LOCUS       NM_001080451            1486 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens serpin family A member 11 (SERPINA11), transcript
            variant 1, mRNA.
ACCESSION   NM_001080451 XM_170754
VERSION     NM_001080451.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1486)
  AUTHORS   Aggarwal,S., Vineeth,V.S., Padwal,S.S., Bhat,S.A., Singh,A.,
            Kulkarni,A., Patil,M., Tallapaka,K., Pasumarthi,D.,
            Venkatapuram,V., Thotakura,P.L., Dalal,A. and Bhandari,R.
  TITLE     SERPINA11 related novel serpinopathy - A perinatal lethal disorder
  JOURNAL   Clin Genet 106 (3), 367-373 (2024)
   PUBMED   38831697
  REMARK    GeneRIF: SERPINA11 related novel serpinopathy - A perinatal lethal
            disorder.
REFERENCE   2  (bases 1 to 1486)
  AUTHORS   Caso,E., Maestro,A., Sabiers,C.C., Godino,M., Caracuel,Z., Pons,J.,
            Gonzalez,F.J., Bautista,R., Claros,M.G., Caso-Onzain,J.,
            Viejo-Allende,E., Giannoudis,P.V., Alvarez,S., Maietta,P. and
            Guerado,E.
  TITLE     Whole-exome sequencing analysis in twin sibling males with an
            anterior cruciate ligament rupture
  JOURNAL   Injury 47 Suppl 3, S41-S50 (2016)
   PUBMED   27692106
REFERENCE   3  (bases 1 to 1486)
  AUTHORS   Lin,K.T., Shann,Y.J., Chau,G.Y., Hsu,C.N. and Huang,C.Y.
  TITLE     Identification of latent biomarkers in hepatocellular carcinoma by
            ultra-deep whole-transcriptome sequencing
  JOURNAL   Oncogene 33 (39), 4786-4794 (2014)
   PUBMED   24141781
  REMARK    Erratum:[Oncogene. 2016 Sep 22;35(38):5078. doi:
            10.1038/onc.2016.62.. PMID: 27477694]
REFERENCE   4  (bases 1 to 1486)
  AUTHORS   Heit,C., Jackson,B.C., McAndrews,M., Wright,M.W., Thompson,D.C.,
            Silverman,G.A., Nebert,D.W. and Vasiliou,V.
  TITLE     Update of the human and mouse SERPIN gene superfamily
  JOURNAL   Hum Genomics 7 (1), 22 (2013)
   PUBMED   24172014
  REMARK    Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1486)
  AUTHORS   Lyons,P.A., Rayner,T.F., Trivedi,S., Holle,J.U., Watts,R.A.,
            Jayne,D.R., Baslund,B., Brenchley,P., Bruchfeld,A., Chaudhry,A.N.,
            Cohen Tervaert,J.W., Deloukas,P., Feighery,C., Gross,W.L.,
            Guillevin,L., Gunnarsson,I., Harper,L., Hruskova,Z., Little,M.A.,
            Martorana,D., Neumann,T., Ohlsson,S., Padmanabhan,S., Pusey,C.D.,
            Salama,A.D., Sanders,J.S., Savage,C.O., Segelmark,M.,
            Stegeman,C.A., Tesar,V., Vaglio,A., Wieczorek,S., Wilde,B.,
            Zwerina,J., Rees,A.J., Clayton,D.G. and Smith,K.G.
  TITLE     Genetically distinct subsets within ANCA-associated vasculitis
  JOURNAL   N Engl J Med 367 (3), 214-223 (2012)
   PUBMED   22808956
REFERENCE   6  (bases 1 to 1486)
  AUTHORS   Parris,T.Z., Danielsson,A., Nemes,S., Kovacs,A., Delle,U.,
            Fallenius,G., Mollerstrom,E., Karlsson,P. and Helou,K.
  TITLE     Clinical implications of gene dosage and gene expression patterns
            in diploid breast carcinoma
  JOURNAL   Clin Cancer Res 16 (15), 3860-3874 (2010)
   PUBMED   20551037
REFERENCE   7  (bases 1 to 1486)
  AUTHORS   Namciu,S.J., Friedman,R.D., Marsden,M.D., Sarausad,L.M.,
            Jasoni,C.L. and Fournier,R.E.
  TITLE     Sequence organization and matrix attachment regions of the human
            serine protease inhibitor gene cluster at 14q32.1
  JOURNAL   Mamm Genome 15 (3), 162-178 (2004)
   PUBMED   15014966
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL132708.3.
            
            On Nov 23, 2018 this sequence version replaced NM_001080451.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.93981.1,
                                           SRR5189664.92467.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA2145122 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000334708.4/ ENSP00000335024.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-15                AL132708.3         63853-63867
            16-72               AL132708.3         63868-63924
            73-718              AL132708.3         67876-68521
            719-992             AL132708.3         70049-70322
            993-1140            AL132708.3         73428-73575
            1141-1486           AL132708.3         73844-74189
FEATURES             Location/Qualifiers
     source          1..1486
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.13"
     gene            1..1486
                     /gene="SERPINA11"
                     /note="serpin family A member 11"
                     /db_xref="GeneID:256394"
                     /db_xref="HGNC:HGNC:19193"
                     /db_xref="MIM:619619"
     exon            1..72
                     /gene="SERPINA11"
                     /inference="alignment:Splign:2.1.0"
     exon            73..718
                     /gene="SERPINA11"
                     /inference="alignment:Splign:2.1.0"
     CDS             76..1344
                     /gene="SERPINA11"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; antiproteinase-like 2; serine (or cysteine)
                     proteinase inhibitor, clade A (alpha-1 antiproteinase,
                     antitrypsin), member 11; serpin A11; serpin peptidase
                     inhibitor, clade A (alpha-1 antiproteinase, antitrypsin),
                     member 11"
                     /codon_start=1
                     /product="serpin A11 isoform 1 precursor"
                     /protein_id="NP_001073920.1"
                     /db_xref="CCDS:CCDS32149.1"
                     /db_xref="GeneID:256394"
                     /db_xref="HGNC:HGNC:19193"
                     /db_xref="MIM:619619"
                     /translation="MGPAWLWLLGTGILASVHCQPLLAHGDKSLQGPQPPRHQLSEPA
                     PAYHRITPTITNFALRLYKELAADAPGNIFFSPVSISTTLALLSLGAQANTSALILEG
                     LGFNLTETPEADIHQGFRSLLHTLALPSPKLELKVGNSLFLDKRLKPRQHYLDSIKEL
                     YGAFAFSANFTDSVTTGRQINDYLRRQTYGQVVDCLPEFSQDTFMVLANYIFFKAKWK
                     HPFSRYQTQKQESFFVDERTSLQVPMMHQKEMHRFLYDQDLACTVLQIEYRGNALALL
                     VLPDPGKMKQVEAALQPQTLRKWGQLLLPSLLDLHLPRFSISGTYNLEDILPQIGLTN
                     ILNLEADFSGVTGQLNKTISKVSHKAMVDMSEKGTEAGAASGLLSQPPSLNTMSDPHA
                     HFNRPFLLLLWEVTTQSLLFLGKVVNPVAG"
     exon            719..992
                     /gene="SERPINA11"
                     /inference="alignment:Splign:2.1.0"
     exon            993..1140
                     /gene="SERPINA11"
                     /inference="alignment:Splign:2.1.0"
     exon            1141..1486
                     /gene="SERPINA11"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1460..1465
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERPINA11"
                     /note="hexamer: AATAAA"
     polyA_site      1486
                     /gene="SERPINA11"
                     /note="major polyA site"
ORIGIN      
        1 aaacaccatt ttcctgtggg tagaggtgat gcagtgctga agacctgggc ccctgctcag
       61 tgcctttgct ctagaatggg tccagcttgg ctttggctac tgggaacagg gatcctggcc
      121 tctgtccact gtcagcccct tcttgcccat ggagataaaa gtctgcaggg gcctcaaccc
      181 cccaggcatc agctctcaga gccagccccc gcctaccaca gaatcacacc caccattacc
      241 aattttgctt tgcgtttgta taaagagctg gcagcagacg cccccggaaa catcttcttc
      301 tcgccagtga gcatctccac caccctggcc ctgctctctc ttggggccca agctaacacc
      361 tcagctctga tcctggaggg cctgggattc aacctcacag aaacccctga agccgacatc
      421 caccagggct tccggagcct cctccacacc cttgccctgc ccagccccaa actcgaacta
      481 aaagtaggaa actccctgtt cctagacaag cgactaaagc ctcggcagca ctatttggac
      541 agcatcaagg agctttatgg agcttttgct ttttctgcca acttcacaga ttctgttaca
      601 actgggaggc agattaatga ctatttgaga aggcaaacat acgggcaagt cgtggactgc
      661 ctcccggagt tcagccagga cacgttcatg gttcttgcca attacatctt cttcaaagcc
      721 aagtggaagc accctttcag tcgctaccag acccagaagc aggaaagttt ctttgtggat
      781 gagaggactt ctctccaggt ccccatgatg caccaaaagg aaatgcacag attcctctat
      841 gaccaggatt tggcttgcac cgtcctccag atagaataca gaggaaatgc cttggcgctg
      901 ctggtcctcc ctgacccggg gaaaatgaag caggtggagg ctgctctgca gccacagacc
      961 ctgagaaaat ggggccaatt gctcctgccc agtctgttgg atttgcactt gccaaggttt
     1021 tcaatttctg gaacatataa cctggaagac atacttcccc aaattggtct caccaacata
     1081 ctcaacttag aagctgactt ctcaggagtc actgggcagc tcaacaaaac catctccaag
     1141 gtgtcacaca aggcgatggt ggacatgagt gagaagggga ccgaggccgg ggctgcttca
     1201 ggcctcctct cccagccccc atctctgaac accatgtcag acccacatgc ccacttcaac
     1261 aggcctttcc tcttgctcct ttgggaggtc accacccaga gcttactctt cctgggaaaa
     1321 gttgtcaacc cagttgcagg gtaaccatgg tgggaggcca ggagttatct tatctcatcc
     1381 tggaccaaac agataggcca gaaccagcct gcatcctggg gctgctatgt ggttcagtta
     1441 atcagtgtgc caagattcta ataaagttga ccttgggttc tgtgaa
//
