LOCUS       NM_005024               2155 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens serpin family B member 10 (SERPINB10), mRNA.
ACCESSION   NM_005024 XM_011526026
VERSION     NM_005024.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2155)
  AUTHORS   Deng,Z., Li,Z., She,Y. and Xie,B.
  TITLE     Increased Expression of SERPINB10 Associated with Postoperative
            Recurrence in Chronic Rhinosinusitis with Nasal Polyps
  JOURNAL   Dis Markers 2022, 7164318 (2022)
   PUBMED   36398030
  REMARK    GeneRIF: Increased Expression of SERPINB10 Associated with
            Postoperative Recurrence in Chronic Rhinosinusitis with Nasal
            Polyps.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2155)
  AUTHORS   Zong,W., Liang,Y. and Mo,Y.
  TITLE     Increased SERPINB10 Expression in Induced Sputum Was Associated
            with Airway Type 2 Inflammation in Asthma
  JOURNAL   Int Arch Allergy Immunol 183 (9), 946-952 (2022)
   PUBMED   35526531
  REMARK    GeneRIF: Increased SERPINB10 Expression in Induced Sputum Was
            Associated with Airway Type 2 Inflammation in Asthma.
REFERENCE   3  (bases 1 to 2155)
  AUTHORS   Majoros,H., Borsos,B.N., Ujfaludi,Z., Pahi,Z.G., Morocz,M.,
            Haracska,L., Boros,I.M. and Pankotai,T.
  TITLE     SerpinB10, a Serine Protease Inhibitor, Is Implicated in UV-Induced
            Cellular Response
  JOURNAL   Int J Mol Sci 22 (16), 8500 (2021)
   PUBMED   34445206
  REMARK    GeneRIF: SerpinB10, a Serine Protease Inhibitor, Is Implicated in
            UV-Induced Cellular Response.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2155)
  AUTHORS   Mo,Y., Zhang,K., Feng,Y., Yi,L., Liang,Y., Wu,W., Zhao,J.,
            Zhang,Z., Xu,Y., Hu,Q., He,J. and Zhen,G.
  TITLE     Epithelial SERPINB10, a novel marker of airway eosinophilia in
            asthma, contributes to allergic airway inflammation
  JOURNAL   Am J Physiol Lung Cell Mol Physiol 316 (1), L245-L254 (2019)
   PUBMED   30382768
  REMARK    GeneRIF: Epithelial SERPINB10 contributes to allergic airway
            eosinophilic inflammation, at least in part, by regulating the
            expression of periostin and CCL26.
REFERENCE   5  (bases 1 to 2155)
  AUTHORS   Heit,C., Jackson,B.C., McAndrews,M., Wright,M.W., Thompson,D.C.,
            Silverman,G.A., Nebert,D.W. and Vasiliou,V.
  TITLE     Update of the human and mouse SERPIN gene superfamily
  JOURNAL   Hum Genomics 7 (1), 22 (2013)
   PUBMED   24172014
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2155)
  AUTHORS   Schleef,R.R. and Chuang,T.L.
  TITLE     Protease inhibitor 10 inhibits tumor necrosis factor alpha -induced
            cell death. Evidence for the formation of intracellular high M(r)
            protease inhibitor 10-containing complexes
  JOURNAL   J Biol Chem 275 (34), 26385-26389 (2000)
   PUBMED   10871600
REFERENCE   7  (bases 1 to 2155)
  AUTHORS   Chuang,T.L. and Schleef,R.R.
  TITLE     Identification of a nuclear targeting domain in the insertion
            between helices C and D in protease inhibitor-10
  JOURNAL   J Biol Chem 274 (16), 11194-11198 (1999)
   PUBMED   10196205
REFERENCE   8  (bases 1 to 2155)
  AUTHORS   Bartuski,A.J., Kamachi,Y., Schick,C., Overhauser,J. and
            Silverman,G.A.
  TITLE     Cytoplasmic antiproteinase 2 (PI8) and bomapin (PI10) map to the
            serpin cluster at 18q21.3
  JOURNAL   Genomics 43 (3), 321-328 (1997)
   PUBMED   9268635
REFERENCE   9  (bases 1 to 2155)
  AUTHORS   Riewald,M. and Schleef,R.R.
  TITLE     Molecular cloning of bomapin (protease inhibitor 10), a novel human
            serpin that is expressed specifically in the bone marrow
  JOURNAL   J Biol Chem 270 (45), 26754-26757 (1995)
   PUBMED   7592909
REFERENCE   10 (bases 1 to 2155)
  AUTHORS   Huber,R. and Carrell,R.W.
  TITLE     Implications of the three-dimensional structure of alpha
            1-antitrypsin for structure and function of serpins
  JOURNAL   Biochemistry 28 (23), 8951-8966 (1989)
   PUBMED   2690952
  REMARK    Review article
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC072051.8, AK314936.1,
            U35459.1, AC009802.13 and AA993220.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005024.2.
            
            Summary: This gene is a member of the serpin peptidase inhibitor,
            clade B family and is found in a cluster of other similar genes on
            chromosome 18. The protein encoded by this gene appears to help
            control the regulation of protease functions during hematopoiesis.
            Variations in this gene may increase the risk of prostate cancer.
            [provided by RefSeq, Dec 2015].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.417906.1,
                                           SRR1163658.514721.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149004, SAMEA2154529
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000238508.8/ ENSP00000238508.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-32                AC072051.8         22359-22390         c
            33-40               AK314936.1         1-8
            41-41               AC072051.8         22350-22350         c
            42-92               AK314936.1         10-60
            93-1286             U35459.1           1-1194
            1287-2078           AC009802.13        132004-132795       c
            2079-2155           AA993220.1         6-82                c
FEATURES             Location/Qualifiers
     source          1..2155
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q22.1"
     gene            1..2155
                     /gene="SERPINB10"
                     /gene_synonym="PI-10; PI10"
                     /note="serpin family B member 10"
                     /db_xref="GeneID:5273"
                     /db_xref="HGNC:HGNC:8942"
                     /db_xref="MIM:602058"
     exon            1..83
                     /gene="SERPINB10"
                     /gene_synonym="PI-10; PI10"
                     /inference="alignment:Splign:2.1.0"
     exon            84..260
                     /gene="SERPINB10"
                     /gene_synonym="PI-10; PI10"
                     /inference="alignment:Splign:2.1.0"
     CDS             93..1286
                     /gene="SERPINB10"
                     /gene_synonym="PI-10; PI10"
                     /note="protease inhibitor 10 (ovalbumin type, bomapin);
                     serine (or cysteine) proteinase inhibitor, clade B
                     (ovalbumin), member 10; peptidase inhibitor 10; serpin
                     peptidase inhibitor, clade B (ovalbumin), member 10;
                     protease inhibitor 10 (ovalbumin type)"
                     /codon_start=1
                     /product="serpin B10"
                     /protein_id="NP_005015.1"
                     /db_xref="CCDS:CCDS11990.1"
                     /db_xref="GeneID:5273"
                     /db_xref="HGNC:HGNC:8942"
                     /db_xref="MIM:602058"
                     /translation="MDSLATSINQFALELSKKLAESAQGKNIFFSSWSISTSLTIVYL
                     GAKGTTAAQMAQVLQFNRDQGVKCDPESEKKRKMEFNLSNSEEIHSDFQTLISEILKP
                     NDDYLLKTANAIYGEKTYAFHNKYLEDMKTYFGAEPQPVNFVEASDQIRKDINSWVER
                     QTEGKIQNLLPDDSVDSTTRMILVNALYFKGIWEHQFLVQNTTEKPFRINETTSKPVQ
                     MMFMKKKLHIFHIEKPKAVGLQLYYKSRDLSLLILLPEDINGLEQLEKAITYEKLNEW
                     TSADMMELYEVQLHLPKFKLEDSYDLKSTLSSMGMSDAFSQSKADFSGMSSARNLFLS
                     NVFHKAFVEINEQGTEAAAGSGSEIDIRIRVPSIEFNANHPFLFFIRHNKTNTILFYG
                     RLCSP"
     exon            261..326
                     /gene="SERPINB10"
                     /gene_synonym="PI-10; PI10"
                     /inference="alignment:Splign:2.1.0"
     exon            327..464
                     /gene="SERPINB10"
                     /gene_synonym="PI-10; PI10"
                     /inference="alignment:Splign:2.1.0"
     exon            465..582
                     /gene="SERPINB10"
                     /gene_synonym="PI-10; PI10"
                     /inference="alignment:Splign:2.1.0"
     exon            583..725
                     /gene="SERPINB10"
                     /gene_synonym="PI-10; PI10"
                     /inference="alignment:Splign:2.1.0"
     exon            726..881
                     /gene="SERPINB10"
                     /gene_synonym="PI-10; PI10"
                     /inference="alignment:Splign:2.1.0"
     exon            882..2155
                     /gene="SERPINB10"
                     /gene_synonym="PI-10; PI10"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2134..2139
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERPINB10"
                     /gene_synonym="PI-10; PI10"
                     /note="hexamer: AATAAA"
     polyA_site      2155
                     /gene="SERPINB10"
                     /gene_synonym="PI-10; PI10"
                     /note="major polyA site"
ORIGIN      
        1 agttgaaagt ttctcaactc ttcagccaca atctcttact acaggagcaa attgccaatt
       61 ctgctccagt gggagaaaac aaggtttcct caatggactc tctagcaaca tcaatcaacc
      121 agtttgccct ggagttgagc aaaaagctag ctgaatctgc tcagggtaaa aatatcttct
      181 tttcttcctg gagcatctca acttccttga ccatagtgta tttgggcgcc aaaggtacca
      241 ctgcagccca aatggcccag gtgcttcaat ttaacagaga ccagggagtc aaatgtgacc
      301 ctgaaagtga aaaaaaaagg aaaatggaat tcaacttgag caactcggaa gaaatacact
      361 ctgatttcca aacacttatc tcagaaatcc tcaagcccaa cgatgactac ttacttaaaa
      421 cagccaatgc gatatatgga gagaaaacgt atgcatttca caataaatat ttagaagaca
      481 tgaaaacata ttttggtgca gaacctcagc ctgttaactt tgtggaagct tctgatcaaa
      541 tcagaaagga catcaactct tgggttgaaa gacagaccga gggtaaaatc cagaatctcc
      601 tgcctgatga ctctgtggat tccacaacca ggatgattct ggtgaacgcc ctatacttta
      661 aaggaatctg ggaacatcaa ttcttagtgc aaaacaccac agaaaagcct tttagaataa
      721 acgagactac aagcaaacca gtgcaaatga tgtttatgaa gaaaaagctt cacatttttc
      781 acatagaaaa gccaaaagca gtgggccttc aactctacta caaaagccgt gacctcagcc
      841 tgcttatact actgccagaa gacattaatg ggctggaaca gctggaaaag gccatcacct
      901 atgagaagct gaatgagtgg accagtgcag acatgatgga gttgtatgaa gtgcagctac
      961 accttcccaa gttcaagctg gaagacagtt atgatctcaa gtcaaccctg agcagtatgg
     1021 ggatgagtga tgccttcagc caaagcaaag ctgatttctc aggaatgtct tcagcaagaa
     1081 acctattttt gtccaatgtt ttccataagg cttttgtgga aataaatgaa caaggtactg
     1141 aagctgcagc tggcagtggg agtgagatag atatacgaat tagagtccca tccattgaat
     1201 tcaatgcaaa tcacccattc ctcttcttca tcaggcacaa taaaaccaac accattcttt
     1261 tttatggaag attatgctcc ccctaaatcc tgcatatctc tcaacaaaca agaccatctt
     1321 acagtgtgaa aaatgtacca tgagatggaa aagcacaatt ttcacaaaaa tgagtttgta
     1381 gtctaaacct ttttcacatt tgaatataag taaatagatc ttgaaataat gcattctaat
     1441 gatcctgtca tatctgtaca gctggagaga atgacgattt ttatttttaa cacgttaaca
     1501 ttttgtctaa tgtgactttc atttacattt cagaagtact atgctattca actgaatgcc
     1561 ttacaattct tgatcacttg caatatccat gatacttgtt atcatatatt tcatatacat
     1621 cattaaatga aaaaaaatct ttataaaggt gatatgatat tgataaatac gaagtttctc
     1681 aagaatatcg ttttgatcaa aaatttagcc cggcatggtg gtgcacacct gtgttcccag
     1741 ctactcagga ggctgaggta ggaggattgc ttgagcccag gaggttgaga ctgcagtgag
     1801 ccaagatcac accagtgcac tccaacctgg gcaacagagc aagaccctgt ctcaaaaaaa
     1861 tcattttggt ggctcataaa ttatgattgt aaaactaaac cccctttttc tgctatttaa
     1921 aaaatactta tattgacatt agcttaaaaa actagtgaaa tccaaatgaa atttgaagtt
     1981 tagctagtag caatctctca atgttggtgc cctagttttg acaaatgtac cgtggtcatg
     2041 taagatgtta tcacttgggg aaactgtact ggagtatatg agaattagct gtattatctc
     2101 tgcacctctt ctgccaatct aaaattattc caaaataaaa gttttattaa aaata
//
