LOCUS       NM_001100607            4970 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens serpin family A member 10 (SERPINA10), transcript
            variant 2, mRNA.
ACCESSION   NM_001100607
VERSION     NM_001100607.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4970)
  AUTHORS   Huang,X., Swanson,R. and Olson,S.T.
  TITLE     Heparin activation of protein Z-dependent protease inhibitor (ZPI)
            allosterically blocks protein Z activation through an extended
            heparin-binding site
  JOURNAL   J Biol Chem 298 (6), 102022 (2022)
   PUBMED   35551912
  REMARK    GeneRIF: Heparin activation of protein Z-dependent protease
            inhibitor (ZPI) allosterically blocks protein Z activation through
            an extended heparin-binding site.
REFERENCE   2  (bases 1 to 4970)
  AUTHORS   Zhang,P., Li,Y.C., Li,L. and Lu,Y.
  TITLE     Plasma concentration of protein Z-dependent protease inhibitor and
            ZPI exon 3 mutations in preeclampsia
  JOURNAL   J Obstet Gynaecol 41 (7), 1053-1056 (2021)
   PUBMED   33427552
  REMARK    GeneRIF: Plasma concentration of protein Z-dependent protease
            inhibitor and ZPI exon 3 mutations in preeclampsia.
REFERENCE   3  (bases 1 to 4970)
  AUTHORS   Huang,X., Swanson,R., Kroh,H.K. and Bock,P.E.
  TITLE     Protein Z-dependent protease inhibitor (ZPI) is a physiologically
            significant inhibitor of prothrombinase function
  JOURNAL   J Biol Chem 294 (19), 7644-7657 (2019)
   PUBMED   30918026
  REMARK    GeneRIF: these results suggest an important anticoagulant role for
            the ZPI-PZ complex in regulating both free FXa generated in the
            initiation phase of coagulation as well as prothrombinase-bound FXa
            in the propagation phase that complement prothrombinase regulation
            by APC.
REFERENCE   4  (bases 1 to 4970)
  AUTHORS   Karakoyun,S., Ozan Gursoy,M., Kalcik,M., Yesin,M., Gunduz,S., Ali
            Astarcioglu,M., Bayram,Z., Cakal,B., Bayam,E. and Ozkan,M.
  TITLE     The Role of Protein Z and Protein Z-Dependent Protease Inhibitor
            Polymorphisms in the Development of Prosthetic Heart Valve
            Thrombosis
  JOURNAL   J Heart Valve Dis 26 (4), 460-466 (2017)
   PUBMED   29302946
  REMARK    GeneRIF: PZ/ZPI polymorphisms do not appear to play an active role
            in the development of prosthesis heart valve thrombosis.
REFERENCE   5  (bases 1 to 4970)
  AUTHORS   Clark,H.F., Gurney,A.L., Abaya,E., Baker,K., Baldwin,D., Brush,J.,
            Chen,J., Chow,B., Chui,C., Crowley,C., Currell,B., Deuel,B.,
            Dowd,P., Eaton,D., Foster,J., Grimaldi,C., Gu,Q., Hass,P.E.,
            Heldens,S., Huang,A., Kim,H.S., Klimowski,L., Jin,Y., Johnson,S.,
            Lee,J., Lewis,L., Liao,D., Mark,M., Robbie,E., Sanchez,C.,
            Schoenfeld,J., Seshagiri,S., Simmons,L., Singh,J., Smith,V.,
            Stinson,J., Vagts,A., Vandlen,R., Watanabe,C., Wieand,D., Woods,K.,
            Xie,M.H., Yansura,D., Yi,S., Yu,G., Yuan,J., Zhang,M., Zhang,Z.,
            Goddard,A., Wood,W.I., Godowski,P. and Gray,A.
  TITLE     The secreted protein discovery initiative (SPDI), a large-scale
            effort to identify novel human secreted and transmembrane proteins:
            a bioinformatics assessment
  JOURNAL   Genome Res 13 (10), 2265-2270 (2003)
   PUBMED   12975309
  REMARK    Erratum:[Genome Res. 2003 Dec;13(12):2759]
REFERENCE   6  (bases 1 to 4970)
  AUTHORS   Bray,C., Son,J.H., Kumar,P., Harris,J.D. and Meizel,S.
  TITLE     A role for the human sperm glycine receptor/Cl(-) channel in the
            acrosome reaction initiated by recombinant ZP3
  JOURNAL   Biol Reprod 66 (1), 91-97 (2002)
   PUBMED   11751269
REFERENCE   7  (bases 1 to 4970)
  AUTHORS   Han,X., Fiehler,R. and Broze,G.J. Jr.
  TITLE     Characterization of the protein Z-dependent protease inhibitor
  JOURNAL   Blood 96 (9), 3049-3055 (2000)
   PUBMED   11049983
REFERENCE   8  (bases 1 to 4970)
  AUTHORS   Yin,Z.F., Huang,Z.F., Cui,J., Fiehler,R., Lasky,N., Ginsburg,D. and
            Broze,G.J. Jr.
  TITLE     Prothrombotic phenotype of protein Z deficiency
  JOURNAL   Proc Natl Acad Sci U S A 97 (12), 6734-6738 (2000)
   PUBMED   10829076
REFERENCE   9  (bases 1 to 4970)
  AUTHORS   Han,X., Huang,Z.F., Fiehler,R. and Broze,G.J. Jr.
  TITLE     The protein Z-dependent protease inhibitor is a serpin
  JOURNAL   Biochemistry 38 (34), 11073-11078 (1999)
   PUBMED   10460162
REFERENCE   10 (bases 1 to 4970)
  AUTHORS   Han,X., Fiehler,R. and Broze,G.J. Jr.
  TITLE     Isolation of a protein Z-dependent plasma protease inhibitor
  JOURNAL   Proc Natl Acad Sci U S A 95 (16), 9250-9255 (1998)
   PUBMED   9689066
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC022261.1, AF181467.1 and
            AL117259.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 23, 2018 this sequence version replaced NM_001100607.2.
            
            Summary: The protein encoded by this gene belongs to the serpin
            family. It is predominantly expressed in the liver and secreted in
            plasma. It inhibits the activity of coagulation factors Xa and XIa
            in the presence of protein Z, calcium and phospholipid. Mutations
            in this gene are associated with venous thrombosis. Alternatively
            spliced transcript variants have been found for this gene.[provided
            by RefSeq, May 2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1 and 2 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR5189664.132982.1,
                                           SRR5189664.165771.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2155590, SAMEA2162895
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261994.9/ ENSP00000261994.4
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-2113              BC022261.1         4-2116
            2114-2117           AF181467.1         2449-2452
            2118-4970           AL117259.6         107260-110112
FEATURES             Location/Qualifiers
     source          1..4970
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="14"
                     /map="14q32.13"
     gene            1..4970
                     /gene="SERPINA10"
                     /gene_synonym="PZI; ZPI"
                     /note="serpin family A member 10"
                     /db_xref="GeneID:51156"
                     /db_xref="HGNC:HGNC:15996"
                     /db_xref="MIM:605271"
     exon            1..80
                     /gene="SERPINA10"
                     /gene_synonym="PZI; ZPI"
                     /inference="alignment:Splign:2.1.0"
     exon            81..848
                     /gene="SERPINA10"
                     /gene_synonym="PZI; ZPI"
                     /inference="alignment:Splign:2.1.0"
     CDS             131..1465
                     /gene="SERPINA10"
                     /gene_synonym="PZI; ZPI"
                     /note="protein Z-dependent protease inhibitor; serine (or
                     cysteine) proteinase inhibitor, clade A (alpha-1
                     antiproteinase, antitrypsin), member 10; PZ-dependent
                     protease inhibitor; serpin A10; serpin peptidase
                     inhibitor, clade A (alpha-1 antiproteinase, antitrypsin),
                     member 10; Protein-Z dependent proteinase inhibitor"
                     /codon_start=1
                     /product="protein Z-dependent protease inhibitor
                     precursor"
                     /protein_id="NP_001094077.1"
                     /db_xref="CCDS:CCDS9923.1"
                     /db_xref="GeneID:51156"
                     /db_xref="HGNC:HGNC:15996"
                     /db_xref="MIM:605271"
                     /translation="MKVVPSLLLSVLLAQVWLVPGLAPSPQSPETPAPQNQTSRVVQA
                     PKEEEEDEQEASEEKASEEEKAWLMASRQQLAKETSNFGFSLLRKISMRHDGNMVFSP
                     FGMSLAMTGLMLGATGPTETQIKRGLHLQALKPTKPGLLPSLFKGLRETLSRNLELGL
                     TQGSFAFIHKDFDVKETFFNLSKRYFDTECVPMNFRNASQAKRLMNHYINKETRGKIP
                     KLFDEINPETKLILVDYILFKGKWLTPFDPVFTEVDTFHLDKYKTIKVPMMYGAGKFA
                     STFDKNFRCHVLKLPYQGNATMLVVLMEKMGDHLALEDYLTTDLVETWLRNMKTRNME
                     VFFPKFKLDQKYEMHELLRQMGIRRIFSPFADLSELSATGRNLQVSRVLQRTVIEVDE
                     RGTEAVAGILSEITAYSMPPVIKVDRPFHFMIYEETSGMLLFLGRVVNPTLL"
     exon            849..1122
                     /gene="SERPINA10"
                     /gene_synonym="PZI; ZPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1123..1273
                     /gene="SERPINA10"
                     /gene_synonym="PZI; ZPI"
                     /inference="alignment:Splign:2.1.0"
     exon            1274..4970
                     /gene="SERPINA10"
                     /gene_synonym="PZI; ZPI"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2094..2099
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERPINA10"
                     /gene_synonym="PZI; ZPI"
                     /note="hexamer: ATTAAA"
     polyA_site      2119
                     /gene="SERPINA10"
                     /gene_synonym="PZI; ZPI"
                     /note="major polyA site"
     regulatory      2263..2268
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERPINA10"
                     /gene_synonym="PZI; ZPI"
                     /note="hexamer: GATAAA"
     polyA_site      2292
                     /gene="SERPINA10"
                     /gene_synonym="PZI; ZPI"
     regulatory      4949..4954
                     /regulatory_class="polyA_signal_sequence"
                     /gene="SERPINA10"
                     /gene_synonym="PZI; ZPI"
                     /note="hexamer: AATAAA"
     polyA_site      4970
                     /gene="SERPINA10"
                     /gene_synonym="PZI; ZPI"
ORIGIN      
        1 gaaggttctg ggctgcaaag ctgaagcttt ggtttctgct ctaaatgaag gacttttcca
       61 ggacccaagg ccacacactg gaagtcttgc agctgaaggg aggcactcct tggcctccgc
      121 agccgatcac atgaaggtgg tgccaagtct cctgctctcc gtcctcctgg cacaggtgtg
      181 gctggtaccc ggcttggccc ccagtcctca gtcgccagag accccagccc ctcagaacca
      241 gaccagcagg gtagtgcagg ctcccaagga ggaagaggaa gatgagcagg aggccagcga
      301 ggagaaggcc agtgaggaag agaaagcctg gctgatggcc agcaggcagc agcttgccaa
      361 ggagacttca aacttcggat tcagcctgct gcgaaagatc tccatgaggc acgatggcaa
      421 catggtcttc tctccatttg gcatgtcctt ggccatgaca ggcttgatgc tgggggccac
      481 agggccgact gaaacccaga tcaagagagg gctccacttg caggccctga agcccaccaa
      541 gcccgggctc ctgccttccc tctttaaggg actcagagag accctctccc gcaacctgga
      601 actgggcctc acacagggga gttttgcctt catccacaag gattttgatg tcaaagagac
      661 tttcttcaat ttatccaaga ggtattttga tacagagtgc gtgcctatga attttcgcaa
      721 tgcctcacag gccaaaaggc tcatgaatca ttacattaac aaagagactc gggggaaaat
      781 tcccaaactg tttgatgaga ttaatcctga aaccaaatta attcttgtgg attacatctt
      841 gttcaaaggg aaatggttga ccccatttga ccctgtcttc accgaagtcg acactttcca
      901 cctggacaag tacaagacca ttaaggtgcc catgatgtac ggtgcaggca agtttgcctc
      961 cacctttgac aagaattttc gttgtcatgt cctcaaactg ccctaccaag gaaatgccac
     1021 catgctggtg gtcctcatgg agaaaatggg tgaccacctc gcccttgaag actacctgac
     1081 cacagacttg gtggagacat ggctcagaaa catgaaaacc agaaacatgg aagttttctt
     1141 tccgaagttc aagctagatc agaagtatga gatgcatgag ctgcttaggc agatgggaat
     1201 cagaagaatc ttctcaccct ttgctgacct tagtgaactc tcagctactg gaagaaatct
     1261 ccaagtatcc agggttttac aaagaacagt gattgaagtt gatgaaaggg gcactgaggc
     1321 agtggcagga atcttgtcag aaattactgc ttattccatg cctcctgtca tcaaagtgga
     1381 ccggccattt catttcatga tctatgaaga aacctctgga atgcttctgt ttctgggcag
     1441 ggtggtgaat ccgactctcc tataattcag gacacgcata agcacttcgt gctgtagtag
     1501 atgctgaatc tgaggtatca aacacacaca ggataccagc aatggatggc aggggagagt
     1561 gttccttttg ttcttaacta gtttagggtg ttctcaaata aatacagtag tccccactta
     1621 tctgaggggg atacattcaa agacccccag cagatgcctg aaacggtgga cagtgctgaa
     1681 ccttatatat attttttcct acacatacat acctatgata aagtttaatt tataaattag
     1741 gcacagtaag agattaacaa taataacaac attaagtaaa atgagttact tgaatgcaag
     1801 cactgcaata ccataacagt caaactgatt atagagaagg ctactaagtg actcatgggc
     1861 gaggagcata gacagtgtgg agacattggg caaggggaga attcacatcc tgggtgggac
     1921 agagcaggac aatgcaagat tccatcccac tactcagaat ggcatgctgc ttaagacttt
     1981 tagattgttt atttctggaa tttttcattt aatgtttttg gaccatggtt gaccatggtt
     2041 aactgagact gcagaaagca aaaccatgga taagggagga ctactacaaa agcattaaat
     2101 tgatacatat tttttaagat gtttgtgcaa tctgtctggt attttaagct tgtttctaag
     2161 aaccttagtt acttggctaa agactagctg ggtagaatat cttttctctg ttgctcacat
     2221 attttcattt ttaaaaagtt gcagatgaga acactatgtc aagataaagc ctttgggagg
     2281 aacacatgta aacattctcc ttgagtcatg tgcttctctc tctttccttc tctctggtgc
     2341 aaaataagtg ttttatttta atctattacg gagtcatttc ttgctgactg acatcagaag
     2401 aaaatagctc taaccagtcc tgatcacagc atctgcttcc atggtgcatc aaatcgcttg
     2461 gcagaggcat tggctgaatc acagatcatc tagttcaata ccttcatttt acaaaggaaa
     2521 gaaagaggga cccagaaaca ggtccatatt cttactttca tgggccctag gcacgtttaa
     2581 ccttgtagac tcctccttcc ttcatgaaga tatatatgtt ctatggctgc attggtagaa
     2641 agatgaatat attcgtcttt caaagttgca tatctagctt caaagttata tgtctagcat
     2701 atggcaataa gcaaaacacc ttcatgggcc cttacagtac tgtcagcctt gggcactgtg
     2761 tcttctgcat ctagtggata agtcatacct tatataccag tgggaacaaa atacttgtcc
     2821 aaggtcttcc agtgtggcaa tggcagagtc agaagcctac ctttcctgag tctagtctcc
     2881 aagccctttt tactcttcct tccatctaaa acatctgatg gggaccaggt aaacagcatg
     2941 cactacagct acccatgggg gttaaacaga atataagcat gaactttgtc ccagggtgaa
     3001 aaggaaaatc gtaaatatcc ctgatcttcc ttaggcagtt attttctgtc acagaaacag
     3061 aaaagactat attcagagaa tcctgaatag agctgattta cagtgtgaac tatgttaact
     3121 aaatgcctaa ttggatttct gtctgtctgc tatctaatgt ttaaaaaaac ctaaaattca
     3181 tttattgatt agttgtttaa tataattcag agtaatgtga ataggtaata atattaatat
     3241 gcagtctaaa tactgacttt tcatcattcc ataacctgga ctgatgaaaa gtcagtattt
     3301 agactgcata ttaataaaat aaaattcatt cctgtattca ttccaagagt actaattgac
     3361 acttatgaag ggacaggcaa ttctaggccc tagagggcca aagacagagg actaactcta
     3421 tctgacattc ttaagtcacc ttgtttgtgt tcaattagtc agatttgttt gtggaaaaat
     3481 agtagaaaga ggaataaagt agcatccagt ccaatttccc acttttaaga gatgaaatct
     3541 ggaaaaataa gtctgtgaga gcacaatact cactgaaatc aatatggcca aacccagtaa
     3601 taaaaaggta cattattatt gaaggattca tatagcatgc agataaaaaa ctcctgcctt
     3661 cttcccacca catacactgc aaagcaacaa cagcataata attgtattta atatactact
     3721 ctttaaggta gaaaatggac ctattctata ttttaaatat actttttaat gttccctcac
     3781 atttgcttta agaagttcct aagacactca gtttcagatt tcccaagtac acaggcatga
     3841 cagaaaaacg cagaccaata aaaaatgtaa cttaccttac acaaatacat acacacaaat
     3901 tcagggtttc caaccgagcg ggggaaatct taacattgta gaagtcttca ctatatatgt
     3961 gtcgagtttt tgtttttgtt tttgtttttg ttttgagaca gagtcttgct ctgtcaccca
     4021 ggctggagtg cagtggtgcg atctcagctc actgcaacct ccacctcccg ggttcgtgcc
     4081 attctcctgc ctcagcctcc cgagtagctg ggactacagg cacctgccac cacgaccggc
     4141 taattttttg tattttaagt agagatgggg tttcactgtg ttagtcagga tggtcttgat
     4201 ctcctgacct tgtgatctgc ccgcctcggc ctcccaaagt gctgggatta caggcatgag
     4261 ccaccacgcc cggccaagtg tcgagtctta aaaattgttc ctacacagac acactcaacc
     4321 acacgttctc acatatatat gctgtaacaa ctgagaacag gttactgact taatctaatt
     4381 cattctatct tcattgtaaa acttccactc cagctgaaga gcctgtttca tttcaattca
     4441 aagatttctc atatatccac taattgtatg gcaaaactga ctcatctcca gactaagata
     4501 ttcaagctca ggaagtcaaa taatagaaat gattttttaa atgtgtaaga ggttataaag
     4561 aaaaacttta tgtgctcctt atttaacctc tattaagtaa aatcctttat agacctatct
     4621 ccatttctgc agtaaaagtg agctctacag ttagcttgta aggctaacta gtgaaattcc
     4681 tggacttgtt cttaaaaatg caagttttag taattaacaa aatgatgatg aagatgtccc
     4741 ttttccctac aactacagat ggagggagat ttttctttgc catacaacta gcttaaagga
     4801 ttaatttgat aagttgttaa actgagaact ttcacaaaag tatccatctt gtttttgata
     4861 taaatggaga tacatgtagt tattcataac tgtcagtaat ttgctgttta tcctgtttct
     4921 atatatctgt ccttgagagt ataattttaa taaatatttc aaagatttta
//
