LOCUS       NM_173850               2065 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens serpin family A member 12 (SERPINA12), transcript
            variant 1, mRNA.
ACCESSION   NM_173850
VERSION     NM_173850.4
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2065)
  AUTHORS   Jakubek-Kipa,K., Galiniak,S. and Mazur,A.
  TITLE     Progranulin and Vaspin as Potential Novel Markers in the Etiology
            of Type 1 Diabetes in Children
  JOURNAL   Medicina (Kaunas) 60 (7), 1165 (2024)
   PUBMED   39064594
  REMARK    GeneRIF: Progranulin and Vaspin as Potential Novel Markers in the
            Etiology of Type 1 Diabetes in Children.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2065)
  AUTHORS   Liu,Y., Liu,J., Chen,Y., Mo,R., Xiang,R., Song,Z., Yang,Y. and
            Chen,Z.
  TITLE     Potential digenic inheritance of SERPINB7 and SERPINA12 variants in
            Chinese patients with Nagashima-type palmoplantar keratosis
  JOURNAL   Br J Dermatol 191 (1), 136-138 (2024)
   PUBMED   38529670
  REMARK    GeneRIF: Potential digenic inheritance of SERPINB7 and SERPINA12
            variants in Chinese patients with Nagashima-type palmoplantar
            keratosis.
REFERENCE   3  (bases 1 to 2065)
  AUTHORS   Tindall,C.A., Mohlis,K., Rapohn,I., Dommel,S., Riedl,V.,
            Schneekonig,M., Hofling,C., Rossner,S., Stichel,J.,
            Beck-Sickinger,A.G., Weiner,J. and Heiker,J.T.
  TITLE     LRP1 is the cell-surface endocytosis receptor for vaspin in
            adipocytes
  JOURNAL   FEBS J 291 (10), 2134-2154 (2024)
   PUBMED   37921063
  REMARK    GeneRIF: LRP1 is the cell-surface endocytosis receptor for vaspin
            in adipocytes.
REFERENCE   4  (bases 1 to 2065)
  AUTHORS   Al-Barwani,R. and Sarhat,E.
  TITLE     BREAST CANCER-MODULATED OMENTIN AND VASPIN PLASMA LEVELS
  JOURNAL   Georgian Med News (347), 66-69 (2024)
   PUBMED   38609116
  REMARK    GeneRIF: BREAST CANCER-MODULATED OMENTIN AND VASPIN PLASMA LEVELS.
REFERENCE   5  (bases 1 to 2065)
  AUTHORS   Zhou,B., Liu,Y., Ren,Y., Yan,X., Fan,J., Tang,L. and Wen,M.
  TITLE     Serum Vaspin Levels in Gestational Diabetes Mellitus: A
            Meta-Analysis
  JOURNAL   Metab Syndr Relat Disord 21 (10), 535-544 (2023)
   PUBMED   37883666
  REMARK    GeneRIF: Serum Vaspin Levels in Gestational Diabetes Mellitus: A
            Meta-Analysis.
            Review article
REFERENCE   6  (bases 1 to 2065)
  AUTHORS   Tan,B.K., Heutling,D., Chen,J., Farhatullah,S., Adya,R., Keay,S.D.,
            Kennedy,C.R., Lehnert,H. and Randeva,H.S.
  TITLE     Metformin decreases the adipokine vaspin in overweight women with
            polycystic ovary syndrome concomitant with improvement in insulin
            sensitivity and a decrease in insulin resistance
  JOURNAL   Diabetes 57 (6), 1501-1507 (2008)
   PUBMED   18375437
  REMARK    GeneRIF: Elevated serum and omental adipose tissue levels of vaspin
            in overweight polycystic ovary syndrome women and ex vivo
            regulation of vaspin expression.
REFERENCE   7  (bases 1 to 2065)
  AUTHORS   Youn,B.S., Kloting,N., Kratzsch,J., Lee,N., Park,J.W., Song,E.S.,
            Ruschke,K., Oberbach,A., Fasshauer,M., Stumvoll,M. and Bluher,M.
  TITLE     Serum vaspin concentrations in human obesity and type 2 diabetes
  JOURNAL   Diabetes 57 (2), 372-377 (2008)
   PUBMED   17991760
  REMARK    GeneRIF: Low circulating vaspin correlates with a high fitness
            level, whereas physical training in untrained individuals causes
            increased vaspin serum concentrations.
REFERENCE   8  (bases 1 to 2065)
  AUTHORS   Kloting,N., Berndt,J., Kralisch,S., Kovacs,P., Fasshauer,M.,
            Schon,M.R., Stumvoll,M. and Bluher,M.
  TITLE     Vaspin gene expression in human adipose tissue: association with
            obesity and type 2 diabetes
  JOURNAL   Biochem Biophys Res Commun 339 (1), 430-436 (2006)
   PUBMED   16298335
  REMARK    GeneRIF: Induction of human vaspin mRNA expression in adipose
            tissue is regulated in a fat depot-specific manner and could be
            associated with parameters of obesity, insulin resistance, and
            glucose metabolism.
REFERENCE   9  (bases 1 to 2065)
  AUTHORS   Hida,K., Wada,J., Eguchi,J., Zhang,H., Baba,M., Seida,A.,
            Hashimoto,I., Okada,T., Yasuhara,A., Nakatsuka,A., Shikata,K.,
            Hourai,S., Futami,J., Watanabe,E., Matsuki,Y., Hiramatsu,R.,
            Akagi,S., Makino,H. and Kanwar,Y.S.
  TITLE     Visceral adipose tissue-derived serine protease inhibitor: a unique
            insulin-sensitizing adipocytokine in obesity
  JOURNAL   Proc Natl Acad Sci U S A 102 (30), 10610-10615 (2005)
   PUBMED   16030142
REFERENCE   10 (bases 1 to 2065)
  AUTHORS   Namciu,S.J., Friedman,R.D., Marsden,M.D., Sarausad,L.M.,
            Jasoni,C.L. and Fournier,R.E.
  TITLE     Sequence organization and matrix attachment regions of the human
            serine protease inhibitor gene cluster at 14q32.1
  JOURNAL   Mamm Genome 15 (3), 162-178 (2004)
   PUBMED   15014966
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC040857.1, AL132990.4 and AL132708.3.
            
            On Jun 2, 2019 this sequence version replaced NM_173850.3.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC040857.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA2145893
                                           [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-274               BC040857.1         1-274
            275-388             AL132990.4         106612-106725       c
            389-2061            BC040857.1         389-2061
            2062-2065           AL132708.3         29371-29374
FEATURES             Location/Qualifiers
     source          1..2065
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.13"
     gene            1..2065
                     /gene="SERPINA12"
                     /gene_synonym="OL-64"
                     /note="serpin family A member 12"
                     /db_xref="GeneID:145264"
                     /db_xref="HGNC:HGNC:18359"
                     /db_xref="MIM:617471"
     exon            1..444
                     /gene="SERPINA12"
                     /gene_synonym="OL-64"
                     /inference="alignment:Splign:2.1.0"
     exon            445..779
                     /gene="SERPINA12"
                     /gene_synonym="OL-64"
                     /inference="alignment:Splign:2.1.0"
     exon            780..1430
                     /gene="SERPINA12"
                     /gene_synonym="OL-64"
                     /inference="alignment:Splign:2.1.0"
     CDS             797..2041
                     /gene="SERPINA12"
                     /gene_synonym="OL-64"
                     /note="visceral adipose-specific SERPIN; serine (or
                     cysteine) proteinase inhibitor, clade A (alpha-1
                     antiproteinase, antitrypsin), member 12; vaspin; visceral
                     adipose tissue-derived serine protease inhibitor; serpin
                     peptidase inhibitor, clade A (alpha-1 antiproteinase,
                     antitrypsin), member 12"
                     /codon_start=1
                     /product="serpin A12 precursor"
                     /protein_id="NP_776249.1"
                     /db_xref="CCDS:CCDS9926.1"
                     /db_xref="GeneID:145264"
                     /db_xref="HGNC:HGNC:18359"
                     /db_xref="MIM:617471"
                     /translation="MNPTLGLAIFLAVLLTVKGLLKPSFSPRNYKALSEVQGWKQRMA
                     AKELARQNMDLGFKLLKKLAFYNPGRNIFLSPLSISTAFSMLCLGAQDSTLDEIKQGF
                     NFRKMPEKDLHEGFHYIIHELTQKTQDLKLSIGNTLFIDQRLQPQRKFLEDAKNFYSA
                     ETILTNFQNLEMAQKQINDFISQKTHGKINNLIENIDPGTVMLLANYIFFRARWKHEF
                     DPNVTKEEDFFLEKNSSVKVPMMFRSGIYQVGYDDKLSCTILEIPYQKNITAIFILPD
                     EGKLKHLEKGLQVDTFSRWKTLLSRRVVDVSVPRLHMTGTFDLKKTLSYIGVSKIFEE
                     HGDLTKIAPHRSLKVGEAVHKAELKMDERGTEGAAGTGAQTLPMETPLVVKIDKPYLL
                     LIYSEKIPSVLFLGKIVNPIGK"
     exon            1431..1701
                     /gene="SERPINA12"
                     /gene_synonym="OL-64"
                     /inference="alignment:Splign:2.1.0"
     exon            1702..1849
                     /gene="SERPINA12"
                     /gene_synonym="OL-64"
                     /inference="alignment:Splign:2.1.0"
     exon            1850..2065
                     /gene="SERPINA12"
                     /gene_synonym="OL-64"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2037..2042
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERPINA12"
                     /gene_synonym="OL-64"
                     /note="hexamer: AATAAA"
     polyA_site      2065
                     /gene="SERPINA12"
                     /gene_synonym="OL-64"
                     /note="major polyA site"
ORIGIN      
        1 ctcccaggtg cctggcagag agtcctcacc agccccctgc cggatgtctg gctggcatct
       61 gaggggactg aacatggcaa gaagcaaaac agcagcacaa gaaaccagtt tcttcatctg
      121 aaaccgagca ggctctactc cagaacagaa cccacagtcc caggcgctgg gccttcttct
      181 taagttggga aatcactcat ccccaggaga aaaaaagagc aaaagcttcc agtactgggg
      241 atgtggggag aggtttttta aaaatatcag cccaacatat gggaaaatat gggatgcagg
      301 catccccagg tgtcaagcgt ccagatccgt agacacactg ggacgatggt gatcagtatc
      361 actccctctg actcatcggc cctacaggga agacaccatg ctggtgcaca gtcggtgcca
      421 aacccgcgtt tgtaaatgaa taagtgttgc tgccctggtg gaagcccagc tcatgtggag
      481 gaagccagct tgcagagaga gcaagaacag agccagcaca cacattggag caaaggcaag
      541 ggcagatgga aagttctggc ggcatcatgc caaggctccc atccgaggcc tccctgaacc
      601 ccactctctc ggcgccacct tggatgctgc gggctggtac attccccact tgcaaaactc
      661 tgtggggctg ggttcctctc ttttctttcc aaatatccca ggaagtggat ggttttatcc
      721 aaattcagca gacgagtaaa aagagtcttc gggaggtgca atagctttct aggaatgagg
      781 atattcttca aggaaaatga accccacact aggcctggcc atttttctgg ctgttctcct
      841 cacggtgaaa ggtcttctaa agccgagctt ctcaccaagg aattataaag ctttgagcga
      901 ggtccaagga tggaagcaaa ggatggcagc caaggagctt gcaaggcaga acatggactt
      961 aggctttaag ctgctcaaga agctggcctt ttacaaccct ggcaggaaca tcttcctatc
     1021 ccccttgagc atctctacag ctttctccat gctgtgcctg ggtgcccagg acagcaccct
     1081 ggacgagatc aagcaggggt tcaacttcag aaagatgcca gaaaaagatc ttcatgaggg
     1141 cttccattac atcatccacg agctgaccca gaagacccag gacctcaaac tgagcattgg
     1201 gaacacgctg ttcattgacc agaggctgca gccacagcgt aagtttttgg aagatgccaa
     1261 gaacttttac agtgccgaaa ccatccttac caactttcag aatttggaaa tggctcagaa
     1321 gcagatcaat gactttatca gtcaaaaaac ccatgggaaa attaacaacc tgatcgagaa
     1381 tatagacccc ggcactgtga tgcttcttgc aaattatatt ttctttcgag ccaggtggaa
     1441 acatgagttt gatccaaatg taactaaaga ggaagatttc tttctggaga aaaacagttc
     1501 agtcaaggtg cccatgatgt tccgtagtgg catataccaa gttggctatg acgataagct
     1561 ctcttgcacc atcctggaaa taccctacca gaaaaatatc acagccatct tcatccttcc
     1621 tgatgagggc aagctgaagc acttggagaa gggattgcag gtggacactt tctccagatg
     1681 gaaaacatta ctgtcacgca gggtcgtaga cgtgtctgta cccagactcc acatgacggg
     1741 caccttcgac ctgaagaaga ctctctccta cataggtgtc tccaaaatct ttgaggaaca
     1801 tggtgatctc accaagatcg cccctcatcg cagcctgaaa gtgggcgagg ctgtgcacaa
     1861 ggctgagctg aagatggatg agaggggtac ggaaggggcc gctggcaccg gagcacagac
     1921 tctgcccatg gagacaccac tcgtcgtcaa gatagacaaa ccctatctgc tgctgattta
     1981 cagcgagaaa ataccttccg tgctcttcct gggaaagatt gttaacccta ttggaaaata
     2041 aaggagaatt cctgcttgcc acaga
//
