LOCUS       NM_175739               1705 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens serpin family A member 9 (SERPINA9), transcript
            variant 1, mRNA.
ACCESSION   NM_175739
VERSION     NM_175739.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1705)
  AUTHORS   Berker,N., Yegen,G., Ozluk,Y. and Dogan,O.
  TITLE     Value of GCET1, HGAL (GCET2), and LMO2 in the Determination of
            Germinal Center Phenotype in Diffuse Large B-cell Lymphoma
  JOURNAL   Turk J Haematol 40 (3), 162-173 (2023)
   PUBMED   37519110
  REMARK    GeneRIF: Value of GCET1, HGAL (GCET2), and LMO2 in the
            Determination of Germinal Center Phenotype in Diffuse Large B-cell
            Lymphoma.
REFERENCE   2  (bases 1 to 1705)
  AUTHORS   Menter,T., Gasser,A., Juskevicius,D., Dirnhofer,S. and Tzankov,A.
  TITLE     Diagnostic Utility of the Germinal Center-associated Markers GCET1,
            HGAL, and LMO2 in Hematolymphoid Neoplasms
  JOURNAL   Appl Immunohistochem Mol Morphol 23 (7), 491-498 (2015)
   PUBMED   25203428
  REMARK    GeneRIF: Diagnostic Utility of the Germinal Center-associated
            Markers GCET1, HGAL, and LMO2 in Hematolymphoid Neoplasms.
REFERENCE   3  (bases 1 to 1705)
  AUTHORS   Heit,C., Jackson,B.C., McAndrews,M., Wright,M.W., Thompson,D.C.,
            Silverman,G.A., Nebert,D.W. and Vasiliou,V.
  TITLE     Update of the human and mouse SERPIN gene superfamily
  JOURNAL   Hum Genomics 7 (1), 22 (2013)
   PUBMED   24172014
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1705)
  AUTHORS   Luke,M.M., O'Meara,E.S., Rowland,C.M., Shiffman,D., Bare,L.A.,
            Arellano,A.R., Longstreth,W.T. Jr., Lumley,T., Rice,K., Tracy,R.P.,
            Devlin,J.J. and Psaty,B.M.
  TITLE     Gene variants associated with ischemic stroke: the cardiovascular
            health study
  JOURNAL   Stroke 40 (2), 363-368 (2009)
   PUBMED   19023099
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   5  (bases 1 to 1705)
  AUTHORS   Morrison,A.C., Bare,L.A., Luke,M.M., Pankow,J.S., Mosley,T.H.,
            Devlin,J.J., Willerson,J.T. and Boerwinkle,E.
  TITLE     Single nucleotide polymorphisms associated with coronary heart
            disease predict incident ischemic stroke in the atherosclerosis
            risk in communities study
  JOURNAL   Cerebrovasc Dis 26 (4), 420-424 (2008)
   PUBMED   18799872
  REMARK    GeneRIF: serpinA9 was associated with stroke in both whites and
            blacks
REFERENCE   6  (bases 1 to 1705)
  AUTHORS   Paterson,M.A., Horvath,A.J., Pike,R.N. and Coughlin,P.B.
  TITLE     Molecular characterization of centerin, a germinal centre cell
            serpin
  JOURNAL   Biochem J 405 (3), 489-494 (2007)
   PUBMED   17447896
  REMARK    GeneRIF: The cloning, expression and molecular characterization of
            recombinant serpina9 (centerin) are reported.
REFERENCE   7  (bases 1 to 1705)
  AUTHORS   Namciu,S.J., Friedman,R.D., Marsden,M.D., Sarausad,L.M.,
            Jasoni,C.L. and Fournier,R.E.
  TITLE     Sequence organization and matrix attachment regions of the human
            serine protease inhibitor gene cluster at 14q32.1
  JOURNAL   Mamm Genome 15 (3), 162-178 (2004)
   PUBMED   15014966
REFERENCE   8  (bases 1 to 1705)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   9  (bases 1 to 1705)
  AUTHORS   Pan,Z., Shen,Y., Du,C., Zhou,G., Rosenwald,A., Staudt,L.M.,
            Greiner,T.C., McKeithan,T.W. and Chan,W.C.
  TITLE     Two newly characterized germinal center B-cell-associated genes,
            GCET1 and GCET2, have differential expression in normal and
            neoplastic B cells
  JOURNAL   Am J Pathol 163 (1), 135-144 (2003)
   PUBMED   12819018
  REMARK    GeneRIF: Results report the cloning of germinal center B-cell
            expressed transcripts 1 and 2 (GCET1 and 2), and show that both are
            expressed in follicular lymphoma and diffuse large B-cell lymphoma
            with germinal center B-cell differentiation.
REFERENCE   10 (bases 1 to 1705)
  AUTHORS   Frazer,J.K., Jackson,D.G., Gaillard,J.P., Lutter,M., Liu,Y.J.,
            Banchereau,J., Capra,J.D. and Pascual,V.
  TITLE     Identification of centerin: a novel human germinal center B
            cell-restricted serpin
  JOURNAL   Eur J Immunol 30 (10), 3039-3048 (2000)
   PUBMED   11069088
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL132708.3.
            
            On Jan 17, 2019 this sequence version replaced NM_175739.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC111498.1, AY220118.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            CDS uses downstream in-frame AUG :: upstream AUG and CDS extension
                                                is not conserved
            MANE Ensembl match               :: ENST00000674397.2/
                                                ENSP00000501517.1
            RefSeq Select criteria           :: based on manual assertion,
                                                conservation, expression,
                                                longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-62                AL132708.3         40456-40517
            63-707              AL132708.3         46796-47440
            708-981             AL132708.3         49271-49544
            982-1129            AL132708.3         51799-51946
            1130-1705           AL132708.3         53357-53932
FEATURES             Location/Qualifiers
     source          1..1705
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.13"
     gene            1..1705
                     /gene="SERPINA9"
                     /gene_synonym="GCET1; SERPINA11; SERPINA11b"
                     /note="serpin family A member 9"
                     /db_xref="GeneID:327657"
                     /db_xref="HGNC:HGNC:15995"
                     /db_xref="MIM:615677"
     exon            1..62
                     /gene="SERPINA9"
                     /gene_synonym="GCET1; SERPINA11; SERPINA11b"
                     /inference="alignment:Splign:2.1.0"
     exon            63..707
                     /gene="SERPINA9"
                     /gene_synonym="GCET1; SERPINA11; SERPINA11b"
                     /inference="alignment:Splign:2.1.0"
     CDS             80..1333
                     /gene="SERPINA9"
                     /gene_synonym="GCET1; SERPINA11; SERPINA11b"
                     /note="isoform A precursor is encoded by transcript
                     variant 1; serine proteinase inhibitor A11; serine (or
                     cysteine) proteinase inhibitor, clade A (alpha-1
                     antiproteinase, antitrypsin), member 9; serpin A9;
                     centerin; serpin peptidase inhibitor, clade A (alpha-1
                     antiproteinase, antitrypsin), member 9; germinal center
                     B-cell-expressed transcript 1 protein"
                     /codon_start=1
                     /product="serpin A9 isoform A precursor"
                     /protein_id="NP_783866.3"
                     /db_xref="CCDS:CCDS41982.2"
                     /db_xref="GeneID:327657"
                     /db_xref="HGNC:HGNC:15995"
                     /db_xref="MIM:615677"
                     /translation="MASYLYGVLFAVGLCAPIYCVSPANAPSAYPRPSSTKSTPASQV
                     YSLNTDFAFRLYRRLVLETPSQNIFFSPVSVSTSLAMLSLGAHSVTKTQILQGLGFNL
                     THTPESAIHQGFQHLVHSLTVPSKDLTLKMGSALFVKKELQLQANFLGNVKRLYEAEV
                     FSTDFSNPSIAQARINSHVKKKTQGKVVDIIQGLDLLTAMVLVNHIFFKAKWEKPFHP
                     EYTRKNFPFLVGEQVTVHVPMMHQKEQFAFGVDTELNCFVLQMDYKGDAVAFFVLPSK
                     GKMRQLEQALSARTLRKWSHSLQKRWIEVFIPRFSISASYNLETILPKMGIQNVFDKN
                     ADFSGIAKRDSLQVSKATHKAVLDVSEEGTEATAATTTKFIVRSKDGPSYFTVSFNRT
                     FLMMITNKATDGILFLGKVENPTKS"
     exon            708..981
                     /gene="SERPINA9"
                     /gene_synonym="GCET1; SERPINA11; SERPINA11b"
                     /inference="alignment:Splign:2.1.0"
     exon            982..1129
                     /gene="SERPINA9"
                     /gene_synonym="GCET1; SERPINA11; SERPINA11b"
                     /inference="alignment:Splign:2.1.0"
     exon            1130..1705
                     /gene="SERPINA9"
                     /gene_synonym="GCET1; SERPINA11; SERPINA11b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1675..1680
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERPINA9"
                     /gene_synonym="GCET1; SERPINA11; SERPINA11b"
                     /note="hexamer: AATAAA"
     regulatory      1681..1686
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERPINA9"
                     /gene_synonym="GCET1; SERPINA11; SERPINA11b"
                     /note="hexamer: ACTAAA"
     polyA_site      1693
                     /gene="SERPINA9"
                     /gene_synonym="GCET1; SERPINA11; SERPINA11b"
     polyA_site      1705
                     /gene="SERPINA9"
                     /gene_synonym="GCET1; SERPINA11; SERPINA11b"
                     /note="major polyA site"
ORIGIN      
        1 aagcaagtgt cagggctcac caaccatgca aggacagggc aggagaagag gaacctgcaa
       61 agacatattt tgttccaaaa tggcatctta cctttatgga gtactctttg ctgttggcct
      121 ctgtgctcca atctactgtg tgtccccggc caatgccccc agtgcatacc cccgcccttc
      181 ctccacaaag agcacccctg cctcacaggt gtattccctc aacaccgact ttgccttccg
      241 cctataccgc aggctggttt tggagacccc gagtcagaac atcttcttct cccctgtgag
      301 tgtctccact tccctggcca tgctctccct tggggcccac tcagtcacca agacccagat
      361 tctccagggc ctgggcttca acctcacaca cacaccagag tctgccatcc accagggctt
      421 ccagcacctg gttcactcac tgactgttcc cagcaaagac ctgaccttga agatgggaag
      481 tgccctcttc gtcaagaagg agctgcagct gcaggcaaat ttcttgggca atgtcaagag
      541 gctgtatgaa gcagaagtct tttctacaga tttctccaac ccctccattg cccaggcgag
      601 gatcaacagc catgtgaaaa agaagaccca agggaaggtt gtagacataa tccaaggcct
      661 tgaccttctg acggccatgg ttctggtgaa ccacattttc tttaaagcca agtgggagaa
      721 gccctttcac cctgaatata caagaaagaa cttcccattc ctggtgggcg agcaggtcac
      781 tgtgcatgtc cccatgatgc accagaaaga gcagttcgct tttggggtgg atacagagct
      841 gaactgcttt gtgctgcaga tggattacaa gggagatgcc gtggccttct ttgtcctccc
      901 tagcaagggc aagatgaggc aactggaaca ggccttgtca gccagaacac tgagaaagtg
      961 gagccactca ctccagaaaa ggtggataga ggtgttcatc cccagatttt ccatttctgc
     1021 ctcctacaat ctggaaacca tcctcccgaa gatgggcatc caaaatgtct ttgacaaaaa
     1081 tgctgatttt tctggaattg caaagagaga ctccctgcag gtttctaaag caacccacaa
     1141 ggctgtgctg gatgtcagtg aagagggcac tgaggccaca gcagctacca ccaccaagtt
     1201 catagtccga tcgaaggatg gcccctctta cttcactgtc tccttcaata ggaccttcct
     1261 gatgatgatt acaaataaag ccacagacgg tattctcttt ctagggaaag tggaaaatcc
     1321 cactaaatcc taggtgggaa atggcctgtt aactgatggc acattgctaa tgcacaagaa
     1381 ataacaaacc acatccctct ttctgttctg agggtgcatt tgaccccagt ggagctggat
     1441 tcgctggcag ggatgccact tccaaggctc aatcaccaaa ccatcaacag ggaccccagt
     1501 cacaagccaa cacccattaa ccccagtcag tgcccttttc cacaaattct cccaggtaac
     1561 tagcttcatg ggatgttgct gggttaccat atttccattc cttggggctc ccaggaatgg
     1621 aaatacgcca acccaggtta ggcacctcta ttgcagaatt acaataacac attcaataaa
     1681 actaaaatat gaattcatct gtcaa
//
