LOCUS       NP_001747                405 aa            linear   PRI 27-MAR-2025
DEFINITION  corticosteroid-binding globulin precursor [Homo sapiens].
ACCESSION   NP_001747
VERSION     NP_001747.3
DBSOURCE    REFSEQ: accession NM_001756.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 405)
  AUTHORS   Chernykh,A., Abrahams,J.L., Grant,O.C., Kambanis,L.,
            Sumer-Bayraktar,Z., Ugonotti,J., Kawahara,R., Corcilius,L.,
            Payne,R.J., Woods,R.J. and Thaysen-Andersen,M.
  TITLE     Position-specific N- and O-glycosylation of the reactive center
            loop impacts neutrophil elastase-mediated proteolysis of
            corticosteroid-binding globulin
  JOURNAL   J Biol Chem 300 (1), 105519 (2024)
   PUBMED   38042488
  REMARK    GeneRIF: Position-specific N- and O-glycosylation of the reactive
            center loop impacts neutrophil elastase-mediated proteolysis of
            corticosteroid-binding globulin.
REFERENCE   2  (residues 1 to 405)
  AUTHORS   Bankier,S., Wang,L., Crawford,A., Morgan,R.A., Ruusalepp,A.,
            Andrew,R., Bjorkegren,J.L.M., Walker,B.R. and Michoel,T.
  TITLE     Plasma cortisol-linked gene networks in hepatic and adipose tissues
            implicate corticosteroid-binding globulin in modulating tissue
            glucocorticoid action and cardiovascular risk
  JOURNAL   Front Endocrinol (Lausanne) 14, 1186252 (2023)
   PUBMED   37745713
  REMARK    GeneRIF: Plasma cortisol-linked gene networks in hepatic and
            adipose tissues implicate corticosteroid-binding globulin in
            modulating tissue glucocorticoid action and cardiovascular risk.
            Publication Status: Online-Only
REFERENCE   3  (residues 1 to 405)
  AUTHORS   Carpena,M.X., Sanchez-Luquez,K.Y., Martins-Silva,T., Santos,T.M.,
            Farias,C.P., Leventhal,D.G.P., Berruti,B., Zeni,C.P., Schmitz,M.,
            Chazan,R., Hutz,M.H., Salatino-Oliveira,A., Genro,J.P., Rohde,L.A.
            and Tovo-Rodrigues,L.
  TITLE     Stress-related genetic components in
            attention-deficit/hyperactivity disorder (ADHD): Effects of the
            SERPINA6 and SERPINA1 genetic markers in a family-based brazilian
            sample
  JOURNAL   J Psychiatr Res 149, 1-9 (2022)
   PUBMED   35217314
  REMARK    GeneRIF: Stress-related genetic components in
            attention-deficit/hyperactivity disorder (ADHD): Effects of the
            SERPINA6 and SERPINA1 genetic markers in a family-based brazilian
            sample.
REFERENCE   4  (residues 1 to 405)
  AUTHORS   Crawford,A.A., Bankier,S., Altmaier,E., Barnes,C.L.K., Clark,D.W.,
            Ermel,R., Friedrich,N., van der Harst,P., Joshi,P.K., Karhunen,V.,
            Lahti,J., Mahajan,A., Mangino,M., Nethander,M., Neumann,A.,
            Pietzner,M., Sukhavasi,K., Wang,C.A., Bakker,S.J.L.,
            Bjorkegren,J.L.M., Campbell,H., Eriksson,J., Gieger,C., Hayward,C.,
            Jarvelin,M.R., McLachlan,S., Morris,A.P., Ohlsson,C., Pennell,C.E.,
            Price,J., Rudan,I., Ruusalepp,A., Spector,T., Tiemeier,H.,
            Volzke,H., Wilson,J.F., Michoel,T., Timpson,N.J., Smith,G.D. and
            Walker,B.R.
  CONSRTM   CORtisol NETwork (CORNET) consortium
  TITLE     Variation in the SERPINA6/SERPINA1 locus alters morning plasma
            cortisol, hepatic corticosteroid binding globulin expression, gene
            expression in peripheral tissues, and risk of cardiovascular
            disease
  JOURNAL   J Hum Genet 66 (6), 625-636 (2021)
   PUBMED   33469137
  REMARK    GeneRIF: Variation in the SERPINA6/SERPINA1 locus alters morning
            plasma cortisol, hepatic corticosteroid binding globulin
            expression, gene expression in peripheral tissues, and risk of
            cardiovascular disease.
REFERENCE   5  (residues 1 to 405)
  AUTHORS   Meyer,E.J., Torpy,D.J., Chernykh,A., Thaysen-Andersen,M.,
            Nenke,M.A., Lewis,J.G., Rajapaksha,H., Rankin,W. and Polyak,S.W.
  TITLE     Pyrexia and acidosis act independently of neutrophil elastase
            reactive center loop cleavage to effect cortisol release from
            corticosteroid-binding globulin
  JOURNAL   Protein Sci 29 (12), 2495-2509 (2020)
   PUBMED   33085168
  REMARK    GeneRIF: Pyrexia and acidosis act independently of neutrophil
            elastase reactive center loop cleavage to effect cortisol release
            from corticosteroid-binding globulin.
REFERENCE   6  (residues 1 to 405)
  AUTHORS   Smith,C.L., Power,S.G. and Hammond,G.L.
  TITLE     A Leu----His substitution at residue 93 in human corticosteroid
            binding globulin results in reduced affinity for cortisol
  JOURNAL   J Steroid Biochem Mol Biol 42 (7), 671-676 (1992)
   PUBMED   1504007
REFERENCE   7  (residues 1 to 405)
  AUTHORS   Seralini,G.E., Berube,D., Gagne,R. and Hammond,G.L.
  TITLE     The human corticosteroid binding globulin gene is located on
            chromosome 14q31-q32.1 near two other serine protease inhibitor
            genes
  JOURNAL   Hum Genet 86 (1), 73-75 (1990)
   PUBMED   2253941
REFERENCE   8  (residues 1 to 405)
  AUTHORS   Brotherton,J.
  TITLE     Cortisol and transcortin in human seminal plasma and amniotic fluid
            as estimated by modern specific assays
  JOURNAL   Andrologia 22 (3), 197-204 (1990)
   PUBMED   2240617
REFERENCE   9  (residues 1 to 405)
  AUTHORS   Underhill,D.A. and Hammond,G.L.
  TITLE     Organization of the human corticosteroid binding globulin gene and
            analysis of its 5'-flanking region
  JOURNAL   Mol Endocrinol 3 (9), 1448-1454 (1989)
   PUBMED   2608068
REFERENCE   10 (residues 1 to 405)
  AUTHORS   Rosner,W., Beers,P.C., Awan,T. and Khan,M.S.
  TITLE     Identification of corticosteroid-binding globulin in human milk:
            measurement with a filter disk assay
  JOURNAL   J Clin Endocrinol Metab 42 (6), 1064-1073 (1976)
   PUBMED   932172
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL117259.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NP_001747.2.
            
            Summary: This gene encodes an alpha-globulin protein with
            corticosteroid-binding properties. This is the major transport
            protein for glucorticoids and progestins in the blood of most
            vertebrates. The gene localizes to a chromosomal region containing
            several closely related serine protease inhibitors which may have
            evolved by duplication events. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.100985.1,
                                           SRR5189664.110076.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000341584.4/ ENSP00000342850.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..405
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.13"
     Protein         1..405
                     /product="corticosteroid-binding globulin precursor"
                     /note="serine (or cysteine) proteinase inhibitor, clade A
                     (alpha-1 antiproteinase, antitrypsin), member 6;
                     transcortin; corticosteroid-binding globulin; serpin A6;
                     serpin peptidase inhibitor, clade A (alpha-1
                     antiproteinase, antitrypsin), member 6"
                     /calculated_mol_wt=42639
     sig_peptide     1..22
                     /inference="COORDINATES: ab initio prediction:SignalP:6.0"
                     /calculated_mol_wt=2520
     mat_peptide     23..405
                     /product="corticosteroid-binding globulin"
                     /calculated_mol_wt=42639
     Site            31
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:16335952; propagated from
                     UniProtKB/Swiss-Prot (P08185.1)"
     Region          33..404
                     /region_name="serpinA6_CBG"
                     /note="serpin family A member 6, corticosteroid-binding
                     globulin; cd19554"
                     /db_xref="CDD:381022"
     Site            order(40..41,44,254,262,264,282,285..286,289,388,390,393)
                     /site_type="other"
                     /note="cortisol binding site [polypeptide binding]"
                     /db_xref="CDD:381022"
     Site            96
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:14760718,
                     ECO:0000269|PubMed:16335952, ECO:0000269|PubMed:19159218;
                     propagated from UniProtKB/Swiss-Prot (P08185.1)"
     Site            176
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000255; propagated from
                     UniProtKB/Swiss-Prot (P08185.1)"
     Site            250
                     /site_type="other"
                     /note="Conserved cysteine within steroid binding domain;
                     propagated from UniProtKB/Swiss-Prot (P08185.1)"
     Site            260
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine; propagated from
                     UniProtKB/Swiss-Prot (P08185.1)"
     Site            330
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:16335952,
                     ECO:0000269|PubMed:19159218; propagated from
                     UniProtKB/Swiss-Prot (P08185.1)"
     Site            order(357..374,376..382)
                     /site_type="other"
                     /note="reactive center loop (RCL)"
                     /db_xref="CDD:381022"
     Site            369
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) asparagine.
                     /evidence=ECO:0000269|PubMed:16335952; propagated from
                     UniProtKB/Swiss-Prot (P08185.1)"
     CDS             1..405
                     /gene="SERPINA6"
                     /gene_synonym="CBG"
                     /coded_by="NM_001756.4:90..1307"
                     /db_xref="CCDS:CCDS9924.1"
                     /db_xref="GeneID:866"
                     /db_xref="HGNC:HGNC:1540"
                     /db_xref="MIM:122500"
ORIGIN      
        1 mplllytcll wlptsglwtv qamdpnaayv nmsnhhrgla sanvdfafsl ykhlvalspk
       61 knifispvsi smalamlslg tcghtraqll qglgfnlter seteihqgfq hlhqlfaksd
      121 tslemtmgna lfldgslell esfsadikhy yesevlamnf qdwatasrqi nsyvknktqg
      181 kivdlfsgld spailvlvny iffkgtwtqp fdlastreen fyvdettvvk vpmmlqssti
      241 sylhdselpc qlvqmnyvgn gtvffilpdk gkmntviaal srdtinrwsa gltssqvdly
      301 ipkvtisgvy dlgdvleemg iadlftnqan fsritqdaql ksskvvhkav lqlneegvdt
      361 agstgvtlnl tskpiilrfn qpfiimifdh ftwsslflar vmnpv
//
