LOCUS       NM_000624               2278 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens serpin family A member 5 (SERPINA5), mRNA.
ACCESSION   NM_000624
VERSION     NM_000624.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2278)
  AUTHORS   Matchett,B.J., Lincoln,S.J., Baker,M., Tamvaka,N., Labuzan,S.A.,
            Hicks Sirmans,T.N., Moloney,C.M., Helminger,J., Hinkle,K.M.,
            Cabrera-Rodriguez,J., Wickland,D.P., Johnson,P.W., Heckman,M.G.,
            Reddy,J.S., Younkin,S.G., Carrasquillo,M.M., Duara,R.,
            Graff-Radford,N.R., Pottier,C., Ertekin-Taner,N., Ross,O.A.,
            Rademakers,R., Dickson,D.W. and Murray,M.E.
  TITLE     The SERPINA5 coding variant E228Q does not contribute to
            clinicopathologic characteristics in Alzheimer's disease: A
            cross-sectional study
  JOURNAL   Medicine (Baltimore) 102 (24), e34017 (2023)
   PUBMED   37327267
  REMARK    GeneRIF: The SERPINA5 coding variant E228Q does not contribute to
            clinicopathologic characteristics in Alzheimer's disease: A
            cross-sectional study.
REFERENCE   2  (bases 1 to 2278)
  AUTHORS   Afsari,M., Fesahat,F., Talebi,A.R., Agarwal,A., Henkel,R., Zare,F.,
            Gul,M., Iraci,N., Cannarella,R., Makki,M., Anvari,M.,
            Sarcheshmeh,A.A. and Talebi,A.H.
  TITLE     ANXA2, SP17, SERPINA5, PRDX2 genes, and sperm DNA fragmentation
            differentially represented in male partners of infertile couples
            with normal and abnormal sperm parameters
  JOURNAL   Andrologia 54 (10), e14556 (2022)
   PUBMED   36177795
  REMARK    GeneRIF: ANXA2, SP17, SERPINA5, PRDX2 genes, and sperm DNA
            fragmentation differentially represented in male partners of
            infertile couples with normal and abnormal sperm parameters.
REFERENCE   3  (bases 1 to 2278)
  AUTHORS   Fan,M., Xiong,X., Han,L., Zhang,L., Gao,S., Liu,L., Wang,X.,
            Huang,C., Tong,D., Yang,J., Zhao,L. and Shao,Y.
  TITLE     SERPINA5 promotes tumour cell proliferation by modulating the
            PI3K/AKT/mTOR signalling pathway in gastric cancer
  JOURNAL   J Cell Mol Med 26 (18), 4837-4846 (2022)
   PUBMED   36000536
  REMARK    GeneRIF: SERPINA5 promotes tumour cell proliferation by modulating
            the PI3K/AKT/mTOR signalling pathway in gastric cancer.
REFERENCE   4  (bases 1 to 2278)
  AUTHORS   Hayashi,T. and Suzuki,K.
  TITLE     Gene organization of human protein C inhibitor, a member of SERPIN
            family proteins encoded in five exons
  JOURNAL   Int J Hematol 58 (3), 213-224 (1993)
   PUBMED   8148499
REFERENCE   5  (bases 1 to 2278)
  AUTHORS   Yasuda,T., Nadano,D., Iida,R., Tanaka,Y., Nakanaga,M. and Kishi,K.
  TITLE     Discovery of a genetic polymorphism of human plasma protein C
            inhibitor (PCI): genetic survey utilizing isoelectric focusing
            followed by immunoblotting, immunological and biochemical
            characterization
  JOURNAL   Hum Genet 89 (3), 265-269 (1992)
   PUBMED   1318261
REFERENCE   6  (bases 1 to 2278)
  AUTHORS   Laurell,M., Christensson,A., Abrahamsson,P.A., Stenflo,J. and
            Lilja,H.
  TITLE     Protein C inhibitor in human body fluids. Seminal plasma is rich in
            inhibitor antigen deriving from cells throughout the male
            reproductive system
  JOURNAL   J Clin Invest 89 (4), 1094-1101 (1992)
   PUBMED   1372913
REFERENCE   7  (bases 1 to 2278)
  AUTHORS   Espana,F., Gilabert,J., Estelles,A., Romeu,A., Aznar,J. and Cabo,A.
  TITLE     Functionally active protein C inhibitor/plasminogen activator
            inhibitor-3 (PCI/PAI-3) is secreted in seminal vesicles, occurs at
            high concentrations in human seminal plasma and complexes with
            prostate-specific antigen
  JOURNAL   Thromb Res 64 (3), 309-320 (1991)
   PUBMED   1725227
REFERENCE   8  (bases 1 to 2278)
  AUTHORS   Meijers,J.C. and Chung,D.W.
  TITLE     Organization of the gene coding for human protein C inhibitor
            (plasminogen activator inhibitor-3). Assignment of the gene to
            chromosome 14
  JOURNAL   J Biol Chem 266 (23), 15028-15034 (1991)
   PUBMED   1714450
REFERENCE   9  (bases 1 to 2278)
  AUTHORS   Laurell,M. and Stenflo,J.
  TITLE     Protein C inhibitor from human plasma: characterization of native
            and cleaved inhibitor and demonstration of inhibitor complexes with
            plasma kallikrein
  JOURNAL   Thromb Haemost 62 (3), 885-891 (1989)
   PUBMED   2556811
REFERENCE   10 (bases 1 to 2278)
  AUTHORS   Suzuki,K., Deyashiki,Y., Nishioka,J., Kurachi,K., Akira,M.,
            Yamamoto,S. and Hashimoto,S.
  TITLE     Characterization of a cDNA for human protein C inhibitor. A new
            member of the plasma serine protease inhibitor superfamily
  JOURNAL   J Biol Chem 262 (2), 611-616 (1987)
   PUBMED   3027058
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY003178.1, BC008915.2,
            DC394575.1, AK293192.1 and AI114432.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_000624.5.
            
            Summary: The protein encoded by this gene is a member of the serpin
            family of proteins, a group of proteins that inhibit serine
            proteases. This gene is one in a cluster of serpin genes located on
            the q arm of chromosome 14. This family member is a glycoprotein
            that can inhibit several serine proteases, including protein C and
            various plasminogen activators and kallikreins, and it thus plays
            diverse roles in hemostasis and thrombosis in multiple organs.
            [provided by RefSeq, Aug 2012].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189667.134082.1,
                                           SRR5189667.263624.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000329597.12/ ENSP00000333203.7
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-48                HY003178.1         58-105
            49-368              BC008915.2         1-320
            369-655             DC394575.1         286-572
            656-1284            BC008915.2         608-1236
            1285-1787           AK293192.1         1037-1539
            1788-2278           AI114432.1         138-628
FEATURES             Location/Qualifiers
     source          1..2278
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.13"
     gene            1..2278
                     /gene="SERPINA5"
                     /gene_synonym="PAI-3; PAI3; PCI; PCI-B; PLANH3; PROCI"
                     /note="serpin family A member 5"
                     /db_xref="GeneID:5104"
                     /db_xref="HGNC:HGNC:8723"
                     /db_xref="MIM:601841"
     exon            1..65
                     /gene="SERPINA5"
                     /gene_synonym="PAI-3; PAI3; PCI; PCI-B; PLANH3; PROCI"
                     /inference="alignment:Splign:2.1.0"
     exon            66..161
                     /gene="SERPINA5"
                     /gene_synonym="PAI-3; PAI3; PCI; PCI-B; PLANH3; PROCI"
                     /inference="alignment:Splign:2.1.0"
     exon            162..797
                     /gene="SERPINA5"
                     /gene_synonym="PAI-3; PAI3; PCI; PCI-B; PLANH3; PROCI"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..1399
                     /gene="SERPINA5"
                     /gene_synonym="PAI-3; PAI3; PCI; PCI-B; PLANH3; PROCI"
                     /note="serine (or cysteine) proteinase inhibitor, clade A
                     (alpha-1 antiproteinase, antitrypsin), member 5; plasma
                     serine protease inhibitor; serpin peptidase inhibitor,
                     clade A (alpha-1 antiproteinase, antitrypsin), member 5;
                     plasminogen activator inhibitor III; plasminogen activator
                     inhibitor-3; acrosomal serine protease inhibitor; protein
                     C inhibitor"
                     /codon_start=1
                     /product="plasma serine protease inhibitor preproprotein"
                     /protein_id="NP_000615.3"
                     /db_xref="CCDS:CCDS9928.1"
                     /db_xref="GeneID:5104"
                     /db_xref="HGNC:HGNC:8723"
                     /db_xref="MIM:601841"
                     /translation="MQLFLLLCLVLLSPQGASLHRHHPREMKKRVEDLHVGATVAPSS
                     RRDFTFDLYRALASAAPSQSIFFSPVSISMSLAMLSLGAGSSTKMQILEGLGLNLQKS
                     SEKELHRGFQQLLQELNQPRDGFQLSLGNALFTDLVVDLQDTFVSAMKTLYLADTFPT
                     NFRDSAGAMKQINDYVAKQTKGKIVDLLKNLDSNAVVIMVNYIFFKAKWETSFNHKGT
                     QEQDFYVTSETVVRVPMMSREDQYHYLLDRNLSCRVVGVPYQGNATALFILPSEGKMQ
                     QVENGLSEKTLRKWLKMFKKRQLELYLPKFSIEGSYQLEKVLPSLGISNVFTSHADLS
                     GISNHSNIQVSEMVHKAVVEVDESGTRAAAATGTIFTFRSARLNSQRLVFNRPFLMFI
                     VDNNILFLGKVNRP"
     exon            798..1068
                     /gene="SERPINA5"
                     /gene_synonym="PAI-3; PAI3; PCI; PCI-B; PLANH3; PROCI"
                     /inference="alignment:Splign:2.1.0"
     exon            1069..1216
                     /gene="SERPINA5"
                     /gene_synonym="PAI-3; PAI3; PCI; PCI-B; PLANH3; PROCI"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..2278
                     /gene="SERPINA5"
                     /gene_synonym="PAI-3; PAI3; PCI; PCI-B; PLANH3; PROCI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2256..2261
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERPINA5"
                     /gene_synonym="PAI-3; PAI3; PCI; PCI-B; PLANH3; PROCI"
                     /note="hexamer: AATAAA"
     polyA_site      2278
                     /gene="SERPINA5"
                     /gene_synonym="PAI-3; PAI3; PCI; PCI-B; PLANH3; PROCI"
                     /note="major polyA site"
ORIGIN      
        1 ctctgccctt tctgagcccg agggactgcc acctccactg tgtgcacact cagctacggg
       61 acacatttca ggtatccaag gcagcagagg tgagtgggtc ccccgagctc tgtgacctta
      121 tgctccacac taactctggc agagcctccg tttcctcata gaacaaagaa cagccaccat
      181 gcagctcttc ctcctcttgt gcctggtgct tctcagccct cagggggcct cccttcaccg
      241 ccaccacccc cgggagatga agaagagagt cgaggacctc catgtaggtg ccacggtggc
      301 ccccagcagc agaagggact ttacctttga cctctacagg gccttggctt ccgctgcccc
      361 cagccagagc atcttcttct cccctgtgag catctccatg agcctggcca tgctctccct
      421 gggggctggg tccagcacaa agatgcagat cctggagggc ctgggcctca acctccagaa
      481 aagctcagag aaggagctgc acagaggctt tcagcagctc cttcaggaac tcaaccagcc
      541 cagagatggc ttccagctga gcctcggcaa tgcccttttc accgacctgg tggtagacct
      601 gcaggacacc ttcgtaagtg ccatgaagac gctgtacctg gcagacactt tccctaccaa
      661 ctttagggac tctgcagggg ccatgaagca gatcaatgat tatgtggcaa agcaaacgaa
      721 gggcaagatt gtggacttgc ttaagaacct cgatagcaat gcggtcgtga tcatggtgaa
      781 ttacatcttc tttaaagcta agtgggagac aagcttcaac cacaaaggca cccaagagca
      841 agacttctac gtgacctcgg agactgtggt gcgggtaccc atgatgagcc gcgaggatca
      901 gtatcactac ctcctggacc ggaacctctc ctgcagggtg gtgggggtcc cctaccaagg
      961 caatgccacg gctttgttca ttctccccag tgagggaaag atgcagcagg tggagaatgg
     1021 actgagtgag aaaacgctga ggaagtggct taagatgttc aaaaagaggc agctcgagct
     1081 ttaccttccc aaattctcca ttgagggctc ctatcagctg gagaaagtcc tccccagtct
     1141 ggggatcagt aacgtcttca cctcccatgc tgatctgtcc ggcatcagca accactcaaa
     1201 tatccaggtg tctgagatgg tgcacaaagc tgtggtggag gtggacgagt cgggaaccag
     1261 agcagcggca gccacgggga caatattcac tttcaggtcg gcccgcctga actctcagag
     1321 gctagtgttc aacaggccct ttctgatgtt cattgtggat aacaacatcc tcttccttgg
     1381 caaagtgaac cgcccctgag gtggggcttc tcctgaaatc tacaggcctc agggtgggag
     1441 atgaaggggg ctaagctatg gcccatctgt atgctggtag ctagtgattt acacaggttt
     1501 agttgactaa tgaggcatta caaataatat tactctatga tgattgcttc cacccacacg
     1561 actgcaacat acaggtgcct tggggaaatg tggagaacat tcaatcttgc cgtcactatt
     1621 catcaatgaa gattaacact gagatccaga gaggctggat gacttgctca agttcaccag
     1681 catggtagtg gcaaagagag gtccagagtc ctggcccttg atgcccagct cagtgccaca
     1741 aagctcaata ggagggatgt tccagtggat gagggccacc aggaagcaca ggtccaaggc
     1801 tggtcccaca cttatcagca gcaacaactg tcagttcatc ctgcatggga aaaatgttgg
     1861 aatgggagtc tgaaatgggg ctactgtttc agtcctaatg tgctgtgtga cattgggaca
     1921 acactttccc tctctggacc tcagtttccc tctgtataca aggatcagat tcttgctgtg
     1981 acccaagaac tcctgaaatc atatagaaag gctggggtgg gccctgtcat tcgtggttga
     2041 tttcaataca ctcaagtgcc attcatcctt taagaaaaac atctggatat caaggtggaa
     2101 atggcccatt taatgattga ttatatcatt ttgtggatat agttataatc tgatgggcct
     2161 ggctgggagt ggaagaaggg aagccttttg caaatagtag agtatcagtt gcaggtgcca
     2221 atgactaact ttttgaattc tatgttggca ttaacaataa agcattttgc aaacactg
//
