LOCUS       NP_001369196             414 aa            linear   PRI 30-APR-2025
DEFINITION  serpin A12 precursor [Homo sapiens].
ACCESSION   NP_001369196 XP_011534753
VERSION     NP_001369196.1
DBSOURCE    REFSEQ: accession NM_001382267.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 414)
  AUTHORS   Jakubek-Kipa,K., Galiniak,S. and Mazur,A.
  TITLE     Progranulin and Vaspin as Potential Novel Markers in the Etiology
            of Type 1 Diabetes in Children
  JOURNAL   Medicina (Kaunas) 60 (7), 1165 (2024)
   PUBMED   39064594
  REMARK    GeneRIF: Progranulin and Vaspin as Potential Novel Markers in the
            Etiology of Type 1 Diabetes in Children.
            Publication Status: Online-Only
REFERENCE   2  (residues 1 to 414)
  AUTHORS   Liu,Y., Liu,J., Chen,Y., Mo,R., Xiang,R., Song,Z., Yang,Y. and
            Chen,Z.
  TITLE     Potential digenic inheritance of SERPINB7 and SERPINA12 variants in
            Chinese patients with Nagashima-type palmoplantar keratosis
  JOURNAL   Br J Dermatol 191 (1), 136-138 (2024)
   PUBMED   38529670
  REMARK    GeneRIF: Potential digenic inheritance of SERPINB7 and SERPINA12
            variants in Chinese patients with Nagashima-type palmoplantar
            keratosis.
REFERENCE   3  (residues 1 to 414)
  AUTHORS   Tindall,C.A., Mohlis,K., Rapohn,I., Dommel,S., Riedl,V.,
            Schneekonig,M., Hofling,C., Rossner,S., Stichel,J.,
            Beck-Sickinger,A.G., Weiner,J. and Heiker,J.T.
  TITLE     LRP1 is the cell-surface endocytosis receptor for vaspin in
            adipocytes
  JOURNAL   FEBS J 291 (10), 2134-2154 (2024)
   PUBMED   37921063
  REMARK    GeneRIF: LRP1 is the cell-surface endocytosis receptor for vaspin
            in adipocytes.
REFERENCE   4  (residues 1 to 414)
  AUTHORS   Al-Barwani,R. and Sarhat,E.
  TITLE     BREAST CANCER-MODULATED OMENTIN AND VASPIN PLASMA LEVELS
  JOURNAL   Georgian Med News (347), 66-69 (2024)
   PUBMED   38609116
  REMARK    GeneRIF: BREAST CANCER-MODULATED OMENTIN AND VASPIN PLASMA LEVELS.
REFERENCE   5  (residues 1 to 414)
  AUTHORS   Zhou,B., Liu,Y., Ren,Y., Yan,X., Fan,J., Tang,L. and Wen,M.
  TITLE     Serum Vaspin Levels in Gestational Diabetes Mellitus: A
            Meta-Analysis
  JOURNAL   Metab Syndr Relat Disord 21 (10), 535-544 (2023)
   PUBMED   37883666
  REMARK    GeneRIF: Serum Vaspin Levels in Gestational Diabetes Mellitus: A
            Meta-Analysis.
            Review article
REFERENCE   6  (residues 1 to 414)
  AUTHORS   Tan,B.K., Heutling,D., Chen,J., Farhatullah,S., Adya,R., Keay,S.D.,
            Kennedy,C.R., Lehnert,H. and Randeva,H.S.
  TITLE     Metformin decreases the adipokine vaspin in overweight women with
            polycystic ovary syndrome concomitant with improvement in insulin
            sensitivity and a decrease in insulin resistance
  JOURNAL   Diabetes 57 (6), 1501-1507 (2008)
   PUBMED   18375437
  REMARK    GeneRIF: Elevated serum and omental adipose tissue levels of vaspin
            in overweight polycystic ovary syndrome women and ex vivo
            regulation of vaspin expression.
REFERENCE   7  (residues 1 to 414)
  AUTHORS   Youn,B.S., Kloting,N., Kratzsch,J., Lee,N., Park,J.W., Song,E.S.,
            Ruschke,K., Oberbach,A., Fasshauer,M., Stumvoll,M. and Bluher,M.
  TITLE     Serum vaspin concentrations in human obesity and type 2 diabetes
  JOURNAL   Diabetes 57 (2), 372-377 (2008)
   PUBMED   17991760
  REMARK    GeneRIF: Low circulating vaspin correlates with a high fitness
            level, whereas physical training in untrained individuals causes
            increased vaspin serum concentrations.
REFERENCE   8  (residues 1 to 414)
  AUTHORS   Kloting,N., Berndt,J., Kralisch,S., Kovacs,P., Fasshauer,M.,
            Schon,M.R., Stumvoll,M. and Bluher,M.
  TITLE     Vaspin gene expression in human adipose tissue: association with
            obesity and type 2 diabetes
  JOURNAL   Biochem Biophys Res Commun 339 (1), 430-436 (2006)
   PUBMED   16298335
  REMARK    GeneRIF: Induction of human vaspin mRNA expression in adipose
            tissue is regulated in a fat depot-specific manner and could be
            associated with parameters of obesity, insulin resistance, and
            glucose metabolism.
REFERENCE   9  (residues 1 to 414)
  AUTHORS   Hida,K., Wada,J., Eguchi,J., Zhang,H., Baba,M., Seida,A.,
            Hashimoto,I., Okada,T., Yasuhara,A., Nakatsuka,A., Shikata,K.,
            Hourai,S., Futami,J., Watanabe,E., Matsuki,Y., Hiramatsu,R.,
            Akagi,S., Makino,H. and Kanwar,Y.S.
  TITLE     Visceral adipose tissue-derived serine protease inhibitor: a unique
            insulin-sensitizing adipocytokine in obesity
  JOURNAL   Proc Natl Acad Sci U S A 102 (30), 10610-10615 (2005)
   PUBMED   16030142
REFERENCE   10 (residues 1 to 414)
  AUTHORS   Namciu,S.J., Friedman,R.D., Marsden,M.D., Sarausad,L.M.,
            Jasoni,C.L. and Fournier,R.E.
  TITLE     Sequence organization and matrix attachment regions of the human
            serine protease inhibitor gene cluster at 14q32.1
  JOURNAL   Mamm Genome 15 (3), 162-178 (2004)
   PUBMED   15014966
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL132708.3.
            
            On Apr 28, 2020 this sequence version replaced XP_011534753.1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: DRR138522.617298.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2145893 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000677451.1/ ENSP00000503935.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..414
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.13"
     Protein         1..414
                     /product="serpin A12 precursor"
                     /note="visceral adipose-specific SERPIN; serine (or
                     cysteine) proteinase inhibitor, clade A (alpha-1
                     antiproteinase, antitrypsin), member 12; vaspin; visceral
                     adipose tissue-derived serine protease inhibitor; serpin
                     peptidase inhibitor, clade A (alpha-1 antiproteinase,
                     antitrypsin), member 12"
                     /calculated_mol_wt=45109
     sig_peptide     1..20
                     /note="/evidence=ECO:0000250; propagated from
                     UniProtKB/Swiss-Prot (Q8IW75.1)"
                     /calculated_mol_wt=2085
     mat_peptide     21..414
                     /product="Serpin A12. /id=PRO_0000041976"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IW75.1)"
                     /calculated_mol_wt=45109
     Region          40..411
                     /region_name="serpinA12_vaspin"
                     /note="serpin family A member 12, visceral adipose
                     tissue-derived serpin; cd19558"
                     /db_xref="CDD:381026"
     Site            221
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) (complex) asparagine.
                     /evidence=ECO:0000269|PubMed:28668641; propagated from
                     UniProtKB/Swiss-Prot (Q8IW75.1)"
     Site            233
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) (complex) asparagine.
                     /evidence=ECO:0000269|PubMed:28668641; propagated from
                     UniProtKB/Swiss-Prot (Q8IW75.1)"
     Site            267
                     /site_type="glycosylation"
                     /note="N-linked (GlcNAc...) (high mannose) asparagine.
                     /evidence=ECO:0000269|PubMed:28668641; propagated from
                     UniProtKB/Swiss-Prot (Q8IW75.1)"
     Site            364..389
                     /site_type="other"
                     /note="reactive center loop (RCL)"
                     /db_xref="CDD:381026"
     Region          364..382
                     /region_name="Reactive center loop.
                     /evidence=ECO:0000269|PubMed:26529565,
                     ECO:0000305|PubMed:23370777, ECO:0000305|PubMed:26199422"
                     /note="propagated from UniProtKB/Swiss-Prot (Q8IW75.1)"
     Site            378..379
                     /site_type="cleavage"
                     /note="Cleavage. /evidence=ECO:0000269|PubMed:26529565;
                     propagated from UniProtKB/Swiss-Prot (Q8IW75.1)"
     CDS             1..414
                     /gene="SERPINA12"
                     /gene_synonym="OL-64"
                     /coded_by="NM_001382267.1:162..1406"
                     /db_xref="CCDS:CCDS9926.1"
                     /db_xref="GeneID:145264"
                     /db_xref="HGNC:HGNC:18359"
                     /db_xref="MIM:617471"
ORIGIN      
        1 mnptlglaif lavlltvkgl lkpsfsprny kalsevqgwk qrmaakelar qnmdlgfkll
       61 kklafynpgr niflsplsis tafsmlclga qdstldeikq gfnfrkmpek dlhegfhyii
      121 heltqktqdl klsigntlfi dqrlqpqrkf ledaknfysa etiltnfqnl emaqkqindf
      181 isqkthgkin nlienidpgt vmllanyiff rarwkhefdp nvtkeedffl eknssvkvpm
      241 mfrsgiyqvg yddklsctil eipyqknita ifilpdegkl khlekglqvd tfsrwktlls
      301 rrvvdvsvpr lhmtgtfdlk ktlsyigvsk ifeehgdltk iaphrslkvg eavhkaelkm
      361 dergtegaag tgaqtlpmet plvvkidkpy llliysekip svlflgkivn pigk
//
