LOCUS       NM_001382267            1430 bp    mRNA    linear   PRI 01-OCT-2024
DEFINITION  Homo sapiens serpin family A member 12 (SERPINA12), transcript
            variant 3, mRNA.
ACCESSION   NM_001382267 XM_011536451
VERSION     NM_001382267.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1430)
  AUTHORS   Jakubek-Kipa,K., Galiniak,S. and Mazur,A.
  TITLE     Progranulin and Vaspin as Potential Novel Markers in the Etiology
            of Type 1 Diabetes in Children
  JOURNAL   Medicina (Kaunas) 60 (7), 1165 (2024)
   PUBMED   39064594
  REMARK    GeneRIF: Progranulin and Vaspin as Potential Novel Markers in the
            Etiology of Type 1 Diabetes in Children.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1430)
  AUTHORS   Liu,Y., Liu,J., Chen,Y., Mo,R., Xiang,R., Song,Z., Yang,Y. and
            Chen,Z.
  TITLE     Potential digenic inheritance of SERPINB7 and SERPINA12 variants in
            Chinese patients with Nagashima-type palmoplantar keratosis
  JOURNAL   Br J Dermatol 191 (1), 136-138 (2024)
   PUBMED   38529670
  REMARK    GeneRIF: Potential digenic inheritance of SERPINB7 and SERPINA12
            variants in Chinese patients with Nagashima-type palmoplantar
            keratosis.
REFERENCE   3  (bases 1 to 1430)
  AUTHORS   Tindall,C.A., Mohlis,K., Rapohn,I., Dommel,S., Riedl,V.,
            Schneekonig,M., Hofling,C., Rossner,S., Stichel,J.,
            Beck-Sickinger,A.G., Weiner,J. and Heiker,J.T.
  TITLE     LRP1 is the cell-surface endocytosis receptor for vaspin in
            adipocytes
  JOURNAL   FEBS J 291 (10), 2134-2154 (2024)
   PUBMED   37921063
  REMARK    GeneRIF: LRP1 is the cell-surface endocytosis receptor for vaspin
            in adipocytes.
REFERENCE   4  (bases 1 to 1430)
  AUTHORS   Al-Barwani,R. and Sarhat,E.
  TITLE     BREAST CANCER-MODULATED OMENTIN AND VASPIN PLASMA LEVELS
  JOURNAL   Georgian Med News (347), 66-69 (2024)
   PUBMED   38609116
  REMARK    GeneRIF: BREAST CANCER-MODULATED OMENTIN AND VASPIN PLASMA LEVELS.
REFERENCE   5  (bases 1 to 1430)
  AUTHORS   Zhou,B., Liu,Y., Ren,Y., Yan,X., Fan,J., Tang,L. and Wen,M.
  TITLE     Serum Vaspin Levels in Gestational Diabetes Mellitus: A
            Meta-Analysis
  JOURNAL   Metab Syndr Relat Disord 21 (10), 535-544 (2023)
   PUBMED   37883666
  REMARK    GeneRIF: Serum Vaspin Levels in Gestational Diabetes Mellitus: A
            Meta-Analysis.
            Review article
REFERENCE   6  (bases 1 to 1430)
  AUTHORS   Tan,B.K., Heutling,D., Chen,J., Farhatullah,S., Adya,R., Keay,S.D.,
            Kennedy,C.R., Lehnert,H. and Randeva,H.S.
  TITLE     Metformin decreases the adipokine vaspin in overweight women with
            polycystic ovary syndrome concomitant with improvement in insulin
            sensitivity and a decrease in insulin resistance
  JOURNAL   Diabetes 57 (6), 1501-1507 (2008)
   PUBMED   18375437
  REMARK    GeneRIF: Elevated serum and omental adipose tissue levels of vaspin
            in overweight polycystic ovary syndrome women and ex vivo
            regulation of vaspin expression.
REFERENCE   7  (bases 1 to 1430)
  AUTHORS   Youn,B.S., Kloting,N., Kratzsch,J., Lee,N., Park,J.W., Song,E.S.,
            Ruschke,K., Oberbach,A., Fasshauer,M., Stumvoll,M. and Bluher,M.
  TITLE     Serum vaspin concentrations in human obesity and type 2 diabetes
  JOURNAL   Diabetes 57 (2), 372-377 (2008)
   PUBMED   17991760
  REMARK    GeneRIF: Low circulating vaspin correlates with a high fitness
            level, whereas physical training in untrained individuals causes
            increased vaspin serum concentrations.
REFERENCE   8  (bases 1 to 1430)
  AUTHORS   Kloting,N., Berndt,J., Kralisch,S., Kovacs,P., Fasshauer,M.,
            Schon,M.R., Stumvoll,M. and Bluher,M.
  TITLE     Vaspin gene expression in human adipose tissue: association with
            obesity and type 2 diabetes
  JOURNAL   Biochem Biophys Res Commun 339 (1), 430-436 (2006)
   PUBMED   16298335
  REMARK    GeneRIF: Induction of human vaspin mRNA expression in adipose
            tissue is regulated in a fat depot-specific manner and could be
            associated with parameters of obesity, insulin resistance, and
            glucose metabolism.
REFERENCE   9  (bases 1 to 1430)
  AUTHORS   Hida,K., Wada,J., Eguchi,J., Zhang,H., Baba,M., Seida,A.,
            Hashimoto,I., Okada,T., Yasuhara,A., Nakatsuka,A., Shikata,K.,
            Hourai,S., Futami,J., Watanabe,E., Matsuki,Y., Hiramatsu,R.,
            Akagi,S., Makino,H. and Kanwar,Y.S.
  TITLE     Visceral adipose tissue-derived serine protease inhibitor: a unique
            insulin-sensitizing adipocytokine in obesity
  JOURNAL   Proc Natl Acad Sci U S A 102 (30), 10610-10615 (2005)
   PUBMED   16030142
REFERENCE   10 (bases 1 to 1430)
  AUTHORS   Namciu,S.J., Friedman,R.D., Marsden,M.D., Sarausad,L.M.,
            Jasoni,C.L. and Fournier,R.E.
  TITLE     Sequence organization and matrix attachment regions of the human
            serine protease inhibitor gene cluster at 14q32.1
  JOURNAL   Mamm Genome 15 (3), 162-178 (2004)
   PUBMED   15014966
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL132708.3.
            
            On Apr 28, 2020 this sequence version replaced XM_011536451.3.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138522.617298.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000677451.1/ ENSP00000503935.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-128               AL132708.3         7184-7311
            129-795             AL132708.3         18223-18889
            796-1066            AL132708.3         20010-20280
            1067-1214           AL132708.3         26886-27033
            1215-1430           AL132708.3         29159-29374
FEATURES             Location/Qualifiers
     source          1..1430
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.13"
     gene            1..1430
                     /gene="SERPINA12"
                     /gene_synonym="OL-64"
                     /note="serpin family A member 12"
                     /db_xref="GeneID:145264"
                     /db_xref="HGNC:HGNC:18359"
                     /db_xref="MIM:617471"
     exon            1..128
                     /gene="SERPINA12"
                     /gene_synonym="OL-64"
                     /inference="alignment:Splign:2.1.0"
     exon            129..795
                     /gene="SERPINA12"
                     /gene_synonym="OL-64"
                     /inference="alignment:Splign:2.1.0"
     CDS             162..1406
                     /gene="SERPINA12"
                     /gene_synonym="OL-64"
                     /note="visceral adipose-specific SERPIN; serine (or
                     cysteine) proteinase inhibitor, clade A (alpha-1
                     antiproteinase, antitrypsin), member 12; vaspin; visceral
                     adipose tissue-derived serine protease inhibitor; serpin
                     peptidase inhibitor, clade A (alpha-1 antiproteinase,
                     antitrypsin), member 12"
                     /codon_start=1
                     /product="serpin A12 precursor"
                     /protein_id="NP_001369196.1"
                     /db_xref="CCDS:CCDS9926.1"
                     /db_xref="GeneID:145264"
                     /db_xref="HGNC:HGNC:18359"
                     /db_xref="MIM:617471"
                     /translation="MNPTLGLAIFLAVLLTVKGLLKPSFSPRNYKALSEVQGWKQRMA
                     AKELARQNMDLGFKLLKKLAFYNPGRNIFLSPLSISTAFSMLCLGAQDSTLDEIKQGF
                     NFRKMPEKDLHEGFHYIIHELTQKTQDLKLSIGNTLFIDQRLQPQRKFLEDAKNFYSA
                     ETILTNFQNLEMAQKQINDFISQKTHGKINNLIENIDPGTVMLLANYIFFRARWKHEF
                     DPNVTKEEDFFLEKNSSVKVPMMFRSGIYQVGYDDKLSCTILEIPYQKNITAIFILPD
                     EGKLKHLEKGLQVDTFSRWKTLLSRRVVDVSVPRLHMTGTFDLKKTLSYIGVSKIFEE
                     HGDLTKIAPHRSLKVGEAVHKAELKMDERGTEGAAGTGAQTLPMETPLVVKIDKPYLL
                     LIYSEKIPSVLFLGKIVNPIGK"
     exon            796..1066
                     /gene="SERPINA12"
                     /gene_synonym="OL-64"
                     /inference="alignment:Splign:2.1.0"
     exon            1067..1214
                     /gene="SERPINA12"
                     /gene_synonym="OL-64"
                     /inference="alignment:Splign:2.1.0"
     exon            1215..1430
                     /gene="SERPINA12"
                     /gene_synonym="OL-64"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1402..1407
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERPINA12"
                     /gene_synonym="OL-64"
                     /note="hexamer: AATAAA"
     polyA_site      1430
                     /gene="SERPINA12"
                     /gene_synonym="OL-64"
                     /note="major polyA site"
ORIGIN      
        1 ggaacatacc tggaacctga aggctgcagg accaggaccg aaaaaggact aggaggctgg
       61 gatcagcaac aactggggaa ggccaaggaa gactgacctg aggggaaagg agaaactggg
      121 gaggtgaggt ctactactca acaggatatt cttcaaggaa aatgaacccc acactaggcc
      181 tggccatttt tctggctgtt ctcctcacgg tgaaaggtct tctaaagccg agcttctcac
      241 caaggaatta taaagctttg agcgaggtcc aaggatggaa gcaaaggatg gcagccaagg
      301 agcttgcaag gcagaacatg gacttaggct ttaagctgct caagaagctg gccttttaca
      361 accctggcag gaacatcttc ctatccccct tgagcatctc tacagctttc tccatgctgt
      421 gcctgggtgc ccaggacagc accctggacg agatcaagca ggggttcaac ttcagaaaga
      481 tgccagaaaa agatcttcat gagggcttcc attacatcat ccacgagctg acccagaaga
      541 cccaggacct caaactgagc attgggaaca cgctgttcat tgaccagagg ctgcagccac
      601 agcgtaagtt tttggaagat gccaagaact tttacagtgc cgaaaccatc cttaccaact
      661 ttcagaattt ggaaatggct cagaagcaga tcaatgactt tatcagtcaa aaaacccatg
      721 ggaaaattaa caacctgatc gagaatatag accccggcac tgtgatgctt cttgcaaatt
      781 atattttctt tcgagccagg tggaaacatg agtttgatcc aaatgtaact aaagaggaag
      841 atttctttct ggagaaaaac agttcagtca aggtgcccat gatgttccgt agtggcatat
      901 accaagttgg ctatgacgat aagctctctt gcaccatcct ggaaataccc taccagaaaa
      961 atatcacagc catcttcatc cttcctgatg agggcaagct gaagcacttg gagaagggat
     1021 tgcaggtgga cactttctcc agatggaaaa cattactgtc acgcagggtc gtagacgtgt
     1081 ctgtacccag actccacatg acgggcacct tcgacctgaa gaagactctc tcctacatag
     1141 gtgtctccaa aatctttgag gaacatggtg atctcaccaa gatcgcccct catcgcagcc
     1201 tgaaagtggg cgaggctgtg cacaaggctg agctgaagat ggatgagagg ggtacggaag
     1261 gggccgctgg caccggagca cagactctgc ccatggagac accactcgtc gtcaagatag
     1321 acaaacccta tctgctgctg atttacagcg agaaaatacc ttccgtgctc ttcctgggaa
     1381 agattgttaa ccctattgga aaataaagga gaattcctgc ttgccacaga
//
