtgag ggtaaaaatg taactgtgga aatgatgtat caaattggaa
      721 catttaaact ggcctttgta aaggagccgc agatgcaagt tcttgagctg ccctacgtta
      781 acaacaaatt aagcatgatt attctgcttc cagtaggcat agctaatctg aaacagatag
      841 aaaagcagct gaattcgggg acgtttcatg agtggacaag ctcttctaac atgatggaaa
      901 gagaagttga agtacacctc ccccgattca aacttgaaac taagtatgag ctaaattccc
      961 tgttaaaatc tctaggggtg acagatctct tcaaccaggt caaagctgat ctttctggaa
     1021 tgtcaccaac caagggccta tatttatcaa aagccatcca caagtcatac ctggatgtca
     1081 gcgaagaggg cacggaggca gcagcagcca ctggggacag catcgctgta aaaagcctac
     1141 caatgagagc tcagttcaag gcgaaccacc ccttcctttt ctttataagg cacactcata
     1201 ccaacacgat cctattctgt ggcaagcttg cctctcccta atcagatggg gttgagcaag
     1261 gctcagagtt gcagatgagg tgcagagaca atcctgtgac tttcccacgg ccaaaaagct
     1321 gttcacacct cacacacctc tgtgcctcag tttgctcatc tgcaaaatag gtctaggatt
     1381 tcttccaacc atttcatgag ttgtgaagct aaggctttgt taatcatgga aaaaggtaga
     1441 tttatgcaga aagcctttct ggctttctta tctgtggtgt ctcatttgag tgctgtccag
     1501 tgacatgatc aagtcaatga gtaaaatttt aagggattag attttcttga cttgtatgta
     1561 tctgtgagat cttgaataag tgacctgaca tctctgctta aagaaaacca gctgaagggc
     1621 ttcaactttg cttggatttt taaatatttt ccttgcatat gtaaatagaa tgtggtgagt
     1681 tttagttcaa aattctctgt tgagaataat aaatgcatga aataccttaa agctc
//
